The Experts below are selected from a list of 1434 Experts worldwide ranked by ideXlab platform
Gabriela Mazzanti - One of the best experts on this subject based on the ideXlab platform.
-
genotoxicity of Lavender Oil linalyl acetate and linalool on human lymphocytes in vitro
Environmental and Molecular Mutagenesis, 2011Co-Authors: Antonella Di Sotto, Gabriela Mazzanti, Fabio Carbone, Patrizia Hrelia, Francesca MaffeiAbstract:The potential genotoxicity of Lavender essential Oil and its major components, linalool, and linalyl acetate, was evaluated in vitro by the micronucleus test on peripheral human lymphocytes. In the range of non-toxic concentrations (0.5–100 μg/ml), linalyl acetate increased the frequency of micronuclei significantly and in concentration-dependent manner; Lavender Oil did so only at the highest concentration tested, whereas linalool was devoid of genotoxicity. None of the tested substances led to an increase in nucleoplasmic bridges or nuclear buds frequency. These findings suggest that the mutagenic activity of Lavender Oil can be related to the presence of linalyl acetate, which seems to have a profile of an aneugenic agent. Environ. Mol. Mutagen. 52:69–71, 2011. © 2010 Wiley-Liss, Inc.
-
the antimutagenic activity of lavandula angustifolia Lavender essential Oil in the bacterial reverse mutation assay
Food and Chemical Toxicology, 2005Co-Authors: Maria Grazia Evandri, L. Battinelli, Stefano Mastrangelo, Philippe Bolle, Claudia Daniele, Gabriela MazzantiAbstract:Essential Oils from Melaleuca alternifolia (tea-tree Oil) and Lavandula angustifolia (Lavender Oil) are commonly used to treat minor health problems. Tea-tree Oil possesses broad-spectrum antimicrobial activity, and is increasingly used for skin problems. Lavender Oil, traditionally used as an antiseptic agent, is now predominantly used as a relaxant, carminative, and sedative in aromatherapy. Despite their growing use no data are available on their mutagenic potential. In this study, after determining the chemical composition of tea-tree Oil and Lavender Oil, by gas-chromatography and mass spectrometry, we investigated their mutagenic and antimutagenic activities by the bacterial reverse mutation assay in Salmonella typhimurium TA98 and TA100 strains and in Escherichia coli WP2 uvrA strain, with and without an extrinsic metabolic activation system. Neither essential Oil had mutagenic activity on the two tested Salmonella strains or on E. coli, with or without the metabolic activation system. Conversely, Lavender Oil exerted strong antimutagenic activity, reducing mutant colonies in the TA98 strain exposed to the direct mutagen 2-nitrofluorene. Antimutagenicity was concentration-dependent: the maximal concentration (0.80 mg/plate) reduced the number of histidine-independent revertant colonies by 66.4%. Lavender Oil (0.80 mg/plate) also showed moderate antimutagenicity against the TA98 strain exposed to the direct mutagen 1-nitropyrene. Its antimutagenic property makes Lavender Oil a promising candidate for new applications in human healthcare.
Maria Grazia Evandri - One of the best experts on this subject based on the ideXlab platform.
-
the antimutagenic activity of lavandula angustifolia Lavender essential Oil in the bacterial reverse mutation assay
Food and Chemical Toxicology, 2005Co-Authors: Maria Grazia Evandri, L. Battinelli, Stefano Mastrangelo, Philippe Bolle, Claudia Daniele, Gabriela MazzantiAbstract:Essential Oils from Melaleuca alternifolia (tea-tree Oil) and Lavandula angustifolia (Lavender Oil) are commonly used to treat minor health problems. Tea-tree Oil possesses broad-spectrum antimicrobial activity, and is increasingly used for skin problems. Lavender Oil, traditionally used as an antiseptic agent, is now predominantly used as a relaxant, carminative, and sedative in aromatherapy. Despite their growing use no data are available on their mutagenic potential. In this study, after determining the chemical composition of tea-tree Oil and Lavender Oil, by gas-chromatography and mass spectrometry, we investigated their mutagenic and antimutagenic activities by the bacterial reverse mutation assay in Salmonella typhimurium TA98 and TA100 strains and in Escherichia coli WP2 uvrA strain, with and without an extrinsic metabolic activation system. Neither essential Oil had mutagenic activity on the two tested Salmonella strains or on E. coli, with or without the metabolic activation system. Conversely, Lavender Oil exerted strong antimutagenic activity, reducing mutant colonies in the TA98 strain exposed to the direct mutagen 2-nitrofluorene. Antimutagenicity was concentration-dependent: the maximal concentration (0.80 mg/plate) reduced the number of histidine-independent revertant colonies by 66.4%. Lavender Oil (0.80 mg/plate) also showed moderate antimutagenicity against the TA98 strain exposed to the direct mutagen 1-nitropyrene. Its antimutagenic property makes Lavender Oil a promising candidate for new applications in human healthcare.
