The Experts below are selected from a list of 24159 Experts worldwide ranked by ideXlab platform
Jamshed Bomanji - One of the best experts on this subject based on the ideXlab platform.
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Diagnostic accuracy of FDG PET/CT for clinical evaluation at the end of treatment of HL and NHL: a comparison of the Deauville Criteria (DC) and the International Harmonization Project Criteria (IHPC)
European journal of nuclear medicine and molecular imaging, 2016Co-Authors: Federico Fallanca, Pierpaolo Alongi, Elena Incerti, Luigi Gianolli, Maria Picchio, Irfan Kayani, Jamshed BomanjiAbstract:Purpose To evaluate the accuracy and prognostic value of FDG PET/CT for response assessment after treatment in patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) when using the Deauville Criteria (DC) and the International Harmonization Project Criteria (IHPC).
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diagnostic accuracy of fdg pet ct for clinical evaluation at the end of treatment of hl and nhl a comparison of the deauville criteria dc and the International Harmonization project criteria ihpc
European Journal of Nuclear Medicine and Molecular Imaging, 2016Co-Authors: Federico Fallanca, Pierpaolo Alongi, Elena Incerti, Luigi Gianolli, Maria Picchio, Irfan Kayani, Jamshed BomanjiAbstract:Purpose To evaluate the accuracy and prognostic value of FDG PET/CT for response assessment after treatment in patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) when using the Deauville Criteria (DC) and the International Harmonization Project Criteria (IHPC).
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Deauville Criteria and International Harmonization Project Criteria at the end of 1st line therapy in lymphoma patients: response assessment and prognostic evaluation.
The Journal of Nuclear Medicine, 2015Co-Authors: Federico Fallanca, Pierpaolo Alongi, Elena Incerti, Luigi Gianolli, Maria Picchio, Jamshed BomanjiAbstract:1355 Objectives The accuracy and prognostic value of FDG-PET/CT at the end of 1st line therapy (etPET/CT) using Deauville Criteria (DC) and International Harmonization Project Criteria (IHPC) was compared in lymphoma patients (pts). Methods etPET/CT scans, performed at least 3 weeks after chemotherapy or 8 weeks after radiotherapy in 101 consecutive pts (HL:35; NHL:66) were retrospectively evaluated using IHPC and DC criteria. DC was considered positive for scores of 3, 4 and 5 (DC3) and then for scores of 4 and 5 (DC4). To evaluate the accuracy of each method of etPET/CT the following parameters were considered: evaluation conventional diagnostic procedures, multidisciplinary team case notes and further PET/CT scans and/or follow-up (median:18 months; range:10-72 months). Two years progression-free survival (2yrsPFS), overall survival (OS) using Kaplan-Meier method, and relative risk of progression (RRP) with Cox regression analysis were calculated. Results Sensitivity, specificity, positive and negative predictive value, and accuracy of etPET/CT were 74%, 63%, 58%, 77% 67% for IHPC, 69%, 69%, 62%, 76%, 69% for DC3, 64%, 86%, 77%, 77%, 77% for DC4. A median PFS and OS of 14 and 18 months, respectively, were observed (average PFS:17months; range:0-72; average OS:23months; range:10-72). 2yrsPFS for etPET/CT positive pts was 47% for DC3 (Chi-Sq=9.0; P=0.003), 23% for DC4 (Chi-Sq=16.3; P=0.0001) and 49% for IHPC (Chi-Sq=8.9; P=0.003). etPET/CT negative pts using DC3, DC4 and IHPC showed a 2yrsPFS of 74%, 72% and 75%, respectively. No significant differences in OS was observed. The highest RRP was found for DC4 (Hazard Ratio: DC3=0.7, DC4=3.2, IHP=1.57; P=0.008). Conclusions Clinically etPET/CT using DC4 shows better diagnostic accuracy in lymphoma pts and prognostic value in predicting clinical outcome than the other two methods proposed.
Rupert Kellner - One of the best experts on this subject based on the ideXlab platform.
