The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Hiroyuki Shimasaki - One of the best experts on this subject based on the ideXlab platform.
-
safety of garcinia cambogia extract in healthy volunteers high dose administration study ii
Journal of Oleo Science, 2003Co-Authors: Yuri Ishii, Kohsuke Hayamizu, Izuru Kaneko, Manzhen Shen, Norihiro Shigematsu, Hironori Tomi, Gen Yoshino, Hiroyuki ShimasakiAbstract:The purpose of this study was to review the safety of long-term excessive ingestion of Garcinia extract. For 12 weeks, a dosage of 5000 mg Garcinia extract powder (3000 mg/day as (-)-Hydroxycitric Acid [(-)-HCA]) was administered to healthy subjects (men 24, women 24). Hematology, hemobiochemistry, endocrinology and urinalysis were carried out every four weeks. Endocrinologically, serum inhibin B increased in men (P<0.05), from 162.1 ± 46.2 pg/mL to 186.7 ± 61.6 pg/mL. In addition, Follicle Stimulating Hormone (FSH) increased (P<0.05), from 4.68 ± 2.65 mIU/mL to 5.18 ± 2.75 mIU/mL. It is hard to conceive the changes had a testiculus influence, because the changes were very slight and no reciprocal relationships existed between them. In women, no significant change of sex hormone was noted and no influence on menstrual cycles was observed. Neither remarkable changes in hematology, hemobiochemistry and urinalysis nor adverse events were observed. These findings support the safety for humans of long-term excessive administration of Garcinia extract (3000 mg/day as HCA, 12 weeks) was high.
-
effects of garcinia cambogia Hydroxycitric Acid on visceral fat accumulation a double blind randomized placebo controlled trial
Current Therapeutic Research-clinical and Experimental, 2003Co-Authors: Kohsuke Hayamizu, Yuri Ishii, Izuru Kaneko, Manzhen Shen, Yasuhide Okuhara, Norihiro Shigematsu, Mitsuhiro Furuse, Hironori Tomi, Gen Yoshino, Hiroyuki ShimasakiAbstract:Background: (-)-Hydroxycitric Acid (HCA) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. Objective: The primary end point of this study was the effects of 12 weeks of G cambogia extract administration on visceral fat accumulation. The secondary end points were body indices (including height, body weight, body mass index [BMI], waist and hip circumference, and waist–hip ratio) and laboratory values (including total cholesterol, triacylglycerol, and free fatty Acid). Methods: This study was performed according to a double-blind, randomized, placebo-controlled, parallel-group design. Subjects aged 20 to 65 years with a visceral fat area 90 cm 2 were enrolled. Subjects were randomly assigned to receive treatment for 12 weeks with G cambogia (containing 1000 mg of HCA per day) or placebo. At the end of the treatment period, both groups were administered placebo for 4 weeks to assess any rebound effect. Each subject underwent a computed tomography scan at the umbilical level at –2, 0, 12, and 16 weeks. Results: Forty-four subjects were randomized at baseline, and 39 completed the study (G cambogia group, n 18; placebo group, n 21). At 16 weeks, the G cambogia group had significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group (all indices P 0.001). No severe adverse effect was observed at any time in the test period. There were no
-
safety of garcinia cambogia extract in healthy men high doses administration study i
Journal of Oleo Science, 2003Co-Authors: Kohsuke Hayamizu, Yuri Ishii, Yasuhide Okuhara, Norihiro Shigematsu, Mitsuhiro Furuse, Hironori Tomi, Gen Yoshino, Hiroyuki ShimasakiAbstract:(-)-Hydroxycitric Acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss. Recently, it was reported in a 52w toxicity study that Garcinia extract powder induced testicular atrophy in rats. In order to study the safety, Garcinia extract was administered to 10 healthy adult men at dose of 3,000 mg/day as HCA for 30 days. No toxicological changes were observed on anthropometric indices or clinical analysis. In addition, serum testosterone showed no change throughout the test period. In regard to subjective symptoms, very slight anorexia (two cases) and headache (one case) occurred. Therefore, we consider that Garcinia extract is safe as administered under the condition of this study.
