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Hasan Erdogan - One of the best experts on this subject based on the ideXlab platform.
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Hypo- versus hyper-thyroidism in 2 cats: the culprit for Miliary Dermatitis/hypersensitivity versus growth retardation
Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 2019Co-Authors: Songul Erdogan, Kerem Ural, Hasan ErdoganAbstract:Bu olgu sunumunda iki farkli kedide karsilasilan hipotiroidizme karsi hipertiroidizm iliskili farkli klinik bulgular sunuldu. Ilk olgumuz 3 aylik yasta, erkek, short-hair irki yavru kedi olup asiri cucelik sikayeti ile klinigimize getirilmistir. Radyografik bulgularinda uzun kemiklerde epifiziyal disgenezis ve epifiziyal kemiklesmede gecikme tespit edildi. Kongenital hipotiroidzm tanisi dusuk total tiroksin seviyesiyle desteklendi ve levotiroksin ile sagaltima baslanildi. Ikinci olgumuz ise sagaltima ragmen duzelmeyen dermatolojik bulgular ile klinigimize basvurdu. Klinik muayenede alopesi, yaygin kabuklanma ve kil ortusunde matlasma goruldu. Deriden alinan punc biyopsi sonuclari, artan serum total tiroksin ve serbest T4 ve iliskili miliyar Dermatitis ile hipertiroidizm tanisi konuldu. Bu olgumuzda metimazol ve hiperimmun sut faktoru baslanildi. Sonuc olarak her iki olgumuzda da erken tani ve sagaltim iliskili klinik bulgularin giderilmesine ve laboratuvar sonuclarina gore normal tiroid fonksiyonlarina kavusmalarina yol acti.
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hypo versus hyper thyroidism in 2 cats the culprit for Miliary Dermatitis hypersensitivity versus growth retardation
Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 2019Co-Authors: Songul Erdogan, Kerem Ural, Hasan ErdoganAbstract:Bu olgu sunumunda iki farkli kedide karsilasilan hipotiroidizme karsi hipertiroidizm iliskili farkli klinik bulgular sunuldu. Ilk olgumuz 3 aylik yasta, erkek, short-hair irki yavru kedi olup asiri cucelik sikayeti ile klinigimize getirilmistir. Radyografik bulgularinda uzun kemiklerde epifiziyal disgenezis ve epifiziyal kemiklesmede gecikme tespit edildi. Kongenital hipotiroidzm tanisi dusuk total tiroksin seviyesiyle desteklendi ve levotiroksin ile sagaltima baslanildi. Ikinci olgumuz ise sagaltima ragmen duzelmeyen dermatolojik bulgular ile klinigimize basvurdu. Klinik muayenede alopesi, yaygin kabuklanma ve kil ortusunde matlasma goruldu. Deriden alinan punc biyopsi sonuclari, artan serum total tiroksin ve serbest T4 ve iliskili miliyar Dermatitis ile hipertiroidizm tanisi konuldu. Bu olgumuzda metimazol ve hiperimmun sut faktoru baslanildi. Sonuc olarak her iki olgumuzda da erken tani ve sagaltim iliskili klinik bulgularin giderilmesine ve laboratuvar sonuclarina gore normal tiroid fonksiyonlarina kavusmalarina yol acti.
Songul Erdogan - One of the best experts on this subject based on the ideXlab platform.
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Hypo- versus hyper-thyroidism in 2 cats: the culprit for Miliary Dermatitis/hypersensitivity versus growth retardation
Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 2019Co-Authors: Songul Erdogan, Kerem Ural, Hasan ErdoganAbstract:Bu olgu sunumunda iki farkli kedide karsilasilan hipotiroidizme karsi hipertiroidizm iliskili farkli klinik bulgular sunuldu. Ilk olgumuz 3 aylik yasta, erkek, short-hair irki yavru kedi olup asiri cucelik sikayeti ile klinigimize getirilmistir. Radyografik bulgularinda uzun kemiklerde epifiziyal disgenezis ve epifiziyal kemiklesmede gecikme tespit edildi. Kongenital hipotiroidzm tanisi dusuk total tiroksin seviyesiyle desteklendi ve levotiroksin ile sagaltima baslanildi. Ikinci olgumuz ise sagaltima ragmen duzelmeyen dermatolojik bulgular ile klinigimize basvurdu. Klinik muayenede alopesi, yaygin kabuklanma ve kil ortusunde matlasma goruldu. Deriden alinan punc biyopsi sonuclari, artan serum total tiroksin ve serbest T4 ve iliskili miliyar Dermatitis ile hipertiroidizm tanisi konuldu. Bu olgumuzda metimazol ve hiperimmun sut faktoru baslanildi. Sonuc olarak her iki olgumuzda da erken tani ve sagaltim iliskili klinik bulgularin giderilmesine ve laboratuvar sonuclarina gore normal tiroid fonksiyonlarina kavusmalarina yol acti.
