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Guilian Zhang - One of the best experts on this subject based on the ideXlab platform.
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Contrast-Induced Encephalopathy Resulting From Use of Ioversol and Iopromide.
Clinical neuropharmacology, 2019Co-Authors: Guilian Zhang, Heying Wang, Lili Zhao, Man Sun, Yiheng Zhang, Guoliang Teng, Jingju Chen, Yating JianAbstract:Background Contrast-induced encephalopathy (CIE) is a rare disease, whose etiology and risk factors remain unclear and need investigation. Methods We collected 7 CIE cases from 2646 patients injected with Ioversol and 5 CIE cases from 526 patients injected with iopromide, all of whom underwent neurointervention surgery in our regional centers. The incidence of CIE, its characteristics, and risks were analyzed in both groups. Results The overall incidence of CIE was 0.38%, specifically 0.95% and 0.26% in the iopromide and Ioversol groups, respectively; the former incidence was significantly higher than the latter (P = 0.029). The risk of CIE with iopromide was 3.567 to 3.618 times higher than that with Ioversol (single-factor analysis odds ratio [OR], 3.618; 95% confidence interval [CI], 1.144-11.443; P = 0.029; multifactor analysis OR, 3.567 (95% CI, 0.827-15.379); P = 0.088). Moreover, acute cerebral infarction was an independent risk factor for CIE (OR, 4.024; 95% CI, 1.137-14.236; P = 0.031). Contrast-induced encephalopathy could occur within 5 minutes after injecting contrast media. The CIE characteristics differed according to the medium. In the Ioversol group, the most common characteristic was visual disorder (71.43%), whereas in the iopromide group, the most common characteristic was delirium (100%). Conclusions Compared with Ioversol, iopromide appeared more likely to lead to CIE. Acute cerebral infarction was an independent risk factor for CIE. The earliest CIE onset was within 5 minutes after injecting contrast. The characteristics of CIE varied significantly for different contrast media.
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Dynamic Effects of Ioversol on the Permeability of the Blood-Brain Barrier and the Expression of ZO-1/Occludin in Rats.
Journal of molecular neuroscience : MN, 2019Co-Authors: Heying Wang, Jiao Liu, Lili Zhao, Man Sun, Yiheng Zhang, Yating Jian, Meijuan Dang, Guilian ZhangAbstract:Blood-brain barrier (BBB) dysfunction is involved in the pathogenesis of contrast-induced encephalopathy (CIE), which is a rare adverse event following angiography. In this study, we observed the dynamic effect and potential mechanism of Ioversol on the BBB in rats. Eighty-one healthy rats were randomly divided into a normal control group (n = 9), Ioversol group (n = 36), and 0.9% NaCl group (n = 36); the latter two groups were separately subdivided into four groups based on time points after treatment (0.5, 3, 6, and 24 h) (n = 9/group). Permeability of the BBB was measured by an Evans Blue (EB) assay. Levels of the tight junction (TJ) proteins ZO-1 and occludin were determined by western blot and immunofluorescence staining. EB content increased at 3 h after the administration of Ioversol via the carotid artery and reached a peak at 6 h (P
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dynamic effects of Ioversol on the permeability of the blood brain barrier and the expression of zo 1 occludin in rats
Journal of Molecular Neuroscience, 2019Co-Authors: Heying Wang, Jiao Liu, Lili Zhao, Man Sun, Yiheng Zhang, Yating Jian, Meijuan Dang, Guilian ZhangAbstract:Blood-brain barrier (BBB) dysfunction is involved in the pathogenesis of contrast-induced encephalopathy (CIE), which is a rare adverse event following angiography. In this study, we observed the dynamic effect and potential mechanism of Ioversol on the BBB in rats. Eighty-one healthy rats were randomly divided into a normal control group (n = 9), Ioversol group (n = 36), and 0.9% NaCl group (n = 36); the latter two groups were separately subdivided into four groups based on time points after treatment (0.5, 3, 6, and 24 h) (n = 9/group). Permeability of the BBB was measured by an Evans Blue (EB) assay. Levels of the tight junction (TJ) proteins ZO-1 and occludin were determined by western blot and immunofluorescence staining. EB content increased at 3 h after the administration of Ioversol via the carotid artery and reached a peak at 6 h (P < 0.05), whereas it decreased to its normal level at 24 h. Western blot and immunofluorescence staining indicated that the expression of ZO-1 in brain tissues gradually decreased to its lowest level at 3 h, and then increased gradually, but was still lower than that of the normal control group at 24 h (P < 0.05). Occludin was similar, but its lowest expression appeared at 0.5 h. This study demonstrated that the permeability of BBB in rats increased first and then decreased after Ioversol was injected into the carotid artery. The mechanism may be related to altered protein expression of TJs, which are important structures in BBB. Early intervention against TJ proteins may be an effective measure to prevent and treat CIE.
