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Sarah E Coupland - One of the best experts on this subject based on the ideXlab platform.
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concomitant orbital tumours small Lymphocytic lymphoma involving the lacrimal gland of a patient with clinical diagnoses of muir torre syndrome and extensive sebaceous gland carcinoma of the ipsilateral eyelid
Ocular Oncology and Pathology, 2020Co-Authors: Konstantinos Kopsidas, Rebecca Ford, Ibrar Ahmed, Sarah E CouplandAbstract:Background/Aims: We present a case of 2 concomitant tumours, i.e., a sebaceous carcinoma (SC) and a small Lymphocytic lymphoma (SLL), in the lacrimal gland of a patient with Muir-Torre syndrome. Methods: Clinical history, orbital examination, diagnostic biopsy, excisional biopsy, and histopathologic analysis were utilized. Results: An 89-year-old female presented to the eye casualty with corneal ulcer, anterior uveitis, proptosis, and restricted ocular motility. She has a clinical history of breast cancer, colon carcinoma, and SC of the eyelid, which had been resected completely 2 years before. Clinical examination, imaging, and diagnostic biopsy confirmed orbital SC recurrence. Exenteration and subsequent histopathologic analysis of the specimen revealed Lymphocytic Infiltrates consistent with SLL within the lacrimal gland. Conclusion: We report for the first time a case of a patient with Muir-Torre syndrome who developed an orbital recurrent SC with an incidental finding of a lacrimal gland B non-Hodgkin lymphoma consistent with SLL. Clinicians should be aware of the possibility of this coexistence of multiple cancer types in patients with sebaceous carcinoma and Muir-Torre syndrome.
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concomitant orbital tumours small Lymphocytic lymphoma involving the lacrimal gland of a patient with clinical diagnoses of muir torre syndrome and extensive sebaceous gland carcinoma of the ipsilateral eyelid
Ocular Oncology and Pathology, 2020Co-Authors: Konstantinos Kopsidas, Rebecca Ford, Ibrar Ahmed, Sarah E CouplandAbstract:© 2019 S. Karger AG, Basel. Background/Aims: We present a case of 2 concomitant tumours, i.e., a sebaceous carcinoma (SC) and a small Lymphocytic lymphoma (SLL), in the lacrimal gland of a patient with Muir-Torre syndrome. Methods: Clinical history, orbital examination, diagnostic biopsy, excisional biopsy, and histopathologic analysis were utilized. Results: An 89-year-old female presented to the eye casualty with corneal ulcer, anterior uveitis, proptosis, and restricted ocular motility. She has a clinical history of breast cancer, colon carcinoma, and SC of the eyelid, which had been resected completely 2 years before. Clinical examination, imaging, and diagnostic biopsy confirmed orbital SC recurrence. Exenteration and subsequent histopathologic analysis of the specimen revealed Lymphocytic Infiltrates consistent with SLL within the lacrimal gland. Conclusion: We report for the first time a case of a patient with Muir-Torre syndrome who developed an orbital recurrent SC with an incidental finding of a lacrimal gland B non-Hodgkin lymphoma consistent with SLL. Clinicians should be aware of the possibility of this coexistence of multiple cancer types in patients with sebaceous carcinoma and Muir-Torre syndrome.
Pierre Miossec - One of the best experts on this subject based on the ideXlab platform.
