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Ki Ho Park - One of the best experts on this subject based on the ideXlab platform.

  • topographic correlation between macular superficial microvessel density and ganglion cell Inner Plexiform Layer thickness in glaucoma suspect and early normal tension glaucoma
    British Journal of Ophthalmology, 2020
    Co-Authors: Jin Soo Kim, Jin Wook Jeoung, Young Kook Kim, Yong Woo Kim, Sung Uk Baek, Ki Ho Park
    Abstract:

    Background/Aims To investigate the topographic relationship between macular superficial microvessel density (SMD) and macular ganglion cell-Inner Plexiform Layer (GCIPL) thickness in eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG). Methods A total of 86 eyes of 86 patients with early NTG (standard automated perimetry mean deviation >−5.5 decibels) and a total of 25 eyes of 25 patients with GS were retrospectively reviewed. All of the subjects underwent optical coherence tomography (OCT) and OCT angiography (OCTA) scan. On the OCTA scan images, macular SMD was analysed by customised software. Results In GS and patients with early NTG, macular GCIPL thickness showed significant correlations with macular SMD in the superotemporal (ST), inferotemporal (IT) and inferoinferior (II) sectors (r=0.191, 0.373 and 0.346 for ST, IT and II sector, respectively). Additionally, circumpapillary retinal nerve fibre Layer (RNFL) thickness and macular SMD showed significant correlations between the ST sector of the macula and the 1, 9 clock-hour peripapillary regions and between the IT and II sectors of the macula and the 6, 7, 8 clock-hour peripapillary regions. The IT sector macular SMD showed fair diagnostic power (area under the receiver operating characteristic curve [AUROC] = 0.758) and showed high diagnostic power when combined with IT sector macular GCIPL thickness (AUROC=0.954). Conclusions Sectoral macular SMD showed topographic correlations with macular GCIPL thickness and circumpapillary RNFL thickness in patients with GS and early-stage NTG. Macular SMD analysis is potentially useful in the clinical evaluation of early glaucoma.

  • evaluation of ganglion cell Inner Plexiform Layer thinning in eyes with optic disc hemorrhage a trend based progression analysis
    Investigative Ophthalmology & Visual Science, 2017
    Co-Authors: Jin Wook Jeoung, Ki Ho Park, Young Kook Kim, Won June Lee
    Abstract:

    Purpose To evaluate the rate of change in ganglion cell-Inner Plexiform Layer (GCIPL) thickness measured by optical coherence tomography (OCT) using a trend-based approach in early-stage glaucomatous eyes with disc hemorrhage (DH) and to compare the GCIPL thinning rate with that in glaucomatous eyes without DH. Methods This prospective observational study included 46 patients with early-stage open-angle glaucoma and DH who underwent serial spectral-domain OCT measurements for at least 30 months. The GCIPL thinning rate was determined in the global, superior, or inferior hemiretinas and in six macular sectors by linear regression and was compared between glaucomatous eyes with DH and fellow glaucomatous eyes without DH and between glaucomatous eyes with DH and non-DH glaucomatous control eyes. Results The GCIPL thinning rate (mean ± standard deviation) was significantly more rapid in glaucomatous eyes with DH than in fellow eyes without DH in the inferior hemiretina (-1.07 ± 0.75 vs. -0.44 ± 0.54 μm/y, P = 0.001), inferotemporal sector (-1.13 ± 1.00 vs. -0.61 ± 0.66 μm/y, P = 0.028), and inferior sector (-1.33 ± 0.79 vs. -0.42 ± 0.78 μm/y, P < 0.001). The GCIPL thinning rate was significantly more rapid in glaucomatous eyes with DH than in glaucomatous controls without DH in the global area (-0.78 ± 0.85 vs. -0.32 ± 0.48 μm/y, P = 0.002), the inferior hemiretina (-1.00 ± 0.94 vs. -0.37 ± 0.67 μm/y, P < 0.001), and the inferotemporal sector (-1.31 ± 1.07 vs. -0.34 ± 0.75 μm/y, P < 0.001). Conclusions The GCIPL thinning rate on OCT was significantly more rapid in glaucomatous eyes with DH than in fellow glaucomatous eyes without DH or glaucomatous control eyes without DH. DH could be associated with progression of glaucoma in terms of GCIPL thinning.

  • rate of macular ganglion cell Inner Plexiform Layer thinning in glaucomatous eyes with vascular endothelial growth factor inhibition
    Journal of Glaucoma, 2017
    Co-Authors: Won June Lee, Jin Wook Jeoung, Young Kook Kim, Yong Woo Kim, Seok Hwan Kim, Jang Won Heo, Ki Ho Park
    Abstract:

    PURPOSE To evaluate the rate of progressive macular ganglion cell-Inner Plexiform Layer (GCIPL) thinning in patients with open-angle glaucoma (OAG) who had been treated with intravitreal antivascular endothelial growth factor (VEGF) injection for wet age-related macular degeneration (AMD). METHODS This study was a retrospective modified case control study with fellow eye comparison. We enrolled bilateral OAG patients who had been treated with repeated anti-VEGF injections for unilateral wet AMD and followed-up on for a minimum of 24 months by Cirrus high-definition optical coherence tomography. The rate of macular GCIPL thinning was determined by linear regression of serial optical coherence tomography GCIPL thickness measurements over time. We compared the rate of macular GCIPL thinning between anti-VEGF-treated eyes and fellow untreated dry AMD eyes. RESULTS This study involved 32 OAG eyes of 16 subjects. The total follow-up period was 58.4±25.5 (24 to 98) months, and the mean number of anti-VEGF injections was 10.6±10.4 (3 to 40). The eyes with repeated anti-VEGF treatment differed significantly from their fellow eyes in the rate of GCIPL thinning (-2.95±3.58 vs. -0.77±0.95 µm/y, P=0.015). Also, multivariable regression analyses showed that anti-VEGF injection was significantly associated with the rate of GCIPL thinning (P=0.025). CONCLUSIONS In subjects with bilateral OAG, the rate of GCIPL thinning is significantly faster in eyes treated with anti-VEGF injection for wet AMD than in untreated dry AMD fellow eyes. This finding suggests that in glaucomatous eyes, VEGF inhibition could play a role, at least in part, in progressive change of Inner retinal Layers.

  • trend based analysis of ganglion cell Inner Plexiform Layer thickness changes on optical coherence tomography in glaucoma progression
    Ophthalmology, 2017
    Co-Authors: Jin Wook Jeoung, Ki Ho Park, Young Kook Kim, Won June Lee
    Abstract:

    Purpose To evaluate the rate of thinning in ganglion cell–Inner Plexiform Layer (GCIPL) thickness by optical coherence tomography (OCT) in glaucomatous eyes and to use a trend-based approach to determine its diagnostic ability for detecting glaucoma progression. Design Prospective, observational study. Participants Sixty-five patients with primary open-angle glaucoma with a minimum 3-year follow-up involving serial spectral-domain OCT measurement of GCIPL thickness. Methods Patients were divided into a nonprogressor group (n = 38) and a progressor group (n = 27) on the basis of serial red-free photography or visual field tests. The rates of GCIPL thinning in the global region, affected hemifield, and 6 macular sectors, and the minimum thickness, were determined by linear regression and compared between groups. The area under the receiver operating characteristic curves (AUCs) were calculated for each parameter. The GCIPL thinning rates were compared between affected hemifields and unaffected hemifields. Main Outcome Measures The macular GCIPL thinning rates in the progressor and nonprogressor groups and the ability of the GCIPL thinning rate to diagnose glaucoma progression. Results The GCIPL thinning rate was significantly faster in progressors than in nonprogressors in the global area ( P P  = 0.001); in the temporal, vertical, and nasal sectors of the affected hemifield ( P  = 0.017, 0.032, and 0.030, respectively); and in the minimum GCIPL thickness ( P P  = 0.013). The best GCIPL parameters were the global (AUC = 0.791), minimum (AUC = 0.755), inferior hemifield (AUC = 0.708), and affected hemifield (AUC = 0.702) thinning rates. The global circumpapillary retinal nerve fiber Layer thinning rate correlated significantly with the global and inferotemporal sector GCIPL thinning rates (rho = 0.259 and 0.366, respectively). Conclusions The GCIPL thinning rate on OCT was significantly faster for patients with glaucoma with progression than for those without progression. The GCIPL thinning rate of the temporal sector was faster in the affected than in the unaffected hemifield, suggesting that the glaucomatous damage may progress locally in a specific sequence. Trend-based analysis of GCIPL thickness on OCT may be useful for assessing glaucoma progression objectively and quantitatively.

  • patterns of glaucoma progression in retinal nerve fiber and macular ganglion cell Inner Plexiform Layer in spectral domain optical coherence tomography
    Japanese Journal of Ophthalmology, 2017
    Co-Authors: Hae Jin Kim, Jin Wook Jeoung, Byeong Wook Yoo, H S Kim, Ki Ho Park
    Abstract:

    Purpose To evaluate the progressive changes of circumpapillary retinal nerve fiber Layer (RNFL) and macular ganglion cell-Inner Plexiform Layer (GCIPL) thicknesses measured by spectral-domain optical coherence tomography (Cirrus SD-OCT) in open-angle glaucoma.

Jin Wook Jeoung - One of the best experts on this subject based on the ideXlab platform.

  • macular ganglion cell Inner Plexiform Layer thickness prediction from red free fundus photography using hybrid deep learning model
    Scientific Reports, 2020
    Co-Authors: Jin Wook Jeoung, Jinho Lee, Young Kook Kim, Sukkyu Sun, Yong Woo Kim, Jin Soo Kim
    Abstract:

    We developed a hybrid deep learning model (HDLM) algorithm that quantitatively predicts macular ganglion cell-Inner Plexiform Layer (mGCIPL) thickness from red-free retinal nerve fiber Layer photographs (RNFLPs). A total of 789 pairs of RNFLPs and spectral domain-optical coherence tomography (SD-OCT) scans for 431 eyes of 259 participants (183 eyes of 114 healthy controls, 68 eyes of 46 glaucoma suspects, and 180 eyes of 99 glaucoma patients) were enrolled. An HDLM was built by combining a pre-trained deep learning network and support vector machine. The correlation coefficient and mean absolute error (MAE) between the predicted and measured mGCIPL thicknesses were calculated. The measured (OCT-based) and predicted (HDLM-based) average mGCIPL thicknesses were 73.96 ± 8.81 µm and 73.92 ± 7.36 µm, respectively (P = 0.844). The predicted mGCIPL thickness showed a strong correlation and good agreement with the measured mGCIPL thickness (Correlation coefficient r = 0.739; P < 0.001; MAE = 4.76 µm). Even when the peripapillary area (diameter: 1.5 disc diameters) was masked, the correlation (r = 0.713; P < 0.001) and agreement (MAE = 4.87 µm) were not changed significantly (P = 0.378 and 0.724, respectively). The trained HDLM algorithm showed a great capability for mGCIPL thickness prediction from RNFLPs.

