The Experts below are selected from a list of 432 Experts worldwide ranked by ideXlab platform
Michael Uder - One of the best experts on this subject based on the ideXlab platform.
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reversibility and time dependency of contrast medium induced inhibition of 3 4 5 dimethylthiazol 2 yl 2 5 diphenyl tetrazolium bromide mtt conversion in renal proximal tubular cells in vitro comparison of a monomeric and a dimeric nonionic iodinated contrast medium
Investigative Radiology, 2007Co-Authors: Marc Heinrich, Mario Scheer, Martina Heckmann, W Bautz, Michael UderAbstract:Objectives:To evaluate the time-course and reversibility of toxicity of a low-osmolar and an iso-osmolar radiographic contrast medium on renal tubular cell cultures.Materials and Methods:LLC-PK1-cells were incubated with Iomeprol, iodixanol, and mannitol (4.7–75 mg I/mL, 2–24 hours). Metabolic activ
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Cytotoxicity of Iodinated and Gadolinium-based Contrast Agents in Renal Tubular Cells at Angiographic Concentrations: In Vitro Study
Radiology, 2007Co-Authors: Marc Heinrich, Aleksandar Grgic, Martin K. Kuhlmann, Sonja Kohlbacher, Mario Scheer, M Heckmann, Michael UderAbstract:Purpose: To test in vitro whether gadolinium-based contrast agents induce fewer toxic effects on renal tubular cells than does an iodinated contrast medium at concentrations used for angiography. Materials and Methods: LLC-PK1 cells were incubated with Iomeprol, gadopentetate dimeglumine, gadobenate dimeglumine, gadoterate meglumine, gadodiamide, and corresponding mannitol solutions for 24 hours at 37°C in two experimental settings: measurements with equally attenuating solutions and measurements with equimolar solutions. Cytotoxicity was assessed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, trypan blue testing, and an assay to detect apoptosis and necrosis. Data were analyzed with analyses of variance and post hoc tests. Results: Yielding the same x-ray attenuation, Iomeprol-300 and Iomeprol-150 at concentrations of 2.34–18.75 mg of iodine per milliliter induced significantly (P < .001) lower inhibition of MTT conversion (74%–102% of undamaged control cells) compared wi...
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cytotoxic effects of ionic high osmolar nonionic monomeric and nonionic iso osmolar dimeric iodinated contrast media on renal tubular cells in vitro
Radiology, 2005Co-Authors: Marc Heinrich, Aleksandar Grgic, B Kramann, Martin K. Kuhlmann, M Heckmann, Michael UderAbstract:PURPOSE: To compare the cytotoxic effects of dimeric and monomeric iodinated contrast media on renal tubular cells in vitro with regard to osmolality. MATERIALS AND METHODS: LLC-PK1 cells were incubated with ioxithalamate, ioversol, Iomeprol-300, Iomeprol-150, iodixanol, iotrolan, and hyperosmolar mannitol solutions for 1–24 hours at concentrations from 18.75 to 150 mg of iodine per milliliter. Cytotoxic effects were assessed with 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Data were analyzed with one-way analysis of variance; post hoc tests were performed. RESULTS: At equal iodine concentrations, ioxithalamate showed stronger cytotoxic effects than did other contrast media (MTT conversion for ioxithalamate was 4% vs that for ioversol of 32%, that for Iomeprol-300 of 34%, that for iodixanol of 40%, and that for iotrolan of 41% of undamaged control cells at 75 mg of iodine per milliliter, n = 61–90, P < .001); there was no significant difference between low-osmolar monomer...
