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Farrokh Saidi - One of the best experts on this subject based on the ideXlab platform.
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Predicting the outcome of asymptomatic univesicular liver Hydatids: diagnostic accuracy of unenhanced CT
European Radiology, 2021Co-Authors: Farrokh Habibzadeh, Parham Habibzadeh, Alireza Shakibafard, Farrokh SaidiAbstract:Objectives To establish the role of unenhanced CT in predicting the outcome of liver hydatid cysts. We sought to determine whether the presence of laminated membrane detachment (LMD) or pericyst degenerative changes (PDCs) detected on CT were reliable signs for predicting a favorable outcome of liver Hydatids. Methods In a 20-year-long study, we prospectively followed changes occurred in CT of 106 cysts of 98 patients with incidentally discovered asymptomatic univesicular liver Hydatids who accepted to enter a watch-and-wait program. An “unfavorable” outcome was defined as the occurrence of a complication (most commonly, cyst fistula or infection) or increase in the cyst size during the follow-up; otherwise, the outcome was considered “favorable.” The parameters derived from a binary logistic regression analysis (with the outcome taken as the dependent variable), after appropriate transformation of the independent variables (presence of LMD or PDCs on CT), were used to calculate the sensitivity, specificity, positive and negative likelihood ratios, and positive and negative predictive values of the presence of either the abovementioned CT findings for the prediction of a favorable outcome. Results The presence of LMD or PDCs had a high specificity (88%) and positive predictive value (96%) for a favorable outcome; they had high false-negative rates. Conclusions The presence of either LMD or PDCs on unenhanced CT, in incidentally discovered asymptomatic univesicular liver Hydatids, was associated with a high probability of a favorable outcome. Their absence does not rule out a favorable outcome. Key Points • Computed tomography can be used for predicting the outcome of those with incidentally discovered univesicular liver Hydatids. • The presence of laminated membrane detachment and/or pericyst degenerative changes is associated with a favorable outcome. • Their absence does not necessarily indicate an unfavorable outcome.
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predicting the outcome of asymptomatic univesicular liver Hydatids diagnostic accuracy of unenhanced ct
European Radiology, 2021Co-Authors: Farrokh Habibzadeh, Parham Habibzadeh, Alireza Shakibafard, Farrokh SaidiAbstract:To establish the role of unenhanced CT in predicting the outcome of liver hydatid cysts. We sought to determine whether the presence of laminated membrane detachment (LMD) or pericyst degenerative changes (PDCs) detected on CT were reliable signs for predicting a favorable outcome of liver Hydatids. In a 20-year-long study, we prospectively followed changes occurred in CT of 106 cysts of 98 patients with incidentally discovered asymptomatic univesicular liver Hydatids who accepted to enter a watch-and-wait program. An “unfavorable” outcome was defined as the occurrence of a complication (most commonly, cyst fistula or infection) or increase in the cyst size during the follow-up; otherwise, the outcome was considered “favorable.” The parameters derived from a binary logistic regression analysis (with the outcome taken as the dependent variable), after appropriate transformation of the independent variables (presence of LMD or PDCs on CT), were used to calculate the sensitivity, specificity, positive and negative likelihood ratios, and positive and negative predictive values of the presence of either the abovementioned CT findings for the prediction of a favorable outcome. The presence of LMD or PDCs had a high specificity (88%) and positive predictive value (96%) for a favorable outcome; they had high false-negative rates. The presence of either LMD or PDCs on unenhanced CT, in incidentally discovered asymptomatic univesicular liver Hydatids, was associated with a high probability of a favorable outcome. Their absence does not rule out a favorable outcome. • Computed tomography can be used for predicting the outcome of those with incidentally discovered univesicular liver Hydatids. • The presence of laminated membrane detachment and/or pericyst degenerative changes is associated with a favorable outcome. • Their absence does not necessarily indicate an unfavorable outcome.
