The Experts below are selected from a list of 150 Experts worldwide ranked by ideXlab platform
Catherine Ghezzi - One of the best experts on this subject based on the ideXlab platform.
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Preclinical characterization of a novel radiolabeled analog of practolol for the molecular imaging of myocardial β-adrenoceptor density
Journal of Nuclear Cardiology, 2014Co-Authors: Eric Carbonnelle, Veronique Josserand, Laurent Riou, Olivier Ormezzano, Alexis Broisat, Pascale Perret, Daniel Fagret, Gilles Barone-rochette, Catherine GhezziAbstract:Background The great clinical potential of myocardial β-AR imaging has been shown by recent studies evaluating the β-AR-specific, non-selective agent [^11C]-CGP12177 in the setting of idiopathic-dilated cardiomyopathy, and myocardial infarction. However, the short half-life of ^11C hampers the potential of [^11C]-CGP12177 for routine clinical use. AMI9 is an analog of the β-adrenoceptor ligand practolol that can readily be labeled using radioactive Isotopes of Iodine. The present study was aimed at characterizing the in vitro, ex vivo, and in vivo β-AR binding properties of [^125I]-AMI9. Methods and Results Newborn rat cardiomyocytes were used for saturation and kinetic binding assays as well as for displacement and competition experiments. Isolated perfused rat hearts were used to evaluate the pharmacological activity of AMI9. The in vivo kinetics of [^125I]-AMI9 were studied using biodistribution experiments in mice. [1^25I]-AMI9 displayed high specific affinity for β-AR with no β-AR subtype selectivity ( K _D, 5.6 ± 0.3 nM; B _max, 231 ± 7 fmol·(mg protein)^−1). AMI9 potently inhibited the inotropic effects of isoproterenol. The early in vivo cardiac and lung activities of [^125I]-AMI9 compared favorably with those of the clinically validated tracer CGP12177. Conclusion Iodine-labeled AMI9 is a promising agent for the molecular imaging of myocardial β-AR density.
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preclinical characterization of a novel radiolabeled analog of practolol for the molecular imaging of myocardial β adrenoceptor density
Journal of Nuclear Cardiology, 2014Co-Authors: Eric Carbonnelle, Veronique Josserand, Laurent Riou, Olivier Ormezzano, Alexis Broisat, Pascale Perret, Gilles Baronerochette, Daniel Fagret, Catherine GhezziAbstract:Background The great clinical potential of myocardial β-AR imaging has been shown by recent studies evaluating the β-AR-specific, non-selective agent [11C]-CGP12177 in the setting of idiopathic-dilated cardiomyopathy, and myocardial infarction. However, the short half-life of 11C hampers the potential of [11C]-CGP12177 for routine clinical use. AMI9 is an analog of the β-adrenoceptor ligand practolol that can readily be labeled using radioactive Isotopes of Iodine. The present study was aimed at characterizing the in vitro, ex vivo, and in vivo β-AR binding properties of [125I]-AMI9.
M C Thorne - One of the best experts on this subject based on the ideXlab platform.
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estimation of animal transfer factors for radioactive Isotopes of Iodine technetium selenium and uranium
Journal of Environmental Radioactivity, 2003Co-Authors: M C ThorneAbstract:Abstract In post-closure radiological safety assessments of repositories for solid radioactive wastes, transfers of radionuclides to animal products are typically characterised using Transfer Factors ( TF s), defined as the ratio of the concentration of the radionuclide in the animal product of interest to the rate of intake in diet. Such transfer factors can be measured directly in experimental studies, but they can also be estimated by use of biokinetic models for uptake and retention of radionuclides in animals. Based on a review of the literature, biokinetic models have been developed for the uptake and retention of Iodine, technetium, selenium and uranium. These biokinetic models allow TF values to be estimated for different types of animals and for different animal lifetimes. For each radionuclide considered, reference values and ranges of TF values are estimated. These are summarised in Table 1.
Eric Carbonnelle - One of the best experts on this subject based on the ideXlab platform.
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Preclinical characterization of a novel radiolabeled analog of practolol for the molecular imaging of myocardial β-adrenoceptor density
Journal of Nuclear Cardiology, 2014Co-Authors: Eric Carbonnelle, Veronique Josserand, Laurent Riou, Olivier Ormezzano, Alexis Broisat, Pascale Perret, Daniel Fagret, Gilles Barone-rochette, Catherine GhezziAbstract:Background The great clinical potential of myocardial β-AR imaging has been shown by recent studies evaluating the β-AR-specific, non-selective agent [^11C]-CGP12177 in the setting of idiopathic-dilated cardiomyopathy, and myocardial infarction. However, the short half-life of ^11C hampers the potential of [^11C]-CGP12177 for routine clinical use. AMI9 is an analog of the β-adrenoceptor ligand practolol that can readily be labeled using radioactive Isotopes of Iodine. The present study was aimed at characterizing the in vitro, ex vivo, and in vivo β-AR binding properties of [^125I]-AMI9. Methods and Results Newborn rat cardiomyocytes were used for saturation and kinetic binding assays as well as for displacement and competition experiments. Isolated perfused rat hearts were used to evaluate the pharmacological activity of AMI9. The in vivo kinetics of [^125I]-AMI9 were studied using biodistribution experiments in mice. [1^25I]-AMI9 displayed high specific affinity for β-AR with no β-AR subtype selectivity ( K _D, 5.6 ± 0.3 nM; B _max, 231 ± 7 fmol·(mg protein)^−1). AMI9 potently inhibited the inotropic effects of isoproterenol. The early in vivo cardiac and lung activities of [^125I]-AMI9 compared favorably with those of the clinically validated tracer CGP12177. Conclusion Iodine-labeled AMI9 is a promising agent for the molecular imaging of myocardial β-AR density.
