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Simin Liu - One of the best experts on this subject based on the ideXlab platform.
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relation of Magnesium Intake with cardiac function and heart failure hospitalizations in black adults the jackson heart study
Circulation-heart Failure, 2016Co-Authors: Tracey H Taveira, Danielle Ouellette, Alev Gulum, Gaurav Choudhary, Charles B Eaton, Simin LiuAbstract:Background—Little is known about Magnesium Intake and risk of heart failure (HF) hospitalizations, particularly in blacks. We hypothesize that Magnesium Intake relates to HF hospitalization in blacks. Methods and Results—From the Jackson Heart Study cohort (n=5301), we studied 4916 blacks recruited during 2000 to 2004 in Jackson (Mississippi), who completed an 158-item Food-Frequency Questionnaire that included dietary supplements. Daily Magnesium Intake derived from the questionnaire was divided by the body weight to account for body storage and stratified by quartiles (0.522–2.308, 2.309–3.147, 3.148–4.226, and ≥4.227 mg Magnesium Intake/kg). Cox proportional hazards modeling assessed the association between quartiles of Magnesium Intake/kg and hospitalizations for HF adjusting for HF risk, energy Intake, and dietary factors. The cohort had a mean age=55.3 (SD=12.7 years) and composed of 63.4% women, 21.6% diabetes mellitus, 62.7% hypertension, 7.1% coronary disease, and 2.8% with known HF. When compare...
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Magnesium Intake genetic variants and diabetes risk
2013Co-Authors: Yiqing Song, Qi Dai, Cuilin Zhang, Lu Wang, Simin LiuAbstract:Type 2 diabetes mellitus (DM) is a major global public health burden, affecting more than 170 million individuals worldwide [1]. Overall, it is estimated that the prevalence of diabetes will increase by 42 % among adults living in developed countries and by 170 % among adults in developing countries by 2025 [2, 3]. More alarmingly, by the time type 2 DM is diagnosed, most individuals have developed complications such as peripheral artery disease, renal failure, and neuropathy, and the vast majority of diabetic patients die of these complications [4]. Given the rising global burden of type 2 DM and its devastating complications, there is a great urgency to develop effective strategies to curb the epidemic by identifying individuals at high risk and optimizing prevention and early treatment. The predisposition to type 2 DM varies widely in the population and is largely determined by complex gene–environment interactions.
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Relations of Dietary Magnesium Intake to Biomarkers of Inflammation and Endothelial Dysfunction in an Ethnically Diverse Cohort of Postmenopausal Women
Diabetes Care, 2009Co-Authors: Sara A. Chacko, Yiqing Song, Frances A Tylavsky, Lauren Nathan, Lesley F. Tinker, Ian H. De Boer, Robert B. Wallace, Simin LiuAbstract:OBJECTIVE Although Magnesium may favorably affect metabolic outcomes, few studies have investigated the role of Magnesium Intake in systemic inflammation and endothelial dysfunction in humans. RESEARCH DESIGN AND METHODS Among 3,713 postmenopausal women aged 50–79 years in the Women's Health Initiative Observational Study and free of cardiovascular disease, cancer, and diabetes at baseline, we measured plasma concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), turnor necrosis factor-α receptor 2 (TNF-α-R2), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and E-selectin. Magnesium Intake was assessed using a semiquantitative food frequency questionnaire. RESULTS After adjustment for age, ethnicity, clinical center, time of blood draw, smoking, alcohol, physical activity, energy Intake, BMI, and diabetes status, Magnesium Intake was inversely associated with hs-CRP ( P for linear trend = 0.003), IL-6 ( P < 0.0001), TNF-α-R2 ( P = 0.0006), and sVCAM-1 ( P = 0.06). Similar findings remained after further adjustment for dietary fiber, fruit, vegetables, folate, and saturated and trans fat Intake. Multivariable-adjusted geometric means across increasing quintiles of Magnesium Intake were 3.08, 2.63, 2.31, 2.53, and 2.16 mg/l for hs-CRP ( P = 0.005); 2.91, 2.63, 2.45, 2.27, and 2.26 pg/ml for IL-6 ( P = 0.0005); and 707, 681, 673, 671, and 656 ng/ml for sVCAM-1 ( P = 0.04). An increase of 100 mg/day Magnesium was inversely associated with hs-CRP (−0.23 mg/l ± 0.07; P = 0.002), IL-6 (−0.14 ± 0.05 pg/ml; P = 0.004), TNF-α-R2 (−0.04 ± 0.02 pg/ml; P = 0.06), and sVCAM-1 (−0.04 ± 0.02 ng/ml; P = 0.07). No significant ethnic differences were observed. CONCLUSIONS High Magnesium Intake is associated with lower concentrations of certain markers of systemic inflammation and endothelial dysfunction in postmenopausal women.