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effects of dimeric radiographic contrast medium iotrolan on swine renal arteries comparison with monomeric contrast media iohexol and Iomeprol
Investigative Radiology, 2004Co-Authors: Günther Schneider, Aleksandar Grgic, Ulrich Humke, B Kramann, Michael UderAbstract:RATIONALE AND OBJECTIVES: To investigate whether the lower incidence of vasodilatation upon vascular injection of iotrolan, as compared with monomeric contrast media, is solely the result of its isotonicity. MATERIALS AND METHODS: In an organ bath, isolated segments of swine renal arteries, uncontracted or precontracted by 10 microm phenylephrine, were incubated with increasing concentrations of iotrolan-300, iohexol-300, Iomeprol-300, Iomeprol-150, and mannitol solutions with the same molarity as the contrast media. RESULTS: At equal iodine and equimolar concentrations, iotrolan-300 relaxed precontracted arteries less than iohexol-300, Iomeprol-300, and Iomeprol-150, which was, like iotrolan-300, iso-osmolar to blood (P 0.05). Iotrolan had no significant effect on the basal tonus of the vessels whereas iohexol and Iomeprol induced a slight relaxation. CONCLUSIONS: Iotrolan, even at equimolar concentrations, resulted in less vasorelaxation than iohexol and Iomeprol. Both osmolarity and chemotoxicity contribute to the greater vasorelaxant effect on swine renal artery of monomeric contrast media when compared to that of the nonionic dimeric contrast medium, iotrolan.
L Romano - One of the best experts on this subject based on the ideXlab platform.
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enhancement and safety of Iomeprol 400 and iodixanol 320 in patients undergoing abdominal multidetector ct
British Journal of Radiology, 2009Co-Authors: L Romano, Luigi Grazioli, Lorenzo Bonomo, Kemin Chen, R Dore, Angelo Vanzulli, Carlo CatalanoAbstract:The purpose of this study was to compare Iomeprol-400 and iodixanol-320 for contrast enhancement and safety in patients undergoing liver multidetector CT (MDCT). 183 patients undergoing MDCT received equi-iodine (40 gI) Iomeprol-400 (n591) or iodixanol-320 (n592) IV at 4 ml s -1 . Two off-site, independent, blinded readers determined the contrast density (in Hounsfield units (HUs)) in the abdominal aorta, inferior vena cava, portal vein and liver parenchyma during the arterial and portal phases. The mean contrast densities achieved were compared and 95% confidence intervals (CIs) estimated. Heart rate was measured at baseline and at post- dose peak, and a full safety assessment was performed. Study group demographics were comparable. Iomeprol-400 produced significantly greater enhancement of the aorta during the arterial phase (Reader 1: 337.3 HU vs 294.9 HU, 95% CI of difference (19.4, 65.5), p50.0004; Reader 2: 325.7 HU vs 295.3 HU, 95% CI of difference (6.6, 54.3), p50.01) and greater enhancement of the liver parenchyma during the portal venous phase (Reader 1: 115.1 H vs 108.6 HU, 95% CI of difference (0.27, 12.7), p50.04; Reader 2: 115.2 H vs 109.3 HU, 95% CI of difference (-0.1, 11.8), p50.05). Similar enhancement of the inferior vena cava and portal vein was noted. Comparably negligible increases in the mean heart rate were observed. Adverse events occurred in 1/91 (1.1%) subjects after Iomeprol-400 and 4/92 (4.3%) subjects after iodixanol-320. In conclusion, Iomeprol-400 produces greater arterial and portal phase enhancement and has a similarly negligible impact on heart rate and safety.
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the active trial comparison of the effects on renal function of Iomeprol 400 and iodixanol 320 in patients with chronic kidney disease undergoing abdominal computed tomography
Investigative Radiology, 2008Co-Authors: Henrik S Thomsen, Cm Erley, Luigi Grazioli, Lorenzo Bonomo, Sameh K Morcos, L RomanoAbstract:Background:We performed a multicenter, double-blind, randomized, parallel-group study to compare the renal effects of Iomeprol-400 and iodixanol-320 in patients with preexisting chronic kidney disease undergoing contrast-enhanced multidetector computed tomography of the liver.Methods:One hundred for
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The ACTIVE trial: Comparison of the effects on renal function of Iomeprol-400 and iodixanol-320 in patients with chronic kidney disease undergoing abdominal computed tomography
'Ovid Technologies (Wolters Kluwer Health)', 2008Co-Authors: Henrik S Thomsen, Cm Erley, L Romano, Luigi Grazioli, Lorenzo Bonomo, Sameh K Morcos, Carlo CatalanoAbstract:BACKGROUND: We performed a multicenter, double-blind, randomized, parallel-group study to compare the renal effects of Iomeprol-400 and iodixanol-320 in patients with preexisting chronic kidney disease undergoing contrast-enhanced multidetector computed tomography of the liver. METHODS: One hundred forty-eight patients with moderate-to-severe chronic kidney disease, ie, serum creatinine (SCr) ≥1.5 mg/dL (132.6 μmol/L) and/or calculated creatinine clearance (CrCl)
Filippo Cademartiri - One of the best experts on this subject based on the ideXlab platform.
