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Sudarshan Ojha - One of the best experts on this subject based on the ideXlab platform.
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evaluation of antimotility effect of Lantana camara l var acuelata constituents on neostigmine induced gastrointestinal transit in mice
BMC Complementary and Alternative Medicine, 2005Co-Authors: Lenika Sagar, Rajesh Sehgal, Sudarshan OjhaAbstract:Lantana camara L. (Verbenaceae), a widely growing shrub which is toxic to some animal species, has been used in the traditional medicine for treating many ailments. The purpose of the present study was to evaluate the antimotility effects of Lantana camara leaf constituents in mice intestine. Evaluation of antimotility activity was done in intestine of mice treated with Lantana camara leaf powder, Lantana camara methanolic extract (LCME), lantadene A, neostigmine and neostigmine + LCME. Neostigmine was used as a promotility agent. Intestinal motility was assessed by charcoal meal test and gastrointestinal transit rate was expressed as the percentage of the distance traversed by the charcoal divided by the total length of the small intestine. The antidiarrheal effect of LCME was studied against castor oil induced diarrhea model in mice. The intestinal transit with LCME at a dose of 500 mg/kg was 26.46% whereas the higher dose (1 g/kg) completely inhibited the transit of charcoal in normal mice. The % intestinal transit in the neostigmine pretreated groups was 24 and 11 at the same doses respectively. When the plant extracts at 125 and 250 mg/kg doses were administered intraperitonealy, there was significant reduction in fecal output compared with castor oil treated mice. At higher doses (500 and 1000 mg/kg), the fecal output was almost completely stopped. The remarkable antimotility effect of Lantana camara methanolic extract against neostigmine as promotility agent points towards an anticholinergic effect due to Lantana camara constituents and attests to its possible utility in secretory and functional diarrheas and other gastrointestinal disorders. This effect was further confirmed by significant inhibition of castor oil induced diarrhea in mice by various doses of LCME.
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Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice
BMC Complementary and Alternative Medicine, 2005Co-Authors: Lenika Sagar, Rajesh Sehgal, Sudarshan OjhaAbstract:Background Lantana camara L. (Verbenaceae), a widely growing shrub which is toxic to some animal species, has been used in the traditional medicine for treating many ailments. The purpose of the present study was to evaluate the antimotility effects of Lantana camara leaf constituents in mice intestine. Methods Evaluation of antimotility activity was done in intestine of mice treated with Lantana camara leaf powder, Lantana camara methanolic extract (LCME), lantadene A, neostigmine and neostigmine + LCME. Neostigmine was used as a promotility agent. Intestinal motility was assessed by charcoal meal test and gastrointestinal transit rate was expressed as the percentage of the distance traversed by the charcoal divided by the total length of the small intestine. The antidiarrheal effect of LCME was studied against castor oil induced diarrhea model in mice. Results The intestinal transit with LCME at a dose of 500 mg/kg was 26.46% whereas the higher dose (1 g/kg) completely inhibited the transit of charcoal in normal mice. The % intestinal transit in the neostigmine pretreated groups was 24 and 11 at the same doses respectively. When the plant extracts at 125 and 250 mg/kg doses were administered intraperitonealy, there was significant reduction in fecal output compared with castor oil treated mice. At higher doses (500 and 1000 mg/kg), the fecal output was almost completely stopped. Conclusion The remarkable antimotility effect of Lantana camara methanolic extract against neostigmine as promotility agent points towards an anticholinergic effect due to Lantana camara constituents and attests to its possible utility in secretory and functional diarrheas and other gastrointestinal disorders. This effect was further confirmed by significant inhibition of castor oil induced diarrhea in mice by various doses of LCME.
Rosy Mary Dos Santos Isaias - One of the best experts on this subject based on the ideXlab platform.