-
Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial
Elsevier, 2003Co-Authors: Kohsuke Hayamizu, Yuri Ishii, Manzhen Shen, Norihiro Shigematsu, Mitsuhiro Furuse, Hironori Tomi, Izuru Kaneko Dvm, Bs ,yasuhide Okuhara, Md ,gen Yoshino, Hiroyuki ShimasakiAbstract:Background: (-)-Hydroxycitric Acid (HCA) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. Objective: The primary end point of this study was the effects of 12 weeks of G cambogia extract administration on visceral fat accumulation. The secondary end points were body indices (including height, body weight, body mass index [BMI], waist and hip circumference, and waist–hip ratio) and laboratory values (including total cholesterol, triacylglycerol, and free fatty Acid). Methods: This study was performed according to a double-blind, randomized, placebo-controlled, parallel-group design. Subjects aged 20 to 65 years with a visceral fat area >90 cm2 were enrolled. Subjects were randomly assigned to receive treatment for 12 weeks with G cambogia (containing 1000 mg of HCA per day) or placebo. At the end of the treatment period, both groups were administered placebo for 4 weeks to assess any rebound effect. Each subject underwent a computed tomography scan at the umbilical level at −2, 0, 12, and 16 weeks. Results: Forty-four subjects were randomized at baseline, and 39 completed the study (G cambogia group, n=18; placebo group, n=21). At 16 weeks, the G cambogia group had significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group (all indices P
-
No-observed-Adverse-Effect Level(NOAEL) and Sequential-High-Doses Administration Study on Garcinia cambogia Extract in Humans
Journal of Oleo Science, 2002Co-Authors: Kohsuke Hayamizu, Yuri Ishii, Izuru Kaneko, Manzhen Shen, Yasuhide Okuhara, Hiroyuki Sakaguchi, Norihiro Shigematsu, Hiroyuki ShimasakiAbstract:(−)-Hydroxycitric Acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss in humans, and is the principal Acid in the rinds of Garcinia cambogia, a fruit native to Asia. NOAEL (no-observed-adverse-effect level) of G. cambogia extract was determined in the present study and examination was made of adverse effects of high-dose administration to 44 healthy volunteers who had received 4000 mg HCA. No adverse effect was noted in any subjects. NOAEL of G. cambogia extract was estimated as more than 4000 mg HCA. Sequential-high-doses administration study was condusted in subjects who had been given 3000 mg HCA daily for 10 days. Blood samples were used to obtain clinical data before and after treatment. The clinical data were essentially the same for either time. G. cambogia extract at more than 3000 mg HCA may be considered safe for healthy persons.
Kohsuke Hayamizu - One of the best experts on this subject based on the ideXlab platform.
-
effects of garcinia cambogia extract on serum sex hormones in overweight subjects
Fitoterapia, 2008Co-Authors: Kohsuke Hayamizu, Izuru Kaneko, Manzhen Shen, Hironori Tomi, Madhu G Soni, Gen YoshinoAbstract:(-) Hydroxycitric Acid (HCA), an active ingredient extracted from the Garcinia cambogia fruit rind, has been commonly used as a dietary supplement for weight management. Given the controversy over HCA related testicular toxicity in animal studies, we investigated changes in serum sex hormones levels as an extension of our previous double-blind placebo-controlled trial in human subjects, in which 44 participants received either G. cambogia extract (1667.3 mg/day equivalent to 1000 mg HCA/day) or placebo for 12 weeks. Compared to the placebo group, administration of the extract did not significantly alter the serum testosterone, estrone, and estradiol levels. Similarly, hematology, serum triacylglycerol and serum clinical pathology parameters did not reveal any significant adverse effects. The results of this preliminary investigation indicate that ingestion of G. cambogia extract at dose levels commonly recommended for human use does not affect serum sex hormone levels and blood parameters.