  • topographic correlation between macular superficial microvessel density and ganglion cell Inner Plexiform Layer thickness in glaucoma suspect and early normal tension glaucoma
    British Journal of Ophthalmology, 2020
    Co-Authors: Jin Soo Kim, Jin Wook Jeoung, Young Kook Kim, Yong Woo Kim, Sung Uk Baek, Ki Ho Park
    Abstract:

    Background/Aims To investigate the topographic relationship between macular superficial microvessel density (SMD) and macular ganglion cell-Inner Plexiform Layer (GCIPL) thickness in eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG). Methods A total of 86 eyes of 86 patients with early NTG (standard automated perimetry mean deviation >−5.5 decibels) and a total of 25 eyes of 25 patients with GS were retrospectively reviewed. All of the subjects underwent optical coherence tomography (OCT) and OCT angiography (OCTA) scan. On the OCTA scan images, macular SMD was analysed by customised software. Results In GS and patients with early NTG, macular GCIPL thickness showed significant correlations with macular SMD in the superotemporal (ST), inferotemporal (IT) and inferoinferior (II) sectors (r=0.191, 0.373 and 0.346 for ST, IT and II sector, respectively). Additionally, circumpapillary retinal nerve fibre Layer (RNFL) thickness and macular SMD showed significant correlations between the ST sector of the macula and the 1, 9 clock-hour peripapillary regions and between the IT and II sectors of the macula and the 6, 7, 8 clock-hour peripapillary regions. The IT sector macular SMD showed fair diagnostic power (area under the receiver operating characteristic curve [AUROC] = 0.758) and showed high diagnostic power when combined with IT sector macular GCIPL thickness (AUROC=0.954). Conclusions Sectoral macular SMD showed topographic correlations with macular GCIPL thickness and circumpapillary RNFL thickness in patients with GS and early-stage NTG. Macular SMD analysis is potentially useful in the clinical evaluation of early glaucoma.

  • temporal raphe sign for discrimination of glaucoma from optic neuropathy in eyes with macular ganglion cell Inner Plexiform Layer thinning
    Ophthalmology, 2019
    Co-Authors: Jinho Lee, Jin Wook Jeoung, Haengjin Lee, Young Kook Kim, Yong Woo Kim, Jin Soo Kim, Sung Uk Baek, Dai Woo Kim, Seongjoon Kim
    Abstract:

    Purpose To evaluate the potential of the temporal raphe sign on the macular ganglion cell–Inner Plexiform Layer (mGCIPL) thickness map for discriminating glaucomatous from nonglaucomatous optic neuropathy (NGON) in eyes with mGCIPL thinning. Design Cross-sectional study. Participants A total of 175 eyes of 175 patients with mGCIPL thinning on Cirrus (Carl Zeiss Meditec, Dublin, CA) high-definition OCT were retrospectively included. Glaucoma specialists and neuro-ophthalmology specialists evaluated the patients’ medical records for diagnosis of glaucomatous optic neuropathy (GON) or NGON. Finally, by consensus, 67 eyes with GON and 73 eyes with NGON were enrolled. Methods A positive temporal raphe sign was declared in patients in whom there was a straight line longer than one-half of the length between the Inner and outer annulus in the temporal elliptical area of the mGCIPL thickness map. Decision tree analysis was performed to formulate a diagnostic model. Main Outcome Measures Area under receiver operating characteristic curve (AUC) with sensitivity and specificity. Results The temporal raphe sign was observed in 61 of 67 GON eyes (91.0%), but in only 21 of 73 NGON eyes (28.8%) (P Conclusions In clinical practice, determining whether the temporal raphe sign appears on OCT macular scans can be a useful tool for discrimination of glaucomatous from nonglaucomatous mGCIPL thinning.

  • evaluation of ganglion cell Inner Plexiform Layer thinning in eyes with optic disc hemorrhage a trend based progression analysis
    Investigative Ophthalmology & Visual Science, 2017
    Co-Authors: Jin Wook Jeoung, Ki Ho Park, Young Kook Kim, Won June Lee
    Abstract:

    Purpose To evaluate the rate of change in ganglion cell-Inner Plexiform Layer (GCIPL) thickness measured by optical coherence tomography (OCT) using a trend-based approach in early-stage glaucomatous eyes with disc hemorrhage (DH) and to compare the GCIPL thinning rate with that in glaucomatous eyes without DH. Methods This prospective observational study included 46 patients with early-stage open-angle glaucoma and DH who underwent serial spectral-domain OCT measurements for at least 30 months. The GCIPL thinning rate was determined in the global, superior, or inferior hemiretinas and in six macular sectors by linear regression and was compared between glaucomatous eyes with DH and fellow glaucomatous eyes without DH and between glaucomatous eyes with DH and non-DH glaucomatous control eyes. Results The GCIPL thinning rate (mean ± standard deviation) was significantly more rapid in glaucomatous eyes with DH than in fellow eyes without DH in the inferior hemiretina (-1.07 ± 0.75 vs. -0.44 ± 0.54 μm/y, P = 0.001), inferotemporal sector (-1.13 ± 1.00 vs. -0.61 ± 0.66 μm/y, P = 0.028), and inferior sector (-1.33 ± 0.79 vs. -0.42 ± 0.78 μm/y, P < 0.001). The GCIPL thinning rate was significantly more rapid in glaucomatous eyes with DH than in glaucomatous controls without DH in the global area (-0.78 ± 0.85 vs. -0.32 ± 0.48 μm/y, P = 0.002), the inferior hemiretina (-1.00 ± 0.94 vs. -0.37 ± 0.67 μm/y, P < 0.001), and the inferotemporal sector (-1.31 ± 1.07 vs. -0.34 ± 0.75 μm/y, P < 0.001). Conclusions The GCIPL thinning rate on OCT was significantly more rapid in glaucomatous eyes with DH than in fellow glaucomatous eyes without DH or glaucomatous control eyes without DH. DH could be associated with progression of glaucoma in terms of GCIPL thinning.

  • rate of macular ganglion cell Inner Plexiform Layer thinning in glaucomatous eyes with vascular endothelial growth factor inhibition
    Journal of Glaucoma, 2017
    Co-Authors: Won June Lee, Jin Wook Jeoung, Young Kook Kim, Yong Woo Kim, Seok Hwan Kim, Jang Won Heo, Ki Ho Park
    Abstract:

    PURPOSE To evaluate the rate of progressive macular ganglion cell-Inner Plexiform Layer (GCIPL) thinning in patients with open-angle glaucoma (OAG) who had been treated with intravitreal antivascular endothelial growth factor (VEGF) injection for wet age-related macular degeneration (AMD). METHODS This study was a retrospective modified case control study with fellow eye comparison. We enrolled bilateral OAG patients who had been treated with repeated anti-VEGF injections for unilateral wet AMD and followed-up on for a minimum of 24 months by Cirrus high-definition optical coherence tomography. The rate of macular GCIPL thinning was determined by linear regression of serial optical coherence tomography GCIPL thickness measurements over time. We compared the rate of macular GCIPL thinning between anti-VEGF-treated eyes and fellow untreated dry AMD eyes. RESULTS This study involved 32 OAG eyes of 16 subjects. The total follow-up period was 58.4±25.5 (24 to 98) months, and the mean number of anti-VEGF injections was 10.6±10.4 (3 to 40). The eyes with repeated anti-VEGF treatment differed significantly from their fellow eyes in the rate of GCIPL thinning (-2.95±3.58 vs. -0.77±0.95 µm/y, P=0.015). Also, multivariable regression analyses showed that anti-VEGF injection was significantly associated with the rate of GCIPL thinning (P=0.025). CONCLUSIONS In subjects with bilateral OAG, the rate of GCIPL thinning is significantly faster in eyes treated with anti-VEGF injection for wet AMD than in untreated dry AMD fellow eyes. This finding suggests that in glaucomatous eyes, VEGF inhibition could play a role, at least in part, in progressive change of Inner retinal Layers.

Chan Kee Park - One of the best experts on this subject based on the ideXlab platform.

  • segmented Inner Plexiform Layer thickness as a potential biomarker to evaluate open angle glaucoma dendritic degeneration of retinal ganglion cell
    PLOS ONE, 2017
    Co-Authors: Haeyoung Lopilly Park, Chan Kee Park, Eun Kyoung Kim
    Abstract:

    Purpose To evaluate the changes of retinal nerve fiber Layer (RNFL), ganglion cell Layer (GCL), Inner Plexiform Layer (IPL), and ganglion cell-Inner Plexiform Layer (GCIPL) thicknesses and compare structure-function relationships of 4 retinal Layers using spectral-domain optical coherence tomography (SD-OCT) in macular region of glaucoma patients. Methods In cross-sectional study, a total of 85 eyes with pre-perimetric to advanced glaucoma and 26 normal controls were enrolled. The glaucomatous eyes were subdivided into three groups according to the severity of visual field defect: a preperimetric glaucoma group, an early glaucoma group, and a moderate to advanced glaucoma group. RNFL, GCL, IPL, and GCIPL thicknesses were measured at the level of the macula by the Spectralis (Heidelberg Engineering, Heidelberg, Germany) SD-OCT with automated segmentation software. For functional evaluation, corresponding mean sensitivity (MS) values were measured using 24–2 standard automated perimetry (SAP). Results RNFL, GCL, IPL, and GCIPL thicknesses were significantly different among 4 groups (P < .001). Macular structure losses were positively correlated with the MS values of the 24–2 SAP for RNFL, GCL, IPL, and GCIPL (R = 0.553, 0.636, 0.648 and 0.646, respectively, P < .001). In regression analysis, IPL and GCIPL thicknesses showed stronger association with the corresponding MS values of 24–2 SAP compared with RNFL and GCL thicknesses (R2 = 0.420, P < .001 for IPL; R2 = 0.417, P< .001 for GCIPL thickness). Conclusions Segmented IPL thickness was significantly associated with the degree of glaucoma. Segmental analysis of the Inner retinal Layer including the IPL in macular region may provide valuable information for evaluating glaucoma.