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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) progress to date and future plans
Toxicologic pathology, 2014Co-Authors: Charlotte M. Keenan, Dawn G. Goodman, Takanori Harada, Wolfgang Kaufmann, Rupert Kellner, Julia F. M. Baker, Alys Bradley, Ronald A. Herbert, Beth Mahler, Emily K. MeseckAbstract:The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice proposal (INHAND) has been operational since 2005. A Global Editorial Steering Committee manages the overall objectives of the project, and the development of harmonized terminology for each organ system is the responsibility of the Organ Working Groups, drawing upon experts from North America, Europe, and Japan. Great progress has been made with 9 systems published to date—respiratory, hepatobiliary, urinary, central/peripheral nervous systems, male reproductive and mammary, zymbals, clitoral, and preputial glands inToxicologic Pathologyand the integument and softtissueand femalereproductiveintheJournal ofToxicologic Pathology as supplements and on a Web site—www.goReni.org. INHAND nomenclature guides offer diagnostic criteria and guidelines for recording lesions observed in rodent toxicity and carcinogenicity studies. The guides provide representative photomicrographs of morphologic changes, information regarding pathogenesis, and key references. The purpose of this brief communication is to provide an update on the progress of INHAND.
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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) progress to date and future plans.
Journal of toxicologic pathology, 2014Co-Authors: Charlotte M. Keenan, Dawn G. Goodman, Takanori Harada, Wolfgang Kaufmann, Rupert Kellner, Julia F. M. Baker, Alys Bradley, Ronald A. Herbert, Beth Mahler, Emily K. MeseckAbstract:The INHAND Proposal (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) has been operational since 2005. A Global Editorial Steering Committee (GESC) manages the overall objectives of the project and the development of harmonized terminology for each organ system is the responsibility of the Organ Working Groups (OWG), drawing upon experts from North America, Europe and Japan.Great progress has been made with 9 systems published to date – Respiratory, Hepatobiliary, Urinary, Central/Peripheral Nervous Systems, Male Reproductive and Mammary, Zymbals, Clitoral and Preputial Glands in Toxicologic Pathology and the Integument and Soft Tissue and Female Reproductive System in the Journal of Toxicologic Pathology as supplements and on a web site – www.goreni.org. INHAND nomenclature guides offer diagnostic criteria and guidelines for recording lesions observed in rodent toxicity and carcinogenicity studies. The guides provide representative photo-micrographs of morphologic changes, information regarding pathogenesis, and key references. During 2012, INHAND GESC representatives attended meetings with representatives of the FDA Center for Drug Evaluation and Research (CDER), Clinical Data Interchange Standards Consortium (CDISC), and the National Cancer Institute (NCI) Enterprise Vocabulary Services (EVS) to begin incorporation of INHAND terminology as preferred terminology for SEND (Standard for Exchange of Nonclinical Data) submissions to the FDA. The interest in utilizing the INHAND nomenclature, based on input from industry and government toxicologists as well as information technology specialists, suggests that there will be wide acceptance of this nomenclature. The purpose of this publication is to provide an update on the progress of INHAND.
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International Harmonization of Toxicologic Pathology Nomenclature
Toxicologic Pathology, 2012Co-Authors: Peter C. Mann, John Vahle, Charlotte M. Keenan, Julia F. Baker, Alys E. Bradley, Dawn G. Goodman, Takanori Harada, Ronald Herbert, Wolfgang Kaufmann, Rupert KellnerAbstract:The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process
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International Harmonization of toxicologic pathology nomenclature: an overview and review of basic principles.
Toxicologic pathology, 2012Co-Authors: Peter C. Mann, John Vahle, Charlotte M. Keenan, Julia F. Baker, Alys E. Bradley, Dawn G. Goodman, Takanori Harada, Ronald Herbert, Wolfgang Kaufmann, Rupert KellnerAbstract:The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process.
Federico Fallanca - One of the best experts on this subject based on the ideXlab platform.
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Diagnostic accuracy of FDG PET/CT for clinical evaluation at the end of treatment of HL and NHL: a comparison of the Deauville Criteria (DC) and the International Harmonization Project Criteria (IHPC)
European journal of nuclear medicine and molecular imaging, 2016Co-Authors: Federico Fallanca, Pierpaolo Alongi, Elena Incerti, Luigi Gianolli, Maria Picchio, Irfan Kayani, Jamshed BomanjiAbstract:Purpose To evaluate the accuracy and prognostic value of FDG PET/CT for response assessment after treatment in patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) when using the Deauville Criteria (DC) and the International Harmonization Project Criteria (IHPC).