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ontogenese da folha e das galhas induzidas por aceria Lantanae cook acarina eriophyidae em Lantanacamara l verbenaceae
Brazilian Journal of Botany, 2009Co-Authors: Maria Zabele Dantas Moura, Geraldo Luiz Goncalvez Soares, Rosy Mary Dos Santos IsaiasAbstract:Aceria Lantanae e um acaro fitofago indutor de galhas em folhas de Lantana camara. O estudo comparativo de caracteres histologicos e histometricos durante a ontogenese foliar e das galhas visa determinar quais eventos da morfogenese dos tecidos sadios sao alterados pelo galhador. A ontogenese foliar de L. camara segue os padroes descritos na literatura. A inducao de galhas provoca hiperplasia da epiderme e do sistema fundamental. No estagio de crescimento e desenvolvimento, a invaginacao da lâmina foliar origina a câmara ninfal, onde os eriofideos se reproduzem. O revestimento interno dessa câmara constitui o tecido nutritivo, no qual os indutores se alimentam, estimulando as divisoes celulares. No estagio de maturacao, o aumento no tamanho da estrutura e acompanhado pelo aumento no numero de individuos de A. Lantanae. O revestimento externo da galha apresenta alta densidade de tricomas tectores, cujo morfotipo e particular as galhas. A diferenciacao de emergencias e a neoformacao de feixes vasculares promove o aporte de nutrientes aos indutores. Divisoes celulares em diversos planos alteram o padrao laminar da folha resultando em galhas verrucosas. O arranjo dos tecidos antes direcionados a fotossintese passa a garantir um microambiente adequado e fonte nutricional para a colonia de A. Lantanae. No estagio de senescencia, a suberizacao do tecido nutritivo indica o fim da atividade alimentar dos indutores. O fim dos ciclos celulares tem lugar com a suberizacao do tecido nutritivo, evento que pode ser relacionado a morte da femea deutogina, ou ao limite imposto pela idade da folha hospedeira de L. camara.
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ontogenese da folha e das galhas induzidas por aceria Lantanae cook acarina eriophyidae em Lantanacamara l verbenaceae
Brazilian Journal of Botany, 2009Co-Authors: Maria Zabele Dantas Moura, Geraldo Luiz Goncalvez Soares, Rosy Mary Dos Santos IsaiasAbstract:Aceria Lantanae is a phytophagous mite commonly observed inducing galls in Lantana camara leaves. The comparative study of histological and histometric characteristics, during the ontogenesis of leaves and galls, aims to determine which of the healthy tissues morphogenetic events are altered by the galling herbivore. Leaf ontogenetical events of L. camara followed the pattern described in literature. Gall induction causes hyperplasia of epidermis and ground system. At growth and development stage, leaf lamina invagination gives rise to the nymphal chamber, where eriophids reproduce. The cell layer limiting this chamber constitutes the nutritive tissue, where inducers feed, and stimulate cell divisions. At the maturation stage, gall increase in size is followed by an increase in the number of A. Lantanae individuals. Gall external covering is characterized by a high density of non-glandular trichomes whose morphotype is particular to the galls. The differentiation of emergencies and neoformation of vascular bundles promotes an increase in the flux of food resources to the inducers. Cell divisions in diverse angles alter the laminar pattern of the leaf firstly related to photosynthesis, and result in verrucous galls which guarantee an adequate microenvironment and nutrition source to A. Lantanae colony. At senescent stage, nutritive tissue suberization occurs, indicating the end of the inducers feeding activity. The suberization of nutritive tissue indicates the end of cell cycles, an event that may be related to the death of the deutogyne female, or to the limits imposed by the age of L. camara host leaf.