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Intake of dietary Magnesium and the prevalence of the metabolic syndrome among u s adults
Obesity, 2007Co-Authors: Earl S. Ford, Ali H. Mokdad, Lisa C Mcguire, Simin LiuAbstract:FORD, EARL S., CHAOYANG LI, LISA C. MCGUIRE, ALI H. MOKDAD, AND SIMIN LIU. Intake of dietary Magnesium and the prevalence of the metabolic syndrome among U.S. adults. Obesity. 2007;15:1139–1146. Objective: Limited data suggest that people with the metabolic syndrome have lower Intakes or circulating concentrations of Magnesium than those who do not have the syndrome. The aim of this study was to examine the associations between dietary Intake of Magnesium and the prevalence of the metabolic syndrome in a nationally representative sample of U.S. adults. Research Methods and Procedures: We used data for 7669 participants 20 years of age of the Third National Health and Nutrition Examination Survey (1988 to 1994). The metabolic syndrome was defined using the criteria of the National Cholesterol Education Program. Magnesium Intake was determined from a single dietary 24-hour recall. Results: The unadjusted prevalences of the metabolic syndrome were 29.0% (quintile of lowest Magnesium Intake), 27.5%, 25.8%, 23.9%, and 21.8% for increasing quintiles of Magnesium Intake (p for trend 0.002). After multiple adjustment, the odds ratios for the second through the fifth quintiles (highest Intake) of Magnesium Intake among all participants included in the analysis were 0.84 [95% confidence interval (CI): 0.58, 1.23], 0.76 (95% CI: 0.54, 1.07), 0.62 (95% CI: 0.40, 0.98), and 0.56 (95% CI: 0.34, 0.92), respectively (p for trend 0.029). The associations were similar for men and women. Discussion: Our results showing an inverse association between dietary Magnesium Intake and the prevalence of the metabolic syndrome add to the evidence that adequate Magnesium Intake or a diet rich in Magnesium may be important for maintaining good cardiometabolic health.
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dietary Magnesium Intake and risk of incident hypertension among middle aged and older us women in a 10 year follow up study
American Journal of Cardiology, 2006Co-Authors: Yiqing Song, Joann E. Manson, Nancy R. Cook, Julie E. Buring, Simin Liu, Howard D SessoAbstract:To assess the hypothesis that Magnesium Intake is beneficial in the primary prevention of hypertension, 28,349 female United States health professionals aged > or =45 years participating in the Women's Health Study (WHS), who initially reported normal blood pressure (systolic blood pressure <140 mm Hg, diastolic blood pressure <90 mm Hg, no history of hypertension or antihypertensive medications), were prospectively studied. A semi-quantitative food frequency questionnaire was used to estimate Magnesium Intake. During a median follow-up of 9.8 years, 8,544 women developed incident hypertension. After adjustment for age and randomized treatment, Magnesium Intake was inversely associated with the risk for developing hypertension; women in the highest quintile (median 434 mg/day) had a decreased risk for hypertension (relative risk 0.87, 95% confidence interval [CI] 0.81 to 0.93, p for trend <0.0001) compared with those in the lowest quintile (median 256 mg/day). This inverse association was attenuated but remained significant after further adjustment for known risk factors. In the fully adjusted model, the relative risks were 1.00 (95% CI 0.95 to 1.10), 1.02 (95% CI 0.95 to 1.10), 0.96 (95% CI 0.89 to 1.03), and 0.93 (95% CI 0.86 to 1.02) (p for trend = 0.03). Similar associations were observed for women who never smoked and reported no history of high cholesterol or diabetes at baseline. In conclusion, the results suggest that higher Intake of dietary Magnesium may have a modest effect on the development of hypertension in women.
Yiqing Song - One of the best experts on this subject based on the ideXlab platform.
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Magnesium Intake was inversely associated with hostility among american young adults
Nutrition Research, 2021Co-Authors: Chen Lyu, Yiqing Song, David R. Jacobs, Pengcheng Xun, James M. Shikany, Andrea Rosanoff, Cari Lewis Tsinovoi, Carlos Iribarren, Pamela J Schreiner, Ka KaheAbstract:Abstract Hostility is a complex personality trait associated with many cardiovascular risk factor phenotypes. Although Magnesium Intake has been related to mood and cardio-metabolic disease, its relation with hostility remains unclear. We hypothesize that high total Magnesium Intake is associated with lower levels of hostility because of its putative antidepressant mechanisms. To test the hypothesis, we prospectively analyzed data in 4,716 young adults aged 18-30 years at baseline (1985-1986) from four U.S. cities over five years of follow-up using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Magnesium Intake was estimated from a dietary history questionnaire plus supplements at baseline. Levels of hostility were assessed using the Cook-Medley scale at baseline and year 5 (1990-1991). Generalized estimating equations were applied to estimate the association of Magnesium Intake with hostility as repeated measures at the two time-points (baseline and year 5). General linear model was used to determine the association between Magnesium Intake and change in hostility over 5 years. After adjustment for socio-demographic and major lifestyle factors, a significant inverse association was observed between Magnesium Intake and hostility level over 5 years of follow-up. Beta coefficients (95% CI) across higher quintiles of Magnesium Intake were 0 (reference), -1.28 (-1.92, -0.65), -1.45 (-2.09, -0.81), -1.41 (-2.08, -0.75) and -2.16 (-2.85, -1.47), respectively (Plinear-trend
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abstract 4258 Magnesium Intake and mortality due to liver cancer and other liver diseases results from the third national health and nutrition examination survey cohort
