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B Flautre - One of the best experts on this subject based on the ideXlab platform.
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volume effect on biological properties of a calcium phosphate Hydraulic Cement experimental study in sheep
Bone, 1999Co-Authors: B Flautre, Jacques Lemaitre, P Van Landuyt, C Delecourt, M C Blary, Pierre HardouinAbstract:Injectable calcium phosphate Hydraulic Cements (CPHC) are a new family of bone substitutes within the class of bone reconstruction biomaterials. In this work, CPHC were tested in two consistencies (preset blocks or liquid paste) in an experimental model of cancellous bone defect in sheep. The defects were eight times larger than those investigated previously in rabbits. Three delays (12, 24, and 52 weeks) were used. Before death, a double label of oxytetracycline and alizarine was made intravenously. The distribution of implants was randomized, histomorphometric evaluation was performed and compared with micrographic observation, and optical microscopy of stained sections was performed either under visible, ultraviolet, or polarized light. The results were compared with spontaneous healing of empty defects and with a control group of normal cancellous bone from sheeps of the same age. No significant difference has been observed between premolded and injected implants. In the sheep model, the degradation and new bone formation rates are three times slower, compared with those observed previously in rabbits. New bone formation increased from 5.9% (12 weeks) up to 11.0% (24 weeks) in the empty defect group. In the Cement groups, 28.3% new bone was obtained at 12 weeks, which seemed then to level off (27.8% new bone at 24 weeks). Cement residues appear as radio-opaque cylinders on microradiographs. In all cases, a radiolucent layer was observed at the Cement/bone interface at 24 weeks. Stained sections showed the formation of a fibroconnective capsule around the residual Cement, which presumably slows down new bone formation. Nevertheless, quantitative bone remodeling was accelerated in the Cement group; mineral apposition as well as adjusted apposition rates were higher, and the formation period as well as the mineralization of osteoid tissue were faster compared with empty cavities and controls. These results point to higher osteoblast activity and better exchange with surrounding tissues in the defects filled with Cement.
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biomechanical characterization of a biodegradable calcium phosphate Hydraulic Cement a comparison with porous biphasic calcium phosphate ceramics
Journal of Biomedical Materials Research, 1998Co-Authors: Minoru Ikenaga, Jacques Lemaitre, Hortense Andrianjatovo, Pierre Hardouin, B FlautreAbstract:Biomechanical properties of a biodegradable calcium phosphate Hydraulic Cement (CPHC) were tested with rabbits. The Cement was composed of β-tricalcium phosphate (β-TCP), monocalcium phosphate monohydrate (MCPM), and calcium sulfate hemihydrate (CSH), β-TCP-MCPM-CSH Cement. Cylinders of 4.7 mm in diameter and 10 mm in length were put into bone cavities created in the distal epiphysis of femurs in rabbits. Cylinders of the same size of porous biphasic calcium phosphate ceramics (BCPC, 75% hydroxyapatite and 25% β-TCP) were implanted as references. Two, 4, 12, and 16 weeks after the operation, the rabbits were sacrificed. Histomorphometry showed that the Cement was resorbed, leaving only 7.67 ± 1.81% of bone cavity after 12 weeks. Newly formed bone occupied 34.59 ± 4.00% of the cavity. Cylindrical bone–material composites were cut out with a small dental burr. Compressive force was applied to the specimens and compressive strength, elastic modulus, and toughness were calculated. The same tests were performed on cylinders of normal bone from the same site, which served as controls. The compressive strength and the toughness of the Cement–bone composite were higher than those of normal bone and porous ceramics 12 weeks after the operation (p < 0.05). At 16 weeks the compressive strength and the toughness returned to the normal bone values. The elastic modulus of the porous ceramic–bone composite was higher than the normal bone at 4, 12, and 16 weeks after surgery (p < 0.05). We found that the β-TCP-MCPM-CSH Cement is replaced by new bone and that the Cement–new bone composite has similar or better mechanical properties than normal bone within 16 weeks. This study suggests the usefulness of a particular Cement for filling bone defects or for temporary fixation of orthopedic implants. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 40, 139–144, 1998.