-
safety of garcinia cambogia extract in healthy volunteers high dose administration study ii
Journal of Oleo Science, 2003Co-Authors: Yuri Ishii, Kohsuke Hayamizu, Izuru Kaneko, Manzhen Shen, Norihiro Shigematsu, Hironori Tomi, Gen Yoshino, Hiroyuki ShimasakiAbstract:The purpose of this study was to review the safety of long-term excessive ingestion of Garcinia extract. For 12 weeks, a dosage of 5000 mg Garcinia extract powder (3000 mg/day as (-)-Hydroxycitric Acid [(-)-HCA]) was administered to healthy subjects (men 24, women 24). Hematology, hemobiochemistry, endocrinology and urinalysis were carried out every four weeks. Endocrinologically, serum inhibin B increased in men (P<0.05), from 162.1 ± 46.2 pg/mL to 186.7 ± 61.6 pg/mL. In addition, Follicle Stimulating Hormone (FSH) increased (P<0.05), from 4.68 ± 2.65 mIU/mL to 5.18 ± 2.75 mIU/mL. It is hard to conceive the changes had a testiculus influence, because the changes were very slight and no reciprocal relationships existed between them. In women, no significant change of sex hormone was noted and no influence on menstrual cycles was observed. Neither remarkable changes in hematology, hemobiochemistry and urinalysis nor adverse events were observed. These findings support the safety for humans of long-term excessive administration of Garcinia extract (3000 mg/day as HCA, 12 weeks) was high.
-
effects of garcinia cambogia Hydroxycitric Acid on visceral fat accumulation a double blind randomized placebo controlled trial
Current Therapeutic Research-clinical and Experimental, 2003Co-Authors: Kohsuke Hayamizu, Yuri Ishii, Izuru Kaneko, Manzhen Shen, Yasuhide Okuhara, Norihiro Shigematsu, Mitsuhiro Furuse, Hironori Tomi, Gen Yoshino, Hiroyuki ShimasakiAbstract:Background: (-)-Hydroxycitric Acid (HCA) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. Objective: The primary end point of this study was the effects of 12 weeks of G cambogia extract administration on visceral fat accumulation. The secondary end points were body indices (including height, body weight, body mass index [BMI], waist and hip circumference, and waist–hip ratio) and laboratory values (including total cholesterol, triacylglycerol, and free fatty Acid). Methods: This study was performed according to a double-blind, randomized, placebo-controlled, parallel-group design. Subjects aged 20 to 65 years with a visceral fat area 90 cm 2 were enrolled. Subjects were randomly assigned to receive treatment for 12 weeks with G cambogia (containing 1000 mg of HCA per day) or placebo. At the end of the treatment period, both groups were administered placebo for 4 weeks to assess any rebound effect. Each subject underwent a computed tomography scan at the umbilical level at –2, 0, 12, and 16 weeks. Results: Forty-four subjects were randomized at baseline, and 39 completed the study (G cambogia group, n 18; placebo group, n 21). At 16 weeks, the G cambogia group had significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group (all indices P 0.001). No severe adverse effect was observed at any time in the test period. There were no
-
safety of garcinia cambogia extract in healthy men high doses administration study i
Journal of Oleo Science, 2003Co-Authors: Kohsuke Hayamizu, Yuri Ishii, Yasuhide Okuhara, Norihiro Shigematsu, Mitsuhiro Furuse, Hironori Tomi, Gen Yoshino, Hiroyuki ShimasakiAbstract:(-)-Hydroxycitric Acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss. Recently, it was reported in a 52w toxicity study that Garcinia extract powder induced testicular atrophy in rats. In order to study the safety, Garcinia extract was administered to 10 healthy adult men at dose of 3,000 mg/day as HCA for 30 days. No toxicological changes were observed on anthropometric indices or clinical analysis. In addition, serum testosterone showed no change throughout the test period. In regard to subjective symptoms, very slight anorexia (two cases) and headache (one case) occurred. Therefore, we consider that Garcinia extract is safe as administered under the condition of this study.
-
Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial
Elsevier, 2003Co-Authors: Kohsuke Hayamizu, Yuri Ishii, Manzhen Shen, Norihiro Shigematsu, Mitsuhiro Furuse, Hironori Tomi, Izuru Kaneko Dvm, Bs ,yasuhide Okuhara, Md ,gen Yoshino, Hiroyuki ShimasakiAbstract:Background: (-)-Hydroxycitric Acid (HCA) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. Objective: The primary end point of this study was the effects of 12 weeks of G cambogia extract administration on visceral fat accumulation. The secondary end points were body indices (including height, body weight, body mass index [BMI], waist and hip circumference, and waist–hip ratio) and laboratory values (including total cholesterol, triacylglycerol, and free fatty Acid). Methods: This study was performed according to a double-blind, randomized, placebo-controlled, parallel-group design. Subjects aged 20 to 65 years with a visceral fat area >90 cm2 were enrolled. Subjects were randomly assigned to receive treatment for 12 weeks with G cambogia (containing 1000 mg of HCA per day) or placebo. At the end of the treatment period, both groups were administered placebo for 4 weeks to assess any rebound effect. Each subject underwent a computed tomography scan at the umbilical level at −2, 0, 12, and 16 weeks. Results: Forty-four subjects were randomized at baseline, and 39 completed the study (G cambogia group, n=18; placebo group, n=21). At 16 weeks, the G cambogia group had significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group (all indices P
K K Sakariah - One of the best experts on this subject based on the ideXlab platform.