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hypo versus hyper thyroidism in 2 cats the culprit for Miliary Dermatitis hypersensitivity versus growth retardation
Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 2019Co-Authors: Songul Erdogan, Kerem Ural, Hasan ErdoganAbstract:Bu olgu sunumunda iki farkli kedide karsilasilan hipotiroidizme karsi hipertiroidizm iliskili farkli klinik bulgular sunuldu. Ilk olgumuz 3 aylik yasta, erkek, short-hair irki yavru kedi olup asiri cucelik sikayeti ile klinigimize getirilmistir. Radyografik bulgularinda uzun kemiklerde epifiziyal disgenezis ve epifiziyal kemiklesmede gecikme tespit edildi. Kongenital hipotiroidzm tanisi dusuk total tiroksin seviyesiyle desteklendi ve levotiroksin ile sagaltima baslanildi. Ikinci olgumuz ise sagaltima ragmen duzelmeyen dermatolojik bulgular ile klinigimize basvurdu. Klinik muayenede alopesi, yaygin kabuklanma ve kil ortusunde matlasma goruldu. Deriden alinan punc biyopsi sonuclari, artan serum total tiroksin ve serbest T4 ve iliskili miliyar Dermatitis ile hipertiroidizm tanisi konuldu. Bu olgumuzda metimazol ve hiperimmun sut faktoru baslanildi. Sonuc olarak her iki olgumuzda da erken tani ve sagaltim iliskili klinik bulgularin giderilmesine ve laboratuvar sonuclarina gore normal tiroid fonksiyonlarina kavusmalarina yol acti.
Robert G Sherding - One of the best experts on this subject based on the ideXlab platform.
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Saunders Manual of Small Animal Practice
2006Co-Authors: Stephen J Birchard, Robert G SherdingAbstract:Section 1: Patient Management. Chapter 1: History and Physical . Examination. Practical Methods of Anesthesia. Critical Care Techniques. Radiographic and Ultrasonographic Techniques. Fluid Therapy for Dogs and Cats. Section 2: Infectious Diseases. Feline Leukemia Virus. Feline Immunodeficiency. Virus. Feline Infectious Peritonitis. Feline Infectious Respiratory Diseases Complex: Herpesvirus, Calicivirus, And Chlamydia. Canine Infectious Tracheobronchitis (Kennel Cough Complex). Canine Distemper. Intestinal Viruses. Rabies and Pseudorabies. Other Viral Diseases. Rickettsia. Lyme Disease. Leptospirosis, Brucellosis, Infectious, And Other Bacterial Diseases. Systemic Mycoses. Toxoplasmosis, Neosporosis, And Other Multisystemic Protozoal Infections. Section 3: Hematology/Oncology. Erthrocytes, Leukocytes, And Platelets. Coagulation Diseases. Systemic Immune-Mediated Disease. Diseases of the Spleen. Principles of Oncology. Lymphoproliferative Diseases. Tumors of Soft-Tissue Origin. Mammary Gland Neoplasia. Tumors of the Skin and Subcutaneous Tissue. Section 4: Endocrine & Metabolic Disorders. Thyroid Disorders. Diseases of the Parathyroid and Calcium Metabolism. Adrenal Diseases. Diabetes Mellitus. Pancreatic Beta Cell Neoplasia. Diseases of the Hypothalamus and Pituitary. Section 5: Skin and Ear Diseases. Pyoderma. Mycobacteriosis. Dermatophytosis. Demodicosis. Scabies, Notoedric Mange, And Cheyletiellosis. Flea Allergy. Atopy (Food Hypersensitivity). Recognition and Therapy of Food Allergy Dermatitis. Heart Failure. Immune-Mediated Dermatoses. Keratinization Defects. Growth Hormone-Responsive Alopecia and Sex Hormone-Associated Dermatoses. Necrotizing Skin Diseases. Feline Symmetric Alopecia. Miliary Dermatitis and Eosinophilic Granuloma Complex. Skin Biopsy. Surgery of Intertriginous Dermatoses. Management of the Traumatic Wound By Primary Closure. Management of the Open Wound. Selected Skin