-
The antimutagenic activity of Lavandula angustifolia (Lavender) essential Oil in the bacterial reverse mutation assay
Food and Chemical Toxicology, 2005Co-Authors: Maria Grazia Evandri, L. Battinelli, Stefano Mastrangelo, Philippe Bolle, Claudia Daniele, Gianfranco MazzantiAbstract:Essential Oils from Melaleuca alternifolia (tea-tree Oil) and Lavandula angustifolia (Lavender Oil) are commonly used to treat minor health problems. Tea-tree Oil possesses broad-spectrum antimicrobial activity, and is increasingly used for skin problems. Lavender Oil, traditionally used as an antiseptic agent, is now predominantly used as a relaxant, carminative, and sedative in aromatherapy. Despite their growing use no data are available on their mutagenic potential. In this study, after determining the chemical composition of tea-tree Oil and Lavender Oil, by gas-chromatography and mass spectrometry, we investigated their mutagenic and antimutagenic activities by the bacterial reverse mutation assay in Salmonella typhimurium TA98 and TA100 strains and in Escherichia coli WP2 uvrA strain, with and without an extrinsic metabolic activation system. Neither essential Oil had mutagenic activity on the two tested Salmonella strains or on E. coli, with or without the metabolic activation system. Conversely, Lavender Oil exerted strong antimutagenic activity, reducing mutant colonies in the TA98 strain exposed to the direct mutagen 2-nitrofluorene. Antimutagenicity was concentration-dependent: the maximal concentration (0.80 mg/plate) reduced the number of histidine- independent revertant colonies by 66.4%. Lavender Oil (0.80 mg/plate) also showed moderate antimutagenicity against the TA98 strain exposed to the direct mutagen 1-nitropyrene. Its antimutagenic property makes Lavender Oil a promising candidate for new applications in human healthcare. © 2005 Elsevier Ltd. All rights reserved.
Hirokomiyuki Mori - One of the best experts on this subject based on the ideXlab platform.
-
wound healing potential of Lavender Oil by acceleration of granulation and wound contraction through induction of tgf β in a rat model
BMC Complementary and Alternative Medicine, 2016Co-Authors: Hirokomiyuki Mori, Hiroshi Kawanami, Hirohisa Kawahata, Motokuni AokiAbstract:Although previous studies have suggested that Lavender Oil promote wound healing, no study has examined the molecular mechanisms of its effect. In this study, we investigated the effect of Lavender Oil on various steps of wound healing and its molecular mechanism, focusing on transforming growth factor-β (TGF-β). Circular full-thickness skin wounds were produced on rats. Control solution or Lavender Oil was topically applied to the wounds on alternating days for 14 days. The area of wounds topically treated with Lavender Oil was significantly decreased as compared to that of wounds of control rats at 4, 6, 8, and 10 days after wounding. Topical application of Lavender Oil induced expression of type I and III collagen at 4 days after wounding, accompanied by an increased number of fibroblasts, which synthesize collagen. Induced expression of type III collagen by topical application of Lavender Oil was reduced to control level at 7 days after wounding although increased expression of type I collagen still continued even at 7 days, suggesting rapid collagen replacement from type III to type I in wounds treated with Lavender Oil. Importantly, expression of TGF-β in wounds treated with Lavender Oil was significantly increased as compared to control. Moreover, an increased number of myofibroblasts was observed in wounds treated with Lavender Oil at 4 days after wounding, suggesting promotion of differentiation of fibroblasts through induction of TGF-β, which is needed for wound contraction. This study demonstrated that topical application of Lavender Oil promoted collagen synthesis and differentiation of fibroblasts, accompanied by up-regulation of TGF-β. These data suggest that Lavender Oil has the potential to promote wound healing in the early phase by acceleration of formation of granulation tissue, tissue remodeling by collagen replacement and wound contraction through up-regulation of TGF-β. The beneficial effect of Lavender Oil on wound healing may raise the possibility of new approaches as complementary treatment besides conventional therapy.