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Effect of the Ioversol on early renal function in patients undergoing cerebral vascular intervention
2017Co-Authors: Guilian Zhang, Yingying Guo, Lei Zhang, Heying Wang, Jiao LiuAbstract:Objective To investigate the effect of different doses of Ioversol on renal function, and to explore early renal injury biomarkers on contrast induced kidney injury and safe Ioversol dosage. Methods A total of 158 cases (98 males and 60 females) undergoing cerebral vascular intervention (CVI) in our department was selected with age ranging from 23 to 81 years old (average age 59.70±12.02). Based on Ioversol dosage in surgery, patients were divided into three groups: low dose group (≤150 ml, n=49), middle dose group (151-200 ml, n=74), and high dose group (>200 ml, n=35). U-κ, U-λ, urinary transferrin (UTRF), urine microalbumin (UMA), urinary immunoglobulin IgG (UIgG), urine beta2-microglobulin (Uβ2-MG), Uα1-MG, urinary N-acetyl-beta-D-glucosaminidase (UNAG), plasma cystatin C (CysC) and Scr were detected by scattering turbidimetry, immune turbidimetry and fully automatic biochemical analysis pre-surgery 24 h and post-surgery 72 h. Contrast-induced acute kidney injury (CI-AKI) was defined as laboratory increase of Scr value≥44.2 μmol/L or ≥25% from baseline measurement at 48hours after surgery. The relationship in Ioversol dosage and various factors was assessed by Single and multiple factors binary logistic regression analysis. Results According to the criterion that Scr increase value were ≥44.2 μmol/L, of 158 cases, 3 cases occurred CI-AKI, the AKI incidence was 1.90%. Based on the criterion that Scr increase value was ≥25%, 33 cases occurred CI-AKI, the incidence was 20.89%. The concentration of U-κ, UTRF, Uα1-MG, UNAG and plasma CysC were significantly different in high dose group compared to low Ioversol dose group (P 0.05). Conclusions The contrast media-Ioversol could lead to CI-AKI; when the dosage of Ioversol was more than 200 ml one-time, the concentration of U-κ, UTRF, Uα1-MG, UNAG and plasma CysC increased significantly. U-κ, UTRF, Uα1-MG, UNAG and plasma CysC could predict the early renal injury in patients who undergoing CVI. The rise of U-κ, UTRF, Uα1-MG, UNAG and plasma CysC are related to the dosage of Ioversol. Furthermore, possibility of kidney injury is significantly high when Ioversol dosage is more than 200 ml one-time. Key words: Triiodobenzoic acids/AD; Contrast media/AD; Kidney/IN; Radiography, interventional; Kidney function tests
Amos Norman - One of the best experts on this subject based on the ideXlab platform.
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Induction of micronuclei in lymphocytes of patients undergoing excretory urography with Ioversol.
Investigative radiology, 1994Co-Authors: Sachiko T. Cochran, Amos NormanAbstract:The hypothesis that nonionic contrast medium administered during excretory urography may cause cytogenetic damage was tested. Micronuclei were scored in peripheral blood lymphocytes obtained from 33 patients before and after excretory urography with Ioversol, a nonionic contrast medium. The examination resulted in a highly significant (sign test, P = .005) increase in the median (range) counts of micronuclei per 1,000 binucleate from 18 (0 to 31) before to 24 (5 to 40) after excretory urography. Nonionic Ioversol produces a statistically significant increase in the chromosome damage of lymphocytes from patients undergoing excretory urography. This increase is similar to that reported for the ionic contrast media, ioxaglate and iothalamate, and equal to that produced by 6 to 7 cGy of 100-kilovolt x-rays.
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Induction of micronuclei in lymphocytes of patients undergoing excretory urography with Ioversol.
