The Experts below are selected from a list of 1350 Experts worldwide ranked by ideXlab platform
Janardan P. Pandey - One of the best experts on this subject based on the ideXlab platform.
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Genetic interactions of KIR and G1M Immunoglobulin Allotypes differ in obese from non-obese individuals with type 2 diabetes.
Molecular immunology, 2008Co-Authors: Viviana Romero, Janardan P. Pandey, Joaquín Zúñiga, Jose Azocar, Olga P. Clavijo, Daniel Terreros, Hassan Kidwai, Edmond J. YunisAbstract:We analyzed the natural killer cell Immunoglobulin-like receptor (KIR) genes and Immunoglobulin Allotypes in the development of type 2 diabetes (T2D) based on body mass index (BMI) measurements (obese vs. non-obese) in Puerto Rican Americans. Genetic interactions between the KIR haplotype A homozygotes (HAH) and its fraction containing two inhibitory receptors 2DL3 and 2DL1 and the activating receptor 2DS4 with Immunoglobulin Allotypes were studied. We found a significant association between the HAH and T2D (p = 0.002; OR = 7.97) and its interaction with the Immunoglobulin Allotype z: GM f/f (−) (p =
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Immunoglobulin Allotype gene polymorphisms in systemic sclerosis interactive effect of mhc class ii and km genes on anticentromere antibody production
Annals of the Rheumatic Diseases, 1998Co-Authors: Hideto Kameda, Janardan P. Pandey, Junichi Kaburaki, Hidetoshi Inoko, Masataka KuwanaAbstract:Objective—To examine potential interactions between Immunoglobulin (Ig)Allotype gene polymorphisms and susceptibility to systemic sclerosis (SSc) as well as serological expression in SSc patients. Methods—IgG heavy chain Allotypes G1M(f, z), G2M(n+, n-), G3M(b, g) and Ig light chain Allotype KM(1, (1, 2), 3) were genotyped in 105 Japanese SSc patients and 47 race matched normal controls using polymerase chain reaction (PCR) based methods. Associations of each Ig Allotype with SSc related antinuclear antibodies were examined in combination with or without MHC class II alleles. Results—GM/KM genotypic and allelic frequencies were similar in SSc patients and in normal controls. Frequencies of G1M(f) and G2M(n+) were significantly decreased in anticentromere antibody (ACA) positive SSc patients compared with ACA negative SSc patients (p = 0.04 and 0.02, respectively). Conversely, the presence of DQB1*0501 and KM(1, 2) significantly increased the risk of ACA positivity. Conclusion—Ig Allotype gene polymorphisms were not associated with susceptibility to SSc.Instead,the results suggested that MHC class II and KM genes are associated with autoimmune responses by interactively promoting the production of ACA. (Ann Rheum Dis 1998;57:366‐370)
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The effect of race, smoking and Immunoglobulin Allotypes on IgG subclass concentrations
Journal of periodontal research, 1997Co-Authors: John C. Gunsolley, Janardan P. Pandey, Stephen M. Quinn, John G. Tew, Harvey A. SchenkeinAbstract:In previous studies we have demonstrated that serum IgG subclass concentrations are influenced by both race and periodontal disease diagnosis. Furthermore, we have shown that smoking habits modify the concentrations of some IgG subclasses in specific racial and diagnostic groups. In view of a large amount of data showing strong associations between Immunoglobulin Allotypes and IgG subclass concentrations we have investigated the effects of race, smoking and IgG Allotype on IgG subclass concentration in a population of subjects with or without various forms of periodontitis. The results indicated that there are complex relationships between these factors in their effects on individual IgG subclass levels, and that effects unique to black or white subject groups, or to specific periodontal diagnostic groups and racial subgroups, were evident. In blacks with chronic adult periodontitis IgG1 was lower in smokers, while in generalized early-onset periodontitis patients IgG2 was lower in smokers. IgG4 was independently affected by gender (males higher), smoking (smokers lower) and GM23 (GM23 positive subjects higher), in black subjects only. In white subjects, complex relationships between smoking and allotypic markers were noted but no influence of periodontal diagnosis was found. White GM23 negative subjects who smoked had lower levels of IgG1 than GM23 positive subjects. White GM2 negative subjects who smoked had lower levels of IgG2, than did those who did not smoke. In contrast, smoking had no effect on IgG2 levels in GM2 positive subjects. Thus, in addition to Immunoglobulin Allotype, smoking is associated with IgG subclass concentrations; furthermore, in black subjects, periodontal diagnosis, gender and smoking all influence IgG subclass concentrations. These results demonstrate that genetic and environmental factors can interact to influence levels of individual subclasses.