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diagnostic accuracy of fdg pet ct for clinical evaluation at the end of treatment of hl and nhl a comparison of the deauville criteria dc and the International Harmonization project criteria ihpc
European Journal of Nuclear Medicine and Molecular Imaging, 2016Co-Authors: Federico Fallanca, Pierpaolo Alongi, Elena Incerti, Luigi Gianolli, Maria Picchio, Irfan Kayani, Jamshed BomanjiAbstract:Purpose To evaluate the accuracy and prognostic value of FDG PET/CT for response assessment after treatment in patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) when using the Deauville Criteria (DC) and the International Harmonization Project Criteria (IHPC).
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Deauville Criteria and International Harmonization Project Criteria at the end of 1st line therapy in lymphoma patients: response assessment and prognostic evaluation.
The Journal of Nuclear Medicine, 2015Co-Authors: Federico Fallanca, Pierpaolo Alongi, Elena Incerti, Luigi Gianolli, Maria Picchio, Jamshed BomanjiAbstract:1355 Objectives The accuracy and prognostic value of FDG-PET/CT at the end of 1st line therapy (etPET/CT) using Deauville Criteria (DC) and International Harmonization Project Criteria (IHPC) was compared in lymphoma patients (pts). Methods etPET/CT scans, performed at least 3 weeks after chemotherapy or 8 weeks after radiotherapy in 101 consecutive pts (HL:35; NHL:66) were retrospectively evaluated using IHPC and DC criteria. DC was considered positive for scores of 3, 4 and 5 (DC3) and then for scores of 4 and 5 (DC4). To evaluate the accuracy of each method of etPET/CT the following parameters were considered: evaluation conventional diagnostic procedures, multidisciplinary team case notes and further PET/CT scans and/or follow-up (median:18 months; range:10-72 months). Two years progression-free survival (2yrsPFS), overall survival (OS) using Kaplan-Meier method, and relative risk of progression (RRP) with Cox regression analysis were calculated. Results Sensitivity, specificity, positive and negative predictive value, and accuracy of etPET/CT were 74%, 63%, 58%, 77% 67% for IHPC, 69%, 69%, 62%, 76%, 69% for DC3, 64%, 86%, 77%, 77%, 77% for DC4. A median PFS and OS of 14 and 18 months, respectively, were observed (average PFS:17months; range:0-72; average OS:23months; range:10-72). 2yrsPFS for etPET/CT positive pts was 47% for DC3 (Chi-Sq=9.0; P=0.003), 23% for DC4 (Chi-Sq=16.3; P=0.0001) and 49% for IHPC (Chi-Sq=8.9; P=0.003). etPET/CT negative pts using DC3, DC4 and IHPC showed a 2yrsPFS of 74%, 72% and 75%, respectively. No significant differences in OS was observed. The highest RRP was found for DC4 (Hazard Ratio: DC3=0.7, DC4=3.2, IHP=1.57; P=0.008). Conclusions Clinically etPET/CT using DC4 shows better diagnostic accuracy in lymphoma pts and prognostic value in predicting clinical outcome than the other two methods proposed.
Wolfgang Kaufmann - One of the best experts on this subject based on the ideXlab platform.
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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) progress to date and future plans
Toxicologic pathology, 2014Co-Authors: Charlotte M. Keenan, Dawn G. Goodman, Takanori Harada, Wolfgang Kaufmann, Rupert Kellner, Julia F. M. Baker, Alys Bradley, Ronald A. Herbert, Beth Mahler, Emily K. MeseckAbstract:The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice proposal (INHAND) has been operational since 2005. A Global Editorial Steering Committee manages the overall objectives of the project, and the development of harmonized terminology for each organ system is the responsibility of the Organ Working Groups, drawing upon experts from North America, Europe, and Japan. Great progress has been made with 9 systems published to date—respiratory, hepatobiliary, urinary, central/peripheral nervous systems, male reproductive and mammary, zymbals, clitoral, and preputial glands inToxicologic Pathologyand the integument and softtissueand femalereproductiveintheJournal ofToxicologic Pathology as supplements and on a Web site—www.goReni.org. INHAND nomenclature guides offer diagnostic criteria and guidelines for recording lesions observed in rodent toxicity and carcinogenicity studies. The guides provide representative photomicrographs of morphologic changes, information regarding pathogenesis, and key references. The purpose of this brief communication is to provide an update on the progress of INHAND.