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biomechanical characterization of a biodegradable calcium phosphate Hydraulic Cement a comparison with porous biphasic calcium phosphate ceramics
Journal of Biomedical Materials Research, 1998Co-Authors: Minoru Ikenaga, Jacques Lemaitre, Hortense Andrianjatovo, Pierre Hardouin, B FlautreAbstract:Biomechanical properties of a biodegradable calcium phosphate Hydraulic Cement (CPHC) were tested with rabbits. The Cement was composed of beta-tricalcium phosphate (beta-TCP), monocalcium phosphate monohydrate (MCPM), and calcium sulfate hemihydrate (CSH), beta-TCP-MCPM-CSH Cement. Cylinders of 4.7 mm in diameter and 10 mm in length were put into bone cavities created in the distal epiphysis of femurs in rabbits. Cylinders of the same size of porous biphasic calcium phosphate ceramics (BCPC, 75% hydroxyapatite and 25% beta-TCP) were implanted as references. Two, 4, 12, and 16 weeks after the operation, the rabbits were sacrificed. Histomorphometry showed that the Cement was resorbed, leaving only 7.67 +/- 1.81% of bone cavity after 12 weeks. Newly formed bone occupied 34.59 +/- 4.00% of the cavity. Cylindrical bone-material composites were cut out with a small dental burr. Compressive force was applied to the specimens and compressive strength, elastic modulus, and toughness were calculated. The same tests were performed on cylinders of normal bone from the same site, which served as controls. The compressive strength and the toughness of the Cement-bone composite were higher than those of normal bone and porous ceramics 12 weeks after the operation (p < 0.05). At 16 weeks the compressive strength and the toughness returned to the normal bone values. The elastic modulus of the porous ceramic-bone composite was higher than the normal bone at 4, 12, and 16 weeks after surgery (p < 0.05). We found that the beta-TCP-MCPM-CSH Cement is replaced by new bone and that the Cement-new bone composite has similar or better mechanical properties than normal bone within 16 weeks. This study suggests the usefulness of a particular Cement for filling bone defects or for temporary fixation of orthopedic implants.
Jacques Lemaitre - One of the best experts on this subject based on the ideXlab platform.
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immediate implant plaCement using injectable calcium phosphate Hydraulic Cement in dogs
Journal of Applied Biomaterials & Biomechanics, 2004Co-Authors: Frederic Cuisinier, Jacques Lemaitre, Jf Schaaf, P Van Landuyt, Dominique Roth, Henri TenenbaumAbstract:Techniques allowing implant plaCement in extraction sockets require either high diameter implants in surgically en- larged sockets or grafting and/or regenerative procedures around implants after their primary surgical stabilization. This study aimed to evaluate the ability of calcium phosphate Hydraulic Cement (CPHC) to immobilize commercially available titanium implants in extraction sockets. CPHC was used in seven fresh dog extraction sockets in conjunction with ITI TPS implants. Three extraction sockets without CPHC were used as controls. Initial implant stability was measured after 10 min hardening with periostest. The dogs were sacrificed after 9 months. Non-decalcified specimens were prepared for histologic and histomor- phometric examination. The surface percentage of implant-to-mineralized bone contact and bone density was calculated for each specimen. The periotest values were significantly different for implants stabilized with CPHC than for the controls, and simi- lar to values reported for osteointegrated implants. New alveolar bone was formed in intimate contact with titanium. In two cases, non-resorbed CPHC residues were observed closely bound to the implant. This study clearly demonstrates that CPHC ce- ment is suitable for immediate implant immobilization in extraction sockets. (Journal of Applied Biomaterials & Biomechan- ics 2004; 2: 88-95)
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volume effect on biological properties of a calcium phosphate Hydraulic Cement experimental study in sheep