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HOW TO MANAGE ASYMPTOMATIC LIVER Hydatids
2015Co-Authors: Farrokh SaidiAbstract:ystic echinococcal disease disappeared many decades ago from industrial countries. Only rarely now, and primarily because of increased international travel, liver Hydatids surface as clinical curiosities at medical conferences in western countries. The situation is usually that of a liver hydatid having ruptured into the biliary system causing bile duct obstruction. Invariably the consensus among discussants is that the patient should have been operated upon much earlier to avoid the cyst becoming complicated. Such a verdict, however, is inappropriate and inapplicable in endemic areas of developing countries where echinococcal disease is still rampant.1 In these regions so many cases o
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how to manage asymptomatic liver Hydatids
Archives of Iranian Medicine, 2006Co-Authors: Farrokh SaidiAbstract:ystic echinococcal disease disappeared many decades ago from industrial countries. Only rarely now, and primarily because of increased international travel, liver Hydatids surface as clinical curiosities at medical conferences in western countries. The situation is usually that of a liver hydatid having ruptured into the biliary system causing bile duct obstruction. Invariably the consensus among discussants is that the patient should have been operated upon much earlier to avoid the cyst becoming complicated. Such a verdict, however, is inappropriate and inapplicable in endemic areas of developing countries where echinococcal disease is still rampant. In these regions so many cases of asymptomatic cases of liver Hydatids are detected in the course of ultrasound investigation for other conditions, that it would impossible to handle all of them surgically. The fact that many liver Hydatids are first encountered as irrgularly calcified and clinically silent lesions, suggests that most liver Hydatids undergo a slow process of spontaneous abortion. They can, therefore, be left alone. An equally important reason for a conservative approach to incidentally discovered liver Hydatids in endemic areas is an economic one. To manage all asymptomatic liver Hydatids prophylactically to avert possible complications, would overwhelm available health resources in endemic areas. To operate on the many, fearing complications in the few, cannot be justified in that setting. Can incidentally discovered asymptomatic liver cysts be treated mediaclly when risk taking, even for the few, is unacceptable? About forty years ago benzimidazole carbamate derivatives, mebendazole first and then albendazole, were reported from Europe to have deleterious effects on the larval stage of the parasite Echinococcus granulosus in man. Mebendazole has been used for many years in India as an effective vermifuge with low absorption rate. Enough experience has accumulated to show that clinical efficacy of these drugs against hydatid cyst is no more than about 50%, even after prolonged administration. Fortunately their toxicity over long periods of time is also very low. 4 It would be reasonable, therefore, to empirically administer these drugs to patients in endemic areas who are accidentally found to have a benign cystic lesion of the liver suspected to be echinococcal. Drug treatment should be continuous and not interrupted, with liver function and the blood picture checked at intervals, and pregnancy avoided in the interim. Both the physician and the patient should fully understand that success is neither guaranteed nor apparent until at least a full year of drug treatment. Involution of the cyst may have been the fate of the cyst and not the effect of the medicine. Given the fact that pharmaceutical companies of industrial countries are not likely to invest money in discovering better drugs for Echinococcosis, a disease seen only in endemic areas of the world, one should not expect a truly effective drug for this parasitic condition becoming available soon. The problem of how and when asymptomatic liver Hydatids should be treated, remains unknown. Another approach to asymptomatic liver Hydatids, also originating in the West, is percutaneous needle aspiration of the cyst followed by instillation of hypertonic saline and 90% alcohol. For a number of reasons this particular form of treatment, while in line with the now fashionable mode of minimal access cannot be recommended, for two reasons: a) While univesicular liver cysts can be needle aspirated, only centrally located multivesicular Hydatids are likely to rupture into major bile ducts and precipitate acute biliary obstruction. Hitting each and every small daughter cyst in these multivesiular lesions is technically impossible and Opinion
Wanzhong Jia - One of the best experts on this subject based on the ideXlab platform.