Investigative radiology, 1994Co-Authors: Sachiko T. Cochran, Amos NormanAbstract:RATIONALE AND OBJECTIVES The hypothesis that nonionic contrast medium administered during excretory urography may cause cytogenetic damage was tested. METHODS Micronuclei were scored in peripheral blood lymphocytes obtained from 33 patients before and after excretory urography with Ioversol, a nonionic contrast medium. RESULTS The examination resulted in a highly significant (sign test, P = .005) increase in the median (range) counts of micronuclei per 1,000 binucleate from 18 (0 to 31) before to 24 (5 to 40) after excretory urography. CONCLUSIONS Nonionic Ioversol produces a statistically significant increase in the chromosome damage of lymphocytes from patients undergoing excretory urography. This increase is similar to that reported for the ionic contrast media, ioxaglate and iothalamate, and equal to that produced by 6 to 7 cGy of 100-kilovolt x-rays.
Niansong Wang - One of the best experts on this subject based on the ideXlab platform.
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Tanshinone IIA Attenuates Contrast-Induced Nephropathy via Nrf2 Activation in Rats
Karger Publishers, 2018Co-Authors: Rulian Liang, Qing Zhao, Guangyuan Zhang, Niansong Wang, Guihua Jian, Dongsheng Cheng, Feng WangAbstract:Background/Aims: Tanshinone IIA is a chemical compound extracted from Salvia miltiorrhiza Bunge, a perennial plant also known as red sage used in traditional Chinese medicine. Tanshinone IIA has been shown to protect against various organ injuries. In this study, we hypothesized that Tanshinone IIA could play an anti-oxidative role in contrast-induced nephropathy (CIN) through enhancing Nrf2/ARE activation. Methods: To test whether Tanshinone IIA can attenuate CIN, oxidative stress, and apoptosis, we utilized two models: an in vivo Sprague-Dawley rat model of Ioversol-induced CIN and an in vitro cell model of oxidative stress in which HK2 cells, a human renal tubular cell line, are treated with hydrogen peroxide (H2O2). Rats were randomly assigned to 4 groups (n = 6 per group): control group, Ioversol group (Ioversol-induced CIN), vehicle group (Ioversol-induced CIN rats pretreated with vehicle), and Tanshinone IIA group (Ioversol-induced CIN rats pretreated with 25mg/kg Tanshinone IIA). Renal functions, renal injuries and apoptosis were evaluated by using serum creatinine, histological scoring, and TUNEL staning respectively. Malondialdehyde, 8-hydroxy-2’ –deoxyguanosine, and intracellular reactive oxygen species were used for oxidative stress assessment. Levels of Nrf2 and heme oxygenase-1 (HO-1) were measured in vivo and in vitro. Results: Tanshinone IIA attenuated renal tubular necrosis, apoptosis and oxidative stress in rats and oxidative stress in HK2 cells. Furthermore, Tanshinone IIA activated Nrf2, and up-regulated HO-1 expression in vivo and in vitro, resulting in a reduction in oxidative stress. Conclusion: Tanshinone IIA may protect against CIN through enhancing Nrf2/ARE activation
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Renalase protects against contrast-induced nephropathy in Sprague-Dawley rats.
PloS one, 2015Co-Authors: Binghui Zhao, Qing Zhao, Feng Wang, Tao Xing, Niansong WangAbstract:Background Contrast-induced nephropathy (CIN) is the third leading cause of hospital-acquired acute renal failure. Oxidative stress, apoptosis and inflammation play crucial roles in CIN. Renalase is a newly discovered monoamine oxidase from the kidney. We hypothesize that renalase could protect against CIN through anti-oxidation, anti-inflammation and anti-apoptosis pathways. Methods We tested our hypothesis in vivo with a rat model of Ioversol-induced CIN and in vitro. Sprague-Dawley rats were divided into 4 groups (n = 6 per group): control group, Ioversol group (rats subjected to Ioversol-induced CIN), Ioversol plus vehicle group (CIN rats pretreated with vehicle) and Ioversol plus renalase group (CIN rats pretreated with 2 mg/kg recombinant renalase). HK2 cells were treated with Ioversol or H2O2. Results The results showed that pretreatment with renalase attenuated the deterioration of renal function, tubular necrosis, oxidative stress, apoptosis and inflammation (P
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Renalase ameliorated renal histological damage.