Bone, 1999Co-Authors: B Flautre, Jacques Lemaitre, P Van Landuyt, C Delecourt, M C Blary, Pierre HardouinAbstract:Injectable calcium phosphate Hydraulic Cements (CPHC) are a new family of bone substitutes within the class of bone reconstruction biomaterials. In this work, CPHC were tested in two consistencies (preset blocks or liquid paste) in an experimental model of cancellous bone defect in sheep. The defects were eight times larger than those investigated previously in rabbits. Three delays (12, 24, and 52 weeks) were used. Before death, a double label of oxytetracycline and alizarine was made intravenously. The distribution of implants was randomized, histomorphometric evaluation was performed and compared with micrographic observation, and optical microscopy of stained sections was performed either under visible, ultraviolet, or polarized light. The results were compared with spontaneous healing of empty defects and with a control group of normal cancellous bone from sheeps of the same age. No significant difference has been observed between premolded and injected implants. In the sheep model, the degradation and new bone formation rates are three times slower, compared with those observed previously in rabbits. New bone formation increased from 5.9% (12 weeks) up to 11.0% (24 weeks) in the empty defect group. In the Cement groups, 28.3% new bone was obtained at 12 weeks, which seemed then to level off (27.8% new bone at 24 weeks). Cement residues appear as radio-opaque cylinders on microradiographs. In all cases, a radiolucent layer was observed at the Cement/bone interface at 24 weeks. Stained sections showed the formation of a fibroconnective capsule around the residual Cement, which presumably slows down new bone formation. Nevertheless, quantitative bone remodeling was accelerated in the Cement group; mineral apposition as well as adjusted apposition rates were higher, and the formation period as well as the mineralization of osteoid tissue were faster compared with empty cavities and controls. These results point to higher osteoblast activity and better exchange with surrounding tissues in the defects filled with Cement.
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biomechanical characterization of a biodegradable calcium phosphate Hydraulic Cement a comparison with porous biphasic calcium phosphate ceramics
Journal of Biomedical Materials Research, 1998Co-Authors: Minoru Ikenaga, Jacques Lemaitre, Hortense Andrianjatovo, Pierre Hardouin, B FlautreAbstract:Biomechanical properties of a biodegradable calcium phosphate Hydraulic Cement (CPHC) were tested with rabbits. The Cement was composed of β-tricalcium phosphate (β-TCP), monocalcium phosphate monohydrate (MCPM), and calcium sulfate hemihydrate (CSH), β-TCP-MCPM-CSH Cement. Cylinders of 4.7 mm in diameter and 10 mm in length were put into bone cavities created in the distal epiphysis of femurs in rabbits. Cylinders of the same size of porous biphasic calcium phosphate ceramics (BCPC, 75% hydroxyapatite and 25% β-TCP) were implanted as references. Two, 4, 12, and 16 weeks after the operation, the rabbits were sacrificed. Histomorphometry showed that the Cement was resorbed, leaving only 7.67 ± 1.81% of bone cavity after 12 weeks. Newly formed bone occupied 34.59 ± 4.00% of the cavity. Cylindrical bone–material composites were cut out with a small dental burr. Compressive force was applied to the specimens and compressive strength, elastic modulus, and toughness were calculated. The same tests were performed on cylinders of normal bone from the same site, which served as controls. The compressive strength and the toughness of the Cement–bone composite were higher than those of normal bone and porous ceramics 12 weeks after the operation (p < 0.05). At 16 weeks the compressive strength and the toughness returned to the normal bone values. The elastic modulus of the porous ceramic–bone composite was higher than the normal bone at 4, 12, and 16 weeks after surgery (p < 0.05). We found that the β-TCP-MCPM-CSH Cement is replaced by new bone and that the Cement–new bone composite has similar or better mechanical properties than normal bone within 16 weeks. This study suggests the usefulness of a particular Cement for filling bone defects or for temporary fixation of orthopedic implants. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 40, 139–144, 1998.
