Lymphomatoid Papulosis

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 240 Experts worldwide ranked by ideXlab platform

M E Kadin - One of the best experts on this subject based on the ideXlab platform.

  • chromosomal rearrangements of 6p25 3 define a new subtype of Lymphomatoid Papulosis
    The American Journal of Surgical Pathology, 2013
    Co-Authors: Laszlo J Karai, M E Kadin, Jason C Sluzevich, Rhett P Ketterling, Ryan A Knudson, Andrew L Feldman
    Abstract:

    Lymphomatoid Papulosis (LyP) is an indolent cutaneous lymphoproliferative disorder with clinical and pathologic features overlapping those of both reactive conditions and aggressive lymphomas. Recurrent genetic abnormalities in LyP have not been previously identified. Here, we describe the clinical,

  • extracutaneous origin of Lymphomatoid Papulosis
    Blood, 2003
    Co-Authors: M E Kadin
    Abstract:

    Lymphomatoid Papulosis (LyP) is a cutaneous clonal T-cell lymphoproliferative disorder that manifests as papulonodular lesions that regress spontaneously, only to reappear at the same or other sites. Despite the usual benign clinical course, 10% to 20% of LyP patients develop a systemic malignant

  • is it lymphoma or Lymphomatoid Papulosis
    Journal of The American Academy of Dermatology, 1997
    Co-Authors: Mariefrance Demierre, Lynne J Goldberg, M E Kadin
    Abstract:

    Distinguishing malignancy from premalignant conditions can be difficult. Controversy surrounds both the clinical and histologic criteria used to distinguish Lymphomatoid Papulosis, a benign disorder, from CD30 + anaplastic large-cell lymphoma. Three case histories illustrate important points in categorizing different lymphoproliferative disorders as benign or malignant. We emphasize a multidisciplinary approach to improve diagnosis and patient management.

  • Lymphomatoid Papulosis in children
    Journal of The American Academy of Dermatology, 1995
    Co-Authors: G M Zirbel, S E Gellis, M E Kadin, N B Esterly
    Abstract:

    Abstract Background: Although Lymphomatoid Papulosis is well described in adults, the clinical course, prognosis, risk for lymphoma, and recommendations for follow-up have not been established in children. Objective: Our aim was to analyze our data on six children with Lymphomatoid Papulosis and to analyze available information on reported cases from the literature to characterize better Lymphomatoid Papulosis in childhood and to compare it with adult-onset Lymphomatoid Papulosis. Methods: Clinical records, laboratory studies, and histopathologic evaluation of skin biopsy specimens from six children with Lymphomatoid Papulosis were reviewed. A literature search was also performed and disclosed detailed information on 17 childhood cases. Results: In most cases childhood Lymphomatoid Papulosis is clinically and histologically similar to Lymphomatoid Papulosis in adults, but three unusual patterns were identified in our children: first, after initial outbreak, dwindling outbreaks (both in frequency and number of lesions) until the eruption ceased completely; second, Lymphomatoid Papulosis localized to one area for years before generalizing, and third, presentation of Lymphomatoid Papulosis with hundreds of lesions. In our children and in those previously reported, response to systemic antibiotics and potent topical steroids was variable, as in adults. All our children to date have remained healthy; the longest period of follow-up is 9 years. However, in previously reported cases two patients with childhood-onset Lymphomatoid Papulosis had lymphoma as adults. Conclusion: Childhood Lymphomatoid Papulosis may be more likely to resolve spontaneously than adult Lymphomatoid Papulosis; nevertheless these children may still be at risk for lymphoma and thus need lifelong follow-up.

  • Lymphomatoid Papulosis in children.
    Journal of the American Academy of Dermatology, 1995
    Co-Authors: G M Zirbel, S E Gellis, M E Kadin, N B Esterly
    Abstract:

    Although Lymphomatoid Papulosis is well described in adults, the clinical course, prognosis, risk for lymphoma, and recommendations for follow-up have not been established in children. Our aim was to analyze our data on six children with Lymphomatoid Papulosis and to analyze available information on reported cases from the literature to characterize better Lymphomatoid Papulosis in childhood and to compare it with adult-onset Lymphomatoid Papulosis. Clinical records, laboratory studies, and histopathologic evaluation of skin biopsy specimens from six children with Lymphomatoid Papulosis were reviewed. A literature search was also performed and disclosed detailed information on 17 childhood cases. In most cases childhood Lymphomatoid Papulosis is clinically and histologically similar to Lymphomatoid Papulosis in adults, but three unusual patterns were identified in our children: first, after initial outbreak, dwindling outbreaks (both in frequency and number of lesions) until the eruption ceased completely; second, Lymphomatoid Papulosis localized to one area for years before generalizing, and third, presentation of Lymphomatoid Papulosis with hundreds of lesions. In our children and in those previously reported, response to systemic antibiotics and potent topical steroids was variable, as in adults. All our children to date have remained healthy; the longest period of follow-up is 9 years. However, in previously reported cases two patients with childhood-onset Lymphomatoid Papulosis had lymphoma as adults. Childhood Lymphomatoid Papulosis may be more likely to resolve spontaneously than adult Lymphomatoid Papulosis; nevertheless these children may still be at risk for lymphoma and thus need lifelong follow-up.

M Rogers - One of the best experts on this subject based on the ideXlab platform.