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species specific changes in tissue morphogenesis induced by two arthropod leaf gallers in Lantana camara l verbenaceae
Australian Journal of Botany, 2008Co-Authors: Maria Zabele Dantas Moura, Geraldo Luiz Goncalves Soares, Rosy Mary Dos Santos IsaiasAbstract:When different cecidogenous species attack the same plant species, each one causes distinct plant tissue reorganisation, and forms typical gall structures. Two Lantana camara L. leaf galls induced by Aceria Lantanae (Cook) (Acarina: Eriophyidae) and Schismatodiplosis Lantanae (Rubsaamen) (Diptera: Cecidomyiidae) were collected in a subspontaneous population at Rio Grande do Sul, Brazil. A. Lantanae crinckle galls were uni- or multi-chambered and contained several mites, caused by several leaf foldings, and consisted of hyperplasic epidermis and parenchyma. S. Lantanae induced uni-chambered pouch galls inhabited by one larvae or pupa. This gall consisted predominantly of hypertrophied spongy parenchyma. Our results documented how these herbivores acted in cells with the same initial morphogenetic competence, altering leaf pattern, and inducing their specific extended phenotype.
Lenika Sagar - One of the best experts on this subject based on the ideXlab platform.
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evaluation of antimotility effect of Lantana camara l var acuelata constituents on neostigmine induced gastrointestinal transit in mice
BMC Complementary and Alternative Medicine, 2005Co-Authors: Lenika Sagar, Rajesh Sehgal, Sudarshan OjhaAbstract:Lantana camara L. (Verbenaceae), a widely growing shrub which is toxic to some animal species, has been used in the traditional medicine for treating many ailments. The purpose of the present study was to evaluate the antimotility effects of Lantana camara leaf constituents in mice intestine. Evaluation of antimotility activity was done in intestine of mice treated with Lantana camara leaf powder, Lantana camara methanolic extract (LCME), lantadene A, neostigmine and neostigmine + LCME. Neostigmine was used as a promotility agent. Intestinal motility was assessed by charcoal meal test and gastrointestinal transit rate was expressed as the percentage of the distance traversed by the charcoal divided by the total length of the small intestine. The antidiarrheal effect of LCME was studied against castor oil induced diarrhea model in mice. The intestinal transit with LCME at a dose of 500 mg/kg was 26.46% whereas the higher dose (1 g/kg) completely inhibited the transit of charcoal in normal mice. The % intestinal transit in the neostigmine pretreated groups was 24 and 11 at the same doses respectively. When the plant extracts at 125 and 250 mg/kg doses were administered intraperitonealy, there was significant reduction in fecal output compared with castor oil treated mice. At higher doses (500 and 1000 mg/kg), the fecal output was almost completely stopped. The remarkable antimotility effect of Lantana camara methanolic extract against neostigmine as promotility agent points towards an anticholinergic effect due to Lantana camara constituents and attests to its possible utility in secretory and functional diarrheas and other gastrointestinal disorders. This effect was further confirmed by significant inhibition of castor oil induced diarrhea in mice by various doses of LCME.
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Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice
BMC Complementary and Alternative Medicine, 2005Co-Authors: Lenika Sagar, Rajesh Sehgal, Sudarshan OjhaAbstract:Background Lantana camara L. (Verbenaceae), a widely growing shrub which is toxic to some animal species, has been used in the traditional medicine for treating many ailments. The purpose of the present study was to evaluate the antimotility effects of Lantana camara leaf constituents in mice intestine. Methods Evaluation of antimotility activity was done in intestine of mice treated with Lantana camara leaf powder, Lantana camara methanolic extract (LCME), lantadene A, neostigmine and neostigmine + LCME. Neostigmine was used as a promotility agent. Intestinal motility was assessed by charcoal meal test and gastrointestinal transit rate was expressed as the percentage of the distance traversed by the charcoal divided by the total length of the small intestine. The antidiarrheal effect of LCME was studied against castor oil induced diarrhea model in mice. Results The intestinal transit with LCME at a dose of 500 mg/kg was 26.46% whereas the higher dose (1 g/kg) completely inhibited the transit of charcoal in normal mice. The % intestinal transit in the neostigmine pretreated groups was 24 and 11 at the same doses respectively. When the plant extracts at 125 and 250 mg/kg doses were administered intraperitonealy, there was significant reduction in fecal output compared with castor oil treated mice. At higher doses (500 and 1000 mg/kg), the fecal output was almost completely stopped. Conclusion The remarkable antimotility effect of Lantana camara methanolic extract against neostigmine as promotility agent points towards an anticholinergic effect due to Lantana camara constituents and attests to its possible utility in secretory and functional diarrheas and other gastrointestinal disorders. This effect was further confirmed by significant inhibition of castor oil induced diarrhea in mice by various doses of LCME.
