The Experts below are selected from a list of 354 Experts worldwide ranked by ideXlab platform
Francois Authier - One of the best experts on this subject based on the ideXlab platform.
-
Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?
Bulletin De L Academie Nationale De Medecine, 2020Co-Authors: Romain K. Gherardi, Josette Cadusseau, Francois AuthierAbstract:Aluminium oxyhydroxide (alum), a nanocrystalline compound that forms agglomerates, has been widely used as a vaccine adjuvant since 1927, but the mechanisms by which it stimulates immune responses remain poorly understood. Although generally well tolerated, alum may occasionally cause chronic health problems in presumably susceptible individuals. Some individuals may rarely develop delayed-onset diffuse myalgia, chronic exhaustion and cognitive dysfunction, associated with long-term persistence (up to 12 years) of alum-loaded macrophages at site of i.m. immunization, defining so-called Macrophagic Myofasciitis (MMF). Symptoms are consistent with the chronic fatigue/myalgic encephalomyelitis (CFS/ME) syndrome, and have been used as a paradigm of the "autoimmune/inflammatory syndrome induced by adjuvants" (ASIA). Cognitive dysfunction is reminiscent of that described in workers exposed to inhaled Al particles. Individual susceptibility may influence both alum biopersistence and difusion away from injection sites. Biopersistent particles such as fluorescent alum-coated nanohybrids, when injected into mouse muscle, are captured by monocyte-lineage cells and then carried to distant organs, draining lymph nodes and blood, probably via the thoracic duct, with delayed and accumulative translocation to the brain (microglial cells). Brain penetration occurs at extremely low levels in normal conditions, possibly explaining the good tolerance of alum despite its high neurotoxic potential. However, systemic diffusion is considerably enhanced by the potentiating effect of MCP-1, the main monocyte chemoattractant factor, the production of which is subject to marked variations linked to age and to genetic and environmental factors. Selective MCP-1 elevation is the only known circulating biomarker of MMF.
-
myalgia and chronic fatigue syndrome following immunization Macrophagic Myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system
Autoimmunity Reviews, 2019Co-Authors: R Gherardi, Guillemette Crepeaux, Francois AuthierAbstract:Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multifactorial and poorly undersood disabling disease. We present epidemiological, clinical and experimental evidence that ME/CFS constitutes a major type of adverse effect of vaccines, especially those containing poorly degradable particulate aluminum adjuvants. Evidence has emerged very slowly due to the multiplicity, lack of specificity, delayed onset, and frequent medical underestimation of ME/CFS symptoms. It was supported by an epidemiological study comparing vaccinated vs unvaccinated militaries that remained undeployed during Gulf War II. Affected patients suffer from cognitive dysfunction affecting attention, memory and inter-hemispheric connexions, well correlated to brain perfusion defects and associated with a stereotyped and distinctive pattern of cerebral glucose hypometabolism. Deltoid muscle biopsy performed to investigate myalgia typically yields Macrophagic Myofasciitis (MMF), a histological biomarker assessing longstanding persistency of aluminum agglomerates within innate immune cells at site of previous immunization. MMF is seemingly linked to altered mineral particle detoxification by the xeno/autophagy machinery. Comparing toxicology of different forms of aluminum and different types of exposure is misleading and inadequate and small animal experiments have turned old dogma upside down. Instead of being rapidly solubilized in the extracellular space, injected aluminum particles are quickly captured by immune cells and transported to distant organs and the brain where they elicit an inflammatory response and exert selective low dose long-term neurotoxicity. Clinical observations and experiments in sheep, a large animal like humans, confirmed both systemic diffusion and neurotoxic effects of aluminum adjuvants. Post-immunization ME/CFS represents the core manifestation of “autoimmune/inflammatory syndrome induced by adjuvants” (ASIA).
-
predictive value of brain 18f fdg pet ct in Macrophagic Myofasciitis a case report
Medicine, 2017Co-Authors: Axel Van Der Gucht, Francois Authier, R Gherardi, Mukedaisi Abulizi, Paul Blancdurand, Mehdi Aounsebaiti, Berivan Emsen, Antoine Verger, Emmanuel IttiAbstract:AbstractRationale:Although several functional studies have demonstrated that positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (18F-FDG PET/CT) appears to be efficient to identify a cerebral substrate in patients with known Macrophagic Myofasciitis (MMF), the predictive va
-
Predictive value of brain 18F-FDG PET/CT in Macrophagic Myofasciitis?: A case report.