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biomechanical characterization of a biodegradable calcium phosphate Hydraulic Cement a comparison with porous biphasic calcium phosphate ceramics
Journal of Biomedical Materials Research, 1998Co-Authors: Minoru Ikenaga, Jacques Lemaitre, Hortense Andrianjatovo, Pierre Hardouin, B FlautreAbstract:Biomechanical properties of a biodegradable calcium phosphate Hydraulic Cement (CPHC) were tested with rabbits. The Cement was composed of beta-tricalcium phosphate (beta-TCP), monocalcium phosphate monohydrate (MCPM), and calcium sulfate hemihydrate (CSH), beta-TCP-MCPM-CSH Cement. Cylinders of 4.7 mm in diameter and 10 mm in length were put into bone cavities created in the distal epiphysis of femurs in rabbits. Cylinders of the same size of porous biphasic calcium phosphate ceramics (BCPC, 75% hydroxyapatite and 25% beta-TCP) were implanted as references. Two, 4, 12, and 16 weeks after the operation, the rabbits were sacrificed. Histomorphometry showed that the Cement was resorbed, leaving only 7.67 +/- 1.81% of bone cavity after 12 weeks. Newly formed bone occupied 34.59 +/- 4.00% of the cavity. Cylindrical bone-material composites were cut out with a small dental burr. Compressive force was applied to the specimens and compressive strength, elastic modulus, and toughness were calculated. The same tests were performed on cylinders of normal bone from the same site, which served as controls. The compressive strength and the toughness of the Cement-bone composite were higher than those of normal bone and porous ceramics 12 weeks after the operation (p < 0.05). At 16 weeks the compressive strength and the toughness returned to the normal bone values. The elastic modulus of the porous ceramic-bone composite was higher than the normal bone at 4, 12, and 16 weeks after surgery (p < 0.05). We found that the beta-TCP-MCPM-CSH Cement is replaced by new bone and that the Cement-new bone composite has similar or better mechanical properties than normal bone within 16 weeks. This study suggests the usefulness of a particular Cement for filling bone defects or for temporary fixation of orthopedic implants.
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Bone Repair of Defects Filled With a Phosphocalcic Hydraulic Cement - An In-vivo Study
Journal of Materials Science: Materials in Medicine, 1993Co-Authors: Everard Munting, Aa. Mirtchi, Jacques LemaitreAbstract:A quickly setting calcium phosphate-based Hydraulic Cement mixed with particles of tricalcium phosphate (TCP) ceramic was implanted in 56 metaphysial defects made in the long bones of ten adult mongrel dogs. Microradiography, histology and scanning electron microscopy (SEM) demonstrated the slow resorption of the Cement and the bony incorporation of the calcium phosphate ceramic particles which were consistently embedded in bone. The original structural pattern of the bone tended to be restored 7 months after implantation. The Cement did not hinder the incorporation of the calcium phosphate ceramic particles, neither did it elicit any inflammatory or foreign-body response. The Cement was easily shaped and allowed a perfect filling of any defect, resulting in close contact of the whole implant surface with the host bone at the time of surgery, associated with appreciable mechanical strength. Most of the practical problems associated with the use of calcium phosphate ceramics in the repair of bone defects could be overcome with the Cement.
Minoru Ikenaga - One of the best experts on this subject based on the ideXlab platform.
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biomechanical characterization of a biodegradable calcium phosphate Hydraulic Cement a comparison with porous biphasic calcium phosphate ceramics
Journal of Biomedical Materials Research, 1998Co-Authors: Minoru Ikenaga, Jacques Lemaitre, Hortense Andrianjatovo, Pierre Hardouin, B FlautreAbstract:Biomechanical properties of a biodegradable calcium phosphate Hydraulic Cement (CPHC) were tested with rabbits. The Cement was composed of β-tricalcium phosphate (β-TCP), monocalcium phosphate monohydrate (MCPM), and calcium sulfate hemihydrate (CSH), β-TCP-MCPM-CSH Cement. Cylinders of 4.7 mm in diameter and 10 mm in length were put into bone cavities created in the distal epiphysis of femurs in rabbits. Cylinders of the same size of porous biphasic calcium phosphate ceramics (BCPC, 75% hydroxyapatite and 25% β-TCP) were implanted as references. Two, 4, 12, and 16 weeks after the operation, the rabbits were sacrificed. Histomorphometry showed that the Cement was resorbed, leaving only 7.67 ± 1.81% of bone cavity after 12 weeks. Newly formed bone occupied 34.59 ± 4.00% of the cavity. Cylindrical bone–material composites were cut out with a small dental burr. Compressive force was applied to the specimens and compressive strength, elastic modulus, and toughness were calculated. The same tests were performed on cylinders of normal bone from the same site, which served as controls. The compressive strength and the toughness of the Cement–bone composite were higher than those of normal bone and porous ceramics 12 weeks after the operation (p < 0.05). At 16 weeks the compressive strength and the toughness returned to the normal bone values. The elastic modulus of the porous ceramic–bone composite was higher than the normal bone at 4, 12, and 16 weeks after surgery (p < 0.05). We found that the β-TCP-MCPM-CSH Cement is replaced by new bone and that the Cement–new bone composite has similar or better mechanical properties than normal bone within 16 weeks. This study suggests the usefulness of a particular Cement for filling bone defects or for temporary fixation of orthopedic implants. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 40, 139–144, 1998.