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Influence of convolution filtering on coronary plaque attenuation values: Observations in an ex vivo model of multislice computed tomography coronary angiography
European radiology, 2007Co-Authors: Filippo Cademartiri, Nico R Mollet, Ludovico La Grutta, Giuseppe Runza, Alessandro Palumbo, Erica Maffei, Tommaso Vincenzo Bartolotta, Pamela Somers, Michiel W.m. Knaapen, Stefan VerheyeAbstract:Attenuation variability (measured in Hounsfield Units, HU) of human coronary plaques using multislice computed tomography (MSCT) was evaluated in an ex vivo model with increasing convolution kernels. MSCT was performed in seven ex vivo left coronary arteries sunk into oil followingthe instillation of saline (1/∞) and a 1/50 solution of contrast material (400 mgI/ml Iomeprol). Scan parameters were: slices/collimation, 16/0.75 mm; rotation time, 375 ms. Four convolution kernels were used: b30f-smooth, b36f-medium smooth, b46f-medium and b60f-sharp. An experienced radiologist scored for the presence of plaques and measured the attenuation in lumen, calcified and noncalcified plaques and the surrounding oil. The results were compared by the ANOVA test and correlated with Pearson’s test. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. The mean attenuation values were significantly different between the four filters (p
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high iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography iopromide 370 versus Iomeprol 400
Investigative Radiology, 2006Co-Authors: Filippo Cademartiri, Nico R Mollet, Pim J De Feyter, Giuseppe Runza, Cecile De Monye, Francesca Pugliese, Aad Van Der Lugt, Massimo Midiri, Roberto Lagalla, Gabriel P KrestinAbstract:Objective:The objective of this study was to compare intracoronary attenuation on 16-row multislice computed tomography (16-MSCT) coronary angiography using 2 contrast materials (CM) with high iodine concentration.Material and Methods:Forty consecutive patients (29 male, 11 female; mean age, 61 ± 11
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intravenous contrast material administration at helical 16 detector row ct coronary angiography effect of iodine concentration on vascular attenuation
Radiology, 2005Co-Authors: Filippo Cademartiri, Nico R Mollet, Aad Van Der Lugt, Eugene P Mcfadden, Theo Stijnen, Pim J De Feyter, Gabriel P KrestinAbstract:The institutional review board approved this study, and all patients gave written informed consent. One hundred twenty-five patients scheduled to undergo retrospectively electrocardiographically gated 16–detector row computed tomographic coronary angiography were prospectively randomized into the following five groups with respect to the intravenous administration of a 140-mL bolus of contrast material at 4 mL/sec: group 1 (iohexol [300 mg of iodine per milliliter]), group 2 (iodixanol [320 mg I/mL]), group 3 (iohexol [350 mg I/mL]), group 4 (Iomeprol [350 mg I/mL]), and group 5 (Iomeprol [400 mg I/mL]). Attenuation was measured in the descending aorta and coronary arteries. One-way analysis of variance was used to compare groups. Mean attenuation values in the descending aorta were significantly (P < .05) lower in group 1 and higher in group 5 compared with the mean values in the other three groups. The same pattern was observed in the coronary arteries. Contrast materials with higher iodine concentratio...