Medicine, 2017Co-Authors: Axel Van Der Gucht, Francois Authier, Mukedaisi Abulizi, Berivan Emsen, Antoine Verger, Paul Blanc-durand, Mehdi Aoun-sebaiti, Romain K. Gherardi, Emmanuel IttiAbstract:AbstractRationale:Although several functional studies have demonstrated that positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (18F-FDG PET/CT) appears to be efficient to identify a cerebral substrate in patients with known Macrophagic Myofasciitis (MMF), the predictive va
-
cerebral 18f fdg pet in Macrophagic Myofasciitis an individual svm based approach
PLOS ONE, 2017Co-Authors: Paul Blancdurand, Francois Authier, Axel Van Der Gucht, Mukedaisi Abulizi, Mehdi Aounsebaiti, Antoine Verger, Eric Guedj, Lionel Lerman, Emmanuel IttiAbstract:Macrophagic Myofasciitis (MMF) is an emerging condition with highly specific myopathological alterations. A peculiar spatial pattern of a cerebral glucose hypometabolism involving occipito-temporal cortex and cerebellum have been reported in patients with MMF; however, the full pattern is not systematically present in routine interpretation of scans, and with varying degrees of severity depending on the cognitive profile of patients. Aim was to generate and evaluate a support vector machine (SVM) procedure to classify patients between healthy or MMF 18F-FDG brain profiles.
R Gherardi - One of the best experts on this subject based on the ideXlab platform.
-
myalgia and chronic fatigue syndrome following immunization Macrophagic Myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system
Autoimmunity Reviews, 2019Co-Authors: R Gherardi, Guillemette Crepeaux, Francois AuthierAbstract:Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multifactorial and poorly undersood disabling disease. We present epidemiological, clinical and experimental evidence that ME/CFS constitutes a major type of adverse effect of vaccines, especially those containing poorly degradable particulate aluminum adjuvants. Evidence has emerged very slowly due to the multiplicity, lack of specificity, delayed onset, and frequent medical underestimation of ME/CFS symptoms. It was supported by an epidemiological study comparing vaccinated vs unvaccinated militaries that remained undeployed during Gulf War II. Affected patients suffer from cognitive dysfunction affecting attention, memory and inter-hemispheric connexions, well correlated to brain perfusion defects and associated with a stereotyped and distinctive pattern of cerebral glucose hypometabolism. Deltoid muscle biopsy performed to investigate myalgia typically yields Macrophagic Myofasciitis (MMF), a histological biomarker assessing longstanding persistency of aluminum agglomerates within innate immune cells at site of previous immunization. MMF is seemingly linked to altered mineral particle detoxification by the xeno/autophagy machinery. Comparing toxicology of different forms of aluminum and different types of exposure is misleading and inadequate and small animal experiments have turned old dogma upside down. Instead of being rapidly solubilized in the extracellular space, injected aluminum particles are quickly captured by immune cells and transported to distant organs and the brain where they elicit an inflammatory response and exert selective low dose long-term neurotoxicity. Clinical observations and experiments in sheep, a large animal like humans, confirmed both systemic diffusion and neurotoxic effects of aluminum adjuvants. Post-immunization ME/CFS represents the core manifestation of “autoimmune/inflammatory syndrome induced by adjuvants” (ASIA).
-
Macrophagic Myofasciitis associated dysfunctioning an update of neuropsychological and neuroimaging features
Best Practice & Research: Clinical Rheumatology, 2018Co-Authors: Mehdi Aoun Sebaiti, Axel Van Der Gucht, Emmanuel Itti, R Gherardi, Paul Blancdurand, Paul Kauv, Marie Abrivard, Sarah Souvannanorath, F AuthierAbstract:Abstract Macrophagic Myofasciitis (MMF) syndrome is a subtype of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) or Shoenfeld's syndrome, characterized by the presence of stereotyped inflammatory lesions at muscle biopsy attesting the long-term persistence of aluminum hydroxide particles at the site of previous immunization. Most frequently reported symptoms are chronic arthromyalgias and fatigue and cognitive complaint. MMF-associated cognitive disorder (MACD) is characterized by the dysfunctioning of attention, executive functions, short-term term and long-term memory, and, in some instances, left ear extinction. MACD is expressed in a chronic, nonevolving, well-defined syndromic framework within which the expression in terms of severity differs from one patient to another. While brain MRI is usually noncontributive, functional imaging using SPECT and PET has revealed the existence of a suggestive pathological pattern with involvement of posterior associative areas, temporal lobes, limbic system, and cerebellum. Put together, neuropsychological and functional neuroimaging investigations support the view that MACD relates to organic central nervous system involvement.