Cancer Research, 2018Co-Authors: Zhu Xiangzhu, Yiqing Song, Martha J. Shrubsole, Lifang Hou, Edmond K Kabagambe, Meng-hua Tao, Lei Fan, Xiaosong Zhong, Jie Liu, Qi DaiAbstract:People with fatty liver disease are at high risk of Magnesium deficiency. Meanwhile, low Magnesium status is linked to both chronic inflammation and insulin resistance. However, no study has investigated the association between Intake of Magnesium and risk of mortality due to liver cancer and other liver diseases. We evaluated the association between total Magnesium Intake and mortality due to liver cancer and other liver diseases in the Third National Health and Nutrition Examination Study (NHANES III) cohort, which included 13,504 participants who completed liver ultrasound examination for hepatic steatosis. Overall Magnesium Intake was associated with a reduced risk of mortality due to liver cancer and other liver disease at borderline significance (P=0.05). In multi-variable adjusted models, every 100 mg increase in Intake of Magnesium was associated with a 49% reduction in the risk for mortality due to liver cancer and other liver diseases. Although interactions between Magnesium Intake and alcohol use and hepatic steatosis at baseline were not significant (P>0.05), inverse associations between Magnesium Intake with liver cancer and other liver disease mortality were stronger among alcohol drinkers and those with hepatic steatosis. Our novel findings suggest higher Intakes of Magnesium may be associated with a reduced risk of mortality due to liver cancer and other liver disease particularly among alcohol drinkers and those with hepatic steatosis. Further studies are warranted to confirm the findings. Citation Format: Zhu Xiangzhu, Lijun Wu, Lei Fan, Edmond K Kabagambe, Yiqing Song, Menghua Tao, Xiaosong Zhong, Lifang Hou, Martha J. Shrubsole, Jie Liu, Qi Dai. Magnesium Intake and mortality due to liver cancer and other liver diseases: Results from the Third National Health and Nutrition Examination Survey Cohort [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4258.
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Magnesium Intake and mortality due to liver diseases: Results from the Third National Health and Nutrition Examination Survey Cohort.
Scientific Reports, 2017Co-Authors: Xiangzhu Zhu, Yiqing Song, Martha J. Shrubsole, Lifang Hou, Edmond K Kabagambe, Meng-hua Tao, Lei Fan, Xiaosong Zhong, Jie LiuAbstract:People with fatty liver disease are at high risk of Magnesium deficiency. Meanwhile, low Magnesium status is linked to both chronic inflammation and insulin resistance. However, no study has investigated the association between Intake of Magnesium and risk of mortality due to liver diseases. We evaluated the association between total Magnesium Intake and mortality due to liver diseases in the Third National Health and Nutrition Examination Study (NHANES III) cohort, which included 13,504 participants who completed liver ultrasound examination for hepatic steatosis. Overall Magnesium Intake was associated with a reduced risk of mortality due to liver disease at borderline significance (P = 0.05). In fully-adjusted analyses, every 100 mg increase in Intake of Magnesium was associated with a 49% reduction in the risk for mortality due to liver diseases. Although interactions between Magnesium Intake and alcohol use and hepatic steatosis at baseline were not significant (P > 0.05), inverse associations between Magnesium Intake and liver disease mortality were stronger among alcohol drinkers and those with hepatic steatosis. Our findings suggest higher Intakes of Magnesium may be associated with a reduced risk of mortality due to liver disease particularly among alcohol drinkers and those with hepatic steatosis. Further studies are warranted to confirm the findings.
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Magnesium vitamin d status and mortality results from us national health and nutrition examination survey nhanes 2001 to 2006 and nhanes iii
BMC Medicine, 2013Co-Authors: Xinqing Deng, Yiqing Song, Martha J. Shrubsole, Reid M. Ness, Joann E. Manson, Lisa B Signorello, Shumin M Zhang, Douglas L Seidner, Qi DaiAbstract:Background: Magnesium plays an essential role in the synthesis and metabolism of vitamin D and Magnesium supplementation substantially reversed the resistance to vitamin D treatment in patients with Magnesiumdependent vitamin-D-resistant rickets. We hypothesized that dietary Magnesium alone, particularly its interaction with vitamin D Intake, contributes to serum 25-hydroxyvitamin D (25(OH)D) levels, and the associations between serum 25(OH)D and risk of mortality may be modified by Magnesium Intake level. Methods: We tested these novel hypotheses utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2001 to 2006, a population-based cross-sectional study, and the NHANES III cohort, a populationbased cohort study. Serum 25(OH)D was used to define vitamin D status. Mortality outcomes in the NHANES III cohort were determined by using probabilistic linkage with the National Death Index (NDI). Results: High Intake of total, dietary or supplemental Magnesium was independently associated with significantly reduced risks of vitamin D deficiency and insufficiency respectively. Intake of Magnesium significantly interacted with Intake of vitamin D in relation to risk of both vitamin D deficiency and insufficiency. Additionally, the inverse association between total Magnesium Intake and vitamin D insufficiency primarily appeared among populations at high risk of vitamin D insufficiency. Furthermore, the associations of serum 25(OH)D with mortality, particularly due to cardiovascular disease (CVD) and colorectal cancer, were modified by Magnesium Intake, and the inverse associations were primarily present among those with Magnesium Intake above the median. Conclusions: Our preliminary findings indicate it is possible that Magnesium Intake alone or its interaction with vitamin D Intake may contribute to vitamin D status. The associations between serum 25(OH)D and risk of mortality may be modified by the Intake level of Magnesium. Future studies, including cohort studies and clinical trials, are necessary to confirm the findings.