Maria Zabele Dantas Moura - One of the best experts on this subject based on the ideXlab platform.
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ontogenese da folha e das galhas induzidas por aceria Lantanae cook acarina eriophyidae em Lantanacamara l verbenaceae
Brazilian Journal of Botany, 2009Co-Authors: Maria Zabele Dantas Moura, Geraldo Luiz Goncalvez Soares, Rosy Mary Dos Santos IsaiasAbstract:Aceria Lantanae e um acaro fitofago indutor de galhas em folhas de Lantana camara. O estudo comparativo de caracteres histologicos e histometricos durante a ontogenese foliar e das galhas visa determinar quais eventos da morfogenese dos tecidos sadios sao alterados pelo galhador. A ontogenese foliar de L. camara segue os padroes descritos na literatura. A inducao de galhas provoca hiperplasia da epiderme e do sistema fundamental. No estagio de crescimento e desenvolvimento, a invaginacao da lâmina foliar origina a câmara ninfal, onde os eriofideos se reproduzem. O revestimento interno dessa câmara constitui o tecido nutritivo, no qual os indutores se alimentam, estimulando as divisoes celulares. No estagio de maturacao, o aumento no tamanho da estrutura e acompanhado pelo aumento no numero de individuos de A. Lantanae. O revestimento externo da galha apresenta alta densidade de tricomas tectores, cujo morfotipo e particular as galhas. A diferenciacao de emergencias e a neoformacao de feixes vasculares promove o aporte de nutrientes aos indutores. Divisoes celulares em diversos planos alteram o padrao laminar da folha resultando em galhas verrucosas. O arranjo dos tecidos antes direcionados a fotossintese passa a garantir um microambiente adequado e fonte nutricional para a colonia de A. Lantanae. No estagio de senescencia, a suberizacao do tecido nutritivo indica o fim da atividade alimentar dos indutores. O fim dos ciclos celulares tem lugar com a suberizacao do tecido nutritivo, evento que pode ser relacionado a morte da femea deutogina, ou ao limite imposto pela idade da folha hospedeira de L. camara.
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ontogenese da folha e das galhas induzidas por aceria Lantanae cook acarina eriophyidae em Lantanacamara l verbenaceae
Brazilian Journal of Botany, 2009Co-Authors: Maria Zabele Dantas Moura, Geraldo Luiz Goncalvez Soares, Rosy Mary Dos Santos IsaiasAbstract:Aceria Lantanae is a phytophagous mite commonly observed inducing galls in Lantana camara leaves. The comparative study of histological and histometric characteristics, during the ontogenesis of leaves and galls, aims to determine which of the healthy tissues morphogenetic events are altered by the galling herbivore. Leaf ontogenetical events of L. camara followed the pattern described in literature. Gall induction causes hyperplasia of epidermis and ground system. At growth and development stage, leaf lamina invagination gives rise to the nymphal chamber, where eriophids reproduce. The cell layer limiting this chamber constitutes the nutritive tissue, where inducers feed, and stimulate cell divisions. At the maturation stage, gall increase in size is followed by an increase in the number of A. Lantanae individuals. Gall external covering is characterized by a high density of non-glandular trichomes whose morphotype is particular to the galls. The differentiation of emergencies and neoformation of vascular bundles promotes an increase in the flux of food resources to the inducers. Cell divisions in diverse angles alter the laminar pattern of the leaf firstly related to photosynthesis, and result in verrucous galls which guarantee an adequate microenvironment and nutrition source to A. Lantanae colony. At senescent stage, nutritive tissue suberization occurs, indicating the end of the inducers feeding activity. The suberization of nutritive tissue indicates the end of cell cycles, an event that may be related to the death of the deutogyne female, or to the limits imposed by the age of L. camara host leaf.
