The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Lixin Wang - One of the best experts on this subject based on the ideXlab platform.
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organocatalytic direct asymmetric vinylogous Mannich Reaction of γ butenolides with isatin derived ketimines
RSC Advances, 2014Co-Authors: Yunlong Guo, Yong Zhang, Fang Tian, Lixin WangAbstract:The first direct asymmetric vinylogous Mannich Reaction of γ-butenolides with isatin-derived ketimines has been effectively realized promoted by a bifunctional quinidine-derived catalyst. A series of chiral 3-aminooxindole derivatives bearing adjacent tertiary and quaternary stereocenters with the butenolide moiety were obtained in excellent yields (up to 97%) and high enantioselectivities (up to 96% ee).
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direct asymmetric vinylogous Mannich Reaction of 3 4 dihalofuran 2 5h one with aldimine catalyzed by quinine
Journal of Organic Chemistry, 2012Co-Authors: Yunlong Guo, Fang Tian, Jianfei Bai, Lin Peng, Liangliang Wang, Lina Jia, Xiya Luo, Lixin WangAbstract:The direct asymmetric vinylogous Mannich Reaction of 3,4-dihalofuran-2(5H)-one with aldimine catalyzed by quinine was first reported, and γ-butenolides have been obtained in excellent yield (up to 98%) and enantioselectivities (up to 95% ee). The synthetic applications of this protocol are demonstrated in the preparations of γ-substituted amino butyrolactones and vicinal amino alcohols.
Subhas Chandra Pan - One of the best experts on this subject based on the ideXlab platform.
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primary amino acid catalyzed asymmetric intramolecular Mannich Reaction for the synthesis of 2 aryl 2 3 dihydro 4 quinolones
ChemInform, 2015Co-Authors: Buddhadeb Mondal, Subhas Chandra PanAbstract:Primary amino acids are found to be efficient catalysts for the direct asymmetric Mannich Reaction of 2-aminoacetoacetophenones with aldehydes furnishing 2-aryldihydroguinolones (III) (25 examples) in moderate to good yield and good to high enantioselectivities.
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primary amino acid catalyzed asymmetric intramolecular Mannich Reaction for the synthesis of 2 aryl 2 3 dihydro 4 quinolones
Organic and Biomolecular Chemistry, 2014Co-Authors: Buddhadeb Mondal, Subhas Chandra PanAbstract:Primary amino acids are found to be good enantioselective catalysts for the direct asymmetric Mannich Reaction between 2-amino acetophenone and aldehydes. The 2-aryl-2,3-dihydro-4-quinoline products are obtained in moderate to good yields and good to high enantioselectivities with 10 mol% of the primary amino acid catalyst under mild Reaction conditions.
Yunlong Guo - One of the best experts on this subject based on the ideXlab platform.
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organocatalytic direct asymmetric vinylogous Mannich Reaction of γ butenolides with isatin derived ketimines
RSC Advances, 2014Co-Authors: Yunlong Guo, Yong Zhang, Fang Tian, Lixin WangAbstract:The first direct asymmetric vinylogous Mannich Reaction of γ-butenolides with isatin-derived ketimines has been effectively realized promoted by a bifunctional quinidine-derived catalyst. A series of chiral 3-aminooxindole derivatives bearing adjacent tertiary and quaternary stereocenters with the butenolide moiety were obtained in excellent yields (up to 97%) and high enantioselectivities (up to 96% ee).
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direct asymmetric vinylogous Mannich Reaction of 3 4 dihalofuran 2 5h one with aldimine catalyzed by quinine
Journal of Organic Chemistry, 2012Co-Authors: Yunlong Guo, Fang Tian, Jianfei Bai, Lin Peng, Liangliang Wang, Lina Jia, Xiya Luo, Lixin WangAbstract:The direct asymmetric vinylogous Mannich Reaction of 3,4-dihalofuran-2(5H)-one with aldimine catalyzed by quinine was first reported, and γ-butenolides have been obtained in excellent yield (up to 98%) and enantioselectivities (up to 95% ee). The synthetic applications of this protocol are demonstrated in the preparations of γ-substituted amino butyrolactones and vicinal amino alcohols.
Gonghua Song - One of the best experts on this subject based on the ideXlab platform.
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concise synthesis of aromatic tertiary amines via a double petasis borono Mannich Reaction of aromatic amines formaldehyde and organoboronic acids
ChemInform, 2014Co-Authors: Jiayi Wang, Qiaoying Shen, Gonghua SongAbstract:A simple protocol for the conversion of various primary amines into tertiary amines via a double Petasis—borono Mannich Reaction is presented.
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concise synthesis of aromatic tertiary amines via a double petasis borono Mannich Reaction of aromatic amines formaldehyde and organoboronic acids
Tetrahedron Letters, 2014Co-Authors: Jiayi Wang, Qiaoying Shen, Gonghua SongAbstract:Abstract A simple and efficient strategy to construct aromatic tertiary amines via a double Petasis–borono Mannich Reaction of aromatic amines, formaldehyde, and organoboronic acids has been developed. The transformation provides a useful method for the synthesis of amine derivatives.
Danfeng Huang - One of the best experts on this subject based on the ideXlab platform.
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bifunctional thiourea catalyzed asymmetric Mannich Reaction using trifluoromethyl aldimine as trifluoromethyl building blocks
ChemInform, 2015Co-Authors: Ahmed Ebrahim Alkhalil, Xiaowen Xia, Siying Chong, Kehu Wang, Danfeng HuangAbstract:A bifunctional thiourea-catalyzed asymmetric Mannich Reaction using trifluoromethyl aldimine as trifluoromethyl building block affords indanecarboxylates as diastereomeric mixtures (III), each of them with high enantioselectivity.
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bifunctional thiourea catalyzed asymmetric Mannich Reaction using trifluoromethyl aldimine as trifluoromethyl building blocks
Synlett, 2015Co-Authors: Ahmed Ebrahim Alkhalil, Xiaowen Xia, Siying Chong, Kehu Wang, Danfeng HuangAbstract:An efficient bifunctional thiourea catalyzed asymmetric Mannich Reaction with trifluoromethyl aldimine as trifluoromethyl building block was achieved to give the products in good diastereoselectivity and enantioselectivity.