Gabriel P Krestin - One of the best experts on this subject based on the ideXlab platform.
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high iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography iopromide 370 versus Iomeprol 400
Investigative Radiology, 2006Co-Authors: Filippo Cademartiri, Nico R Mollet, Pim J De Feyter, Giuseppe Runza, Cecile De Monye, Francesca Pugliese, Aad Van Der Lugt, Massimo Midiri, Roberto Lagalla, Gabriel P KrestinAbstract:Objective:The objective of this study was to compare intracoronary attenuation on 16-row multislice computed tomography (16-MSCT) coronary angiography using 2 contrast materials (CM) with high iodine concentration.Material and Methods:Forty consecutive patients (29 male, 11 female; mean age, 61 ± 11
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intravenous contrast material administration at helical 16 detector row ct coronary angiography effect of iodine concentration on vascular attenuation
Radiology, 2005Co-Authors: Filippo Cademartiri, Nico R Mollet, Aad Van Der Lugt, Eugene P Mcfadden, Theo Stijnen, Pim J De Feyter, Gabriel P KrestinAbstract:The institutional review board approved this study, and all patients gave written informed consent. One hundred twenty-five patients scheduled to undergo retrospectively electrocardiographically gated 16–detector row computed tomographic coronary angiography were prospectively randomized into the following five groups with respect to the intravenous administration of a 140-mL bolus of contrast material at 4 mL/sec: group 1 (iohexol [300 mg of iodine per milliliter]), group 2 (iodixanol [320 mg I/mL]), group 3 (iohexol [350 mg I/mL]), group 4 (Iomeprol [350 mg I/mL]), and group 5 (Iomeprol [400 mg I/mL]). Attenuation was measured in the descending aorta and coronary arteries. One-way analysis of variance was used to compare groups. Mean attenuation values in the descending aorta were significantly (P < .05) lower in group 1 and higher in group 5 compared with the mean values in the other three groups. The same pattern was observed in the coronary arteries. Contrast materials with higher iodine concentratio...
Henrik S Thomsen - One of the best experts on this subject based on the ideXlab platform.
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Analytical Interference by Contrast Agents in Biochemical Assays
Hindawi-Wiley, 2017Co-Authors: Sigrid Otnes, Niels Fogh-andersen, Janne Rømsing, Henrik S ThomsenAbstract:Objective. To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods. The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and Iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spiked with doses of each agent such that the gadolinium agents and the iodine agents reached concentrations of 0.5 mM and 12 mg iodine/mL, respectively. Subsequently, 12 assays were reexamined using 1/2 and 1/4 of these CA concentrations. The results were assessed statistically by a paired Student’s t-test. Results. Iodixanol produced a negative interference on the bicarbonate (p=0.011), lactate dehydrogenase (p
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Nephropathy after administration of iso-osmolar and low-osmolar contrast media: Evidence from a network meta-analysis
'Elsevier BV', 2014Co-Authors: Giuseppe Biondi Zoccai, Henrik S Thomsen, Marzia Lotrionte, Enrico Romagnoli, Fabrizio D'ascenzo, Arturo Giordano, Giacomo FratiAbstract:Background/objectives: Contrast-induced nephropathy (CIN) may be a severe complication to the administration of iodine-based contrast media for diagnostic or interventional procedure using radiation exposure. Whether there is a difference in nephrotoxic potential between the various agents is uncertain. We aimed to perform a systematic review and network meta-analysis of randomized trials on iodine-based contrast agents. Methods: Randomized trials of low-osmolar or iso-osmolar contrast media were searched in CENTRAL, Google Scholar, MEDLINE/PubMed, and Scopus. Risk of CIN was appraised within a hierarchical Bayesian model computing absolute