Kisan M. Kodam - One of the best experts on this subject based on the ideXlab platform.
-
Correction: Encapsulation of therapeutic Lavender Oil in an electrolyte assisted polyacrylonitrile nanofibres for antibacterial applications
RSC Advances, 2020Co-Authors: K. Balasubramanian, Kisan M. KodamAbstract:Correction for ‘Encapsulation of therapeutic Lavender Oil in an electrolyte assisted polyacrylonitrile nanofibres for antibacterial applications’ by K. Balasubramanian et al., RSC Adv., 2014, 4, 54892–54901.
-
encapsulation of therapeutic Lavender Oil in an electrolyte assisted polyacrylonitrile nanofibres for antibacterial applications
RSC Advances, 2014Co-Authors: K. Balasubramanian, Kisan M. KodamAbstract:Electrospinning, a feasible nanotechnology, has been exploited to engineer polyacrylonitrile (PAN) nanofibrous mats enclosing a representative hydrophobic drug like essential Oil of Lavender. The incorporation of electrolytic solution (NaCl) to polymer solution enhanced the electrospinning capability. Concentration as small as 0.3% (w/w) of electrolyte resulted in significant nanofibre morphologies, reduced average fibre diameter (88.44 nm) and it exhibited a narrow degree of polydispersity. The dosage of drug loaded in PAN nanofibres were varied from 12.5 to 200 μg mL−1 and their cytotoxicity against mouse fibroblast NIH/3T3 were studied in vitro. The antibacterial proficiency was gauged by challenging the material against Staphylococcus aureus and Klebsiella pneumoniae bacteria. The PAN nanofibres exhibited effective bactericidal properties of 14–15 mm zone of inhibition in at least 8 h, and it remained unaltered over 30 days. The in vitro release of the drug resulted in a dual drug release profiles with an initial burst as well as the diffusion dominated release, ensuing an enduring antibacterial activity. The incorporation of Lavender Oil improved the thermal stability resulting in a 20% residual mass at 800 °C, higher than pristine PAN nanofibers. The modelling of the interactions between PAN and the major antimicrobial components of Lavender was performed to understand the chemistry between the additive and polymer. Thus, PAN nanofibres can be used to be a promising antibacterial material in various fields like biomedical, textile and water treatment applications.
Gianfranco Mazzanti - One of the best experts on this subject based on the ideXlab platform.
-
The antimutagenic activity of Lavandula angustifolia (Lavender) essential Oil in the bacterial reverse mutation assay
Food and Chemical Toxicology, 2005Co-Authors: Maria Grazia Evandri, L. Battinelli, Stefano Mastrangelo, Philippe Bolle, Claudia Daniele, Gianfranco MazzantiAbstract:Essential Oils from Melaleuca alternifolia (tea-tree Oil) and Lavandula angustifolia (Lavender Oil) are commonly used to treat minor health problems. Tea-tree Oil possesses broad-spectrum antimicrobial activity, and is increasingly used for skin problems. Lavender Oil, traditionally used as an antiseptic agent, is now predominantly used as a relaxant, carminative, and sedative in aromatherapy. Despite their growing use no data are available on their mutagenic potential. In this study, after determining the chemical composition of tea-tree Oil and Lavender Oil, by gas-chromatography and mass spectrometry, we investigated their mutagenic and antimutagenic activities by the bacterial reverse mutation assay in Salmonella typhimurium TA98 and TA100 strains and in Escherichia coli WP2 uvrA strain, with and without an extrinsic metabolic activation system. Neither essential Oil had mutagenic activity on the two tested Salmonella strains or on E. coli, with or without the metabolic activation system. Conversely, Lavender Oil exerted strong antimutagenic activity, reducing mutant colonies in the TA98 strain exposed to the direct mutagen 2-nitrofluorene. Antimutagenicity was concentration-dependent: the maximal concentration (0.80 mg/plate) reduced the number of histidine- independent revertant colonies by 66.4%. Lavender Oil (0.80 mg/plate) also showed moderate antimutagenicity against the TA98 strain exposed to the direct mutagen 1-nitropyrene. Its antimutagenic property makes Lavender Oil a promising candidate for new applications in human healthcare. © 2005 Elsevier Ltd. All rights reserved.