  • ocular dominance is associated with the ganglion cell Inner Plexiform Layer thickness profile in the macula
    PLOS ONE, 2016
    Co-Authors: Jin A. Choi, Jung-sub Kim, Hyun Jin Jeong, Jin Ah Lee, Chan Kee Park
    Abstract:

    Purpose To investigate the characteristics of macular ganglion cell-Inner Plexiform Layer (GCIPL) thickness profiles associated with ocular dominance. Setting Private practice, Seoul, Republic of Korea. Design Comparative case-control study. Methods Both eyes of 199 participants with no ophthalmic abnormalities were included. Participants were imaged by spectral-domain optical coherence tomography, and underwent dominant eye testing using a hole-in-a-card test (sighting dominance) at the same visit. Macular GCIPL, as well as circumpapillary retinal nerve fiber Layer (RNFL) thickness were compared for individual patients, according to ocular dominance. Results Ocular dominance occurred predominantly in the right eye (right vs. left: 72.36 vs. 27.60%; P < 0.001). In the comparison of macular GCIPL thickness, the average (81.27±5.01 μm vs. 80.66±6.31 μm in dominant vs. non-dominant eyes), inferonasal (81.39±5.47μm vs. 80.33±6.82μm, and inferior sectors (77.95±6.05μm vs. 76.97±8.15μm) were significantly different between dominant and non-dominant eyes (P = 0.040, 0.005, and 0.032, respectively). Significant predictors of average GCIPL thickness were spherical equivalent (β = 1.37, P<0.001), astigmatic power (β = 1.44, P = 0.009), disc area (β = 3.90, P < 0.001), average RNFL thickness (β = 0.22, P<0.001), average cup-to-disc ratio (β = 5.74, P = 0.002), difference between the inferior and superior quadrant RNFL thicknesses (β = 0.08, P = 0.024), and ocular dominance (β = 2.10, P = 0.020). On multivariate regression analysis, ocular dominance was correlated with average GCIPL thickness after adjusting for potential confounders (β = 1.63, P = 0.048). Conclusions Dominant eyes accompanied significantly thicker average macular GCIPL. This information suggests that macular GCIPL thickness may provide an indicator of the relative dominance of an eye.

  • macular ganglion cell Inner Plexiform Layer thinning in patients with visual field defect that respects the vertical meridian
    Graefes Archive for Clinical and Experimental Ophthalmology, 2014
    Co-Authors: Hyeyoung Shin, Haeyoung Lopilly Park, Jin A. Choi, Chan Kee Park
    Abstract:

    The aim of this work is to compare the thinning patterns of the ganglion cell Inner-Plexiform Layer (GCIPL) and peripapillary retinal nerve fiber Layer (pRNFL) as measured using Cirrus high-definition optical coherence tomography (HD-OCT) in patients with visual field (VF) defects that respect the vertical meridian. Twenty eyes of 11 patients with VF defects that respect the vertical meridian were enrolled retrospectively. The thicknesses of the macular GCIPL and pRNFL were measured using Cirrus HD-OCT. The 5 and 1 % thinning area index (TAI) was calculated as the proportion of abnormally thin sectors at the 5 and 1 % probability level within the area corresponding to the affected VF. The 5 and 1 % TAI were compared between the GCIPL and pRNFL measurements. The color-coded GCIPL deviation map showed a characteristic vertical thinning pattern of the GCIPL, which is also seen in the VF of patients with brain lesions. The 5 and 1 % TAI were significantly higher in the GCIPL measurements than in the pRNFL measurements (all p < 0.01). Macular GCIPL analysis clearly visualized a characteristic topographic pattern of retinal ganglion cell (RGC) loss in patients with VF defects that respect the vertical meridian, unlike pRNFL measurements. Macular GCIPL measurements provide more valuable information than pRNFL measurements for detecting the loss of RGCs in patients with retrograde degeneration of the optic nerve fibers.

  • comparative study of macular ganglion cell Inner Plexiform Layer and peripapillary retinal nerve fiber Layer measurement structure function analysis
    Investigative Ophthalmology & Visual Science, 2013
    Co-Authors: Hyeyoung Shin, Haeyoung Lopilly Park, Kyoung In Jung, Chan Kee Park
    Abstract:

    PURPOSE. We explored and compared the relationships between the visual field (VF) sensitivities assessed by standard automated perimetry (SAP), and the ganglion cell–Inner Plexiform Layer (GCIPL) and peripapillary retinal nerve fiber Layer (pRNFL) thicknesses as measured by Cirrus high-definition optical coherence tomography (HD-OCT) in glaucomatous eyes. METHODS. We enrolled 213 eyes of 213 patients with glaucoma. The thicknesses of the average/sectoral GCIPL and pRNFL were measured by Cirrus HD-OCT. The mean sensitivity (MS) of 24-2 SAP was recorded on decibel and 1/L scales. The topographic relationships between structure and function were investigated. RESULTS. Statistically significant correlations between the corresponding VF sensitivity and the macular GCIPL thickness were found in all GCIPL sectors. Among six GCIPL sectors, the strongest association was observed between superonasal center MS and inferotemporal GCIPL thickness. In comparative analysis, the association between the central cluster MS and average GCIPL thickness was significantly stronger than that of temporal pRNFL thickness using the decibel scale (P < 0.001). The association between regional VF sensitivities, and the inferior hemifield and inferior GCIPL thicknesses were significantly stronger than those of the corresponding pRNFL thickness using the decibel scale (P ¼ 0.001 and 0.007). CONCLUSIONS. The average and sectoral GCIPL thicknesses determined by Cirrus HD-OCT were associated significantly with global and regional VF sensitivity in patients with glaucoma. The macular GCIPL thickness values may provide more valuable information than temporal pRNFL thickness values for understanding the structure–function relationships of the macular region.