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biomechanical characterization of a biodegradable calcium phosphate Hydraulic Cement a comparison with porous biphasic calcium phosphate ceramics
Journal of Biomedical Materials Research, 1998Co-Authors: Minoru Ikenaga, Jacques Lemaitre, Hortense Andrianjatovo, Pierre Hardouin, B FlautreAbstract:Biomechanical properties of a biodegradable calcium phosphate Hydraulic Cement (CPHC) were tested with rabbits. The Cement was composed of beta-tricalcium phosphate (beta-TCP), monocalcium phosphate monohydrate (MCPM), and calcium sulfate hemihydrate (CSH), beta-TCP-MCPM-CSH Cement. Cylinders of 4.7 mm in diameter and 10 mm in length were put into bone cavities created in the distal epiphysis of femurs in rabbits. Cylinders of the same size of porous biphasic calcium phosphate ceramics (BCPC, 75% hydroxyapatite and 25% beta-TCP) were implanted as references. Two, 4, 12, and 16 weeks after the operation, the rabbits were sacrificed. Histomorphometry showed that the Cement was resorbed, leaving only 7.67 +/- 1.81% of bone cavity after 12 weeks. Newly formed bone occupied 34.59 +/- 4.00% of the cavity. Cylindrical bone-material composites were cut out with a small dental burr. Compressive force was applied to the specimens and compressive strength, elastic modulus, and toughness were calculated. The same tests were performed on cylinders of normal bone from the same site, which served as controls. The compressive strength and the toughness of the Cement-bone composite were higher than those of normal bone and porous ceramics 12 weeks after the operation (p < 0.05). At 16 weeks the compressive strength and the toughness returned to the normal bone values. The elastic modulus of the porous ceramic-bone composite was higher than the normal bone at 4, 12, and 16 weeks after surgery (p < 0.05). We found that the beta-TCP-MCPM-CSH Cement is replaced by new bone and that the Cement-new bone composite has similar or better mechanical properties than normal bone within 16 weeks. This study suggests the usefulness of a particular Cement for filling bone defects or for temporary fixation of orthopedic implants.
Philippe Boudeville - One of the best experts on this subject based on the ideXlab platform.
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calcium strontium mixed phosphate as novel injectable and radio opaque Hydraulic Cement
Acta Biomaterialia, 2010Co-Authors: Guilhem Romieu, Xavier Garric, Sylvie Munier, Michel Vert, Philippe BoudevilleAbstract:Abstract Sterile calcium hydrogenophosphate dihydrate (DCPD) (CaHPO4·2H2O), calcium oxide and strontium carbonate powders were mixed in various liquid phases. Among these, ammonium phosphate buffer (0.75 M, pH 6.9) led to a novel strontium-containing calcium phosphate Cement. At a 6/2.5/1.5 M ratio and for a liquid to powder ratio (L/P) of 0.5 ml g−1, the initial paste was fluid and remained injectable for 12 min at 25 °C. It was easily obtained by mixing sterile powders and the liquid phase using the push–pull technique, avoiding complex mixing apparatus. The Cement set after 15 min at 37 °C and was hard after 1 h. The compressive strength was in the 20 MPa range, a value higher than that generally assigned to trabecular bone (5–15 MPa). This strength appeared sufficient for repairing non-loading sites or reinforcing osteoporotic vertebrae (vertebroplasty). After setting, the initial mixture formed a strontium–calcium-deficient carbonate apatite. The radio-opacity of the resulting Cement was three times greater than that of cortical bone because of the presence of strontium ions, a feature that complies with the requirements for vertebroplasty. Furthermore, the Cement powder remained stable and retained its properties for at least 4 years.