2015Co-Authors: Binghui Zhao, Qing Zhao, Feng Wang, Tao Xing, Niansong WangAbstract:A, representative renal sections from normal control, Ioversol, Ioversol+Vehicle, and Ioversol+renalase groups (PAS staining, 400x). B, tubular injury scoring and quantitative analysis. Animal number in each group is 6. **P
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Renalase inhibited renal apoptosis induced by Contrast.
2015Co-Authors: Binghui Zhao, Qing Zhao, Feng Wang, Tao Xing, Niansong WangAbstract:A, representative renal sections from normal control, Ioversol, Ioversol+vehicle, and Ioversol+renalase groups (TUNEL staining, 400x). B, quantitative analysis of renal apoptosis. C, renal Capase-3 activity. Animal number in each group is 6. **P
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Renalase protected against oxidative stress and apoptosis in vivo.
2015Co-Authors: Binghui Zhao, Qing Zhao, Feng Wang, Tao Xing, Niansong WangAbstract:A, LDH release of HK2 cells treated with Ioversol. B, apoptosis of HK2 cells treated with Ioversol. C, ROS levels of HK2 cells treated with H2O2. D, Caspase-3 activities of HK2 cells treated with H2O2. E, apoptosis of HK2 cells treated with H2O2. Iov, Ioversol; Veh, Vehicle; Ren0.6, renalase 0.6 µg/ml; Ren6, renalase 6 µg/ml; Ren60, renalase 60µg/ml. The number of repeated wells is 6 in each group. **P
Heying Wang - One of the best experts on this subject based on the ideXlab platform.
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Contrast-Induced Encephalopathy Resulting From Use of Ioversol and Iopromide.
Clinical neuropharmacology, 2019Co-Authors: Guilian Zhang, Heying Wang, Lili Zhao, Man Sun, Yiheng Zhang, Guoliang Teng, Jingju Chen, Yating JianAbstract:Background Contrast-induced encephalopathy (CIE) is a rare disease, whose etiology and risk factors remain unclear and need investigation. Methods We collected 7 CIE cases from 2646 patients injected with Ioversol and 5 CIE cases from 526 patients injected with iopromide, all of whom underwent neurointervention surgery in our regional centers. The incidence of CIE, its characteristics, and risks were analyzed in both groups. Results The overall incidence of CIE was 0.38%, specifically 0.95% and 0.26% in the iopromide and Ioversol groups, respectively; the former incidence was significantly higher than the latter (P = 0.029). The risk of CIE with iopromide was 3.567 to 3.618 times higher than that with Ioversol (single-factor analysis odds ratio [OR], 3.618; 95% confidence interval [CI], 1.144-11.443; P = 0.029; multifactor analysis OR, 3.567 (95% CI, 0.827-15.379); P = 0.088). Moreover, acute cerebral infarction was an independent risk factor for CIE (OR, 4.024; 95% CI, 1.137-14.236; P = 0.031). Contrast-induced encephalopathy could occur within 5 minutes after injecting contrast media. The CIE characteristics differed according to the medium. In the Ioversol group, the most common characteristic was visual disorder (71.43%), whereas in the iopromide group, the most common characteristic was delirium (100%). Conclusions Compared with Ioversol, iopromide appeared more likely to lead to CIE. Acute cerebral infarction was an independent risk factor for CIE. The earliest CIE onset was within 5 minutes after injecting contrast. The characteristics of CIE varied significantly for different contrast media.
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Dynamic Effects of Ioversol on the Permeability of the Blood-Brain Barrier and the Expression of ZO-1/Occludin in Rats.