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Magnesium Intake genetic variants and diabetes risk
2013Co-Authors: Yiqing Song, Qi Dai, Cuilin Zhang, Lu Wang, Simin LiuAbstract:Type 2 diabetes mellitus (DM) is a major global public health burden, affecting more than 170 million individuals worldwide [1]. Overall, it is estimated that the prevalence of diabetes will increase by 42 % among adults living in developed countries and by 170 % among adults in developing countries by 2025 [2, 3]. More alarmingly, by the time type 2 DM is diagnosed, most individuals have developed complications such as peripheral artery disease, renal failure, and neuropathy, and the vast majority of diabetic patients die of these complications [4]. Given the rising global burden of type 2 DM and its devastating complications, there is a great urgency to develop effective strategies to curb the epidemic by identifying individuals at high risk and optimizing prevention and early treatment. The predisposition to type 2 DM varies widely in the population and is largely determined by complex gene–environment interactions.
Joann E. Manson - One of the best experts on this subject based on the ideXlab platform.
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Magnesium Intake, Quality of Carbohydrates, and Risk of Type 2 Diabetes: Results From Three U.S. Cohorts.
Diabetes Care, 2017Co-Authors: Adela Hruby, Joann E. Manson, Walter C. Willett, Marta Guasch-ferré, Shilpa N Bhupathiraju, Nicola M. MckeownAbstract:OBJECTIVE Magnesium Intake is inversely associated with risk of type 2 diabetes in many observational studies, but few have assessed this association in the context of the carbohydrate quality of the diet. We hypothesized that higher Magnesium Intake is associated with lower risk of type 2 diabetes, especially in the context of a poor-carbohydrate-quality diet characterized by low cereal fiber or high glycemic index (GI) or glycemic load (GL). RESEARCH DESIGN AND METHODS In the Nurses’ Health Study (NHS; 1984–2012, n = 69,176), NHS2 (1991–2013, n = 91,471), and the Health Professionals’ Follow-Up Study (1986–2012, n = 42,096), dietary Intake was assessed from food frequency questionnaires every 4 years. Type 2 diabetes was ascertained by biennial and supplementary questionnaires. We calculated multivariate hazard ratios (HRs) of Magnesium Intake and incident diabetes, adjusted for age, BMI, family history of diabetes, physical activity, smoking, hypertension, hypercholesterolemia, GL, energy Intake, alcohol, cereal fiber, polyunsaturated fats, trans fatty acids, and processed meat, and we considered the joint associations of Magnesium and carbohydrate quality on diabetes risk. RESULTS We documented 17,130 incident cases of type 2 diabetes over 28 years of follow-up. In pooled analyses across the three cohorts, those with the highest Magnesium Intake had 15% lower risk of type 2 diabetes compared with those with the lowest Intake (pooled multivariate HR in quintile 5 vs. 1: 0.85 [95% CI 0.80–0.91], P P interaction CONCLUSIONS Higher Magnesium Intake is associated with lower risk of type 2 diabetes, especially in the context of lower-carbohydrate-quality diets.
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Magnesium vitamin d status and mortality results from us national health and nutrition examination survey nhanes 2001 to 2006 and nhanes iii
BMC Medicine, 2013Co-Authors: Xinqing Deng, Yiqing Song, Martha J. Shrubsole, Reid M. Ness, Joann E. Manson, Lisa B Signorello, Shumin M Zhang, Douglas L Seidner, Qi DaiAbstract:Background: Magnesium plays an essential role in the synthesis and metabolism of vitamin D and Magnesium supplementation substantially reversed the resistance to vitamin D treatment in patients with Magnesiumdependent vitamin-D-resistant rickets. We hypothesized that dietary Magnesium alone, particularly its interaction with vitamin D Intake, contributes to serum 25-hydroxyvitamin D (25(OH)D) levels, and the associations between serum 25(OH)D and risk of mortality may be modified by Magnesium Intake level. Methods: We tested these novel hypotheses utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2001 to 2006, a population-based cross-sectional study, and the NHANES III cohort, a populationbased cohort study. Serum 25(OH)D was used to define vitamin D status. Mortality outcomes in the NHANES III cohort were determined by using probabilistic linkage with the National Death Index (NDI). Results: High Intake of total, dietary or supplemental Magnesium was independently associated with significantly reduced risks of vitamin D deficiency and insufficiency respectively. Intake of Magnesium significantly interacted with Intake of vitamin D in relation to risk of both vitamin D deficiency and insufficiency. Additionally, the inverse association between total Magnesium Intake and vitamin D insufficiency primarily appeared among populations at high risk of vitamin D insufficiency. Furthermore, the associations of serum 25(OH)D with mortality, particularly due to cardiovascular disease (CVD) and colorectal cancer, were modified by Magnesium Intake, and the inverse associations were primarily present among those with Magnesium Intake above the median. Conclusions: Our preliminary findings indicate it is possible that Magnesium Intake alone or its interaction with vitamin D Intake may contribute to vitamin D status. The associations between serum 25(OH)D and risk of mortality may be modified by the Intake level of Magnesium. Future studies, including cohort studies and clinical trials, are necessary to confirm the findings.