Young Kook Kim - One of the best experts on this subject based on the ideXlab platform.

  • macular ganglion cell Inner Plexiform Layer thickness prediction from red free fundus photography using hybrid deep learning model
    Scientific Reports, 2020
    Co-Authors: Jin Wook Jeoung, Jinho Lee, Young Kook Kim, Sukkyu Sun, Yong Woo Kim, Jin Soo Kim
    Abstract:

    We developed a hybrid deep learning model (HDLM) algorithm that quantitatively predicts macular ganglion cell-Inner Plexiform Layer (mGCIPL) thickness from red-free retinal nerve fiber Layer photographs (RNFLPs). A total of 789 pairs of RNFLPs and spectral domain-optical coherence tomography (SD-OCT) scans for 431 eyes of 259 participants (183 eyes of 114 healthy controls, 68 eyes of 46 glaucoma suspects, and 180 eyes of 99 glaucoma patients) were enrolled. An HDLM was built by combining a pre-trained deep learning network and support vector machine. The correlation coefficient and mean absolute error (MAE) between the predicted and measured mGCIPL thicknesses were calculated. The measured (OCT-based) and predicted (HDLM-based) average mGCIPL thicknesses were 73.96 ± 8.81 µm and 73.92 ± 7.36 µm, respectively (P = 0.844). The predicted mGCIPL thickness showed a strong correlation and good agreement with the measured mGCIPL thickness (Correlation coefficient r = 0.739; P < 0.001; MAE = 4.76 µm). Even when the peripapillary area (diameter: 1.5 disc diameters) was masked, the correlation (r = 0.713; P < 0.001) and agreement (MAE = 4.87 µm) were not changed significantly (P = 0.378 and 0.724, respectively). The trained HDLM algorithm showed a great capability for mGCIPL thickness prediction from RNFLPs.

  • topographic correlation between macular superficial microvessel density and ganglion cell Inner Plexiform Layer thickness in glaucoma suspect and early normal tension glaucoma
    British Journal of Ophthalmology, 2020
    Co-Authors: Jin Soo Kim, Jin Wook Jeoung, Young Kook Kim, Yong Woo Kim, Sung Uk Baek, Ki Ho Park
    Abstract:

    Background/Aims To investigate the topographic relationship between macular superficial microvessel density (SMD) and macular ganglion cell-Inner Plexiform Layer (GCIPL) thickness in eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG). Methods A total of 86 eyes of 86 patients with early NTG (standard automated perimetry mean deviation >−5.5 decibels) and a total of 25 eyes of 25 patients with GS were retrospectively reviewed. All of the subjects underwent optical coherence tomography (OCT) and OCT angiography (OCTA) scan. On the OCTA scan images, macular SMD was analysed by customised software. Results In GS and patients with early NTG, macular GCIPL thickness showed significant correlations with macular SMD in the superotemporal (ST), inferotemporal (IT) and inferoinferior (II) sectors (r=0.191, 0.373 and 0.346 for ST, IT and II sector, respectively). Additionally, circumpapillary retinal nerve fibre Layer (RNFL) thickness and macular SMD showed significant correlations between the ST sector of the macula and the 1, 9 clock-hour peripapillary regions and between the IT and II sectors of the macula and the 6, 7, 8 clock-hour peripapillary regions. The IT sector macular SMD showed fair diagnostic power (area under the receiver operating characteristic curve [AUROC] = 0.758) and showed high diagnostic power when combined with IT sector macular GCIPL thickness (AUROC=0.954). Conclusions Sectoral macular SMD showed topographic correlations with macular GCIPL thickness and circumpapillary RNFL thickness in patients with GS and early-stage NTG. Macular SMD analysis is potentially useful in the clinical evaluation of early glaucoma.

  • temporal raphe sign for discrimination of glaucoma from optic neuropathy in eyes with macular ganglion cell Inner Plexiform Layer thinning
    Ophthalmology, 2019
    Co-Authors: Jinho Lee, Jin Wook Jeoung, Haengjin Lee, Young Kook Kim, Yong Woo Kim, Jin Soo Kim, Sung Uk Baek, Dai Woo Kim, Seongjoon Kim
    Abstract:

    Purpose To evaluate the potential of the temporal raphe sign on the macular ganglion cell–Inner Plexiform Layer (mGCIPL) thickness map for discriminating glaucomatous from nonglaucomatous optic neuropathy (NGON) in eyes with mGCIPL thinning. Design Cross-sectional study. Participants A total of 175 eyes of 175 patients with mGCIPL thinning on Cirrus (Carl Zeiss Meditec, Dublin, CA) high-definition OCT were retrospectively included. Glaucoma specialists and neuro-ophthalmology specialists evaluated the patients’ medical records for diagnosis of glaucomatous optic neuropathy (GON) or NGON. Finally, by consensus, 67 eyes with GON and 73 eyes with NGON were enrolled. Methods A positive temporal raphe sign was declared in patients in whom there was a straight line longer than one-half of the length between the Inner and outer annulus in the temporal elliptical area of the mGCIPL thickness map. Decision tree analysis was performed to formulate a diagnostic model. Main Outcome Measures Area under receiver operating characteristic curve (AUC) with sensitivity and specificity. Results The temporal raphe sign was observed in 61 of 67 GON eyes (91.0%), but in only 21 of 73 NGON eyes (28.8%) (P Conclusions In clinical practice, determining whether the temporal raphe sign appears on OCT macular scans can be a useful tool for discrimination of glaucomatous from nonglaucomatous mGCIPL thinning.