Journal of molecular neuroscience : MN, 2019Co-Authors: Heying Wang, Jiao Liu, Lili Zhao, Man Sun, Yiheng Zhang, Yating Jian, Meijuan Dang, Guilian ZhangAbstract:Blood-brain barrier (BBB) dysfunction is involved in the pathogenesis of contrast-induced encephalopathy (CIE), which is a rare adverse event following angiography. In this study, we observed the dynamic effect and potential mechanism of Ioversol on the BBB in rats. Eighty-one healthy rats were randomly divided into a normal control group (n = 9), Ioversol group (n = 36), and 0.9% NaCl group (n = 36); the latter two groups were separately subdivided into four groups based on time points after treatment (0.5, 3, 6, and 24 h) (n = 9/group). Permeability of the BBB was measured by an Evans Blue (EB) assay. Levels of the tight junction (TJ) proteins ZO-1 and occludin were determined by western blot and immunofluorescence staining. EB content increased at 3 h after the administration of Ioversol via the carotid artery and reached a peak at 6 h (P
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dynamic effects of Ioversol on the permeability of the blood brain barrier and the expression of zo 1 occludin in rats
Journal of Molecular Neuroscience, 2019Co-Authors: Heying Wang, Jiao Liu, Lili Zhao, Man Sun, Yiheng Zhang, Yating Jian, Meijuan Dang, Guilian ZhangAbstract:Blood-brain barrier (BBB) dysfunction is involved in the pathogenesis of contrast-induced encephalopathy (CIE), which is a rare adverse event following angiography. In this study, we observed the dynamic effect and potential mechanism of Ioversol on the BBB in rats. Eighty-one healthy rats were randomly divided into a normal control group (n = 9), Ioversol group (n = 36), and 0.9% NaCl group (n = 36); the latter two groups were separately subdivided into four groups based on time points after treatment (0.5, 3, 6, and 24 h) (n = 9/group). Permeability of the BBB was measured by an Evans Blue (EB) assay. Levels of the tight junction (TJ) proteins ZO-1 and occludin were determined by western blot and immunofluorescence staining. EB content increased at 3 h after the administration of Ioversol via the carotid artery and reached a peak at 6 h (P < 0.05), whereas it decreased to its normal level at 24 h. Western blot and immunofluorescence staining indicated that the expression of ZO-1 in brain tissues gradually decreased to its lowest level at 3 h, and then increased gradually, but was still lower than that of the normal control group at 24 h (P < 0.05). Occludin was similar, but its lowest expression appeared at 0.5 h. This study demonstrated that the permeability of BBB in rats increased first and then decreased after Ioversol was injected into the carotid artery. The mechanism may be related to altered protein expression of TJs, which are important structures in BBB. Early intervention against TJ proteins may be an effective measure to prevent and treat CIE.
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Effect of the Ioversol on early renal function in patients undergoing cerebral vascular intervention
2017Co-Authors: Guilian Zhang, Yingying Guo, Lei Zhang, Heying Wang, Jiao LiuAbstract:Objective To investigate the effect of different doses of Ioversol on renal function, and to explore early renal injury biomarkers on contrast induced kidney injury and safe Ioversol dosage. Methods A total of 158 cases (98 males and 60 females) undergoing cerebral vascular intervention (CVI) in our department was selected with age ranging from 23 to 81 years old (average age 59.70±12.02). Based on Ioversol dosage in surgery, patients were divided into three groups: low dose group (≤150 ml, n=49), middle dose group (151-200 ml, n=74), and high dose group (>200 ml, n=35). U-κ, U-λ, urinary transferrin (UTRF), urine microalbumin (UMA), urinary immunoglobulin IgG (UIgG), urine beta2-microglobulin (Uβ2-MG), Uα1-MG, urinary N-acetyl-beta-D-glucosaminidase (UNAG), plasma cystatin C (CysC) and Scr were detected by scattering turbidimetry, immune turbidimetry and fully automatic biochemical analysis pre-surgery 24 h and post-surgery 72 h. Contrast-induced acute kidney injury (CI-AKI) was defined as laboratory increase of Scr value≥44.2 μmol/L or ≥25% from baseline measurement at 48hours after surgery. The relationship in Ioversol dosage and various factors was assessed by Single and multiple factors binary logistic regression analysis. Results According to the criterion that Scr increase value were ≥44.2 μmol/L, of 158 cases, 3 cases occurred CI-AKI, the AKI incidence was 1.90%. Based on the criterion that Scr increase value was ≥25%, 33 cases occurred CI-AKI, the incidence was 20.89%. The concentration of U-κ, UTRF, Uα1-MG, UNAG and plasma CysC were significantly different in high dose group compared to low Ioversol dose group (P 0.05). Conclusions The contrast media-Ioversol could lead to CI-AKI; when the dosage of Ioversol was more than 200 ml one-time, the concentration of U-κ, UTRF, Uα1-MG, UNAG and plasma CysC increased significantly. U-κ, UTRF, Uα1-MG, UNAG and plasma CysC could predict the early renal injury in patients who undergoing CVI. The rise of U-κ, UTRF, Uα1-MG, UNAG and plasma CysC are related to the dosage of Ioversol. Furthermore, possibility of kidney injury is significantly high when Ioversol dosage is more than 200 ml one-time. Key words: Triiodobenzoic acids/AD; Contrast media/AD; Kidney/IN; Radiography, interventional; Kidney function tests
Paul Sherwin - One of the best experts on this subject based on the ideXlab platform.