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common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 trpm6 and trpm7 Magnesium Intake and risk of type 2 diabetes in women
BMC Medical Genetics, 2009Co-Authors: Yiqing Song, Joann E. Manson, Julie E. BuringAbstract:Ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7) play a central role in Magnesium homeostasis, which is critical for maintaining glucose and insulin metabolism. However, it is unclear whether common genetic variation in TRPM6 and TRPM7 contributes to risk of type 2 diabetes. We conducted a nested case-control study in the Women's Health Study. During a median of 10 years of follow-up, 359 incident diabetes cases were diagnosed and matched by age and ethnicity with 359 controls. We analyzed 20 haplotype-tagging single nucleotide polymorphisms (SNPs) in TRPM6 and 5 common SNPs in TRPM7 for their association with diabetes risk. Overall, there was no robust and significant association between any single SNP and diabetes risk. Neither was there any evidence of association between common TRPM6 and TRPM7 haplotypes and diabetes risk. Our haplotype analyses suggested a significant risk of type 2 diabetes among carriers of both the rare alleles from two non-synomous SNPs in TRPM6 (Val1393Ile in exon 26 [rs3750425] and Lys1584Glu in exon 27 [rs2274924]) when their Magnesium Intake was lower than 250 mg per day. Compared with non-carriers, women who were carriers of the haplotype 1393Ile-1584Glu had an increased risk of type 2 diabetes (OR, 4.92, 95% CI, 1.05–23.0) only when they had low Magnesium Intake (<250 mg/day). Our results provide suggestive evidence that two common non-synonymous TRPM6 coding region variants, Ile1393Val and Lys1584Glu polymorphisms, might confer susceptibility to type 2 diabetes in women with low Magnesium Intake. Further replication in large-scale studies is warranted.
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Magnesium Intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women
The American Journal of Clinical Nutrition, 2007Co-Authors: Yiqing Song, Rob M. Van Dam, Joann E. MansonAbstract:Background: Relations between Magnesium Intake and systemic inflammation and endothelial dysfunction are not well established. Objective:Theaimofthepresentstudywastoexaminewhetherand to what extent Magnesium Intake is related to inflammatory and endothelial markers. Design: We conducted a cross-sectional study of 657 women from theNurses’HealthStudycohortwhowereaged43–69yandfreeof cardiovascular disease, cancer, and diabetes mellitus when blood was drawn in 1989 and 1990. Plasma concentrations of C-reactive protein (CRP), interleukin 6 (IL-6), soluble tumor necrosis factor receptor 2 (sTNF-R2), E-selectin, soluble intercellular adhesion molecule1(sICAM-1),andsolublevascularcelladhesionmolecule 1 (sVCAM-1) were measured. Estimates from 2 semiquantitative food-frequency questionnaires, administered in 1986 and 1990, were averaged to assess dietary Intakes. Results: In age-adjusted linear regression analyses, Magnesium Intake was inversely associated with plasma concentrations of CRP (P for linear trend 0.003), E-selectin (P 0.001), and sICAM-1 (P 0.03). After further adjustment for physical activity, smoking status, alcohol use, postmenopausal hormone use, and body mass index,dietaryMagnesiumIntakeremainedinverselyassociatedwith CRP and E-selectin. Multivariate-adjusted geometric means for women in the highest quintile of dietary Magnesium Intake were 24%lowerforCRP(1.700.18comparedwith1.300.10mg/dL; P for trend 0.03) and 14% lower for E-selectin (48.5 1.84 comparedwith41.91.58ng/mL;Pfortrend0.01)thanthosefor women in the lowest quintile. Conclusion:MagnesiumIntakefromdietismodestlyandinversely associatedwithsomebutnotallmarkersofsystematicinflammation andendothelialdysfunctioninapparentlyhealthywomen. AmJ Clin Nutr 2007;85:1068–74.