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mitochondrial genome data confirm that yaks can serve as the intermediate host of echinococcus canadensis g10 on the tibetan plateau
Parasites & Vectors, 2018Co-Authors: Guoqiang Zhu, Xingqua Zhu, Nianzhang Zhang, Wenju Tia, Gang Yao, Wanzhong JiaAbstract:Cervids used to be considered the only animal intermediate hosts of the G10 genotype of Echinococcus canadensis. Yaks are often herded in the Qinghai-Tibet Plateau, China, where echinococcosis remains prevalent. However, no E. canadensis G10 cases have been recorded in yaks until now. The aim of our study was to identify causative agents of echinococcosis in yaks in this region. Total genomic DNA was extracted from the germinal layer of one hydatid using a Blood and Tissue Kit. Full-length mitochondrial (mt) cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) genes were amplified by PCR. All purified PCR products were directly sequenced in both directions. Then seven pairs of overlap primers were designed to amplify the entire mt genome sequence of a suspected E. canadensis G10 isolate. Phylogenetic analyses were performed based on concatenated nucleotides from the 12 protein-coding genes of mt genomes of Echinococcus species in a Bayesian framework using MrBayes v3.1 and implementing the GTR + I + G model. Hydatids were found in yaks (n = 129) when organs were inspected at the slaughterhouse in Maqu county, Gannan Tibetan Autonomous Prefecture, Gansu Province, China in October 2016. Of these, 33 (25.6%) harbored up to a dozen hydatid cysts. One cyst from each yak was characterized by sequencing its mitochondrial (mt) cox1 and nad1 genes. On the basis of these sequence data, 32 cysts were identified as Echinococcus granulosus (sensu stricto) (G1-G3) and the remaining one was identified as the G10 genotype of E. canadensis. Its mt genome was then fully sequenced and compared with that of the G10 genotype in GenBank (AB745463). Phylogenetic analysis using complete mt genomes confirmed the Chinese cyst as belonging to the G10 genotype. To our knowledge, this is the first report globally of E. canadensis (G10) from yaks in China, which suggests that the G10 genotype has a wider geographical distribution and broader host range than previously believed. This genotype has therefore potential risks to human health and animal husbandry.
Habib Thameur - One of the best experts on this subject based on the ideXlab platform.
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Acute pulmonary embolism due to the rupture of a right ventricle hydatic cyst.
European Journal of Cardio-Thoracic Surgery, 2002Co-Authors: Hatem Lahdhili, Sabeur Hachicha, Mohamed Ziadi, Habib ThameurAbstract:Hydatid pulmonary embolism is an uncommon condition resulting from the rupture of a hydatid heart cyst or the opening of a visceral hydatid cyst (often in the liver) into the venous circulation. We report a case of hydatid pulmonary embolism following rupture of a hydatic cyst in the right ventricle. Pulmonary angiography showed right pulmonary occlusion. Echocardiography, computed tomography scan and magnetic resonance imaging showed images suggesting a hydatid cyst. The patient underwent sternotomy and cardiopulmonary bypass in order to treat the heart cyst and remove the hydatic pulmonary obstruction. A concomitant lung hydatid cyst was extirpated.
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Case report Acute pulmonary embolism due to the rupture of a right ventricle hydatic cyst
2002Co-Authors: Hatem Lahdhili, Sabeur Hachicha, Mohamed Ziadi, Habib ThameurAbstract:Hydatid pulmonary embolism is an uncommon condition resulting from the rupture of a hydatid heart cyst or the opening of a visceral hydatid cyst (often in the liver) into the venous circulation. We report a case of hydatid pulmonary embolism following rupture of a hydatic cyst in the right ventricle. Pulmonary angiography showed right pulmonary occlusion. Echocardiography, computed tomography scan and magnetic resonance imaging showed images suggesting a hydatid cyst. The patient underwent sternotomy and cardiopulmonary bypass in order to treat the heart cyst and remove the hydatic pulmonary obstruction. A concomitant lung hydatid cyst was extirpated. q 2002 Published by Elsevier Science B.V.
Guoqiang Zhu - One of the best experts on this subject based on the ideXlab platform.