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calcium strontium mixed phosphate as novel injectable and radio opaque Hydraulic Cement
Acta Biomaterialia, 2010Co-Authors: Guilhem Romieu, Xavier Garric, Sylvie Munier, Michel Vert, Philippe BoudevilleAbstract:Sterile calcium hydrogenophosphate dihydrate (DCPD) (CaHPO(4).2H(2)O), calcium oxide and strontium carbonate powders were mixed in various liquid phases. Among these, ammonium phosphate buffer (0.75 M, pH 6.9) led to a novel strontium-containing calcium phosphate Cement. At a 6/2.5/1.5 M ratio and for a liquid to powder ratio (L/P) of 0.5 mlg(-1), the initial paste was fluid and remained injectable for 12 min at 25 degrees C. It was easily obtained by mixing sterile powders and the liquid phase using the push-pull technique, avoiding complex mixing apparatus. The Cement set after 15 min at 37 degrees C and was hard after 1h. The compressive strength was in the 20 MPa range, a value higher than that generally assigned to trabecular bone (5-15MPa). This strength appeared sufficient for repairing non-loading sites or reinforcing osteoporotic vertebrae (vertebroplasty). After setting, the initial mixture formed a strontium-calcium-deficient carbonate apatite. The radio-opacity of the resulting Cement was three times greater than that of cortical bone because of the presence of strontium ions, a feature that complies with the requirements for vertebroplasty. Furthermore, the Cement powder remained stable and retained its properties for at least 4 years.
Pierre Hardouin - One of the best experts on this subject based on the ideXlab platform.
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volume effect on biological properties of a calcium phosphate Hydraulic Cement experimental study in sheep
Bone, 1999Co-Authors: B Flautre, Jacques Lemaitre, P Van Landuyt, C Delecourt, M C Blary, Pierre HardouinAbstract:Injectable calcium phosphate Hydraulic Cements (CPHC) are a new family of bone substitutes within the class of bone reconstruction biomaterials. In this work, CPHC were tested in two consistencies (preset blocks or liquid paste) in an experimental model of cancellous bone defect in sheep. The defects were eight times larger than those investigated previously in rabbits. Three delays (12, 24, and 52 weeks) were used. Before death, a double label of oxytetracycline and alizarine was made intravenously. The distribution of implants was randomized, histomorphometric evaluation was performed and compared with micrographic observation, and optical microscopy of stained sections was performed either under visible, ultraviolet, or polarized light. The results were compared with spontaneous healing of empty defects and with a control group of normal cancellous bone from sheeps of the same age. No significant difference has been observed between premolded and injected implants. In the sheep model, the degradation and new bone formation rates are three times slower, compared with those observed previously in rabbits. New bone formation increased from 5.9% (12 weeks) up to 11.0% (24 weeks) in the empty defect group. In the Cement groups, 28.3% new bone was obtained at 12 weeks, which seemed then to level off (27.8% new bone at 24 weeks). Cement residues appear as radio-opaque cylinders on microradiographs. In all cases, a radiolucent layer was observed at the Cement/bone interface at 24 weeks. Stained sections showed the formation of a fibroconnective capsule around the residual Cement, which presumably slows down new bone formation. Nevertheless, quantitative bone remodeling was accelerated in the Cement group; mineral apposition as well as adjusted apposition rates were higher, and the formation period as well as the mineralization of osteoid tissue were faster compared with empty cavities and controls. These results point to higher osteoblast activity and better exchange with surrounding tissues in the defects filled with Cement.