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dietary Magnesium Intake and risk of incident hypertension among middle aged and older us women in a 10 year follow up study
American Journal of Cardiology, 2006Co-Authors: Yiqing Song, Joann E. Manson, Nancy R. Cook, Julie E. Buring, Simin Liu, Howard D SessoAbstract:To assess the hypothesis that Magnesium Intake is beneficial in the primary prevention of hypertension, 28,349 female United States health professionals aged > or =45 years participating in the Women's Health Study (WHS), who initially reported normal blood pressure (systolic blood pressure <140 mm Hg, diastolic blood pressure <90 mm Hg, no history of hypertension or antihypertensive medications), were prospectively studied. A semi-quantitative food frequency questionnaire was used to estimate Magnesium Intake. During a median follow-up of 9.8 years, 8,544 women developed incident hypertension. After adjustment for age and randomized treatment, Magnesium Intake was inversely associated with the risk for developing hypertension; women in the highest quintile (median 434 mg/day) had a decreased risk for hypertension (relative risk 0.87, 95% confidence interval [CI] 0.81 to 0.93, p for trend <0.0001) compared with those in the lowest quintile (median 256 mg/day). This inverse association was attenuated but remained significant after further adjustment for known risk factors. In the fully adjusted model, the relative risks were 1.00 (95% CI 0.95 to 1.10), 1.02 (95% CI 0.95 to 1.10), 0.96 (95% CI 0.89 to 1.03), and 0.93 (95% CI 0.86 to 1.02) (p for trend = 0.03). Similar associations were observed for women who never smoked and reported no history of high cholesterol or diabetes at baseline. In conclusion, the results suggest that higher Intake of dietary Magnesium may have a modest effect on the development of hypertension in women.
Qi Dai - One of the best experts on this subject based on the ideXlab platform.
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physical activity dietary calcium to Magnesium Intake and mortality in the national health and examination survey 1999 2006 cohort
International Journal of Cancer, 2020Co-Authors: Xiangzhu Zhu, Martha J. Shrubsole, Elizabeth A. Hibler, Lifang Hou, Qi DaiAbstract:Calcium and Magnesium affect muscle mass and function. Magnesium and calcium are also important for optimal vitamin D status. Vitamin D status modifies the associations between physical activity and risk of incident cardiovascular disease (CVD) and CVD mortality. However, no study examined whether levels of Magnesium and calcium and the ratio of dietary calcium to Magnesium (Ca:Mg) Intake modify the relationship between physical activity and mortality. We included 20,295 National Health and Nutrition Examination Survey participants (1999-2006) aged >20 years with complete dietary, physical activity and mortality data (2,663 deaths). We assessed physical activity based on public health guidelines and sex-specific tertiles of MET-minutes/week. We used Cox proportional hazards models adjusted for potential confounding factors and stratified by the Intakes of Magnesium, calcium, Ca:Mg ratio. We found higher physical activity was significantly associated with reduced risk of total mortality and cause-specific mortality, regardless of Ca:Mg ratio, Magnesium or calcium Intake. In contrast, both moderate and high physical activity were significantly associated with substantially reduced risks of mortality due to cancer when Magnesium Intake was above the RDA level. We also found higher physical activity was significantly associated with a reduced risk of mortality due to cancer only when Ca:Mg ratios were between 1.7 and 2.6, although the interaction was not significant. Overall, dietary Magnesium and, potentially, the Ca:Mg ratio modify the relationship between physical activity and cause-specific mortality. Further study is important to understand the modifying effects of the balance between calcium and Magnesium Intake on physical activity for chronic disease prevention.
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associations between calcium and Magnesium Intake and the risk of incident gastric cancer a prospective cohort analysis of the national institutes of health american association of retired persons nih aarp diet and health study
International Journal of Cancer, 2020Co-Authors: Shailja C Shah, Xiangzhu Zhu, Qi Dai, Richard M Peek, Walter E Smalley, Christianne L Roumie, Martha J. ShrubsoleAbstract:Gastric cancer remains a leading cause of cancer-related mortality. Identifying dietary and other modifiable disease determinants has important implications for risk attenuation in susceptible individuals. Our primary aim was to estimate the association between dietary and supplemental Intakes of calcium and Magnesium and the risk of incident gastric cancer. We conducted a prospective cohort analysis of the National Institutes of Health-American Association of Retired Persons Diet and Health Study. We used Cox proportional hazard modeling to estimate the association between calcium and Magnesium Intakes with risk of incident gastric adenocarcinoma (GA) overall and by anatomic location, noncardia GA (NCGA) and cardia GA (CGA). A total of 536,403 respondents (59% males, 41% females) were included for analysis, among whom 1,518 incident GAs (797 NCGA and 721 CGA) occurred. Increasing calcium Intake was associated with lower risk of GA overall (p-trend = 0.05), driven primarily by the association with NCGA, where the above median calcium Intakes were associated with a 23% reduction in risk compared to the lowest quartile (p-trend = 0.05). This magnitude of NCGA risk reduction was greater among nonwhite ethnic group and Hispanics (hazard ratio [HR] 0.51, 95% confidence interval [CI]: 0.24-1.07, p-trend = 0.04), current/former smokers (HR 0.58, 95% CI: 0.41-0.81), obese individuals (HR 0.54, 95% CI: 0.31-0.96) and those with high NCGA risk scores (HR 0.50, 95% CI: 0.31-0.80). Among men only, increasing Magnesium Intake was associated with 22-27% reduced risk of NCGA (p-trend = 0.05), while for the cohort, dietary Magnesium Intake in the highest vs. lowest quartile was associated with a 34% reduced risk of NCGA (HR 0.66, 95% CI: 0.48-0.90). These findings have important implications for risk factor modification. Future investigations are needed not only to confirm our results, but to define mechanisms underlying these associations.