-
cognitive dysfunction associated with aluminum hydroxide induced Macrophagic Myofasciitis a reappraisal of neuropsychological profile
Journal of Inorganic Biochemistry, 2017Co-Authors: Mehdi Aoun Sebaiti, Axel Van Der Gucht, Emmanuel Itti, R Gherardi, Annecatherine Bachoudlevi, Paul Blancdurand, Paul Kauv, Anais Charlesnelson, Francois AuthierAbstract:Abstract Patients with Macrophagic Myofasciitis (MMF) present with diffuse arthromyalgias, chronic fatigue, and cognitive disorder. Representative features of MMF-associated cognitive dysfunction include attentional dysfunction, dysexecutive syndrome, visual memory deficit and left ear extinction. Our study aims to reevaluate the neuropsychological profile of MMF. 105 unselected consecutive MMF patients were subjected to a neuropsychological battery of screen short term and long-term memory, executive functions, attentional abilities, instrumental functions and dichotic listening. From these results, patients were classified in four different groups: Subsymptomatic patients (n = 41) with performance above pathological threshold (− 1.65 SD) in all tests; Fronto-subcortical patients (n = 31) who showed pathological results at executive functions and selective attention tests; Papezian patients (n = 24) who showed pathological results in storage, recognition and consolidation functions for episodic verbal memory, in addition to fronto-subcortical dysfunction; and Extinction patients (n = 9) who had a left ear extinction at dichotic listening test in association to fronto-subcortical and papezian dysfunction. In addition, inter-test analysis showed that patients with apparently normal cognitive functions (Subsymptomatic group) performed significantly worse to attention tests compared to others. In conclusion, our study shows that (i) most patients have specific cognitive deficits; (ii) all patients with cognitive deficit have impairment of executive functions and selective attention; (iii) patients without measurable cognitive deficits display significant weakness in attention; (iv) episodic memory impairment affects verbal, but not visual, memory; (v) none of the patients show an instrumental dysfunction.
-
predictive value of brain 18f fdg pet ct in Macrophagic Myofasciitis a case report
Medicine, 2017Co-Authors: Axel Van Der Gucht, Francois Authier, R Gherardi, Mukedaisi Abulizi, Paul Blancdurand, Mehdi Aounsebaiti, Berivan Emsen, Antoine Verger, Emmanuel IttiAbstract:AbstractRationale:Although several functional studies have demonstrated that positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (18F-FDG PET/CT) appears to be efficient to identify a cerebral substrate in patients with known Macrophagic Myofasciitis (MMF), the predictive va
-
brain fdg pet metabolic abnormalities in patients with long lasting Macrophagic Myofasciitis
The Journal of Nuclear Medicine, 2017Co-Authors: Axel Van Der Gucht, Mehdi Aoun Sebaiti, Jessie Aouizerate, Eva Evangelista, Julia Chalaye, R Gherardi, Eric Guedj, Sabrina Yara, Anne Segolene Cottereau, Antoine VergerAbstract:The aim of this study was to characterize brain metabolic abnormalities in patients with Macrophagic myofascitis (MMF) and the relationship with cognitive dysfunction through the use of PET with 18F-FDG. Methods:18F-FDG PET brain imaging and a comprehensive battery of neuropsychological tests were performed in 100 consecutive MMF patients (age [mean ± SD], 45.9 ± 12 y; 74% women). Images were analyzed with statistical parametric mapping (SPM12). Through the use of analysis of covariance, all 18F-FDG PET brain images of MMF patients were compared with those of a reference population of 44 healthy subjects similar in age (45.4 ± 16 y; P = 0.87) and sex (73% women; P = 0.88). The neuropsychological assessment identified 4 categories of patients: those with no significant cognitive impairment (n = 42), those with frontal subcortical (FSC) dysfunction (n = 29), those with Papez circuit dysfunction (n = 22), and those with callosal disconnection (n = 7). Results: In comparison with healthy subjects, the whole population of patients with MMF exhibited a spatial pattern of cerebral glucose hypometabolism (P < 0.001) involving the occipital lobes, temporal lobes, limbic system, cerebellum, and frontoparietal cortices, as shown by analysis of covariance. The subgroup of patients with FSC dysfunction exhibited a larger extent of involved areas (35,223 voxels vs. 13,680 voxels in the subgroup with Papez circuit dysfunction and 5,453 voxels in patients without cognitive impairment). Nonsignificant results were obtained for the last subgroup because of its small population size. Conclusion: Our study identified a peculiar spatial pattern of cerebral glucose hypometabolism that was most marked in MMF patients with FSC dysfunction. Further studies are needed to determine whether this pattern could represent a diagnostic biomarker of MMF in patients with chronic fatigue syndrome and cognitive dysfunction.