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biomechanical characterization of a biodegradable calcium phosphate Hydraulic Cement a comparison with porous biphasic calcium phosphate ceramics
Journal of Biomedical Materials Research, 1998Co-Authors: Minoru Ikenaga, Jacques Lemaitre, Hortense Andrianjatovo, Pierre Hardouin, B FlautreAbstract:Biomechanical properties of a biodegradable calcium phosphate Hydraulic Cement (CPHC) were tested with rabbits. The Cement was composed of β-tricalcium phosphate (β-TCP), monocalcium phosphate monohydrate (MCPM), and calcium sulfate hemihydrate (CSH), β-TCP-MCPM-CSH Cement. Cylinders of 4.7 mm in diameter and 10 mm in length were put into bone cavities created in the distal epiphysis of femurs in rabbits. Cylinders of the same size of porous biphasic calcium phosphate ceramics (BCPC, 75% hydroxyapatite and 25% β-TCP) were implanted as references. Two, 4, 12, and 16 weeks after the operation, the rabbits were sacrificed. Histomorphometry showed that the Cement was resorbed, leaving only 7.67 ± 1.81% of bone cavity after 12 weeks. Newly formed bone occupied 34.59 ± 4.00% of the cavity. Cylindrical bone–material composites were cut out with a small dental burr. Compressive force was applied to the specimens and compressive strength, elastic modulus, and toughness were calculated. The same tests were performed on cylinders of normal bone from the same site, which served as controls. The compressive strength and the toughness of the Cement–bone composite were higher than those of normal bone and porous ceramics 12 weeks after the operation (p < 0.05). At 16 weeks the compressive strength and the toughness returned to the normal bone values. The elastic modulus of the porous ceramic–bone composite was higher than the normal bone at 4, 12, and 16 weeks after surgery (p < 0.05). We found that the β-TCP-MCPM-CSH Cement is replaced by new bone and that the Cement–new bone composite has similar or better mechanical properties than normal bone within 16 weeks. This study suggests the usefulness of a particular Cement for filling bone defects or for temporary fixation of orthopedic implants. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 40, 139–144, 1998.
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biomechanical characterization of a biodegradable calcium phosphate Hydraulic Cement a comparison with porous biphasic calcium phosphate ceramics
Journal of Biomedical Materials Research, 1998Co-Authors: Minoru Ikenaga, Jacques Lemaitre, Hortense Andrianjatovo, Pierre Hardouin, B FlautreAbstract:Biomechanical properties of a biodegradable calcium phosphate Hydraulic Cement (CPHC) were tested with rabbits. The Cement was composed of beta-tricalcium phosphate (beta-TCP), monocalcium phosphate monohydrate (MCPM), and calcium sulfate hemihydrate (CSH), beta-TCP-MCPM-CSH Cement. Cylinders of 4.7 mm in diameter and 10 mm in length were put into bone cavities created in the distal epiphysis of femurs in rabbits. Cylinders of the same size of porous biphasic calcium phosphate ceramics (BCPC, 75% hydroxyapatite and 25% beta-TCP) were implanted as references. Two, 4, 12, and 16 weeks after the operation, the rabbits were sacrificed. Histomorphometry showed that the Cement was resorbed, leaving only 7.67 +/- 1.81% of bone cavity after 12 weeks. Newly formed bone occupied 34.59 +/- 4.00% of the cavity. Cylindrical bone-material composites were cut out with a small dental burr. Compressive force was applied to the specimens and compressive strength, elastic modulus, and toughness were calculated. The same tests were performed on cylinders of normal bone from the same site, which served as controls. The compressive strength and the toughness of the Cement-bone composite were higher than those of normal bone and porous ceramics 12 weeks after the operation (p < 0.05). At 16 weeks the compressive strength and the toughness returned to the normal bone values. The elastic modulus of the porous ceramic-bone composite was higher than the normal bone at 4, 12, and 16 weeks after surgery (p < 0.05). We found that the beta-TCP-MCPM-CSH Cement is replaced by new bone and that the Cement-new bone composite has similar or better mechanical properties than normal bone within 16 weeks. This study suggests the usefulness of a particular Cement for filling bone defects or for temporary fixation of orthopedic implants.