-
determination of organic Acids in leaves and rinds of garcinia indica desr by lc
Journal of Pharmaceutical and Biomedical Analysis, 2002Co-Authors: G K Jayaprakasha, K K SakariahAbstract:Organic Acids in leaves and rinds of Garcinia indica (Kokam) were determined by high-performance liquid chromatography. The major organic Acid in leaves and rinds has been found to be (-)-Hydroxycitric Acid present to the extent of 4.1-4.6 and 10.3-12.7%, respectively, by isocratic elution with 8 mM sulfuric Acid as mobile phase with a flow rate of 1.0 ml/min using UV detection at 210 nm. Hydroxycitric Acid lactone and citric Acid are present in leaves and rinds in minor quantities. This method has been shown to be very reproducible with the coefficient of variation ranging from 2.8 to 4.2%. This is the first report on the composition of organic Acids in the leaves and rinds of G. indica by HPLC.
-
chemistry and biochemistry of Hydroxycitric Acid from garcinia
Journal of Agricultural and Food Chemistry, 2002Co-Authors: B S Jena, G K Jayaprakasha, R P Singh, K K SakariahAbstract:(-)-Hydroxycitric Acid [(-)-HCA] is the principal Acid of fruit rinds of Garcinia cambogia, Garcinia indica, and Garcinia atroviridis. (-)-HCA was shown to be a potent inhibitor of ATP citrate lyase (EC 4.1.3.8), which catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA: citrate + ATP + CoA --> acetyl-CoA + ADP + P(i) + oxaloacetate. The inhibition of this reaction limits the availability of acetyl-CoA units required for fatty Acid synthesis and lipogenesis during a lipogenic diet, that is, a diet high in carbohydrates. Extensive animal studies indicated that (-)-HCA suppresses the fatty Acid synthesis, lipogenesis, food intake, and induced weight loss. In vitro studies revealed the inhibitions of fatty Acid synthesis and lipogenesis from various precursors. However, a few clinical studies have shown controversial findings. This review explores the literature on a number of topics: the source of (-)-HCA; the discovery of (-)-HCA; the isolation, stereochemistry, properties, methods of estimation, and derivatives of (-)-HCA; and its biochemistry, which includes inhibition of the citrate cleavage enzyme, effects on fatty Acid synthesis and lipogenesis, effects on ketogenesis, other biological effects, possible modes of action on the reduction of food intake, promotion of glycogenesis, gluconeogenesis, and lipid oxidation, (-)-HCA as weight-controlling agent, and some possible concerns about (-)-HCA, which provides a coherent presentation of scattered literature on (-)-HCA and its plausible mechanism of action and is provocative of further research.
-
determination of Hydroxycitric Acid in commercial samples of garcinia cambogia extract by liquid chromatography with ultraviolet detection
Journal of Liquid Chromatography & Related Technologies, 2000Co-Authors: G K Jayaprakasha, K K SakariahAbstract:A high performance liquid chromatography method was developed for the determination of organic Acids in commercial samples of Garcinia cambogia extracts. The major organic Acid in commercially available extracts of Garcinia cambogia has been found to be (-) Hydroxycitric Acid present to the extent of 51–55%. Tartaric, citric, and malic Acids are present in small quantities and have been detected by using 6 mM sulfuric Acid as the mobile phase with a flow rate of 1.0 mL/min and UV detection at 210 nm. This method is shown to estimate accurately (-) Hydroxycitric Acid in the samples of Garcinia cambogia extracts. Thus, the method is ideally suited for rapid routine analysis of commercial Garcinia cambogia extracts.