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mitochondrial genome data confirm that yaks can serve as the intermediate host of echinococcus canadensis g10 on the tibetan plateau
Parasites & Vectors, 2018Co-Authors: Guoqiang Zhu, Xingqua Zhu, Nianzhang Zhang, Wenju Tia, Gang Yao, Wanzhong JiaAbstract:Cervids used to be considered the only animal intermediate hosts of the G10 genotype of Echinococcus canadensis. Yaks are often herded in the Qinghai-Tibet Plateau, China, where echinococcosis remains prevalent. However, no E. canadensis G10 cases have been recorded in yaks until now. The aim of our study was to identify causative agents of echinococcosis in yaks in this region. Total genomic DNA was extracted from the germinal layer of one hydatid using a Blood and Tissue Kit. Full-length mitochondrial (mt) cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) genes were amplified by PCR. All purified PCR products were directly sequenced in both directions. Then seven pairs of overlap primers were designed to amplify the entire mt genome sequence of a suspected E. canadensis G10 isolate. Phylogenetic analyses were performed based on concatenated nucleotides from the 12 protein-coding genes of mt genomes of Echinococcus species in a Bayesian framework using MrBayes v3.1 and implementing the GTR + I + G model. Hydatids were found in yaks (n = 129) when organs were inspected at the slaughterhouse in Maqu county, Gannan Tibetan Autonomous Prefecture, Gansu Province, China in October 2016. Of these, 33 (25.6%) harbored up to a dozen hydatid cysts. One cyst from each yak was characterized by sequencing its mitochondrial (mt) cox1 and nad1 genes. On the basis of these sequence data, 32 cysts were identified as Echinococcus granulosus (sensu stricto) (G1-G3) and the remaining one was identified as the G10 genotype of E. canadensis. Its mt genome was then fully sequenced and compared with that of the G10 genotype in GenBank (AB745463). Phylogenetic analysis using complete mt genomes confirmed the Chinese cyst as belonging to the G10 genotype. To our knowledge, this is the first report globally of E. canadensis (G10) from yaks in China, which suggests that the G10 genotype has a wider geographical distribution and broader host range than previously believed. This genotype has therefore potential risks to human health and animal husbandry.
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Mitochondrial genome data confirm that yaks can serve as the intermediate host of Echinococcus canadensis (G10) on the Tibetan Plateau
BMC, 2018Co-Authors: Guoqiang Zhu, Nianzhang Zhang, Gang Yao, Wenju TiaAbstract:Abstract Background Cervids used to be considered the only animal intermediate hosts of the G10 genotype of Echinococcus canadensis. Yaks are often herded in the Qinghai-Tibet Plateau, China, where echinococcosis remains prevalent. However, no E. canadensis G10 cases have been recorded in yaks until now. The aim of our study was to identify causative agents of echinococcosis in yaks in this region. Methods Total genomic DNA was extracted from the germinal layer of one hydatid using a Blood and Tissue Kit. Full-length mitochondrial (mt) cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) genes were amplified by PCR. All purified PCR products were directly sequenced in both directions. Then seven pairs of overlap primers were designed to amplify the entire mt genome sequence of a suspected E. canadensis G10 isolate. Phylogenetic analyses were performed based on concatenated nucleotides from the 12 protein-coding genes of mt genomes of Echinococcus species in a Bayesian framework using MrBayes v3.1 and implementing the GTR + I + G model. Results Hydatids were found in yaks (n = 129) when organs were inspected at the slaughterhouse in Maqu county, Gannan Tibetan Autonomous Prefecture, Gansu Province, China in October 2016. Of these, 33 (25.6%) harbored up to a dozen hydatid cysts. One cyst from each yak was characterized by sequencing its mitochondrial (mt) cox1 and nad1 genes. On the basis of these sequence data, 32 cysts were identified as Echinococcus granulosus (sensu stricto) (G1-G3) and the remaining one was identified as the G10 genotype of E. canadensis. Its mt genome was then fully sequenced and compared with that of the G10 genotype in GenBank (AB745463). Phylogenetic analysis using complete mt genomes confirmed the Chinese cyst as belonging to the G10 genotype. Conclusions To our knowledge, this is the first report globally of E. canadensis (G10) from yaks in China, which suggests that the G10 genotype has a wider geographical distribution and broader host range than previously believed. This genotype has therefore potential risks to human health and animal husbandry
Farrokh Habibzadeh - One of the best experts on this subject based on the ideXlab platform.