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associations between calcium and Magnesium Intake and the risk of incident oesophageal cancer an analysis of the nih aarp diet and health study prospective cohort
British Journal of Cancer, 2020Co-Authors: Shailja C Shah, Xiangzhu Zhu, Qi Dai, Richard M Peek, Christianne L Roumie, Martha J. ShrubsoleAbstract:Risk reduction through dietary modifications is an adjunct strategy for prevention of oesophageal cancer, a leading cause of cancer-related mortality and morbidity worldwide. We aimed to estimate the association between calcium and Magnesium Intakes and incident oesophageal cancer (OC). We conducted a retrospective analysis of the NIH-AARP Diet and Health Study prospective cohort. We used multivariable Cox proportional hazard modeling to estimate the association between total Intakes and incident OC overall and by histology (oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC)). Sensitivity and stratified analyses were performed. Among 536,359 included respondents, 1414 incident OCs occurred over 6.5 million person-years follow-up time. Increasing dietary calcium Intake was associated with an adjusted 32–41% lower risk of OSCC compared to the lowest quartile (p-trend 0.01). There was a positive association between increasing Magnesium Intake and OAC risk, but only among participants with low calcium:Magnesium Intake ratios (p-trend 0.04). There was a significant interaction with smoking status. Based on a retrospective analysis of the NIH-AARP Diet and Health Study prospective cohort, dietary Intakes of calcium and Magnesium were significantly associated with risk of OSCC and, among certain participants, OAC, respectively. If validated, these findings could inform dietary modifications among at-risk individuals. Mechanistic investigations would provide additional insight.
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abstract 4258 Magnesium Intake and mortality due to liver cancer and other liver diseases results from the third national health and nutrition examination survey cohort
Cancer Research, 2018Co-Authors: Zhu Xiangzhu, Yiqing Song, Martha J. Shrubsole, Lifang Hou, Edmond K Kabagambe, Meng-hua Tao, Lei Fan, Xiaosong Zhong, Jie Liu, Qi DaiAbstract:People with fatty liver disease are at high risk of Magnesium deficiency. Meanwhile, low Magnesium status is linked to both chronic inflammation and insulin resistance. However, no study has investigated the association between Intake of Magnesium and risk of mortality due to liver cancer and other liver diseases. We evaluated the association between total Magnesium Intake and mortality due to liver cancer and other liver diseases in the Third National Health and Nutrition Examination Study (NHANES III) cohort, which included 13,504 participants who completed liver ultrasound examination for hepatic steatosis. Overall Magnesium Intake was associated with a reduced risk of mortality due to liver cancer and other liver disease at borderline significance (P=0.05). In multi-variable adjusted models, every 100 mg increase in Intake of Magnesium was associated with a 49% reduction in the risk for mortality due to liver cancer and other liver diseases. Although interactions between Magnesium Intake and alcohol use and hepatic steatosis at baseline were not significant (P>0.05), inverse associations between Magnesium Intake with liver cancer and other liver disease mortality were stronger among alcohol drinkers and those with hepatic steatosis. Our novel findings suggest higher Intakes of Magnesium may be associated with a reduced risk of mortality due to liver cancer and other liver disease particularly among alcohol drinkers and those with hepatic steatosis. Further studies are warranted to confirm the findings. Citation Format: Zhu Xiangzhu, Lijun Wu, Lei Fan, Edmond K Kabagambe, Yiqing Song, Menghua Tao, Xiaosong Zhong, Lifang Hou, Martha J. Shrubsole, Jie Liu, Qi Dai. Magnesium Intake and mortality due to liver cancer and other liver diseases: Results from the Third National Health and Nutrition Examination Survey Cohort [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4258.