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igg antibody to pneumococcal capsular polysaccharide in human immunodeficiency virus infected subjects persistence of antibody in responders revaccination in nonresponders and relationship of Immunoglobulin Allotype to response
The Journal of Infectious Diseases, 1996Co-Authors: Maria C Rodriguezbarradas, Janardan P. Pandey, Jean E Groover, Christine E Lacke, Dieter W Gump, Christopher J Lahart, Daniel M MusherAbstract:Human immunodeficiency virus (HIV)-infected persons are less likely than are noninfected persons to respond to vaccination with pneumococcal polysaccharides (PPS). Among those who respond, however, similar IgG levels may be achieved. HIV-infected men immunized with pneumococcal vaccine were classified as high- or low-level responders (IgG ≥1 μg/mL for ≥3 of 5 PPS [high] or for ≤1 PPS [low]). One and 2 years after immunization, geometric mean IgG levels and the percentages of subjects with IgG levels ≥1 μg/mL were similar for HIV-infected and for healthy high-level responders (controls) for all PPS except for serotype 8. Among HIV-infected low-level responders, revaccination with a double dose of pneumococcal vaccine did not stimulate IgG responses. Responsiveness of HIV-infected white patients was significantly associated with the Km(1)-negative Allotype. These findings support current general recommended guidelines for administering pneumococcal vaccine to HIV-infected persons. Nonresponders will not benefit from revaccination.
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Immumoglobulin Allotypes in Ecuadorian Cayapa Indians
Human Genetics, 1994Co-Authors: Michael A. Kron, Janardan P. Pandey, Laura Gately, Miguel H. Jurado, Jose Rumbea GuzmanAbstract:Indigenous Indian groups comprise approximately 20% of Ecuador's population, the third largest percentage in all of Central or South America, yet immunogenetic data on these groups are lacking in the literature. In the course of population migration studies, sera collected from 65 Ecuadorians living in the northern province of Esmeraldas were typed for six GM and two KM markers. The study population consisted of 47 Cayapa Indians and 18 blacks of African origin, descendants of slaves imported into the area during the seventeenth century. The Cayapa demonstrated three GM phenotypes, two of which are common to other South American Indian tribes. The frequency of KM1 positive Cayapa Indians (63%) is similar to other South American Indian tribes, but is significantly greater than the Huaorani of eastern Ecuador (2%), the only other Ecuadorian Indian group for whom limited Immunoglobulin Allotype data are available ( χ ^2=35.8, P
Daniel M Musher - One of the best experts on this subject based on the ideXlab platform.
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igg antibody to pneumococcal capsular polysaccharide in human immunodeficiency virus infected subjects persistence of antibody in responders revaccination in nonresponders and relationship of Immunoglobulin Allotype to response
The Journal of Infectious Diseases, 1996Co-Authors: Maria C Rodriguezbarradas, Janardan P. Pandey, Jean E Groover, Christine E Lacke, Dieter W Gump, Christopher J Lahart, Daniel M MusherAbstract:Human immunodeficiency virus (HIV)-infected persons are less likely than are noninfected persons to respond to vaccination with pneumococcal polysaccharides (PPS). Among those who respond, however, similar IgG levels may be achieved. HIV-infected men immunized with pneumococcal vaccine were classified as high- or low-level responders (IgG ≥1 μg/mL for ≥3 of 5 PPS [high] or for ≤1 PPS [low]). One and 2 years after immunization, geometric mean IgG levels and the percentages of subjects with IgG levels ≥1 μg/mL were similar for HIV-infected and for healthy high-level responders (controls) for all PPS except for serotype 8. Among HIV-infected low-level responders, revaccination with a double dose of pneumococcal vaccine did not stimulate IgG responses. Responsiveness of HIV-infected white patients was significantly associated with the Km(1)-negative Allotype. These findings support current general recommended guidelines for administering pneumococcal vaccine to HIV-infected persons. Nonresponders will not benefit from revaccination.
Gregory A Poland - One of the best experts on this subject based on the ideXlab platform.
