The Experts below are selected from a list of 153 Experts worldwide ranked by ideXlab platform

Pius Loetscher - One of the best experts on this subject based on the ideXlab platform.

  • chemokines multiple levels of Leukocyte Migration control
    Trends in Immunology, 2004
    Co-Authors: Bernhard Moser, Marlene Wolf, Alfred Walz, Pius Loetscher
    Abstract:

    Abstract The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to Leukocyte traffic. Chemokines are Leukocyte attractants but also contribute to immune processes that do not directly involve Leukocyte Migration. Recent progress is most evident in the areas of lymphocyte development, immune response initiation and immune pathology. Important observations have also been reported on chemokine–receptor interactions, signal transduction and cellular responses. New insights into the role of chemokines in Leukocyte attraction and relocation will be discussed, with emphasis on the distinct levels of Leukocyte Migration control that ultimately determine the performance of our immune defense system.

  • Chemokines: multiple levels of Leukocyte Migration control☆ ☆
    Trends in Immunology, 2004
    Co-Authors: Bernhard Moser, Marlene Wolf, Alfred Walz, Pius Loetscher
    Abstract:

    Abstract The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to Leukocyte traffic. Chemokines are Leukocyte attractants but also contribute to immune processes that do not directly involve Leukocyte Migration. Recent progress is most evident in the areas of lymphocyte development, immune response initiation and immune pathology. Important observations have also been reported on chemokine–receptor interactions, signal transduction and cellular responses. New insights into the role of chemokines in Leukocyte attraction and relocation will be discussed, with emphasis on the distinct levels of Leukocyte Migration control that ultimately determine the performance of our immune defense system.

Thomas F Tedder - One of the best experts on this subject based on the ideXlab platform.

  • adhesion molecule cascades direct lymphocyte recirculation and Leukocyte Migration during inflammation
    Immunologic Research, 2000
    Co-Authors: Douglas A Steeber, Thomas F Tedder
    Abstract:

    Leukocyte inter actions with vascular endothelium are high lyorchestrated processes that include the capture of free-flow ing Leukocytes from the blood with subsequent Leukocyte rolling, arrest, firm adhesion, and ensuing diapedesis. These interactions occur under high shear stresses within venules and depend on multiple families of adhesion molecules. Many of the adhesion molecules involved are now identified. In addition, precise mechanisms underlying their regulation and our understanding of how different families of adhesion molecules work together is becoming clearer. Specifically, Leukocyte/endothelial cell interactions such as capture, rolling, and firm adhesion can no longer beviewed asoccurring in discrete steps mediated by individual families of adhesion molecules, but rather as a series of overlapping synergistic interactions among adhesion molecules resulting in an adhesion cascade. Although long thought to be mediated by distinct adhesion pathways, overlapping adhesion cascades mediate normal lymphocyte recirculation to peripheral lymphoid tissues and inflammation-induced Leukocyte Migration. These cascades thereby direct Leukocyte Migration, which is essential for the generation of effective inflammatory responses and the development of rapid immune responses.

  • regulation of Leukocyte Migration by activation of the Leukocyte adhesion molecule 1 lam 1 selectin
    Nature, 1991
    Co-Authors: Olivier Spertini, Geoffrey S Kansas, Michael J Munro, James D Griffin, Thomas F Tedder
    Abstract:

    A CENTRAL feature of host defence is the ability of Leukocytes to enter tissues in response to immune or inflammatory stimuli. The Leukocyte adhesion molecule-1 (LAM-1) regulates the Migration of human Leukocytes by mediating the binding both of lymphocytes to high endothelial venules of peripheral lymph nodes and of neutrophils to endothelium at inflammatory sites1–10. As lymphocytes and neutrophils express the same LAM-1 protein11,12, it is not clear how lineage-specific differences in Leukocyte Migration are controlled. We now report that the affinity of LAM-1 for a carbohydrate-based ligand, PPME13–16, is dramatically increased following lymphocyte and neutrophil activation by lineage-specific stimuli. In addition, activation of lymphocytes by physiological stimuli enhanced LAM-1-dependent binding to high endothelial venules. Thus, transient changes in LAM-1 affinity after Leukocyte stimulation probably directly influence Leukocyte Migration.

Bernhard Moser - One of the best experts on this subject based on the ideXlab platform.

