The Experts below are selected from a list of 14595 Experts worldwide ranked by ideXlab platform

Qiong Wang - One of the best experts on this subject based on the ideXlab platform.

  • management of intellectual asset production in Industrial Laboratories
    IISE Transactions, 2020
    Co-Authors: Debasis Mitra, Qiong Wang
    Abstract:

    AbstractIndustrial Laboratories generate profit for their parent companies and in so doing benefit society through spillovers of novel technologies and solutions. However, research’s share of corpo...

  • management of intellectual asset production in Industrial Laboratories
    Social Science Research Network, 2019
    Co-Authors: Debasis Mitra, Qiong Wang
    Abstract:

    Industrial Laboratories generate profit for their parent companies and in so doing benefit society through spillovers of novel technologies and solutions. Yet research's share of corporate investment in RD b) improved investment efficiency at development stages; and c) higher revenue realization from assets produced at early development stages.

  • modeling and optimizing intellectual asset production in Industrial Laboratories
    IIE Annual Conference and Expo 2015, 2015
    Co-Authors: Debasis Mitra, Qiong Wang
    Abstract:

    We present a modeling framework to maximize value output of an Industrial laboratory in which there is open-end research department that generates novel ideas and multiple development stages that commercialize some ideas into intellectual assets as well as final products. Resources control takes place at both tactical and strategic levels. The former decision is made at a fast time scale, and determines whether an individual idea should be advanced to a downstream development stage. As basis for this decision, the potential profitability of an idea is assessed by its option value instead of the expected return. The strategic management is carried out by long-term budget allocation between idea generation and development. We formulate and solve an optimization problem for determining the intrinsic rate of return of the laboratory. Our key finding is that the optimal allocation can be heavily biased towards idea generation, to the extent that its output overwhelms development resources. Such configuration inevitably causes a non-trivial number of generated ideas to be dropped, but the waste is appropriate for maximizing the total profit.

Matthias Beller - One of the best experts on this subject based on the ideXlab platform.

  • transition metal catalyzed carbonylation reactions of olefins and alkynes a personal account
    Accounts of Chemical Research, 2014
    Co-Authors: Xiaofeng Wu, Lipeng Wu, Ralf Jackstell, Helfried Neumann, Xianjie Fang, Matthias Beller
    Abstract:

    Carbon monoxide was discovered and identified in the 18th century. Since the first applications in industry 80 years ago, academic and Industrial Laboratories have broadly explored CO’s use in chemical reactions. Today organic chemists routinely employ CO in organic chemistry to synthesize all kinds of carbonyl compounds. Despite all these achievements and a century of carbonylation catalysis, many important research questions and challenges remain.Notably, apart from academic developments, industry applies carbonylation reactions with CO on bulk scale. In fact, today the largest applications of homogeneous catalysis (regarding scale) are carbonylation reactions, especially hydroformylations. In addition, the vast majority of acetic acid is produced via carbonylation of methanol (Monsanto or Cativa process). The carbonylation of olefins/alkynes with nucleophiles, such as alcohols and amines, represent another important type of such reactions.In this Account, we discuss our work on various carbonylations o...

  • palladium catalyzed oxidative carbonylation reactions
    Chemsuschem, 2013
    Co-Authors: Xiaofeng Wu, Helfried Neumann, Matthias Beller
    Abstract:

    : Palladium-catalyzed coupling reactions have become a powerful tool for advanced organic synthesis. This type of reaction is of significant value for the preparation of pharmaceuticals, agrochemicals, as well as advanced materials. Both, academic as well as Industrial Laboratories continuously investigate new applications of the different methodologies. Clearly, this area constitutes one of the major topics in homogeneous catalysis and organic synthesis. Among the different palladium-catalyzed coupling reactions, several carbonylations have been developed and widely used in organic syntheses and are even applied in the pharmaceutical industry on ton-scale. Furthermore, methodologies such as the carbonylative Suzuki and Sonogashira reactions allow for the preparation of interesting building blocks, which can be easily refined further on. Although carbonylative coupling reactions of aryl halides have been well established, palladium-catalyzed oxidative carbonylation reactions are also interesting. Compared with the reactions of aryl halides, oxidative carbonylation reactions offer an interesting pathway. The oxidative addition step could be potentially avoided in oxidative reactions, but only few reviews exist in this area. In this Minireview, we summarize the recent development in the oxidative carbonylation reactions.

Axel Bube - One of the best experts on this subject based on the ideXlab platform.

  • proliferative and nonproliferative lesions of the rat and mouse male reproductive system
    Toxicologic Pathology, 2012
    Co-Authors: Dianne M Creasy, Thomas Nolte, Axel Bube, Eveline P C T De Rijk, Hitoshi Kandori, Maki Kuwahara, Regis Masson, Rachel Y Reams, Karen S Regan, Sabine Rehm
    Abstract:

    The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the male reproductive system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the Internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and Industrial Laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the male reproductive system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

  • proliferative and nonproliferative lesions of the rat and mouse urinary system
    Toxicologic Pathology, 2012
    Co-Authors: Kendall S Frazier, John C Seely, Gordon C Hard, Graham Betton, Roger Burnett, Shunji Nakatsuji, Akiyoshi Nishikawa, Beate Durchfeldmeyer, Axel Bube
    Abstract:

    The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying lesions observed in the urinary tract of rats and mice. The standardized nomenclature of urinary tract lesions presented in this document is also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and Industrial Laboratories throughout the world. Content includes spontaneous developmental and aging lesions as well as those induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for urinar...

Maike Huisinga - One of the best experts on this subject based on the ideXlab platform.

  • International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog:
    Toxicologic pathology, 2021
    Co-Authors: Jochen Woicke, Muthafar M Al-haddawi, Jean-guy Bienvenu, Jessica M. Caverly Rae, Franck Chanut, Karyn Colman, John M. Cullen, Wendell P Davis, Ryo Fukuda, Maike Huisinga
    Abstract:

    The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions) Project (www.toxpath.org/inhand.asp) is a joint initiative of the societies of toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying lesions observed in most tissues and organs from the dog used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and Industrial Laboratories throughout the world. Content includes spontaneous lesions, lesions induced by exposure to test materials, and relevant infectious and parasitic lesions. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

Sean Mckeag - One of the best experts on this subject based on the ideXlab platform.

  • international harmonization of nomenclature and diagnostic criteria inhand nonproliferative and proliferative lesions of the minipig
    Toxicologic Pathology, 2021
    Co-Authors: Mikala Skydsgaard, Zuhal Dincer, Wanda M Haschek, Kris Helke, Binod Jacob, Bjoern Jacobsen, Gitte Jeppesen, Atsuhiko Kato, Hiroaki Kawaguchi, Sean Mckeag
    Abstract:

    The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions) Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the minipig used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and Industrial Laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.