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preclinical characterization of a novel radiolabeled analog of practolol for the molecular imaging of myocardial β adrenoceptor density
Journal of Nuclear Cardiology, 2014Co-Authors: Eric Carbonnelle, Veronique Josserand, Laurent Riou, Olivier Ormezzano, Alexis Broisat, Pascale Perret, Gilles Baronerochette, Daniel Fagret, Catherine GhezziAbstract:Background The great clinical potential of myocardial β-AR imaging has been shown by recent studies evaluating the β-AR-specific, non-selective agent [11C]-CGP12177 in the setting of idiopathic-dilated cardiomyopathy, and myocardial infarction. However, the short half-life of 11C hampers the potential of [11C]-CGP12177 for routine clinical use. AMI9 is an analog of the β-adrenoceptor ligand practolol that can readily be labeled using radioactive Isotopes of Iodine. The present study was aimed at characterizing the in vitro, ex vivo, and in vivo β-AR binding properties of [125I]-AMI9.
M Majibur Rahman - One of the best experts on this subject based on the ideXlab platform.
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Radiological Concentration Distribution of <sup>131</sup>I, <sup>132</sup>I, <sup>133</sup>I, <sup>134</sup>I, and <sup>135</sup>I Due to a Hypothetical Accident of TRIGA Mark-II Research Re
Journal of Modern Physics, 2020Co-Authors: M. A. Malek, K. J. A. Chisty, M Majibur RahmanAbstract:The present work gives a methodology for assessing radiological concentration of <sup>131</sup>I, <sup>132</sup>I, <sup>133</sup>I, <sup>134</sup>I, and <sup>135</sup>I due to a hypothetical accident of TRIGA Mark-II research Reactor at AERE, Savar, Bangladesh. The concentrations were estimated through different pathways like ingestion of vegetation, milk, and meat from air and ground deposition. The maximum air concentrations for all 16 directions were found at 110 m distance from the core of the reactor and it was found to be highest in the southern (S) direction. The maximum ground concentration occurred immediately just after the accident in different directions. In all pathways, the most concentration was found to be in S-direction. The concentrations in vegetation of <sup>131</sup>I, <sup>133</sup>I, <sup>135</sup>I were significant, while no concentrations of 132I and 134I were observed. The concentration in vegetation for <sup>131</sup>I was found to be highest than all other Isotopes of Iodine. The concentrations of <sup>133</sup>I were found to be higher and concentrations of <sup>134</sup>I were observed to be lower in both milk and meat compared to other radio Isotopes of Iodine. In the case of a radiological accident, the results of the present study will be a valuable guide for adopting radiological safety measures for radiation protection against the ingestion of vegetables, milk and meat from around the research reactor at AERE, Savar, Bangladesh
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Radiological Concentration Distribution of 131 I, 132 I, 133 I, 134 I, and 135 I Due to a Hypothetical Accident of TRIGA Mark-II Research Reactor
Journal of Modern Physics, 2012Co-Authors: M. A. Malek, K. J. A. Chisty, M Majibur RahmanAbstract:The present work gives a methodology for assessing radiological concentration of 131I, 132I, 133I, 134I, and 135I due to a hypothetical accident of TRIGA Mark-II research Reactor at AERE, Savar, Bangladesh. The concentrations were estimated through different pathways like ingestion of vegetation, milk, and meat from air and ground deposition. The maximum air concentrations for all 16 directions were found at 110 m distance from the core of the reactor and it was found to be highest in the southern (S) direction. The maximum ground concentration occurred immediately just after the accident in different directions. In all pathways, the most concentration was found to be in S-direction. The concentrations in vegetation of 131I, 133I, 135I were significant, while no concentrations of 132I and 134I were observed. The concentration in vegetation for 131I was found to be highest than all other Isotopes of Iodine. The concentrations of 133I were found to be higher and concentrations of 134I were observed to be lower in both milk and meat compared to other radio Isotopes of Iodine. In the case of a radiological accident, the results of the present study will be a valuable guide for adopting radiological safety measures for radiation protection against the ingestion of vegetables, milk and meat from around the research reactor at AERE, Savar, Bangladesh.
Jay H Lubin - One of the best experts on this subject based on the ideXlab platform.
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autoimmune thyroiditis and exposure to Iodine 131 in the ukrainian cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident results from the first screening cycle 1998 2000
The Journal of Clinical Endocrinology and Metabolism, 2006Co-Authors: Mykola Tronko, Alina V Brenner, Valery A Olijnyk, John A Robbins, Ovsiy V Epstein, Robert J Mcconnell, T Bogdanova, Daniel Fink, I A Likhtarev, Jay H LubinAbstract:Context: Due to the Chornobyl accident, millions were exposed to radioactive Isotopes of Iodine and some received appreciable Iodine 131 (131I) doses. A subsequent increase in thyroid cancer has been largely attributed to this exposure, but evidence concerning autoimmune thyroiditis (AIT) remains inconclusive. Objective: The objective of the study was to quantify risk of AIT after 131I exposure. Design/Setting/Participants: Baseline data were collected from the first screening cycle (1998–2000) of a large cohort of radiation-exposed individuals (n = 12,240), residents of contaminated, Iodine-deficient territories of Ukraine. Study individuals were under the age of 18 yr on April 26, 1986, and had thyroid radioactivity measurements made shortly after the accident. Outcomes: AIT was defined a priori based on various combinations of elevated antibodies to thyroid peroxidase (ATPO), TSH, and clinical findings; elevated ATPO were considered to be an indicator of thyroid autoimmunity. Results: No significant as...