  • chemokines multiple levels of Leukocyte Migration control
    Trends in Immunology, 2004
    Co-Authors: Bernhard Moser, Marlene Wolf, Alfred Walz, Pius Loetscher
    Abstract:

    Abstract The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to Leukocyte traffic. Chemokines are Leukocyte attractants but also contribute to immune processes that do not directly involve Leukocyte Migration. Recent progress is most evident in the areas of lymphocyte development, immune response initiation and immune pathology. Important observations have also been reported on chemokine–receptor interactions, signal transduction and cellular responses. New insights into the role of chemokines in Leukocyte attraction and relocation will be discussed, with emphasis on the distinct levels of Leukocyte Migration control that ultimately determine the performance of our immune defense system.

  • Chemokines: multiple levels of Leukocyte Migration control☆ ☆
    Trends in Immunology, 2004
    Co-Authors: Bernhard Moser, Marlene Wolf, Alfred Walz, Pius Loetscher
    Abstract:

    Abstract The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to Leukocyte traffic. Chemokines are Leukocyte attractants but also contribute to immune processes that do not directly involve Leukocyte Migration. Recent progress is most evident in the areas of lymphocyte development, immune response initiation and immune pathology. Important observations have also been reported on chemokine–receptor interactions, signal transduction and cellular responses. New insights into the role of chemokines in Leukocyte attraction and relocation will be discussed, with emphasis on the distinct levels of Leukocyte Migration control that ultimately determine the performance of our immune defense system.

Marlene Wolf - One of the best experts on this subject based on the ideXlab platform.

  • chemokines multiple levels of Leukocyte Migration control
    Trends in Immunology, 2004
    Co-Authors: Bernhard Moser, Marlene Wolf, Alfred Walz, Pius Loetscher
    Abstract:

    Abstract The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to Leukocyte traffic. Chemokines are Leukocyte attractants but also contribute to immune processes that do not directly involve Leukocyte Migration. Recent progress is most evident in the areas of lymphocyte development, immune response initiation and immune pathology. Important observations have also been reported on chemokine–receptor interactions, signal transduction and cellular responses. New insights into the role of chemokines in Leukocyte attraction and relocation will be discussed, with emphasis on the distinct levels of Leukocyte Migration control that ultimately determine the performance of our immune defense system.

  • Chemokines: multiple levels of Leukocyte Migration control☆ ☆
    Trends in Immunology, 2004
    Co-Authors: Bernhard Moser, Marlene Wolf, Alfred Walz, Pius Loetscher
    Abstract:

    Abstract The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to Leukocyte traffic. Chemokines are Leukocyte attractants but also contribute to immune processes that do not directly involve Leukocyte Migration. Recent progress is most evident in the areas of lymphocyte development, immune response initiation and immune pathology. Important observations have also been reported on chemokine–receptor interactions, signal transduction and cellular responses. New insights into the role of chemokines in Leukocyte attraction and relocation will be discussed, with emphasis on the distinct levels of Leukocyte Migration control that ultimately determine the performance of our immune defense system.

Alfred Walz - One of the best experts on this subject based on the ideXlab platform.

  • chemokines multiple levels of Leukocyte Migration control
    Trends in Immunology, 2004
    Co-Authors: Bernhard Moser, Marlene Wolf, Alfred Walz, Pius Loetscher
    Abstract:

    Abstract The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to Leukocyte traffic. Chemokines are Leukocyte attractants but also contribute to immune processes that do not directly involve Leukocyte Migration. Recent progress is most evident in the areas of lymphocyte development, immune response initiation and immune pathology. Important observations have also been reported on chemokine–receptor interactions, signal transduction and cellular responses. New insights into the role of chemokines in Leukocyte attraction and relocation will be discussed, with emphasis on the distinct levels of Leukocyte Migration control that ultimately determine the performance of our immune defense system.

  • Chemokines: multiple levels of Leukocyte Migration control☆ ☆
    Trends in Immunology, 2004
    Co-Authors: Bernhard Moser, Marlene Wolf, Alfred Walz, Pius Loetscher
    Abstract:

    Abstract The surge in interest in chemokines is explained by the recognition that numerous aspects of immunity are intimately related to Leukocyte traffic. Chemokines are Leukocyte attractants but also contribute to immune processes that do not directly involve Leukocyte Migration. Recent progress is most evident in the areas of lymphocyte development, immune response initiation and immune pathology. Important observations have also been reported on chemokine–receptor interactions, signal transduction and cellular responses. New insights into the role of chemokines in Leukocyte attraction and relocation will be discussed, with emphasis on the distinct levels of Leukocyte Migration control that ultimately determine the performance of our immune defense system.