Emmanuel Itti - One of the best experts on this subject based on the ideXlab platform.
-
Macrophagic Myofasciitis associated dysfunctioning an update of neuropsychological and neuroimaging features
Best Practice & Research: Clinical Rheumatology, 2018Co-Authors: Mehdi Aoun Sebaiti, Axel Van Der Gucht, Emmanuel Itti, R Gherardi, Paul Blancdurand, Paul Kauv, Marie Abrivard, Sarah Souvannanorath, F AuthierAbstract:Abstract Macrophagic Myofasciitis (MMF) syndrome is a subtype of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) or Shoenfeld's syndrome, characterized by the presence of stereotyped inflammatory lesions at muscle biopsy attesting the long-term persistence of aluminum hydroxide particles at the site of previous immunization. Most frequently reported symptoms are chronic arthromyalgias and fatigue and cognitive complaint. MMF-associated cognitive disorder (MACD) is characterized by the dysfunctioning of attention, executive functions, short-term term and long-term memory, and, in some instances, left ear extinction. MACD is expressed in a chronic, nonevolving, well-defined syndromic framework within which the expression in terms of severity differs from one patient to another. While brain MRI is usually noncontributive, functional imaging using SPECT and PET has revealed the existence of a suggestive pathological pattern with involvement of posterior associative areas, temporal lobes, limbic system, and cerebellum. Put together, neuropsychological and functional neuroimaging investigations support the view that MACD relates to organic central nervous system involvement.
-
cognitive dysfunction associated with aluminum hydroxide induced Macrophagic Myofasciitis a reappraisal of neuropsychological profile
Journal of Inorganic Biochemistry, 2017Co-Authors: Mehdi Aoun Sebaiti, Axel Van Der Gucht, Emmanuel Itti, R Gherardi, Annecatherine Bachoudlevi, Paul Blancdurand, Paul Kauv, Anais Charlesnelson, Francois AuthierAbstract:Abstract Patients with Macrophagic Myofasciitis (MMF) present with diffuse arthromyalgias, chronic fatigue, and cognitive disorder. Representative features of MMF-associated cognitive dysfunction include attentional dysfunction, dysexecutive syndrome, visual memory deficit and left ear extinction. Our study aims to reevaluate the neuropsychological profile of MMF. 105 unselected consecutive MMF patients were subjected to a neuropsychological battery of screen short term and long-term memory, executive functions, attentional abilities, instrumental functions and dichotic listening. From these results, patients were classified in four different groups: Subsymptomatic patients (n = 41) with performance above pathological threshold (− 1.65 SD) in all tests; Fronto-subcortical patients (n = 31) who showed pathological results at executive functions and selective attention tests; Papezian patients (n = 24) who showed pathological results in storage, recognition and consolidation functions for episodic verbal memory, in addition to fronto-subcortical dysfunction; and Extinction patients (n = 9) who had a left ear extinction at dichotic listening test in association to fronto-subcortical and papezian dysfunction. In addition, inter-test analysis showed that patients with apparently normal cognitive functions (Subsymptomatic group) performed significantly worse to attention tests compared to others. In conclusion, our study shows that (i) most patients have specific cognitive deficits; (ii) all patients with cognitive deficit have impairment of executive functions and selective attention; (iii) patients without measurable cognitive deficits display significant weakness in attention; (iv) episodic memory impairment affects verbal, but not visual, memory; (v) none of the patients show an instrumental dysfunction.