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species specific changes in tissue morphogenesis induced by two arthropod leaf gallers in Lantana camara l verbenaceae
Australian Journal of Botany, 2008Co-Authors: Maria Zabele Dantas Moura, Geraldo Luiz Goncalves Soares, Rosy Mary Dos Santos IsaiasAbstract:When different cecidogenous species attack the same plant species, each one causes distinct plant tissue reorganisation, and forms typical gall structures. Two Lantana camara L. leaf galls induced by Aceria Lantanae (Cook) (Acarina: Eriophyidae) and Schismatodiplosis Lantanae (Rubsaamen) (Diptera: Cecidomyiidae) were collected in a subspontaneous population at Rio Grande do Sul, Brazil. A. Lantanae crinckle galls were uni- or multi-chambered and contained several mites, caused by several leaf foldings, and consisted of hyperplasic epidermis and parenchyma. S. Lantanae induced uni-chambered pouch galls inhabited by one larvae or pupa. This gall consisted predominantly of hypertrophied spongy parenchyma. Our results documented how these herbivores acted in cells with the same initial morphogenetic competence, altering leaf pattern, and inducing their specific extended phenotype.
Mairanti Silfani - One of the best experts on this subject based on the ideXlab platform.
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Isolasi dan Uji Bioaktivitas Minyak Atsiri dari Daun Lantana camara Linn yang Diperoleh dari Kabupaten Tanah Datar
2021Co-Authors: Mairanti SilfaniAbstract:Lantana camara Linn adalah tumbuhan gulma dengan famili Verbenaceae yang terdiri dari sekitar 650 spesies yang tersebar di 60 negara dan tumbuh di daerah tropis, sub tropis dan beriklim sedang. Tumbuhan ini telah banyak digunakan secara tradisional untuk mengobati berbagai macam jenis penyakit. Tumbuhan ini mengandung minyak atsiri dengan kandungan kimia yang berbeda-beda berdasarkan perbedaan tempat tumbuhnya. Tujuan dari penelitian ini adalah mengisolasi dan menentukan kandungan kimia dari minyak atsiri dari daun Lantana camara Linn yang diperoleh dari Kabupaten Tanah Datar serta mengetahui toksisitas dan aktivitas antibakteri. Isolasi daun Lantana camara Linn dilakukan dengan menggunakan metode hidrodistilasi dan analisis kandungan kimianya menggunakan Gas Chromatography-Mass Spectrometry (GC-MS). Berdasarkan penelitian yang telah dilakukan didapatkan rendemen dari minyak atsiri hasil isolasi yaitu sebesar 0,11% (v/w). Hasil analisis kandungan kimia minyak atsiri daun Lantana camara Linn didapatkan 50 komponen senyawa dan didapatkan 5 senyawa utama yaitu kariofilen (19,74%), germakrena B (10,29%), β-kostol (6,59%), α-selinene (5,12%), dan O-cimene (4,49%). Uji toksisitas dilakukan dengan metode Brine Shrimp Lethality Test (BSLT) yang menunjukkan toksisitas minyak atsiri daun Lantana camara Linn bersifat sangat toksik dengan nilai LC50 50,35 µg/mL. Uji aktivitas antibakteri menggunakan metode difusi cakram menunjukkan bahwa minyak atsiri daun tumbuhan Lantana camara Linn memiliki aktivitas antibakteri yang lemah terhadap bakteri Escherichia coli dan bakteri Staphylococcus aureus dengan zona hambat pada konsentrasi 100% yaitu 2,83 mm dan 5,43 mm