  • evaluation of ganglion cell Inner Plexiform Layer thinning in eyes with optic disc hemorrhage a trend based progression analysis
    Investigative Ophthalmology & Visual Science, 2017
    Co-Authors: Jin Wook Jeoung, Ki Ho Park, Young Kook Kim, Won June Lee
    Abstract:

    Purpose To evaluate the rate of change in ganglion cell-Inner Plexiform Layer (GCIPL) thickness measured by optical coherence tomography (OCT) using a trend-based approach in early-stage glaucomatous eyes with disc hemorrhage (DH) and to compare the GCIPL thinning rate with that in glaucomatous eyes without DH. Methods This prospective observational study included 46 patients with early-stage open-angle glaucoma and DH who underwent serial spectral-domain OCT measurements for at least 30 months. The GCIPL thinning rate was determined in the global, superior, or inferior hemiretinas and in six macular sectors by linear regression and was compared between glaucomatous eyes with DH and fellow glaucomatous eyes without DH and between glaucomatous eyes with DH and non-DH glaucomatous control eyes. Results The GCIPL thinning rate (mean ± standard deviation) was significantly more rapid in glaucomatous eyes with DH than in fellow eyes without DH in the inferior hemiretina (-1.07 ± 0.75 vs. -0.44 ± 0.54 μm/y, P = 0.001), inferotemporal sector (-1.13 ± 1.00 vs. -0.61 ± 0.66 μm/y, P = 0.028), and inferior sector (-1.33 ± 0.79 vs. -0.42 ± 0.78 μm/y, P < 0.001). The GCIPL thinning rate was significantly more rapid in glaucomatous eyes with DH than in glaucomatous controls without DH in the global area (-0.78 ± 0.85 vs. -0.32 ± 0.48 μm/y, P = 0.002), the inferior hemiretina (-1.00 ± 0.94 vs. -0.37 ± 0.67 μm/y, P < 0.001), and the inferotemporal sector (-1.31 ± 1.07 vs. -0.34 ± 0.75 μm/y, P < 0.001). Conclusions The GCIPL thinning rate on OCT was significantly more rapid in glaucomatous eyes with DH than in fellow glaucomatous eyes without DH or glaucomatous control eyes without DH. DH could be associated with progression of glaucoma in terms of GCIPL thinning.

  • rate of macular ganglion cell Inner Plexiform Layer thinning in glaucomatous eyes with vascular endothelial growth factor inhibition
    Journal of Glaucoma, 2017
    Co-Authors: Won June Lee, Jin Wook Jeoung, Young Kook Kim, Yong Woo Kim, Seok Hwan Kim, Jang Won Heo, Ki Ho Park
    Abstract:

    PURPOSE To evaluate the rate of progressive macular ganglion cell-Inner Plexiform Layer (GCIPL) thinning in patients with open-angle glaucoma (OAG) who had been treated with intravitreal antivascular endothelial growth factor (VEGF) injection for wet age-related macular degeneration (AMD). METHODS This study was a retrospective modified case control study with fellow eye comparison. We enrolled bilateral OAG patients who had been treated with repeated anti-VEGF injections for unilateral wet AMD and followed-up on for a minimum of 24 months by Cirrus high-definition optical coherence tomography. The rate of macular GCIPL thinning was determined by linear regression of serial optical coherence tomography GCIPL thickness measurements over time. We compared the rate of macular GCIPL thinning between anti-VEGF-treated eyes and fellow untreated dry AMD eyes. RESULTS This study involved 32 OAG eyes of 16 subjects. The total follow-up period was 58.4±25.5 (24 to 98) months, and the mean number of anti-VEGF injections was 10.6±10.4 (3 to 40). The eyes with repeated anti-VEGF treatment differed significantly from their fellow eyes in the rate of GCIPL thinning (-2.95±3.58 vs. -0.77±0.95 µm/y, P=0.015). Also, multivariable regression analyses showed that anti-VEGF injection was significantly associated with the rate of GCIPL thinning (P=0.025). CONCLUSIONS In subjects with bilateral OAG, the rate of GCIPL thinning is significantly faster in eyes treated with anti-VEGF injection for wet AMD than in untreated dry AMD fellow eyes. This finding suggests that in glaucomatous eyes, VEGF inhibition could play a role, at least in part, in progressive change of Inner retinal Layers.

Na Rae Kim - One of the best experts on this subject based on the ideXlab platform.