-
predictive value of brain 18f fdg pet ct in Macrophagic Myofasciitis a case report
Medicine, 2017Co-Authors: Axel Van Der Gucht, Francois Authier, R Gherardi, Mukedaisi Abulizi, Paul Blancdurand, Mehdi Aounsebaiti, Berivan Emsen, Antoine Verger, Emmanuel IttiAbstract:AbstractRationale:Although several functional studies have demonstrated that positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (18F-FDG PET/CT) appears to be efficient to identify a cerebral substrate in patients with known Macrophagic Myofasciitis (MMF), the predictive va
-
Predictive value of brain 18F-FDG PET/CT in Macrophagic Myofasciitis?: A case report.
Medicine, 2017Co-Authors: Axel Van Der Gucht, Francois Authier, Mukedaisi Abulizi, Berivan Emsen, Antoine Verger, Paul Blanc-durand, Mehdi Aoun-sebaiti, Romain K. Gherardi, Emmanuel IttiAbstract:AbstractRationale:Although several functional studies have demonstrated that positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (18F-FDG PET/CT) appears to be efficient to identify a cerebral substrate in patients with known Macrophagic Myofasciitis (MMF), the predictive va
-
cerebral 18f fdg pet in Macrophagic Myofasciitis an individual svm based approach
PLOS ONE, 2017Co-Authors: Paul Blancdurand, Francois Authier, Axel Van Der Gucht, Mukedaisi Abulizi, Mehdi Aounsebaiti, Antoine Verger, Eric Guedj, Lionel Lerman, Emmanuel IttiAbstract:Macrophagic Myofasciitis (MMF) is an emerging condition with highly specific myopathological alterations. A peculiar spatial pattern of a cerebral glucose hypometabolism involving occipito-temporal cortex and cerebellum have been reported in patients with MMF; however, the full pattern is not systematically present in routine interpretation of scans, and with varying degrees of severity depending on the cognitive profile of patients. Aim was to generate and evaluate a support vector machine (SVM) procedure to classify patients between healthy or MMF 18F-FDG brain profiles.
Axel Van Der Gucht - One of the best experts on this subject based on the ideXlab platform.
-
Macrophagic Myofasciitis associated dysfunctioning an update of neuropsychological and neuroimaging features
Best Practice & Research: Clinical Rheumatology, 2018Co-Authors: Mehdi Aoun Sebaiti, Axel Van Der Gucht, Emmanuel Itti, R Gherardi, Paul Blancdurand, Paul Kauv, Marie Abrivard, Sarah Souvannanorath, F AuthierAbstract:Abstract Macrophagic Myofasciitis (MMF) syndrome is a subtype of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) or Shoenfeld's syndrome, characterized by the presence of stereotyped inflammatory lesions at muscle biopsy attesting the long-term persistence of aluminum hydroxide particles at the site of previous immunization. Most frequently reported symptoms are chronic arthromyalgias and fatigue and cognitive complaint. MMF-associated cognitive disorder (MACD) is characterized by the dysfunctioning of attention, executive functions, short-term term and long-term memory, and, in some instances, left ear extinction. MACD is expressed in a chronic, nonevolving, well-defined syndromic framework within which the expression in terms of severity differs from one patient to another. While brain MRI is usually noncontributive, functional imaging using SPECT and PET has revealed the existence of a suggestive pathological pattern with involvement of posterior associative areas, temporal lobes, limbic system, and cerebellum. Put together, neuropsychological and functional neuroimaging investigations support the view that MACD relates to organic central nervous system involvement.
-
cognitive dysfunction associated with aluminum hydroxide induced Macrophagic Myofasciitis a reappraisal of neuropsychological profile
Journal of Inorganic Biochemistry, 2017Co-Authors: Mehdi Aoun Sebaiti, Axel Van Der Gucht, Emmanuel Itti, R Gherardi, Annecatherine Bachoudlevi, Paul Blancdurand, Paul Kauv, Anais Charlesnelson, Francois AuthierAbstract:Abstract Patients with Macrophagic Myofasciitis (MMF) present with diffuse arthromyalgias, chronic fatigue, and cognitive disorder. Representative features of MMF-associated cognitive dysfunction include attentional dysfunction, dysexecutive syndrome, visual memory deficit and left ear extinction. Our study aims to reevaluate the neuropsychological profile of MMF. 105 unselected consecutive MMF patients were subjected to a neuropsychological battery of screen short term and long-term memory, executive functions, attentional abilities, instrumental functions and dichotic listening. From these results, patients were classified in four different groups: Subsymptomatic patients (n = 41) with performance above pathological threshold (− 1.65 SD) in all tests; Fronto-subcortical patients (n = 31) who showed pathological results at executive functions and selective attention tests; Papezian patients (n = 24) who showed pathological results in storage, recognition and consolidation functions for episodic verbal memory, in addition to fronto-subcortical dysfunction; and Extinction patients (n = 9) who had a left ear extinction at dichotic listening test in association to fronto-subcortical and papezian dysfunction. In addition, inter-test analysis showed that patients with apparently normal cognitive functions (Subsymptomatic group) performed significantly worse to attention tests compared to others. In conclusion, our study shows that (i) most patients have specific cognitive deficits; (ii) all patients with cognitive deficit have impairment of executive functions and selective attention; (iii) patients without measurable cognitive deficits display significant weakness in attention; (iv) episodic memory impairment affects verbal, but not visual, memory; (v) none of the patients show an instrumental dysfunction.