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anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis interaction with chemokines and th1 cytokine producing cells
Arthritis & Rheumatism, 2004Co-Authors: Guillaume Page, Guillaume Chevrel, Pierre MiossecAbstract:Objective To clarify the involvement of dendritic cells (DCs), chemokines, and proinflammatory Th1 cytokines in the pathogenesis of the chronic muscle diseases dermatomyositis (DM) and polymyositis (PM). Methods We characterized by immunohistochemistry the DC subsets and their interaction with cells producing chemokines and the Th1 cytokines interleukin-17 (IL-17) and interferon-γ (IFNγ). Immature and mature DCs were defined by the expression of CD1a and DC-LAMP/CD83, respectively. Results Immature DCs were mainly detected in Lymphocytic Infiltrates in DM and PM muscle tissue samples. Mature DCs were detected in perivascular Infiltrates and surrounded muscle fibers. IL-17–positive and IFNγ-positive cells were also observed in perivascular Infiltrates in both cases. We then focused on the expression of the CCL20/CCR6 chemokine/receptor complex, which controls immature DC migration, and on the expression of the CCL19/CCR7 and CCL21/CCR7 chemokine/receptor complexes, which control mature DC migration. CCL20 and CCR6 colocalized in Lymphocytic Infiltrates in DM and PM samples. CCL21 was rarely observed in DM samples and never observed in PM samples. CCL19- and CCR7-expressing cells were absent in both tissues. Conclusion The close association between CCL20/CCR6 and immature DCs suggests the contribution of CCL20 to CCR6+ immature DC homing. Detection of mature DCs in DM and PM muscle tissue samples despite the lack of CCL19 and CCR7 is evidence for a local maturation of DCs in inflammatory muscle tissue without lymphoid organ organization.
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anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ correlation with selective chemokine expression in rheumatoid synovium
Journal of Immunology, 2002Co-Authors: Guillaume Page, Serge Lebecque, Pierre MiossecAbstract:It remains to be clarified whether dendritic cells (DC) reach the rheumatoid arthritis (RA) synovium, considered an ectopic lymphoid organ, as mature cells or undergo local maturation. We characterized by immunohistochemistry the DC subsets and used tonsils as a control. Immature and mature DC were defined by CD1a and DC-lysosome-associated membrane protein/CD83 expression, respectively. Immature DC were mainly detected in the lining layer in RA synovium. Mature DC were exclusively detected in the Lymphocytic Infiltrates. The DC-lysosome-associated membrane protein/CD1a ratio was 1.1 in RA synovium and 5.3 in tonsils, suggesting the relative accumulation of immature DC in RA synovium. We then focused on the expression of CCL20/CCR6 and CCL19/CCR7, CCL21/CCR7 chemokine/receptor complex, which control immature and mature DC migration respectively. A close association was observed between CCL20-producing cells and CD1a + cells, suggesting the contribution of CCL20 to CCR6 + cell homing. Conversely, CCL21 and CCL19 expression was only detected in perivascular Infiltrates. The association among CCL19/21-producing cells, CCR7 expression, and mature DC accumulation is in line with the roles of these chemokines in mature CCR7 + DC homing to Lymphocytic Infiltrates. The role of DC in disease initiation and perpetuation makes chemokines involved in DC migration a potential therapeutic target.
Augusto Vaglio - One of the best experts on this subject based on the ideXlab platform.
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association between idiopathic retroperitoneal fibrosis and autoimmune thyroiditis a case control study
Autoimmunity Reviews, 2015Co-Authors: Graziano Ceresini, Maria Letizia Urban, Domenico Corradi, Fulvio Lauretani, Michela Marina, Elisa Usberti, Alessandra Palmisano, Carlo Buzio, Augusto VaglioAbstract:Abstract Background Idiopathic retroperitoneal fibrosis (IRF) is a rare disease often associated with autoimmune disorders. Whether IRF is associated with Hashimoto's thyroiditis (HT) is poorly understood and only addressed by case-reports. We evaluated the prevalence of HT in a large IRF cohort and in matched controls. Methods We studied 73 consecutive patients with new-onset IRF and 71 controls. The association between HT and IRF was cross-sectionally evaluated in a referral center. Longitudinally, thyroid function tests were also performed. Serum concentrations of FT4, TSH, and anti-thyroperoxidase antibodies (AbTPO) were evaluated together with thyroid ultrasound (US). Lymphocytic Infiltrates were characterized in thyroid nodule fine needle aspirates (FNAB). In patients undergoing thyroidectomy, thyroid histology was also reviewed. Results A higher prevalence of AbTPO positivity (P l -thyroxine. Conclusions IRF patients have a higher risk of HT compared to controls. Thyroid function should be monitored in patients with IRF.