Graft and Reconstructive Techniques. Diseases of the Pinna. Otitis Externa. Surgical Management of Otitis Externa. Otitis Media and Otitis Interna. Surgery for Otitis Media and Otitis Interna. Section 6: Cardiopulmonary System. Auscultation and Physical Diagnosis. Radiographic Evaluation. Electrocardiography. Disorders of Cardiac Rhythm. Drugs Used for CV Therapy. Valvular Heart Disease. Cardiomyopathy. Pericardial Diseases and Cardiac Neoplasia. Heartworm Disease. Vascular Diseases. Congenital Heart Diseases. Surgical Correction of Patent. Ductus Arteriosus. Shock. Cardiopulmonary Resuscitation. Diagnostic Methods inRespiratory Disorders. Diagnostic Methods in Respiratory Disease. Diseases of the Nasal Cavity. Obstructive Upper Airway Disorders. Chronic Bronchopulmonary Disease. Respiratory Infection. Pleural Effusion. Respiratory Neoplasia. Thoracic Trauma. Principles of Thoracic Surgery. Section 7: Gastrointestinal Disorders. Dentistry and Diseases of the Oropharynx. Diseases of the Esophagus and Disorders of Swallowing. Surgery of the Esophagus. Diseases of the Stomach. Surgery of the Stomach. Surgery of the Stomach. Diseases of the Intestines. Surgery of the Intestines. Diseases of the Liver and Biliary System. Surgery of the Liver and Biliary System. Diseases and Surgery of the Exocrine Pancreas. Anorectal Diseases. Anorectal Surgery. Peritonitis. Section 8: Disorders of the Urogenital System. Diseases of the Kidney and Ureter. Surgery of the Kidney and Ureter. Diseases of the Urinary Bladder. Surgery of the Urinary Bladder. Diseases of the Urethra. Surgery of the Urethra. Micturition Disorders. Diseases of the Prostate Gland. Surgery of the Prostate Gland. Diseases of the Testes and Scrotum. Surgery of the Testes and Scrotum. Diseases of the Penis and Prepuce. Surgery of the Penis and Prepuce. Diseases of the Ovaries and Uterus. Surgery of the Ovaries and Uterus. Diseases of the Vagina and Vulva. Surgery of the Vagina and Vulva. Breeding Disorders. Section 9: Disorders of the Skeletal System. Fractures of the Skull. Fractures and Dislocations of the Mandible. Fractures of the Maxilla. Neoplasia of the Maxilla and Mandible. Fractures and Dislocation of the Spine. Neoplasia of the Axial Skeleton. Fractures of the Shoulder. Scapulohumeral Luxation. Fractures of the Humerus. Fractures and Growth Deformities of the Radius and Ulna. Fractures and Dislocations of the Carpus.Fractures of the Pelvis. Coxofemoral Joint . Fractures of the Femur. Orthopedic Disorders of the Stifle. Fractures of the Tibia and Fibula. Luxation and Shearing Injuries of the Tarsal Joint. Orthopedic Disorders of the Distal Extremities. Amputation of the Digit. Surgery of Skeletal Muscle and Tendons. Neoplasia of Thoracic and Pelvic Limbs. Miscellaneous Diseases of Bone. Osteochondrosis. Pediatric Fractures. Open Fractures. Osteomyelitis. Delayed Unions, Malunions, And Non-Unions. Osteoarthritis. Immune-Mediated Arthritis. Section 10: Neuromuscular System. Diagnostic Approach to Neurologic Disease. Diseases of the Brain and Cranial Nerves. Seizures. Spinal Cord Disorders. Peripheral Nerve Disorders. Disorders of Muscle and Neuromuscular Junction. Section 11: Ophthalmology . Introduction to Ophthalmology. Diseases of the Eyelids. Diseases of the Conjunctiva. Diseases of the Cornea and Sclera. Diseases of the Lens. Anterior Uveitis. Glaucoma. Diseases of the Retina, Choroid, And Optic Nerve. Diseases of theLacrimal Apparatus. Diseases of the Orbit. Neuro-Ophthalmology.