-
predictive value of brain 18f fdg pet ct in Macrophagic Myofasciitis a case report
Medicine, 2017Co-Authors: Axel Van Der Gucht, Francois Authier, R Gherardi, Mukedaisi Abulizi, Paul Blancdurand, Mehdi Aounsebaiti, Berivan Emsen, Antoine Verger, Emmanuel IttiAbstract:AbstractRationale:Although several functional studies have demonstrated that positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (18F-FDG PET/CT) appears to be efficient to identify a cerebral substrate in patients with known Macrophagic Myofasciitis (MMF), the predictive va
-
Predictive value of brain 18F-FDG PET/CT in Macrophagic Myofasciitis?: A case report.
Medicine, 2017Co-Authors: Axel Van Der Gucht, Francois Authier, Mukedaisi Abulizi, Berivan Emsen, Antoine Verger, Paul Blanc-durand, Mehdi Aoun-sebaiti, Romain K. Gherardi, Emmanuel IttiAbstract:AbstractRationale:Although several functional studies have demonstrated that positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (18F-FDG PET/CT) appears to be efficient to identify a cerebral substrate in patients with known Macrophagic Myofasciitis (MMF), the predictive va
-
cerebral 18f fdg pet in Macrophagic Myofasciitis an individual svm based approach
PLOS ONE, 2017Co-Authors: Paul Blancdurand, Francois Authier, Axel Van Der Gucht, Mukedaisi Abulizi, Mehdi Aounsebaiti, Antoine Verger, Eric Guedj, Lionel Lerman, Emmanuel IttiAbstract:Macrophagic Myofasciitis (MMF) is an emerging condition with highly specific myopathological alterations. A peculiar spatial pattern of a cerebral glucose hypometabolism involving occipito-temporal cortex and cerebellum have been reported in patients with MMF; however, the full pattern is not systematically present in routine interpretation of scans, and with varying degrees of severity depending on the cognitive profile of patients. Aim was to generate and evaluate a support vector machine (SVM) procedure to classify patients between healthy or MMF 18F-FDG brain profiles.
Antoine Verger - One of the best experts on this subject based on the ideXlab platform.
-
predictive value of brain 18f fdg pet ct in Macrophagic Myofasciitis a case report
Medicine, 2017Co-Authors: Axel Van Der Gucht, Francois Authier, R Gherardi, Mukedaisi Abulizi, Paul Blancdurand, Mehdi Aounsebaiti, Berivan Emsen, Antoine Verger, Emmanuel IttiAbstract:AbstractRationale:Although several functional studies have demonstrated that positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (18F-FDG PET/CT) appears to be efficient to identify a cerebral substrate in patients with known Macrophagic Myofasciitis (MMF), the predictive va
-
Predictive value of brain 18F-FDG PET/CT in Macrophagic Myofasciitis?: A case report.
