The Experts below are selected from a list of 47493 Experts worldwide ranked by ideXlab platform
Shuming Nie - One of the best experts on this subject based on the ideXlab platform.
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mesoporous silica beads embedded with semiconductor quantum dots and Iron Oxide nanocrystals dual function microcarriers for optical encoding and magnetic separation
Analytical Chemistry, 2006Co-Authors: Tusha Sathe, And Ami Agrawal, Shuming NieAbstract:Mesoporous beads are promising materials for embedding functional nanoparticles because of their nanometer-sized pores and large surface areas. Here we report the development of silica microbeads embedded with both semiconductor quantum dots (QD) and Iron Oxide (fe3o4) nanocrystals as a new class of dual-function carriers for optical encoding and magnetic separation. The embedding (doping) process is carried out by either simultaneous or sequential addition of quantum dots and Iron Oxide (fe3o4) nanocrystals in solution. The doping process is fast and quantitative, but the incorporated Iron Oxide strongly attenuates the signal intensity of QD fluorescence. We find that this attenuation is not due to conventional fluorescence quenching but is caused by the broad optical absorption spectrum of mixed-valence fe3o4. For improved biocompatibility and reduced nonspecific binding, the encoded beads are further coated with amphiphilic polymers such as octylamine poly(acrylic acid). The results indicate that the p...
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mesoporous silica beads embedded with semiconductor quantum dots and Iron Oxide nanocrystals dual function microcarriers for optical encoding and magnetic separation
Analytical Chemistry, 2006Co-Authors: Tushar R Sathe, And Amit Agrawal, Shuming NieAbstract:Mesoporous beads are promising materials for embedding functional nanoparticles because of their nanometer-sized pores and large surface areas. Here we report the development of silica microbeads embedded with both semiconductor quantum dots (QD) and Iron Oxide (fe3o4) nanocrystals as a new class of dual-function carriers for optical encoding and magnetic separation. The embedding (doping) process is carried out by either simultaneous or sequential addition of quantum dots and Iron Oxide (fe3o4) nanocrystals in solution. The doping process is fast and quantitative, but the incorporated Iron Oxide strongly attenuates the signal intensity of QD fluorescence. We find that this attenuation is not due to conventional fluorescence quenching but is caused by the broad optical absorption spectrum of mixed-valence fe3o4. For improved biocompatibility and reduced nonspecific binding, the encoded beads are further coated with amphiphilic polymers such as octylamine poly(acrylic acid). The results indicate that the polymer-coated beads are well suited for target capturing and enrichment, yielding magnetic separation efficiencies higher than 99%. By combining the multiplexing capability of QDs with the superparamagnetic properties of Iron Oxide nanocrystals, this class of encoded beads is expected to find broad applications in high-throughput and multiplexed biomolecular assays.
Yusuke Yamauchi - One of the best experts on this subject based on the ideXlab platform.
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Trifunctional fe3o4/CaP/Alginate Core–Shell–Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy
2017Co-Authors: Yu-pu Wang, Yu-te Liao, Chia-hung Liu, Hatem R. Alamri, Zeid A. Alothman, Md. Shahriar A. Hossain, Yusuke YamauchiAbstract:Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of Iron Oxide (fe3o4) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-fe3o4/CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-fe3o4/CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-fe3o4/CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems
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functionalized magnetic Iron Oxide alginate core shell nanoparticles for targeting hyperthermia
International Journal of Nanomedicine, 2015Co-Authors: Shih Hsiang Liao, Chia-hung Liu, Yusuke Yamauchi, Bishnu Prasad Bastakoti, Norihiro Suzuki, Yung Chang, Fenghuei LinAbstract:Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic Iron Oxide (fe3o4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as fe3o4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that fe3o4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.
Fenghuei Lin - One of the best experts on this subject based on the ideXlab platform.
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functionalized magnetic Iron Oxide alginate core shell nanoparticles for targeting hyperthermia
International Journal of Nanomedicine, 2015Co-Authors: Shih Hsiang Liao, Chia-hung Liu, Yusuke Yamauchi, Bishnu Prasad Bastakoti, Norihiro Suzuki, Yung Chang, Fenghuei LinAbstract:Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic Iron Oxide (fe3o4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as fe3o4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that fe3o4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.
Chia-hung Liu - One of the best experts on this subject based on the ideXlab platform.
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Trifunctional fe3o4/CaP/Alginate Core–Shell–Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy
2017Co-Authors: Yu-pu Wang, Yu-te Liao, Chia-hung Liu, Hatem R. Alamri, Zeid A. Alothman, Md. Shahriar A. Hossain, Yusuke YamauchiAbstract:Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of Iron Oxide (fe3o4) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-fe3o4/CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-fe3o4/CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-fe3o4/CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems
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functionalized magnetic Iron Oxide alginate core shell nanoparticles for targeting hyperthermia
International Journal of Nanomedicine, 2015Co-Authors: Shih Hsiang Liao, Chia-hung Liu, Yusuke Yamauchi, Bishnu Prasad Bastakoti, Norihiro Suzuki, Yung Chang, Fenghuei LinAbstract:Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic Iron Oxide (fe3o4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as fe3o4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that fe3o4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.
Youngil Lee - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of electrically conductive and superparamagnetic monodispersed Iron Oxide-conjugated polymer composite nanoparticles by in situ chemical oxidative polymerization
Journal of Colloid and Interface Science, 2009Co-Authors: Kakarla Raghava Reddy, Wonjung Park, Byung Cheol Sin, Jaegeun Noh, Youngil LeeAbstract:Core-shell nanocomposites composed of Iron Oxide (fe3o4) nanoparticles and conjugated polymer, poly(3, 4-ethylenedioxythiophene) (PEDOT), were successfully synthesized from a simple and inexpensive in situ chemical oxidative polymerization of EDOT with fe3o4nanoparticles in the micellar solution of lignosulfonic acid (LSA) which serves as both a surfactant and a dopant. These nanocomposites (fe3o4-PEDOT) were subsequently characterized for morphological, crystalline, structural, electrical and magnetic properties by high-resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), four-probe meter and superconductor quantum interference device (SQUID), respectively. Results show that the nanocomposites have a spherical core-shell shape, are ∼10 nm in size and are superparamagnetic with good magnetic saturation and good electrical conductivities. Existence of fe3o4in the nanocomposites was confirmed by using Energy dispersive X-ray photoelectron spectroscopy (EDAX) and X-ray photoelectron microscopy (XPS). We also investigated a possible formation mechanism of the core-shell nanocomposites, and the effect of fe3o4nanoparticles on the electro-magnetic properties of the nanocomposites. Such novel conducting and superparamagnetic composite nanomaterials can be applied to sensors, magnetic data storage, electro-magnetic resonance wave absorption, etc. Crown Copyright © 2009.