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Saunders manual of small animal practice. [electronic book]
Online access with purchase: Elsevier (Veterinary Medicine pre-2007), 2006Co-Authors: Stephen J Birchard, Robert G SherdingAbstract:Summary: Meticulously organized by body system for optimal readability and ease of reference, the 3rd edition of this best-selling manual provides quick, comprehensive, and practical guidance on evaluating and managing a full range of common medical and surgical conditions encountered in small animal practice. Medical chapters discuss etiology, clinical signs, diagnoses and treatment, while surgical chapters discuss anatomy, preoperative considerations, procedures and postoperative care. It also contains an entire section devoted to avian and exotic pets and a comprehensive drug formulary. A consistent outline format provides easy access to information on etiology, clinical signs, diagnosis, and treatment for each disease or disorder, as well as anatomy, preoperative conditions, techniques, and postoperative care for surgical procedures.Key Points draw attention to helpful tips and key concepts.Includes a comprehensive section covering diagnosis, treatment, and surgery for avian and exotic pets. Section 1Patient Management -- 1.History and Physical Examination -- 2.Practical Methods of Anesthesia -- 3.Critical Care Techniques -- 4.Radiographic and Ultrasonographic Techniques -- 5.Fluid Therapy for Dogs and Cats -- 6.Pain Management -- Section 2Infectious Disease -- 7.Vaccination Guidelines -- 8.Feline Leukemia Virus -- 9.Feline Immunodeficiency Virus -- 10.Feline Coronavirus and FIP -- 11.Feline Infectious Respiratory Disease Complex -- 12.Canine Infectious Tracheobronchitis (Kennel Cough) -- 13.Canine Distemper -- 14.Intestinal Viruses -- 15.Rabies and Pseudorabies -- 16.Miscellaneous Viral Diseases -- 17.Rickettsiosis, Ehrlichiosis, Anaplasmosis, and Neorickettsiosis -- 18.Borreliosis (Lyme Disease) -- 19.Systemic Bacterial Infectious Diseases -- 20.Systemic Mycoses -- 21.Toxoplasmosis and Other Systemic Protozoal Infections -- Section 3 Hematology/Oncology -- 22.Erythrocytes, Leukocytes and Platelets -- 23.Coagulation Diseases -- 24.Systemic Immune-Mediated Diseases -- 25.Diseases of the Spleen -- 26.Principles of Oncology -- 27.Lymphoid Neoplasia -- 28.Soft Tissue Sarcomas and Mast Cell Tumors -- 29.Mammary Gland Neoplasia -- 30.Tumors of the Skin and Subcutaneous Tissues -- Section 4Endocrine and Metabolic Disorders -- 31.Diseases of the Thyroid Gland -- 32.Diseases of the Parathyroid Gland and Calcium Metabolism -- 33.Diseases of the Adrenal Gland -- 34.Diabetes Mellitus -- 35.Pancreatic Beta Cell Neoplasia -- 36.Diseases of the Hypothalamus and Pituitary -- Section 5Skin and Ear Diseases -- 37.Skin Cytology and Biopsy -- 38.Pyoderma -- 39.Mycobacteriosis -- 40.Deep Fungal Infections -- 41.Malassezia Dermatitis -- 42.Dermatophytosis -- 43.Demodicosis -- 44.Scabies, Notoedric Mange, Cheyletiellosis -- 45.Flea Allergy Dermatitis -- 46.Atopic Dermatitis -- 47.Food Hypersensitivity -- 48.Immune-Mediated Dermatoses -- 49.Necrotizing Dermatoses -- 50.Keratinization Defects -- 51.Growth Hormone and Sex Hormone 6 Associated Dermatoses -- 52.Feline Symmetric Alopecia -- 53.Miliary Dermatitis and Eosinophilic Granuloma Complex -- 54.Surgery of Intertriginous Dermatoses -- 55.Management of