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abstract 1739 calcium to Magnesium Intake ratio and colorectal carcinogenesis results from the prostate lung colorectal and ovarian cancer screening trial
Cancer Research, 2016Co-Authors: Jing Zhao, Xiangzhu Zhu, Martha J. Shrubsole, Edward Giovannucci, Todd L Edwards, Wei Zheng, Qi DaiAbstract:Background A recent randomized trial found no effect of calcium supplementation on reducing risk of colorectal adenoma recurrence. However, the role of calcium in carcinogenesis is yet unconfirmed. An earlier trial found calcium treatment only reduced recurrence when the baseline calcium: Magnesium Intake ratio was Methods The PLCO is a large, multicenter, population-based randomized trial designed to determine the effects of screening on cancer-related mortality with a median of 12.5 years of follow up. We evaluated the associations between calcium Intake and the risks of incident colorectal adenoma (1,147 cases), recurrent adenoma (855 cases) and incident colorectal cancer (697 and 578 cases in intervention and control arms, respectively) among 108,563 PLCO participants aged 55 to 74 years. Odds ratios (OR) and 95% confidence intervals (95%CIs) for incident adenoma and recurrent adenoma, and hazard ratios (HR) and 95%CIs for colorectal cancer incidence were calculated using unconditional logistic regression models and Cox proportional hazard models after adjusting covariates. Results Compared to low calcium Intake ( Conclusion Intake of calcium may be more strongly related to reduced risks of incident advanced/multiple adenoma and incident colorectal cancer among those without active screening with flexible sigmoidoscopy than to recurrent adenoma and incident colorectal cancer risks among those with active screening with flexible sigmoidoscopy. Citation Format: Jing Zhao, Xiangzhu Zhu, Martha J. Shrubsole, Todd L. Edwards, Edward L. Giovannucci, Wei Zheng, Qi Dai, PLCO Project Team. Calcium to Magnesium Intake ratio and colorectal carcinogenesis, results from the Prostate, Lung, Colorectal, and Ovarian cancer screening trial. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1739.
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dose response relationship between dietary Magnesium Intake and cardiovascular mortality a systematic review and dose based meta regression analysis of prospective studies
Journal of Trace Elements in Medicine and Biology, 2016Co-Authors: Xin Fang, Jan Aaseth, Chun Liang, Scott Montgomery, Yang Cao, Katja FallAbstract:Abstract Background Although epidemiology studies have reported the relationship, including a dose-response relationship, between dietary Magnesium Intake and risk of cardiovascular disease (CVD), the risk for CVD mortality is inconclusive and the evidence for a dose-response relationship has not been summarized. Objective We conducted a systematic review and meta-analysis of prospective studies to summarize the evidence regarding the association of dietary Magnesium Intake with risk of CVD mortality and describe their dose-response relationship. Design We identified relevant studies by searching major scientific literature databases and grey literature resources from their inception to August 2015, and reviewed references lists of retrieved articles. We included population-based studies that reported mortality risks, i.e. relative risks (RRs), odds ratios (ORs) or hazard ratios (HRs) of CVD mortality or cause-specific CVD death. Linear dose-response relationships were assessed using random-effects meta-regression. Potential nonlinear associations were evaluated using restricted cubic splines. Results Out of 3002 articles, 9 articles from 8 independent studies met the eligibility criteria. These studies comprised 449,748 individuals and 10,313 CVD deaths. Compared with the lowest dietary Magnesium consumption group in the population, the risk of CVD mortality was reduced by 16% in women and 8% in men. No significant linear dose-response relationship was found between increment in dietary Magnesium Intake and CVD mortality across all the studies. After adjusting for age and BMI, the risk of CVD mortality was reduced by 24–25% per 100 mg/d increment in dietary Magnesium Intake in women of all the participants and in all the US participants. Conclusion Although the combined data confirm the role of dietary Magnesium Intake in reducing CVD mortality, the dose-response relationship was only found among women and in US population.
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dose response relationship between dietary Magnesium Intake and risk of type 2 diabetes mellitus a systematic review and meta regression analysis of prospective cohort studies
Nutrients, 2016Co-Authors: Xin Fang, Hedong Han, Zhongjie Fan, Jan Aaseth, Chun Liang, Scott Montgomery, Yang CaoAbstract:The epidemiological evidence for a dose-response relationship between Magnesium Intake and risk of type 2 diabetes mellitus (T2D) is sparse. The aim of the study was to summarize the evidence for the association of dietary Magnesium Intake with risk of T2D and evaluate the dose-response relationship. We conducted a systematic review and meta-analysis of prospective cohort studies that reported dietary Magnesium Intake and risk of incident T2D. We identified relevant studies by searching major scientific literature databases and grey literature resources from their inception to February 2016. We included cohort studies that provided risk ratios, i.e., relative risks (RRs), odds ratios (ORs) or hazard ratios (HRs), for T2D. Linear dose-response relationships were assessed using random-effects meta-regression. Potential nonlinear associations were evaluated using restricted cubic splines. A total of 25 studies met the eligibility criteria. These studies comprised 637,922 individuals including 26,828 with a T2D diagnosis. Compared with the lowest Magnesium consumption group in the population, the risk of T2D was reduced by 17% across all the studies; 19% in women and 16% in men. A statistically significant linear dose-response relationship was found between incremental Magnesium Intake and T2D risk. After adjusting for age and body mass index, the risk of T2D incidence was reduced by 8%-13% for per 100 mg/day increment in dietary Magnesium Intake. There was no evidence to support a nonlinear dose-response relationship between dietary Magnesium Intake and T2D risk. The combined data supports a role for Magnesium in reducing risk of T2D, with a statistically significant linear dose-response pattern within the reference dose range of dietary Intake among Asian and US populations. The evidence from Europe and black people is limited and more prospective studies are needed for the two subgroups.