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nephrotoxicity of iodixanol versus Ioversol in patients with chronic kidney disease the visipaque angiography interventions with laboratory outcomes in renal insufficiency valor trial
American Heart Journal, 2008Co-Authors: Michael R Rudnick, Charles J Davidson, Warren K Laskey, Lawrence J Stafford, Paul SherwinAbstract:Background Iso-osmolar contrast medium iodixanol has been reported to be less nephrotoxic than selected low-osmolar contrast media (LOCM) in chronic kidney disease (CKD) patients with diabetes mellitus. This study compared the nephrotoxicity of iodixanol and the LOCM Ioversol in CKD patients undergoing coronary angiography. Methods This is a prospective double-blind trial in 337 patients with stable CKD who were randomly assigned to receive the iso-osmolar contrast medium iodixanol or the LOCM Ioversol. The co-primary end points were the mean peak percentage change (MPPC) in baseline serum creatinine and the incidence of contrast-induced nephropathy (rise of >0.5 mg/dL in baseline serum creatinine within 72 hours postcontrast) for the 2 contrast media in the 72-hour period after contrast administration. Prespecified analyses included stratification on diabetic state and the use of N -acetylcysteine. Results In the 299 patients with complete post–contrast media creatinine data, the incidence of contrast-induced nephropathy was 21.8% in the iodixanol subjects and 23.8% in the Ioversol subjects ( P = .78). For all patients, the MPPC was 14.7% with iodixanol and 20.0% with Ioversol ( P = .06), whereas in the subset of diabetic patients, this value was significantly lower in the iodixanol (12.9%) compared with the Ioversol subjects (22.4%, P = .01). Conclusions Overall, the nephrotoxicity associated with iodixanol was not significantly different from that observed with Ioversol in CKD patients undergoing coronary angiography, although in diabetic patients, MPPC was significantly lower in the iodixanol group.
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Nephrotoxicity of iodixanol versus Ioversol in patients with chronic kidney disease: The Visipaque Angiography/Interventions with Laboratory Outcomes in Renal Insufficiency (VALOR) Trial
American heart journal, 2008Co-Authors: Michael R Rudnick, Charles J Davidson, Warren K Laskey, J. Lawrence Stafford, Paul SherwinAbstract:Background Iso-osmolar contrast medium iodixanol has been reported to be less nephrotoxic than selected low-osmolar contrast media (LOCM) in chronic kidney disease (CKD) patients with diabetes mellitus. This study compared the nephrotoxicity of iodixanol and the LOCM Ioversol in CKD patients undergoing coronary angiography. Methods This is a prospective double-blind trial in 337 patients with stable CKD who were randomly assigned to receive the iso-osmolar contrast medium iodixanol or the LOCM Ioversol. The co-primary end points were the mean peak percentage change (MPPC) in baseline serum creatinine and the incidence of contrast-induced nephropathy (rise of >0.5 mg/dL in baseline serum creatinine within 72 hours postcontrast) for the 2 contrast media in the 72-hour period after contrast administration. Prespecified analyses included stratification on diabetic state and the use of N -acetylcysteine. Results In the 299 patients with complete post–contrast media creatinine data, the incidence of contrast-induced nephropathy was 21.8% in the iodixanol subjects and 23.8% in the Ioversol subjects ( P = .78). For all patients, the MPPC was 14.7% with iodixanol and 20.0% with Ioversol ( P = .06), whereas in the subset of diabetic patients, this value was significantly lower in the iodixanol (12.9%) compared with the Ioversol subjects (22.4%, P = .01). Conclusions Overall, the nephrotoxicity associated with iodixanol was not significantly different from that observed with Ioversol in CKD patients undergoing coronary angiography, although in diabetic patients, MPPC was significantly lower in the iodixanol group.