rates (AR) and odds ratios (OR) with 95% credibility intervals, and probability of being best (Pbest) for each agent. Results: A total of 42 trials (10048 patients) were included focusing on 7 different iodine-based contrast media. Risk of CIN was similarly low with iodixanol (AR = 5.7% [2.2%-13.9%], Pbest = 18.8%), Iomeprol (AR = 6.0% [2.2%-15.4%], Pbest = 24.8%), iopamidol (AR = 6.1% [2.2%-15.5%], Pbest = 21.5%), and ioversol (AR = 6.0% [2.1%-16.4%], Pbest = 31.3%). Conversely, CIN was twice as common with iohexol (AR = 11.2% [4.1%-29.5%], Pbest = 0.1%) and ioxaglate (AR = 11.0% [4.0%-26.9%], Pbest < 0.1%), with both proving less safe than iodixanol (respectively OR = 2.18 [1.22-3.92] and 2.05 [1.26-3.29]), Iomeprol (OR = 2.08 [1.04-4.17] and 1.96 [1.06-3.48]) and iopamidol (OR = 2.04 [1.15-3.85] and 1.92 [1.06-3.45]). Data on iopromide were less conclusive (AR = 6.9% [2.6%-17.1%], Pbest = 3.6%). Conclusions: Iodixanol, Iomeprol, iopamidol and ioversol are iodine-based contrast media with a similar renal safety profile. Iohexol and ioxaglate have a poorer renal safety profile, whereas further data may be required on iopromide. (C) 2014 Elsevier Ireland Ltd. All rights reserved
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risk of contrast medium induced nephropathy in high risk patients undergoing mdct a pooled analysis of two randomized trials
European Radiology, 2009Co-Authors: Henrik S Thomsen, Sameh K MorcosAbstract:The incidence of contrast-medium-induced nephropathy (CIN) following intravenous (IV) CM administration of contrast media to renally impaired patients undergoing multidetector computed tomography (MDCT) is not well characterized. Our objective was to investigate the incidence of CIN in patients with glomerular filtration rate (GFR) 40 ml/min, 4.6% when GFR <40 ml/min and 7.8% in patients with GFR <30 ml/min. The incidence of CIN was significantly higher after iodixanol than after LOCM (seven patients, 4.7% following IOCM, no CIN cases following the LOCM; p = 0.007). Significant differences in favor of the LOCM were also observed in patients with GFR <40 ml/min and GFR <30 ml/min. Following the IV administration of nonionic contrast agents in patients with moderate-to-severe renal insufficiency, the risk of significant CIN seems to be low. The IOCM iodixanol caused a higher rate of CIN than the LOCM iopamidol and Iomeprol, especially in high-risk patients. Differences in osmolality between these LOCM and iodixanol do not play a role in the genesis of CIN.
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the active trial comparison of the effects on renal function of Iomeprol 400 and iodixanol 320 in patients with chronic kidney disease undergoing abdominal computed tomography
Investigative Radiology, 2008Co-Authors: Henrik S Thomsen, Cm Erley, Luigi Grazioli, Lorenzo Bonomo, Sameh K Morcos, L RomanoAbstract:Background:We performed a multicenter, double-blind, randomized, parallel-group study to compare the renal effects of Iomeprol-400 and iodixanol-320 in patients with preexisting chronic kidney disease undergoing contrast-enhanced multidetector computed tomography of the liver.Methods:One hundred for
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The ACTIVE trial: Comparison of the effects on renal function of Iomeprol-400 and iodixanol-320 in patients with chronic kidney disease undergoing abdominal computed tomography
'Ovid Technologies (Wolters Kluwer Health)', 2008Co-Authors: Henrik S Thomsen, Cm Erley, L Romano, Luigi Grazioli, Lorenzo Bonomo, Sameh K Morcos, Carlo CatalanoAbstract:BACKGROUND: We performed a multicenter, double-blind, randomized, parallel-group study to compare the renal effects of Iomeprol-400 and iodixanol-320 in patients with preexisting chronic kidney disease undergoing contrast-enhanced multidetector computed tomography of the liver. METHODS: One hundred forty-eight patients with moderate-to-severe chronic kidney disease, ie, serum creatinine (SCr) ≥1.5 mg/dL (132.6 μmol/L) and/or calculated creatinine clearance (CrCl)
