Hydroxycorticosteroids

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W. Vetter - One of the best experts on this subject based on the ideXlab platform.

  • Urinary free cortisol versus 17-Hydroxycorticosteroids a comparative study of their diagnostic value in Cushing's syndrome
    The clinical investigator, 1992
    Co-Authors: T. Mengden, P. Hubmann, J. Müller, P. Greminger, W. Vetter
    Abstract:

    We evaluated the usefulness of the basal urinary 24-h excretion rates of free cortisol versus 17-Hydroxycorticosteroids in the diagnosis of Cushing's syndrome. On an outpatient basis, both urinary free cortisol and 17-Hydroxycorticosteroids levels were determined in 48 patients with Cushing's syndrome, as well as in 95 obese and 94 healthy control persons of normal weight. Determination of the urinary free cortisol content allowed a clear-cut distinction between the patients with hypercortisolism and the controls, resulting in a sensitivity of 100% and specificity of 98% for the diagnosis of Cushing's syndrome. The diagnostic accuracy of urinary free cortisol was distinctly superior to that of 17-Hydroxycorticosteroids, which showed a wide overlap of values between the groups, with a sensitivity of 73% and a specificity of 94%. In conclusion, the measurement of basal urinary free cortisol provided an excellent diagnostic sensitivity and specificity in the assessment of adrenocortical function. This simple and accurate test thus seems to be particularly useful in the outpatient evaluation of patients with suspected Cushing's syndrome.

Asbjorn Aakvaag - One of the best experts on this subject based on the ideXlab platform.

  • plasma 11 Hydroxycorticosteroids in acute myocardial infarction
    Acta Medica Scandinavica, 2009
    Co-Authors: Sigurd Nitterhauge, Knut Kirkeby, Jensolai Alvsaker, Asbjorn Aakvaag
    Abstract:

    Serial determinations of plasma 11-hydroxy-corticosteroid (11-OH-CS), serum transaminase and venous blood lactate have been carried out over a 3-day period after admission in 26 patients with acute myocardial infarction (AMI). On admission, values for 11-OH-CS above the upper normal range were found in slightly more than one half of the patients. Initial plasma 11-OH-CS levels higher than 40 μg/100 ml heralded a grave prognosis. Normal or moderately elevated levels were found in good risk patients. The study supports the assumption that determination of plasma 11-OH-CS may be of prognostic aid in the early phase of AMI. The rise in plasma 11-OH-CS preceded the rise in serum transaminase, but seemed to parallel the rise in venous blood lactate. Peak values for both the latter parameters showed close correlation with the steroid response.

P. Apostoli - One of the best experts on this subject based on the ideXlab platform.

  • Xenobiotic action on steroid hormone synthesis and sulfonation the example of lead and polychlorinated biphenyls
    International Archives of Occupational and Environmental Health, 2009
    Co-Authors: L. Romeo, S. Catalani, F. Pasini, R. Bergonzi, L. Perbellini, P. Apostoli
    Abstract:

    Objectives In the present study, the metabolism of steroid hormones has been investigated to determine whether and how xenobiotics like lead (Pb) and polychlorinated biphenyls (PCBs) interfere with steroid hormone biotransformation in humans. Methods Three groups of subjects were tested for concentration of urinary total steroids, 17-ketosteroids ( n  = 5), pregnane derivates ( n  = 6), 17-Hydroxycorticosteroids ( n  = 11) and their sulfonated compounds: 14 workers exposed to lead, with a mean Pb blood concentration (PbB) of 29.21 μg/dl; 15 subjects exposed to PCBs, with a mean PCB blood concentration (PCBB) of 61.69 μg/l; a control group ( n  = 25). Results The urinary concentrations of 17-ketosteroids and 17-Hydroxycorticosteroids were significantly lower in the PCB-exposed groups. There were significantly fewer sulfonated 17-Hydroxycorticosteroids in the subjects exposed to PCBs as compared to the controls, while the percentage of sulfonated steroids was lower for both 17-ketosteroids and 17-Hydroxycorticosteroids in the PCB-exposed subjects, but only for the 17-Hydroxycorticosteroids in the group of subjects exposed to Pb ( P  

C F A Van Bezooijen - One of the best experts on this subject based on the ideXlab platform.

  • cortisol production rate and the urinary excretion of 17 Hydroxycorticosteroids free cortisol and 6β hydroxycortisol in healthy elderly men and women
    The Journals of Gerontology, 1993
    Co-Authors: R N Barton, M A Horan, J W M Weijers, A N Sakkee, N A Roberts, C F A Van Bezooijen
    Abstract:

    BACKGROUND: Although many workers have tested adrenal function in the elderly, few have studied the effect of aging on cortisol production rate or urinary free cortisol or 6 beta-hydroxycortisol excretion, and none have published comparisons of these variables between old people of defined health status and young people. METHODS: We have measured cortisol production rate and the urinary excretion of free cortisol, 6 beta-hydroxycortisol, 17-Hydroxycorticosteroids (Porter-Silber chromogens) and creatinine in elderly men and women screened by the SENIEUR protocol and in young men; 17-hydroxycorticosteroid and 6 beta-hydroxycortisol excretion were also measured in young women. The period of measurement was 24 h or, usually, 48 h. RESULTS: Only 6 beta-hydroxycortisol excretion was affected by aging; it was lower in the elderly men and women than in their younger counterparts. Urinary free cortisol excretion was lower in the elderly women than in the elderly men. There were no significant differences between groups in cortisol production rate or 17-hydroxycorticosteroid excretion. Excretion and (over the first 24 h) clearance of creatinine were lower in the old women than in the old men. The cortisol-related variables tended to be positively correlated with each other and with the relevant creatinine-related variables in the elderly subjects; over the first but not the second 24 h, most of the correlations were significant in the men and women combined. CONCLUSIONS: With the exception of 6 beta-hydroxycortisol, the data agree with measurements of plasma cortisol and the results of adrenal function tests in showing little change in hypothalamic-pituitary-adrenal function with aging in healthy people.

Tatsuo Sato - One of the best experts on this subject based on the ideXlab platform.

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