Lycium barbarum

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Jane C J Chao - One of the best experts on this subject based on the ideXlab platform.

  • hot water extracted Lycium barbarum and rehmannia glutinosa inhibit liver inflammation and fibrosis in rats
    The American Journal of Chinese Medicine, 2011
    Co-Authors: Po Shan Wu, Jane C J Chao, Yahui Tsai, Shu Ju Wu
    Abstract:

    Polysaccharide-rich Lycium barbarum and Rehmannia glutinosa have been considered to have immune-modulating activity. This study investigated the effects of water extracted Lycium barbarum and Rehmannia glutinosa (HE) on carbon tetrachloride (CCl4)-induced liver injury in rats. Male Sprague-Dawley rats were randomly divided into: normal diet + peritoneal injection of olive oil (control), normal diet + CCl4 injection (CCl4), 1 × HE (0.05% HE for each) + CCl4 (1 × HE), and 3 × HE (0.15% HE for each) + CCl4 (3 × HE) groups. Rats were injected with 40% CCl4 at a dose of 0.75 ml/kg body weight once a week for seven weeks, one week after herbal extract treatment. After eight week herbal extract treatment, pathohistological examination showed that both 1× and 3 × HE treatments diminished necrotic hepatocytes, chemoattraction of inflammatory cells, and liver fibrosis. Both 1× and 3 × HE treatments decreased plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, and reduced hepatic levels of pro-inflammatory cytokines — tumor necrosis factor-α and interleukin-1β — compared to CCl4 treatment alone. The 1 × HE treatment increased hepatic anti-inflammatory cytokine IL-10 levels. Both the 1× and 3 × HE treatments suppressed liver fibrosis biomarkers — transforming growth factor-β1 and hydroxyproline. Therefore, treatment with water extracted Lycium barbarum and Rehmannia glutinosa (0.05% and 0.15% for each) for eight weeks protects against necrotic damage, indicated by decreases in plasma ALT and AST activities, and suppresses liver fibrosis by down-regulation of liver inflammation in rats with CCl4-induced liver injury.

  • hot water extracted Lycium barbarum and rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells
    World Journal of Gastroenterology, 2006
    Co-Authors: Jane C J Chao, Shih Wen Chiang, Yahui Tsai, Ching Chiung Wang, Ming Shun Wu
    Abstract:

    Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells

Harunobu Amagase - One of the best experts on this subject based on the ideXlab platform.

  • a review of botanical characteristics phytochemistry clinical relevance in efficacy and safety of Lycium barbarum fruit goji
    Food Research International, 2011
    Co-Authors: Harunobu Amagase, Norman R Farnsworth
    Abstract:

    Abstract Lycium barbarum has been used as a traditional Chinese medicine (TCM) to nourish liver and kidney, and brighten the eye. The fruits are dried or freshly squeezed for their juice and concentrated for beverages. Among various constituents, a group of polysaccharides (LBP) with a Glycan-O-Ser glycopeptide structure has been most researched and considered to be important for the efficacy of L. barbarum. Studies indicate effects of L. barbarum on aging, neuroprotection, general well-being, fatigue/endurance, metabolism/energy expenditure, glucose control in diabetics, glaucoma, anti-oxidant properties, immunomodulation, anti-tumor activity and cytoprotection. In addition to TCM, L. barbarum can be sold as a dietary supplement or classified as a food based upon the long and safe traditional usage. This review is to provide background and updated information of chemical constituents and efficacies with safety including a new direction for research and current regulatory situation of L. barbarum.

  • Lycium barbarum goji juice improves in vivo antioxidant biomarkers in serum of healthy adults
    Nutrition Research, 2009
    Co-Authors: Harunobu Amagase, Buxiang Sun, Carmia Borek
    Abstract:

    Although Lycium barbarum (goji) and active compounds, Lycium barbarum polysaccharides (LBP), have a high in vitro antioxidant score as determined by simple chemical reaction methods, their in vivo antioxidant effects in humans have not been extensively examined. After our earlier report that an LBP-standardized Lycium barbarum preparation (GoChi) helps prevent oxidant stress-related conditions in humans, our present study examined the hypothesis that the antioxidant effects of GoChi result from its ability to enhance endogenous antioxidant factors. We investigated the effects of GoChi in a 30-day randomized, double-blind, placebo-controlled clinical study. The study population included 50 Chinese healthy adults aged 55 to 72 years. In vivo antioxidant markers, consisting of serum levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and lipid peroxidation (indicated by decreased levels of malondialdehyde, MDA) were examined preintervention and postintervention with GoChi or placebo (120 mL/d). In the GoChi group, antioxidant markers significantly increased by 8.4% for SOD and 9.9% for GSH-Px between the preintervention and postintervention measurements, whereas MDA were significantly decreased by 8.7%. In addition, the SOD, GSH-Px, and MDA levels in the GoChi group were significantly different from those in the placebo group at the postintervention time point, with increases of 8.1% and 9.0% and a decrease of 6.0%, respectively. No significant differences were detected between the preintervention and postintervention time points in the placebo group. These results indicate that GoChi increased antioxidant efficacies in humans by stimulating endogenous factors and suggest that continued use beyond 30 days might help prevent or reduce free radical-related conditions.

  • a randomized double blind placebo controlled clinical study of the general effects of a standardized Lycium barbarum goji juice gochi
    Journal of Alternative and Complementary Medicine, 2008
    Co-Authors: Harunobu Amagase, Dwight M Nance
    Abstract:

    ABSTRACT Background: This randomized, double-blind, placebo-controlled clinical trial is the first study reported from outside China that has examined the general effects of the orally consumed goji berry, Lycium barbarum, as a standardized juice (GoChi™; FreeLife International LLC, Phoenix, AZ) to healthy adults for 14 days. Methods: Based upon the medicinal properties of Lycium barbarum in traditional Asian medicine, we examined by questionnaire subjective ratings (0–5) of general feelings of well-being, neurologic/psychologic traits, gastrointestinal, musculoskeletal, and cardiovascular complaints as well as any adverse effects. Also, measures of body weight, body–mass index, blood pressure, pulse rate, and visual acuity were assessed before and after consuming 120 mL of GoChi/day or placebo control solution. Data were statistically analyzed for changes between day 1 and day 15. Results: Significant differences between day 1 and day 15 were found in the GoChi group (N = 16) in increased ratings for ene...

Zhengsheng Zhang - One of the best experts on this subject based on the ideXlab platform.

Yahui Tsai - One of the best experts on this subject based on the ideXlab platform.

  • hot water extracted Lycium barbarum and rehmannia glutinosa inhibit liver inflammation and fibrosis in rats
    The American Journal of Chinese Medicine, 2011
    Co-Authors: Po Shan Wu, Jane C J Chao, Yahui Tsai, Shu Ju Wu
    Abstract:

    Polysaccharide-rich Lycium barbarum and Rehmannia glutinosa have been considered to have immune-modulating activity. This study investigated the effects of water extracted Lycium barbarum and Rehmannia glutinosa (HE) on carbon tetrachloride (CCl4)-induced liver injury in rats. Male Sprague-Dawley rats were randomly divided into: normal diet + peritoneal injection of olive oil (control), normal diet + CCl4 injection (CCl4), 1 × HE (0.05% HE for each) + CCl4 (1 × HE), and 3 × HE (0.15% HE for each) + CCl4 (3 × HE) groups. Rats were injected with 40% CCl4 at a dose of 0.75 ml/kg body weight once a week for seven weeks, one week after herbal extract treatment. After eight week herbal extract treatment, pathohistological examination showed that both 1× and 3 × HE treatments diminished necrotic hepatocytes, chemoattraction of inflammatory cells, and liver fibrosis. Both 1× and 3 × HE treatments decreased plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, and reduced hepatic levels of pro-inflammatory cytokines — tumor necrosis factor-α and interleukin-1β — compared to CCl4 treatment alone. The 1 × HE treatment increased hepatic anti-inflammatory cytokine IL-10 levels. Both the 1× and 3 × HE treatments suppressed liver fibrosis biomarkers — transforming growth factor-β1 and hydroxyproline. Therefore, treatment with water extracted Lycium barbarum and Rehmannia glutinosa (0.05% and 0.15% for each) for eight weeks protects against necrotic damage, indicated by decreases in plasma ALT and AST activities, and suppresses liver fibrosis by down-regulation of liver inflammation in rats with CCl4-induced liver injury.

  • hot water extracted Lycium barbarum and rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells
    World Journal of Gastroenterology, 2006
    Co-Authors: Jane C J Chao, Shih Wen Chiang, Yahui Tsai, Ching Chiung Wang, Ming Shun Wu
    Abstract:

    Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells

Ming Shun Wu - One of the best experts on this subject based on the ideXlab platform.

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