Medicine, 2017Co-Authors: Axel Van Der Gucht, Francois Authier, Mukedaisi Abulizi, Berivan Emsen, Antoine Verger, Paul Blanc-durand, Mehdi Aoun-sebaiti, Romain K. Gherardi, Emmanuel IttiAbstract:AbstractRationale:Although several functional studies have demonstrated that positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (18F-FDG PET/CT) appears to be efficient to identify a cerebral substrate in patients with known Macrophagic Myofasciitis (MMF), the predictive va
-
cerebral 18f fdg pet in Macrophagic Myofasciitis an individual svm based approach
PLOS ONE, 2017Co-Authors: Paul Blancdurand, Francois Authier, Axel Van Der Gucht, Mukedaisi Abulizi, Mehdi Aounsebaiti, Antoine Verger, Eric Guedj, Lionel Lerman, Emmanuel IttiAbstract:Macrophagic Myofasciitis (MMF) is an emerging condition with highly specific myopathological alterations. A peculiar spatial pattern of a cerebral glucose hypometabolism involving occipito-temporal cortex and cerebellum have been reported in patients with MMF; however, the full pattern is not systematically present in routine interpretation of scans, and with varying degrees of severity depending on the cognitive profile of patients. Aim was to generate and evaluate a support vector machine (SVM) procedure to classify patients between healthy or MMF 18F-FDG brain profiles.
-
brain fdg pet metabolic abnormalities in patients with long lasting Macrophagic Myofasciitis
The Journal of Nuclear Medicine, 2017Co-Authors: Axel Van Der Gucht, Mehdi Aoun Sebaiti, Jessie Aouizerate, Eva Evangelista, Julia Chalaye, R Gherardi, Eric Guedj, Sabrina Yara, Anne Segolene Cottereau, Antoine VergerAbstract:The aim of this study was to characterize brain metabolic abnormalities in patients with Macrophagic myofascitis (MMF) and the relationship with cognitive dysfunction through the use of PET with 18F-FDG. Methods:18F-FDG PET brain imaging and a comprehensive battery of neuropsychological tests were performed in 100 consecutive MMF patients (age [mean ± SD], 45.9 ± 12 y; 74% women). Images were analyzed with statistical parametric mapping (SPM12). Through the use of analysis of covariance, all 18F-FDG PET brain images of MMF patients were compared with those of a reference population of 44 healthy subjects similar in age (45.4 ± 16 y; P = 0.87) and sex (73% women; P = 0.88). The neuropsychological assessment identified 4 categories of patients: those with no significant cognitive impairment (n = 42), those with frontal subcortical (FSC) dysfunction (n = 29), those with Papez circuit dysfunction (n = 22), and those with callosal disconnection (n = 7). Results: In comparison with healthy subjects, the whole population of patients with MMF exhibited a spatial pattern of cerebral glucose hypometabolism (P < 0.001) involving the occipital lobes, temporal lobes, limbic system, cerebellum, and frontoparietal cortices, as shown by analysis of covariance. The subgroup of patients with FSC dysfunction exhibited a larger extent of involved areas (35,223 voxels vs. 13,680 voxels in the subgroup with Papez circuit dysfunction and 5,453 voxels in patients without cognitive impairment). Nonsignificant results were obtained for the last subgroup because of its small population size. Conclusion: Our study identified a peculiar spatial pattern of cerebral glucose hypometabolism that was most marked in MMF patients with FSC dysfunction. Further studies are needed to determine whether this pattern could represent a diagnostic biomarker of MMF in patients with chronic fatigue syndrome and cognitive dysfunction.
-
FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis
Nuclear Medicine and Molecular Imaging, 2016Co-Authors: Axel Van Der Gucht, Francois Authier, Jessie Aouizerate, Antoine Verger, Mehdi Aoun-sebaiti, Romain K. Gherardi, Eric Guedj, Paul Kauv, Anne-catherine Bachoud-levi, Emmanuel IttiAbstract:Brain Positron Emission Tomography/Computed Tomography with ^18F-fluorodeoxyglucose (FDG PET/CT) was performed in a 44-year-old woman with marked cognitive impairment, diffuse myalgias, sensory, memory and visual disorders, and chronic fatigue, presenting with histopathological features of Macrophagic Myofasciitis (MMF) at deltoid muscle biopsy. Cerebromedullary Magnetic Resonance Imaging (MRI), electromyography, ophthalmic examination, and cerebrospinal fluid analysis were normal. Visual analysis of FDG PET/CT images showed an atypical pattern of hypometabolism, involving symmetrically the occipital cortex, temporal lobes, and limbic system (including in particular amygdalo-hippocampal complexes), and the cerebellum. Posterior cingulate cortex and parietal areas were preserved. This pattern was confirmed by a voxel-based procedure using Statistical Parametric Mapping (SPM12) that compared a patient’s images to normal reference samples from six healthy subjects with adjustment to age obtained using the same PET/CT camera. These results provide a glucose metabolism substrate for cognitive complaints in patients with long-lasting aluminium hydroxide-induced MMF.