Ercument Ciftci - One of the best experts on this subject based on the ideXlab platform.
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mri patterns in orbital malignant lymphoma and atypical Lymphocytic Infiltrates
European Journal of Radiology, 2005Co-Authors: Gur Akansel, L E Hendrix, Beth Erickson, Ali Demirci, Anne Papke, Arzu Arslan, Ercument CiftciAbstract:Abstract Objective: To evaluate the potential of MRI in differentiating between malignant lymphomas and atypical Lymphocytic Infiltrates in the orbit. Materials and Methods: MRI, clinical and histopathological findings in 30 patients presenting with orbital lymphoproliferative diseases (malignant lymphoma and atypical Lymphocytic Infiltrates) were evaluated. Results: MRI detected 28 out of 30 (93%) orbital lymphoid tumors. Seven out of eight (87.5%) atypical Lymphocytic Infiltrates and 21/22 (95.4%) of malignant lymphomas were detected. One conjunctival malignant lymphoma and one conjunctival atypical Lymphocytic infiltrate were missed. Only malignant lymphoma lesions were hyperintense compared to the extraocular muscles on precontrast and postcontrast T1-weighted images. The lacrimal duct was involved only with malignant lymphoma. Bilateral disease was more likely to be malignant lymphoma. Intraconal lesions were more likely to be associated with lesions elsewhere. No malignant lymphoma involved the extraconal fat. Only intraconal atypical Lymphocytic Infiltrates had indistinct margins. Conclusion: In the orbit, MRI features alone may not allow clear-cut differentiation of malignant lymphomas from atypical Lymphocytic Infiltrates. However, certain imaging features increase the likelihood of distinguishing them. MRI may miss conjunctival disease. Both orbits should be imaged when orbital lymphoid disease is a probability. The presence of intraconal disease should prompt a search for lesions elsewhere. The use of a head coil instead of a superficial coil may be advantageous by eliminating coil shine effect and allowing evaluation of both orbits. Comparison of lesion signal to extraocular muscle signal appears to be a better alternative than cerebral gray matter or periorbital fat in differentiating malignant lymphoma from atypical Lymphocytic Infiltrates. Since imaging findings overlap, histopathological diagnosis is necessary in all cases.
Jan Delabie - One of the best experts on this subject based on the ideXlab platform.
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primary marginal zone lymphoma of the subcutis associated with panniculitis and fat necrosis
American Journal of Clinical Pathology, 2015Co-Authors: Herman M Chui, Vishal Kukreti, Jan DelabieAbstract:Objectives: Lymphocytic Infiltrates in the subcutaneous adipose tissue, often accompanied by fat necrosis, are typically seen in benign panniculitis. Diagnostic considerations include subcutaneous panniculitis-like T-cell lymphoma and cutaneous γδ T-cell lymphoma, whereas a primary subcutaneous B-cell lymphoma in this setting has not been previously described. Methods: We report the case of a 72-year-old woman with multiple deep cutaneous nodules on the trunk and upper extremities. Results: During 3 years of clinical follow-up, new skin nodules developed, while existing lesions remained stable or regressed. No other organ involvement was detected. Sequential biopsy specimens of the subcutaneous lesions revealed patchy, predominantly septal, Lymphocytic Infiltrates associated with extensive hyaline fat necrosis. The histologic and immunophenotypic features were consistent with marginal zone lymphoma. Genotyping revealed an identical monoclonal immunoglobulin gene rearrangement across all biopsy specimens. Conclusions: This case represents, to our knowledge, the first reported case of primary subcutaneous B-cell lymphoma closely associated with panniculitis.