-
determination of organic Acids in garcinia cambogia desr by high performance liquid chromatography
Journal of Chromatography A, 1998Co-Authors: G K Jayaprakasha, K K SakariahAbstract:Abstract The major organic Acid in Garcinia cambogia (Malabar tamarind) has been found to be (−)-Hydroxycitric Acid, present in concentrations of 16–18%, using high-performance liquid chromatography with 10 mM sulfuric Acid as eluent. Citric and malic Acids are present in Malabar tamarind in minor quantities.
Debasis Bagchi - One of the best experts on this subject based on the ideXlab platform.
-
effect of a novel Hydroxycitric Acid extract hca sx on oxidative stress insulin resistance and brain serotonin level in obese zucker rats
The FASEB Journal, 2006Co-Authors: Mohammad Asghar, Robert Zeyssig, Emmanuel Monjok, Ghislaine Kouamou, Sunny E Ohia, Mustafa F Lokhandwala, Debasis BagchiAbstract:Super CitriMax (HCA-SX) is a novel calcium/potassium salt of (−)-Hydroxycitric Acid extracted from the dried fruit rind of the plant Garcinia cambogia, which is commonly consumed worldwide as a die...
-
safety assessment of Hydroxycitric Acid and super citrimax a novel calcium potassium salt
Food and Chemical Toxicology, 2004Co-Authors: M G Soni, Sunny E Ohia, Harry G Preuss, George A Burdock, Sidney J Stohs, Debasis BagchiAbstract:Abstract (−)-Hydroxycitric Acid (HCA) is a principle constituent (10–30%) of the dried fruit rind of Garcinia cambogia , a plant native to Southeastern Asia. The dried rind has been used for centuries throughout Southeast Asia as a food preservative, flavoring agent and carminative. Extensive experimental studies show that HCA inhibits fat synthesis and reduces food intake. The objective of this review is to systematically review the available safety/toxicity literature on HCA to determine its safety in-use. The primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty Acid and cholesterol synthesis. Super CitriMax ® , a novel calcium/potassium–HCA extract (HCA-SX), is considerably more soluble and bioavailable than calcium-based HCA ingredients. Acute oral toxicity studies in animals demonstrate that CitriMax (50% HCA as calcium salt) has a low acute oral toxicity. In a subchronic study in rats, the gavage administration of HCA-SX at doses up to 2500 mg/kg/day for a period of 90 days caused a significant decrease in body weight and reduction in feed consumption without any adverse effects. The structure, mechanism of action, long history of use of HCA and other toxicity studies indicate that HCA-SX is unlikely to cause reproductive or developmental effects. HCA-SX was not mutagenic in the presence or absence of metabolic activation in Ames genotoxicity assays in strains TA98 and TA102. HCA-SX-induced increases in number of revertants in other strains (TA100 and TA1535 in the absence of metabolic activation and in strain TA1537 in the presence of metabolic activation) but these were not considered as biologically indicative of a mutagenic effect. In several, placebo-controlled, double-blind trials employing up to 2800 mg/day HCA, no treatment-related adverse effects were reported. There is sufficient qualitative and quantitative scientific evidence, including animal and human data suggesting that intake of HCA at levels up to 2800 mg/day is safe for human consumption.
-
effects of a natural extract of Hydroxycitric Acid hca sx and a combination of hca sx plus niacin bound chromium and gymnema sylvestre extract on weight loss
Diabetes Obesity and Metabolism, 2004Co-Authors: Harry G Preuss, Debasis Bagchi, Manashi Bagchi, S SatyanarayanaAbstract:Aim: The efficacy of optimal doses of highly bioavailable (–)-Hydroxycitric Acid (HCA-SX) alone and in combination with niacin-bound chromium (NBC) and a standardized Gymnema sylvestre extract (GSE) on weight loss in moderately obese subjects was evaluated by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and excretion of urinary fat metabolites. HCA-SX has been shown to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. NBC has demonstrated its ability to maintain healthy insulin levels, while GSE has been shown to regulate weight loss and blood sugar levels. Methods: A randomized, double-blind, placebo-controlled human study was conducted in Elluru, India for 8weeks in 60 moderately obese subjects (ages 21–50, BMI >26kg/m 2 ). Subjects were randomly divided into three groups. Group A was administered HCA-SX 4667mg, group B was administered a combination of HCA-SX 4667mg, NBC 4mg and GSE 400mg, while group C was given placebo daily in three equally divided doses 30–60min before meals. All subjects received a 2000kcal diet/day and participated in supervised walking. Results: At the end of 8weeks, body weight and BMI decreased by 5–6% in both groups A and B. Food intake, total cholesterol, low-density lipoproteins, triglycerides and serum leptin levels were significantly reduced in both groups, while high-density lipoprotein levels and excretion of urinary fat metabolites increased in both groups. A marginal or non-significant effect was observed in all parameters in group C. Conclusion: The present study shows that optimal doses of HCA-SX and, to a greater degree, the combination of HCASX, NBC and GSE can serve as an effective and safe weight-loss formula that can facilitate a reduction in excess body weight and BMI, while promoting healthy blood lipid levels.