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Predicting the outcome of asymptomatic univesicular liver Hydatids: diagnostic accuracy of unenhanced CT
European Radiology, 2021Co-Authors: Farrokh Habibzadeh, Parham Habibzadeh, Alireza Shakibafard, Farrokh SaidiAbstract:Objectives To establish the role of unenhanced CT in predicting the outcome of liver hydatid cysts. We sought to determine whether the presence of laminated membrane detachment (LMD) or pericyst degenerative changes (PDCs) detected on CT were reliable signs for predicting a favorable outcome of liver Hydatids. Methods In a 20-year-long study, we prospectively followed changes occurred in CT of 106 cysts of 98 patients with incidentally discovered asymptomatic univesicular liver Hydatids who accepted to enter a watch-and-wait program. An “unfavorable” outcome was defined as the occurrence of a complication (most commonly, cyst fistula or infection) or increase in the cyst size during the follow-up; otherwise, the outcome was considered “favorable.” The parameters derived from a binary logistic regression analysis (with the outcome taken as the dependent variable), after appropriate transformation of the independent variables (presence of LMD or PDCs on CT), were used to calculate the sensitivity, specificity, positive and negative likelihood ratios, and positive and negative predictive values of the presence of either the abovementioned CT findings for the prediction of a favorable outcome. Results The presence of LMD or PDCs had a high specificity (88%) and positive predictive value (96%) for a favorable outcome; they had high false-negative rates. Conclusions The presence of either LMD or PDCs on unenhanced CT, in incidentally discovered asymptomatic univesicular liver Hydatids, was associated with a high probability of a favorable outcome. Their absence does not rule out a favorable outcome. Key Points • Computed tomography can be used for predicting the outcome of those with incidentally discovered univesicular liver Hydatids. • The presence of laminated membrane detachment and/or pericyst degenerative changes is associated with a favorable outcome. • Their absence does not necessarily indicate an unfavorable outcome.
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predicting the outcome of asymptomatic univesicular liver Hydatids diagnostic accuracy of unenhanced ct
European Radiology, 2021Co-Authors: Farrokh Habibzadeh, Parham Habibzadeh, Alireza Shakibafard, Farrokh SaidiAbstract:To establish the role of unenhanced CT in predicting the outcome of liver hydatid cysts. We sought to determine whether the presence of laminated membrane detachment (LMD) or pericyst degenerative changes (PDCs) detected on CT were reliable signs for predicting a favorable outcome of liver Hydatids. In a 20-year-long study, we prospectively followed changes occurred in CT of 106 cysts of 98 patients with incidentally discovered asymptomatic univesicular liver Hydatids who accepted to enter a watch-and-wait program. An “unfavorable” outcome was defined as the occurrence of a complication (most commonly, cyst fistula or infection) or increase in the cyst size during the follow-up; otherwise, the outcome was considered “favorable.” The parameters derived from a binary logistic regression analysis (with the outcome taken as the dependent variable), after appropriate transformation of the independent variables (presence of LMD or PDCs on CT), were used to calculate the sensitivity, specificity, positive and negative likelihood ratios, and positive and negative predictive values of the presence of either the abovementioned CT findings for the prediction of a favorable outcome. The presence of LMD or PDCs had a high specificity (88%) and positive predictive value (96%) for a favorable outcome; they had high false-negative rates. The presence of either LMD or PDCs on unenhanced CT, in incidentally discovered asymptomatic univesicular liver Hydatids, was associated with a high probability of a favorable outcome. Their absence does not rule out a favorable outcome. • Computed tomography can be used for predicting the outcome of those with incidentally discovered univesicular liver Hydatids. • The presence of laminated membrane detachment and/or pericyst degenerative changes is associated with a favorable outcome. • Their absence does not necessarily indicate an unfavorable outcome.