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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) progress to date and future plans.
Journal of toxicologic pathology, 2014Co-Authors: Charlotte M. Keenan, Dawn G. Goodman, Takanori Harada, Wolfgang Kaufmann, Rupert Kellner, Julia F. M. Baker, Alys Bradley, Ronald A. Herbert, Beth Mahler, Emily K. MeseckAbstract:The INHAND Proposal (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) has been operational since 2005. A Global Editorial Steering Committee (GESC) manages the overall objectives of the project and the development of harmonized terminology for each organ system is the responsibility of the Organ Working Groups (OWG), drawing upon experts from North America, Europe and Japan.Great progress has been made with 9 systems published to date – Respiratory, Hepatobiliary, Urinary, Central/Peripheral Nervous Systems, Male Reproductive and Mammary, Zymbals, Clitoral and Preputial Glands in Toxicologic Pathology and the Integument and Soft Tissue and Female Reproductive System in the Journal of Toxicologic Pathology as supplements and on a web site – www.goreni.org. INHAND nomenclature guides offer diagnostic criteria and guidelines for recording lesions observed in rodent toxicity and carcinogenicity studies. The guides provide representative photo-micrographs of morphologic changes, information regarding pathogenesis, and key references. During 2012, INHAND GESC representatives attended meetings with representatives of the FDA Center for Drug Evaluation and Research (CDER), Clinical Data Interchange Standards Consortium (CDISC), and the National Cancer Institute (NCI) Enterprise Vocabulary Services (EVS) to begin incorporation of INHAND terminology as preferred terminology for SEND (Standard for Exchange of Nonclinical Data) submissions to the FDA. The interest in utilizing the INHAND nomenclature, based on input from industry and government toxicologists as well as information technology specialists, suggests that there will be wide acceptance of this nomenclature. The purpose of this publication is to provide an update on the progress of INHAND.
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proliferative and non proliferative lesions of the rat and mouse integument
Journal of Toxicologic Pathology, 2013Co-Authors: Lars Mecklenburg, Wolfgang Kaufmann, Donna F Kusewitt, Carine Kolly, Silke Treumann, Terence E Adams, Kelly Diegel, Jyoji Yamate, Susanne Muller, Dimitry M DanilenkoAbstract:The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the societies of toxicological pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP). Its aim is to develop an Internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory rodents. A widely accepted International Harmonization of nomenclature in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and will provide a common language to increase and enrich International exchanges of information among toxicologists and pathologists. The purpose of this publication is to provide a standardized nomenclature for classifying microscopical lesions observed in the integument of laboratory rats and mice. Example colour images are provided for most lesions. The standardized nomenclature presented in this document and additional colour images are also available electronically at http://www.goreni.org. The nomenclature presented herein is based on histopathology databases from government, academia, and industrial laboratories throughout the world, and covers lesions that develop spontaneously as well as those induced by exposure to various test materials. (DOI: 10.1293/tox.26.27S; J Toxicol Pathol 2013; 26: 27S-57S).
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International Harmonization of Toxicologic Pathology Nomenclature
Toxicologic Pathology, 2012Co-Authors: Peter C. Mann, John Vahle, Charlotte M. Keenan, Julia F. Baker, Alys E. Bradley, Dawn G. Goodman, Takanori Harada, Ronald Herbert, Wolfgang Kaufmann, Rupert KellnerAbstract:The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process
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International Harmonization of toxicologic pathology nomenclature: an overview and review of basic principles.