  • pityriasis lichenoides and Lymphomatoid Papulosis
    Seminars in Dermatology, 1992
    Co-Authors: M Rogers
    Abstract:

    The clinical features, histopathology, immunopathology, and management of pityriasis lichenoides and Lymphomatoid Papulosis are discussed, with particular emphasis on the pediatric aspects of these conditions. The difficulties in logically separating pityriasis lichenoides into an acute (pityriasis lichenoides et varioliformis acuta) and a chronic (pityriasis lichenoides chronical) form are addressed. The development of lymphoreticular malignancy in patients with Lymphomatoid Papulosis has been well documented, but pityriasis lichenoides has characteristically been regarded as a benign condition. However, recent reports of the development of large plaque parapsoriasis in patients with pityriasis lichenoides have led to a reconsideration. Some of these patients were in the pediatric age group. Although there are significant clinical, histopathological, and immunopathological differences between pityriasis lichenoides and Lymphomatoid Papulosis, the demonstration of similar clonal T cell receptor gene rearrangements and the confirmation of the potentially premalignant nature of both suggests that there may indeed be an interrelationship between these two controversial entities. Close follow-up of patients with both of these conditions is recommended, with observation being discontinued only when the patient has been free of lesions for several years.

K Peris - One of the best experts on this subject based on the ideXlab platform.

  • Mucosal involvement in a patient with Lymphomatoid Papulosis.
    Journal of the American Academy of Dermatology, 2020
    Co-Authors: S Chimenti, M C Fargnoli, A Pacifico, K Peris
    Abstract:

    We report a 38-year-old woman with Lymphomatoid Papulosis (LyP) who had nodular and papulovesicular lesions develop on the genital area and oral commissure. Mucosal involvement in LyP is a rare event, and its clinical relevance is still unknown. Aggressive therapies are not recommended in patients with LyP with either cutaneous or mucosal involvement.

  • mucosal involvement in a patient with Lymphomatoid Papulosis
    Journal of The American Academy of Dermatology, 2001
    Co-Authors: S Chimenti, M C Fargnoli, A Pacifico, K Peris
    Abstract:

    Abstract We report a 38-year-old woman with Lymphomatoid Papulosis (LyP) who had nodular and papulovesicular lesions develop on the genital area and oral commissure. Mucosal involvement in LyP is a rare event, and its clinical relevance is still unknown. Aggressive therapies are not recommended in patients with LyP with either cutaneous or mucosal involvement. (J Am Acad Dermatol 2001;44:339-41.)

Lorenzo Cerroni - One of the best experts on this subject based on the ideXlab platform.

  • Lymphomatoid Papulosis reappraisal of clinicopathologic presentation and classification into subtypes a b and c
    Archives of Dermatology, 2004
    Co-Authors: Laila El Shabrawicaelen, Helmut Kerl, Lorenzo Cerroni
    Abstract:

    Objectives To analyze clinicopathologic features of Lymphomatoid Papulosis and delineate the characteristics of histopathologic variants (types A, B, and C). Design Retrospective nonrandomized study. Setting University-based dermatologic referral center. Patients Eighty-five patients with Lymphomatoid Papulosis. Clinical data and 1 or more biopsy specimens were available for review in all cases. When possible, immunophenotypic and molecular analyses were carried out. Results Of these patients, 78 presented only 1 histopathologic subtype of Lymphomatoid Papulosis (64 had type A, 3 had type B, and 11 had type C). The last 7 patients presented more than 1 subtype (1 had A and B, 5 had A and C, and 1 had A, B, and C). Two patients had regional Lymphomatoid Papulosis, an unusual clinical presentation characterized by groups of lesions localized to 1 anatomic region. We observed, we believe for the first time, that some histopathologic patterns, ie, follicular mucinosis (n = 1), syringotropic infiltrates (n = 1), epidermal vesicle formation (n = 2), and syringosquamous metaplasia (n = 1), were associated with Lymphomatoid Papulosis. A distribution along hair follicles, or follicular Lymphomatoid Papulosis, was observed in 5 biopsy specimens. A bandlike rather than a wedge distribution of the infiltrate was seen in 5 specimens from patients with Lymphomatoid Papulosis type A. Of 8 patients who had associated lymphoid malignancies, 4 had Hodgkin disease and 4 had mycosis fungoides. Conclusions Lymphomatoid Papulosis is a cutaneous disorder with multiple clinicopathologic features. Differentiating between mycosis fungoides and anaplastic large cell lymphoma may be very difficult and sometimes impossible. In the spectrum of CD30 + cutaneous lymphoproliferative disorders, boundaries between these 2 entities are not clear-cut.

  • PUVA-induced Lymphomatoid Papulosis in a patient with mycosis fungoides.
    Journal of The American Academy of Dermatology, 1991
    Co-Authors: Peter Wolf, Lorenzo Cerroni, Josef Smolle, Helmut Kerl
    Abstract:

    The occurrence of Lymphomatoid Papulosis in patients with cutaneous lymphoma, particularly mycosis fungoides, has been described in medical literature. A 68-year-old woman affected by mycosis fungoides in the plaque stage noticed that multiple papulonodular lesions of Lymphomatoid Papulosis developed suddenly after a few sessions of PUVA therapy. The PUVA induction of Lymphomatoid Papulosis was confirmed by the appearance of new lesions after a second cycle of PUVA exposure on a limited area of the body. Complete regression of all PUVA-induced Lymphomatoid Papulosis lesions was achievers within a few weeks with oral prednisone and topical steroids. During the entire treatment the patches and plaques of mycosis fungoides persisted unchanged.

Madeleine Duvic - One of the best experts on this subject based on the ideXlab platform.

Related terms

Lymphomatoid Papulosis - 15 days free trial to Access Experts & Abstracts