  • macular ganglion cell Inner Plexiform Layer thickness is associated with clinical progression in mild cognitive impairment and alzheimers disease
    PLOS ONE, 2016
    Co-Authors: Seong Hye Choi, Sang Jun Park, Na Rae Kim
    Abstract:

    Purpose We investigated the association of the macular ganglion cell-Inner Plexiform Layer (GCIPL) and peripapillary retinal nerve fiber Layer (RNFL) thicknesses with disease progression in mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Methods We recruited 42 patients with AD, 26 with MCI, and 66 normal elderly controls. The thicknesses of the RNFL and GCIPL were measured via spectral-domain optic coherent tomography in all participants at baseline. The patients with MCI or AD underwent clinical and neuropsychological tests at baseline and once every year thereafter for 2 years. Results The Clinical Dementia Rating scale-Sum of Boxes (CDR-SB) score exhibited significant negative relationships with the average GCIPL thickness (β = -0.15, p < 0.05) and the GCIPL thickness in the superotemporal, superonasal, and inferonasal sectors. The composite memory score exhibited significant positive associations with the average GCIPL thickness and the GCIPL thickness in the superotemporal, inferonasal, and inferotemporal sectors. The temporal RNFL thickness, the average and minimum GCIPL thicknesses, and the GCIPL thickness in the inferonasal, inferior, and inferotemporal sectors at baseline were significantly reduced in MCI patients who were converted to AD compared to stable MCI patients. The change of CDR-SB from baseline to 2 years exhibited significant negative associations with the average (β = -0.150, p = 0.006) and minimum GCIPL thicknesses as well as GCIPL thickness in the superotemporal, superior, superonasal, and inferonasal sectors at baseline. Conclusions Our data suggest that macular GCIPL thickness represents a promising biomarker for monitoring the progression of MCI and AD.

  • pattern of macular ganglion cell Inner Plexiform Layer defect generated by spectral domain oct in glaucoma patients and normal subjects
    Journal of Glaucoma, 2015
    Co-Authors: Jae Seung Jeong, Min Gu Kang, Chan Yun Kim, Na Rae Kim
    Abstract:

    Purpose To elucidate patterns of macular ganglion cell-Inner Plexiform Layer (GCIPL) defects by Cirrus optical coherence tomography (OCT) and examine the spatial relationship between GCIPL defect and visual field (VF) defect patterns. Methods A total of 116 eyes of 116 normal subjects and 111 eyes of 111 glaucoma patients were included. The 227 study subjects underwent Cirrus OCT imaging in macular cube mode and reliable standard VF testing. Two ophthalmologists blindly classified GCIPL defect patterns and VF defects. The frequency distribution of GCIPL defect patterns and spatial relationships between GCIPL defects and VF defects were investigated. Results GCIPL defect patterns were classified as minimal, Inner, outer, diffuse mild, diffuse severe, inferior confined, inferior dominant, superior confined, and superior dominant defects in normal controls (71.6%, 7.8%, 4.3%, 1.7%, 0%, 10.3%, 1.7%, 1.7%, and 0.9%, respectively) and in glaucoma patients (11.7%, 3.6%, 4.5%, 7.2%, 21.6%, 22.5%, 18.0%, 4.5%, and 6.3%, respectively). In mild and moderate glaucoma patients, the inferior confined type was most frequent (21.9% and 50.0%, respectively). However, the diffuse severe type was most frequent (59.1%) in advanced glaucoma patients. The locations of the VF defects corresponded to the locations of the GCIPL defects in glaucoma patients (P=0.012). Conclusions Glaucomatous damage of the macula was common and more frequent in the inferior retina. GCIPL defect patterns as determined by SD-OCT imaging corresponded well with central VF defects. It seems macular GCIPL analysis may be useful for evaluating glaucomatous optic neuropathy.

  • variations of retinal nerve fiber Layer thickness and ganglion cell Inner Plexiform Layer thickness according to the torsion direction of optic disc
    Investigative Ophthalmology & Visual Science, 2014
    Co-Authors: Kang Hoon Lee, Chan Yun Kim, Na Rae Kim
    Abstract:

    PURPOSE To examine the relationship between the optic disc torsion and peripapillary retinal nerve fiber Layer (RNFL) thickness through a comparison with the macular ganglion cell Inner Plexiform Layer complex (GCIPL) thickness measured by Cirrus optical coherence tomography (OCT). METHODS Ninety-four eyes of 94 subjects with optic disc torsion and 114 eyes of 114 subjects without optic disc torsion were enrolled prospectively. The participants underwent fundus photography and OCT imaging in peripapillary RNFL mode and macular GCIPL mode. The participants were divided into groups according to the presence or absence of optic disc torsion. The eyes with optic disc torsion were further divided into supranasal torsion and inferotemporal torsion groups according to the direction of optic disc torsion. The mean RNFL and GCIPL thicknesses for the quadrants and subsectors were compared. The superior and inferior peak locations of the RNFL were also measured according to the torsion direction. RESULTS The temporal RNFL thickness was significantly thicker in inferotemporal torsion, whereas the GCIPL thickness at all segments was unaffected. The inferotemporal optic torsion had more temporally positioned superior peak locations of the RNFL than the nontorsion and supranasal-torted optic disc. CONCLUSIONS Thickening of the temporal RNFL with a temporal shift in the superior peak within the eyes with inferotemporal optic disc torsion can lead to interpretation errors. The ganglion cell analysis algorithm can assist in differentiating eyes with optic disc torsion.