Toxicologic pathology, 2012Co-Authors: Peter C. Mann, John Vahle, Charlotte M. Keenan, Julia F. Baker, Alys E. Bradley, Dawn G. Goodman, Takanori Harada, Ronald Herbert, Wolfgang Kaufmann, Rupert KellnerAbstract:The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process.
Charlotte M. Keenan - One of the best experts on this subject based on the ideXlab platform.
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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) progress to date and future plans
Toxicologic pathology, 2014Co-Authors: Charlotte M. Keenan, Dawn G. Goodman, Takanori Harada, Wolfgang Kaufmann, Rupert Kellner, Julia F. M. Baker, Alys Bradley, Ronald A. Herbert, Beth Mahler, Emily K. MeseckAbstract:The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice proposal (INHAND) has been operational since 2005. A Global Editorial Steering Committee manages the overall objectives of the project, and the development of harmonized terminology for each organ system is the responsibility of the Organ Working Groups, drawing upon experts from North America, Europe, and Japan. Great progress has been made with 9 systems published to date—respiratory, hepatobiliary, urinary, central/peripheral nervous systems, male reproductive and mammary, zymbals, clitoral, and preputial glands inToxicologic Pathologyand the integument and softtissueand femalereproductiveintheJournal ofToxicologic Pathology as supplements and on a Web site—www.goReni.org. INHAND nomenclature guides offer diagnostic criteria and guidelines for recording lesions observed in rodent toxicity and carcinogenicity studies. The guides provide representative photomicrographs of morphologic changes, information regarding pathogenesis, and key references. The purpose of this brief communication is to provide an update on the progress of INHAND.
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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) progress to date and future plans.
Journal of toxicologic pathology, 2014Co-Authors: Charlotte M. Keenan, Dawn G. Goodman, Takanori Harada, Wolfgang Kaufmann, Rupert Kellner, Julia F. M. Baker, Alys Bradley, Ronald A. Herbert, Beth Mahler, Emily K. MeseckAbstract:The INHAND Proposal (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) has been operational since 2005. A Global Editorial Steering Committee (GESC) manages the overall objectives of the project and the development of harmonized terminology for each organ system is the responsibility of the Organ Working Groups (OWG), drawing upon experts from North America, Europe and Japan.Great progress has been made with 9 systems published to date – Respiratory, Hepatobiliary, Urinary, Central/Peripheral Nervous Systems, Male Reproductive and Mammary, Zymbals, Clitoral and Preputial Glands in Toxicologic Pathology and the Integument and Soft Tissue and Female Reproductive System in the Journal of Toxicologic Pathology as supplements and on a web site – www.goreni.org. INHAND nomenclature guides offer diagnostic criteria and guidelines for recording lesions observed in rodent toxicity and carcinogenicity studies. The guides provide representative photo-micrographs of morphologic changes, information regarding pathogenesis, and key references. During 2012, INHAND GESC representatives attended meetings with representatives of the FDA Center for Drug Evaluation and Research (CDER), Clinical Data Interchange Standards Consortium (CDISC), and the National Cancer Institute (NCI) Enterprise Vocabulary Services (EVS) to begin incorporation of INHAND terminology as preferred terminology for SEND (Standard for Exchange of Nonclinical Data) submissions to the FDA. The interest in utilizing the INHAND nomenclature, based on input from industry and government toxicologists as well as information technology specialists, suggests that there will be wide acceptance of this nomenclature. The purpose of this publication is to provide an update on the progress of INHAND.
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International Harmonization of Toxicologic Pathology Nomenclature
Toxicologic Pathology, 2012Co-Authors: Peter C. Mann, John Vahle, Charlotte M. Keenan, Julia F. Baker, Alys E. Bradley, Dawn G. Goodman, Takanori Harada, Ronald Herbert, Wolfgang Kaufmann, Rupert KellnerAbstract:The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process
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International Harmonization of toxicologic pathology nomenclature: an overview and review of basic principles.
Toxicologic pathology, 2012Co-Authors: Peter C. Mann, John Vahle, Charlotte M. Keenan, Julia F. Baker, Alys E. Bradley, Dawn G. Goodman, Takanori Harada, Ronald Herbert, Wolfgang Kaufmann, Rupert KellnerAbstract:The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process.