The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform
Kunihiro Sumoto - One of the best experts on this subject based on the ideXlab platform.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type hydantoin derivatives
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Ayumi Naito, Enko Fukami, Nobuhiro Kashige, Fumio Miake, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type hydantoin derivatives (VII) are synthesized.
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Synthesis of New 5‐Substituted Hydantoins and Symmetrical Twin‐Drug Type Hydantoin Derivatives.
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Ayumi Naito, Enko Fukami, Nobuhiro Kashige, Fumio Miake, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type hydantoin derivatives (VII) are synthesized.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type hydantoin derivatives
Chemical & Pharmaceutical Bulletin, 2014Co-Authors: Fumiko Fujisaki, Ayumi Naito, Enko Fukami, Nobuhiro Kashige, Fumio Miake, Kunihiro SumotoAbstract:: In connection with our studies on hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene Hydantoins 4a-c to 5-aminomethyl-substituted Hydantoins 5-10 or to 5-amino-5-methyl-disubstituted Hydantoins 11-14 is described. Synthesis of bivalent twin-drug type hydantoin derivatives 19-24 and the binding property of a bivalent symmetrical hydantoin derivative 24b to sulfated glycosaminoglycans are also described.
Matteo Zanda - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 1 3 5 trisubstituted Hydantoins by regiospecific domino condensation aza michael o n acyl migration of carbodiimides with activated α β unsaturated carboxylic acids
Journal of Organic Chemistry, 2005Co-Authors: Alessandro Volonterio, Carmen Ramirez De Arellano, Matteo ZandaAbstract:Carbodiimides and suitably activated α,β-unsaturated carboxylic acids react effectively to afford a vast array of 1,3,5-trisubstituted Hydantoins by means of a regiospecific domino condensation/aza-Michael/N→O acyl migration. The reaction works well in very mild conditions (20 °C, dichloromethane) with fumaric acid derivatives bearing an electron-withdrawing group in the β position. Good results have been obtained also with less activated substrates bearing only one electron-withdrawing group in the β position, using more polar solvents (acetonitrile, DMF), and in the presence of a base (2,4,6-trimethylpyridine). Reactions with asymmetric carbodiimides are generally highly chemo- and regioselective, giving rise to the formation of a single regioisomeric hydantoin. However, asymmetric carbodiimides bearing one alkyl group and one aryl group can produce variable amounts of N-acylurea byproducts. The latter could be easily recovered and transformed into the corresponding Hydantoins. A detailed study of the i...
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domino condensation aza michael o n acyl migration of carbodiimides with activated α β unsaturated carboxylic acids to form Hydantoins
Tetrahedron Letters, 2003Co-Authors: Alessandro Volonterio, Matteo ZandaAbstract:Activated α,β-unsaturated carboxylic acids undergo an unexpected domino condensation/aza-Michael/O→N acyl migration with carbodiimides, producing N,N-disubstituted Hydantoins in good yields. An array of structurally varied aspartic acid-derived Hydantoins, including some fluorinated derivatives, have been synthesized by this method, whose scope and limits are discussed.
Fumiko Fujisaki - One of the best experts on this subject based on the ideXlab platform.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type hydantoin derivatives
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Ayumi Naito, Enko Fukami, Nobuhiro Kashige, Fumio Miake, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type hydantoin derivatives (VII) are synthesized.
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Synthesis of New 5‐Substituted Hydantoins and Symmetrical Twin‐Drug Type Hydantoin Derivatives.
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Ayumi Naito, Enko Fukami, Nobuhiro Kashige, Fumio Miake, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type hydantoin derivatives (VII) are synthesized.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type hydantoin derivatives
Chemical & Pharmaceutical Bulletin, 2014Co-Authors: Fumiko Fujisaki, Ayumi Naito, Enko Fukami, Nobuhiro Kashige, Fumio Miake, Kunihiro SumotoAbstract:: In connection with our studies on hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene Hydantoins 4a-c to 5-aminomethyl-substituted Hydantoins 5-10 or to 5-amino-5-methyl-disubstituted Hydantoins 11-14 is described. Synthesis of bivalent twin-drug type hydantoin derivatives 19-24 and the binding property of a bivalent symmetrical hydantoin derivative 24b to sulfated glycosaminoglycans are also described.
Wolfgang Rapp - One of the best experts on this subject based on the ideXlab platform.
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Solid phase synthesis of Hydantoins by thermal cyclization and screening of reaction conditions using APOS 1200
Molecular Diversity, 1998Co-Authors: Wilhelm Karnbrock, Martin Deeg, Jürgen Gerhardt, Wolfgang RappAbstract:A novel strategy for solid-phase synthesis of Hydantoins with highoptical purity is described using a thermal pH-neutral cyclization and simultaneous release from resin. Hereby even Hydantoins bearinga pH-sensitive side chain (protection) are available. The reaction conditions are well screened applying the parallel organic synthesizerAPOS 1200.
Alessandro Volonterio - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 1 3 5 trisubstituted Hydantoins by regiospecific domino condensation aza michael o n acyl migration of carbodiimides with activated α β unsaturated carboxylic acids
Journal of Organic Chemistry, 2005Co-Authors: Alessandro Volonterio, Carmen Ramirez De Arellano, Matteo ZandaAbstract:Carbodiimides and suitably activated α,β-unsaturated carboxylic acids react effectively to afford a vast array of 1,3,5-trisubstituted Hydantoins by means of a regiospecific domino condensation/aza-Michael/N→O acyl migration. The reaction works well in very mild conditions (20 °C, dichloromethane) with fumaric acid derivatives bearing an electron-withdrawing group in the β position. Good results have been obtained also with less activated substrates bearing only one electron-withdrawing group in the β position, using more polar solvents (acetonitrile, DMF), and in the presence of a base (2,4,6-trimethylpyridine). Reactions with asymmetric carbodiimides are generally highly chemo- and regioselective, giving rise to the formation of a single regioisomeric hydantoin. However, asymmetric carbodiimides bearing one alkyl group and one aryl group can produce variable amounts of N-acylurea byproducts. The latter could be easily recovered and transformed into the corresponding Hydantoins. A detailed study of the i...
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domino condensation aza michael o n acyl migration of carbodiimides with activated α β unsaturated carboxylic acids to form Hydantoins
Tetrahedron Letters, 2003Co-Authors: Alessandro Volonterio, Matteo ZandaAbstract:Activated α,β-unsaturated carboxylic acids undergo an unexpected domino condensation/aza-Michael/O→N acyl migration with carbodiimides, producing N,N-disubstituted Hydantoins in good yields. An array of structurally varied aspartic acid-derived Hydantoins, including some fluorinated derivatives, have been synthesized by this method, whose scope and limits are discussed.