-
efficacy of a novel natural extract of Hydroxycitric Acid hca sx and a combination of hca sx niacin bound chromium and gymnema sylvestre extract in weight management in human volunteers a pilot study
Nutrition Research, 2004Co-Authors: Harry G Preuss, Debasis Bagchi, Manashi Bagchi, S SatyanarayanaAbstract:In this pilot study, the efficacy of a novel, natural extract of a highly bioavailable, calciumpotassium salt of (‐)-Hydroxycitric Acid (HCA-SX) alone and in combination with a niacin-bound chromium (NBC) and Gymnema sylvestraextract (GSE) was evaluated for weight loss in moderately obese subjects by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and serotonin levels, and enhanced excretion of urinary fat metabolites. Garcinia cambogia-derived (‐)-Hydroxycitric Acid (HCA) has been shown to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. NBC has shown the ability to restore insulin function, metabolize fat, turn protein into muscle, and convert sugar into energy, which plays a role in appetite regulation and facilitates weight loss. Gymnema sylvestreis a traditional herb that helps to promote weight loss possibly through its ability to reduce cravings for sweets and control blood sugar levels. A randomized, double-blind, placebo-controlled human clinical study was conducted in thirty obese subjects (ages 21-50, BMI26 kg/m 2 ) for eight weeks in Elluru, India. The subjects were randomly divided into three groups (10 subjects/group) and given HCA-SX 4,667 mg (60% HCA providing 2,800 mg HCA/day) (Group A), a combination of HCA-SX 4,667 mg, NBC 4 mg (providing 400 g elemental Cr) and GSE 400 mg (providing 100 mg gymnemic Acid) (Group B), or placebo (Group C) daily in 3 equally divided doses 30-60 min before each meal. This
-
dose and time dependent effects of a novel Hydroxycitric Acid extract on body weight hepatic and testicular lipid peroxidation dna fragmentation and histopathological data over a period of 90 days
Molecular and Cellular Biochemistry, 2003Co-Authors: Michael Shara, Sunny E Ohia, Debasis Bagchi, Manashi Bagchi, Taharat Yasmin, Andrea Zardettosmith, Anthony E Kincaid, Archana Chatterjee, Sidney J StohsAbstract:(-)-Hydroxycitric Acid (HCA), a natural extract from the dried fruit rind of Garcinia cambogia (family Guttiferae), is a popular supplement for weight management. The dried fruit rind has been used for centuries as a condiment in Southeastern Asia to make food more filling and satisfying. A significant number of studies highlight the efficacy of Super CitriMax (HCA-SX, a novel 60% calcium-potassium salt of HCA derived from Garcinia cambogia) in weight management. These studies also demonstrate that HCA-SX promotes fat oxidation, inhibits ATP-citrate lyase (a building block for fat synthesis), and lowers the level of leptin in obese subjects. Acute oral, acute dermal, primary dermal irritation and primary eye irritation toxicity studies have demonstrated the safety of HCA-SX. However, no long-term safety of HCA-SX or any other (-)-Hydroxycitric Acid extract has been previously assessed. In this study, we have evaluated the dose- and time-dependent effects of HCA-SX in Sprague-Dawley rats on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation, liver and testis weight, expressed as such and as a % of body weight and brain weight, and histopathological changes over a period of 90 days. The animals were treated with 0, 0.2, 2.0 and 5.0% HCA-SX as feed intake and the animals were sacrificed on 30, 60 or 90 days of treatment. The feed and water intake were assessed and correlated with the reduction in body weight. HCA-SX supplementation demonstrated a reduction in body weight in both male and female rats over a period of 90 days as compared to the corresponding control animals. An advancing age-induced marginal increase in hepatic lipid peroxidation was observed in both male and female rats as compared to the corresponding control animals. However, no such difference in hepatic DNA fragmentation and testicular lipid peroxidation and DNA fragmentation was observed. Furthermore, liver and testis weight, expressed as such and as a percentage of body weight and brain weight, at 30, 60 and 90 days of treatment, exhibited no significant difference between the four groups. Taken together, these results indicate that treatment of HCA-SX over a period of 90 days results in a reduction in body weight, but did not cause any changes in hepatic and testicular lipid peroxidation, DNA fragmentation, or histopathological changes.