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heritability of vaccine induced measles neutralizing antibody titers
Vaccine, 2017Co-Authors: Daniel J Schaid, Iana H Haralambieva, Beth R Larrabee, Inna G Ovsyannikova, Richard B Kennedy, Gregory A PolandAbstract:Understanding how genetics influences inter-individual variation of antibody titers in response to measles vaccination is vital to understanding possible sources of vaccine failure as well as improved vaccine development. Although it is recognized that both the human leukocyte antigen (HLA) genes and the Immunoglobulin Allotype genes play significant roles in immune response, there is significant variation in antibody titers that is not explained by these genes. To obtain a more complete estimate of the role of the entire genome, we used a large panel of single nucleotide polymorphisms to estimate the heritability of antibody response to measles vaccine. Based on 935 subjects with European ancestry, we estimated the heritability to be 49% (standard error 0.17). We also estimated the heritability attributable to each chromosome, and found a large range in chromosome-specific heritabilities. Notably, chromosome 1 had the largest estimate (28%), while chromosome 6, which harbors HLA, had an estimated heritability of 13%. Compared with a prior study of twins in the same community, which resulted in a heritability estimate of 88.5%, our study suggests there are either many rare genetic variants, or many common genetic variants of small effect sizes that contribute to variations of antibody titers in response to measles vaccine.
Guy Bordenave - One of the best experts on this subject based on the ideXlab platform.
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central tolerance induction in natural Immunoglobulin Allotype specific t cells
European Journal of Immunology, 2000Co-Authors: Laleh Majlessi, Christele Sellier, Guy BordenaveAbstract:While self toleance is induced to IgG(b)(2a) in Igh(b / b) mice, an anti-IgG(b)(2a) T cell activity emerges in their Igh(a / a) congenic counterparts. This activity is revealed by postnatal transfer of Igh(a / a) T splenocytes into Igh(a / b) F(1), in which total suppression of IgG(2a)(b) expression is established. Here, we sought to determine whether the natural T cell unresponsiveness to IgG(2a)(b) in Igh(b / b) mice involved a central tolerance. Based on the kinetics of postnatal thymic C(gamma2a)(b) gene expression in Igh(b / b) mice, we transplanted thymi from Igh(b / b) donors of diverse ages into tolerogen-free Igh(a / a) nu / nu recipients. The state of T cell tolerance or responsiveness to IgG(2a)(b) in these reconstituted nu / nu hosts was determined by monitoring the capacity of their splenocytes to induce suppression in Igh(a / b) F(1). These experiments demonstrated that: (i) in the Igh(a / a) nu / nu recipients of adult Igh(b / b) thymi, 33 to 65 % T splenocytes were from nu / nu recipient origin, but these peripheral Igh(a / a) T cells were rendered tolerant to IgG(2a)(b) during their differentiation through the adult Igh(b / b) thymi, (ii) circulating IgG(2a)(b) was not a prerequisite for this tolerance induction, (iii) Igh(b / b) thymic epithelium was unable to induce tolerance to IgG(2a)(b) and (iv) IgG(2a)(b)-producing / presenting cells, colonizing the Igh(b / b) thymi, were certainly responsible of full tolerance induction to IgG(2a)(b).
Maria C Rodriguezbarradas - One of the best experts on this subject based on the ideXlab platform.
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igg antibody to pneumococcal capsular polysaccharide in human immunodeficiency virus infected subjects persistence of antibody in responders revaccination in nonresponders and relationship of Immunoglobulin Allotype to response
The Journal of Infectious Diseases, 1996Co-Authors: Maria C Rodriguezbarradas, Janardan P. Pandey, Jean E Groover, Christine E Lacke, Dieter W Gump, Christopher J Lahart, Daniel M MusherAbstract:Human immunodeficiency virus (HIV)-infected persons are less likely than are noninfected persons to respond to vaccination with pneumococcal polysaccharides (PPS). Among those who respond, however, similar IgG levels may be achieved. HIV-infected men immunized with pneumococcal vaccine were classified as high- or low-level responders (IgG ≥1 μg/mL for ≥3 of 5 PPS [high] or for ≤1 PPS [low]). One and 2 years after immunization, geometric mean IgG levels and the percentages of subjects with IgG levels ≥1 μg/mL were similar for HIV-infected and for healthy high-level responders (controls) for all PPS except for serotype 8. Among HIV-infected low-level responders, revaccination with a double dose of pneumococcal vaccine did not stimulate IgG responses. Responsiveness of HIV-infected white patients was significantly associated with the Km(1)-negative Allotype. These findings support current general recommended guidelines for administering pneumococcal vaccine to HIV-infected persons. Nonresponders will not benefit from revaccination.