S Satyanarayana - One of the best experts on this subject based on the ideXlab platform.
-
effects of a natural extract of Hydroxycitric Acid hca sx and a combination of hca sx plus niacin bound chromium and gymnema sylvestre extract on weight loss
Diabetes Obesity and Metabolism, 2004Co-Authors: Harry G Preuss, Debasis Bagchi, Manashi Bagchi, S SatyanarayanaAbstract:Aim: The efficacy of optimal doses of highly bioavailable (–)-Hydroxycitric Acid (HCA-SX) alone and in combination with niacin-bound chromium (NBC) and a standardized Gymnema sylvestre extract (GSE) on weight loss in moderately obese subjects was evaluated by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and excretion of urinary fat metabolites. HCA-SX has been shown to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. NBC has demonstrated its ability to maintain healthy insulin levels, while GSE has been shown to regulate weight loss and blood sugar levels. Methods: A randomized, double-blind, placebo-controlled human study was conducted in Elluru, India for 8weeks in 60 moderately obese subjects (ages 21–50, BMI >26kg/m 2 ). Subjects were randomly divided into three groups. Group A was administered HCA-SX 4667mg, group B was administered a combination of HCA-SX 4667mg, NBC 4mg and GSE 400mg, while group C was given placebo daily in three equally divided doses 30–60min before meals. All subjects received a 2000kcal diet/day and participated in supervised walking. Results: At the end of 8weeks, body weight and BMI decreased by 5–6% in both groups A and B. Food intake, total cholesterol, low-density lipoproteins, triglycerides and serum leptin levels were significantly reduced in both groups, while high-density lipoprotein levels and excretion of urinary fat metabolites increased in both groups. A marginal or non-significant effect was observed in all parameters in group C. Conclusion: The present study shows that optimal doses of HCA-SX and, to a greater degree, the combination of HCASX, NBC and GSE can serve as an effective and safe weight-loss formula that can facilitate a reduction in excess body weight and BMI, while promoting healthy blood lipid levels.
-
efficacy of a novel natural extract of Hydroxycitric Acid hca sx and a combination of hca sx niacin bound chromium and gymnema sylvestre extract in weight management in human volunteers a pilot study
Nutrition Research, 2004Co-Authors: Harry G Preuss, Debasis Bagchi, Manashi Bagchi, S SatyanarayanaAbstract:In this pilot study, the efficacy of a novel, natural extract of a highly bioavailable, calciumpotassium salt of (‐)-Hydroxycitric Acid (HCA-SX) alone and in combination with a niacin-bound chromium (NBC) and Gymnema sylvestraextract (GSE) was evaluated for weight loss in moderately obese subjects by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and serotonin levels, and enhanced excretion of urinary fat metabolites. Garcinia cambogia-derived (‐)-Hydroxycitric Acid (HCA) has been shown to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. NBC has shown the ability to restore insulin function, metabolize fat, turn protein into muscle, and convert sugar into energy, which plays a role in appetite regulation and facilitates weight loss. Gymnema sylvestreis a traditional herb that helps to promote weight loss possibly through its ability to reduce cravings for sweets and control blood sugar levels. A randomized, double-blind, placebo-controlled human clinical study was conducted in thirty obese subjects (ages 21-50, BMI26 kg/m 2 ) for eight weeks in Elluru, India. The subjects were randomly divided into three groups (10 subjects/group) and given HCA-SX 4,667 mg (60% HCA providing 2,800 mg HCA/day) (Group A), a combination of HCA-SX 4,667 mg, NBC 4 mg (providing 400 g elemental Cr) and GSE 400 mg (providing 100 mg gymnemic Acid) (Group B), or placebo (Group C) daily in 3 equally divided doses 30-60 min before each meal. This