Traumatic Wounds by Primary Closure -- 56.Management of the Open Wound -- 57.Selected Skin Graft and Reconstructive Techniques -- 58.Diseases of the Pinna -- 59.Otitis Externa -- 60.Surgery of External Ear Canal and Pinna -- 61.Otitis Media and Interna -- 62.Surgery for Otitis Media and Otitis Interna -- 63.Disorders of the Claw -- Section 6Digestive System -- 64.Oropharnyx -- 65.Diseases of the Esophagus and Disorders of Swallowing -- 66.Surgery of the Esophagus -- 67.Diseases of the Stomach -- 68.Surgery of the Stomach -- 69.Diseases of the Intestines -- 70.Surgery of the Intestines -- 71.Diseases of the Liver and Biliary Tract -- 72.Surgery of the Liver and Biliary Tract -- 73.Diseases and Surgery of the Exocrine Pancreas -- 74.Anorectal Diseases -- 75.Anorectal Surgery -- 76.Peritonitis -- Section 7Disorders of the Urogenital Sysetm -- 77.Diseases of the Kidney and Ureter -- 78.Surgery of the Kidney and Ureter -- 79.Diseases of the Urinary Bladder -- 80.Surgery of the Urinary Bladder -- 81.Disease of the Urethra -- 82.Surgery of the Urethra -- 83.Disorders of Micturition -- 84.Diseases of the Prostate Gland -- 85.Surgery of the Prostate Gland -- 86.Diseases of the Testes and Scrotum -- 87.Surgery of the Testes and Scrotum -- 88.Disease of the Penis and Prepuce -- 89.Surgery of the Penis and Prepuce -- 90.Disease of the Ovaries and Uterus -- 91.Surgery of the Ovaries and Uterus -- 92.Disease of the Vulva and Vagina -- 93.Surgery of the Vulva and Vagina -- 94.Infertility and Breeding Disorders -- Section 8Skeletal System -- 95.Physical Therapy and Rehabilitation (NEW!) -- 96.Fractures of the Skull -- 97.Fractures and Dislocations of the Mandible -- 98.Fractures of the Maxilla -- 99.Neoplasia of the Maxilla and Mandible -- 100.Fractures and Dislocations of the Spine -- 101.Neoplasia of the Axial Skeleton -- 102.Fractures of the Shoulder -- 103.Scapulo-Humeral Luxation -- 104.Fractures of the Humerus -- 105.Fractures and Grow h Deformities of the Radius and Ulna -- 106.Fractures and Dislocations of the Carpus -- 107.Fractures of the Pelvis -- 108.Disorders of the Coxofemoral Joint -- 109.Fractures of the Femur -- 110.Orthopedic Disorders of the Stifle -- 111.Fractures of the Tibia and Fibula -- 112.Luxation, Subluxation, and Shearing Injuries of the Tarsal Joint -- 113.Orthopedic Disorders of the Distal Extremities -- 114.Amputation of the Digit -- 115.Surgery of the Skeletal Muscle and Tendon -- 116.Neoplasia of the Thoracic and Pelvic Limbs -- 117.Miscellaneous Diseases of the Bone -- 118.Osteochondrosis -- 119.Pediatric Fractures -- 120.Open Fractures -- 121.Osteomyelitis -- 122.Delayed Unions, Nonunions, Malunions -- 123.Osteoarthritis -- 124.Immune-Mediated Arthritis -- Section 9Nervous System -- 125.Diagnostic Approach to Neurologic Disease -- 126.Diseases of the Brain -- 127.Seizures -- 128.Disorders of the Spinal Cord -- 129.Peripheral Nerve Disorders -- 130.Disorders of Muscle and Neuromuscular Junction -- Section 10Ophthalmology -- 131.Ophthalmic Equipment and Techniques -- 132.Diseases of the Eyelid -- 133.Diseases of the Conjunctiva -- 134.Diseases of the Cornea and Sclera -- 135.Diseases of the Lens -- 136.Diseases of the Uvea -- 137.Glaucoma -- 138.Diseases of the Retina, Choroid and Optic Nerve -- 139.Diseases of the Lacrimal Apparatus -- 140.Diseases of the Orbit -- 141.Neuro-ophthalmology -- Section 11 Cardiopulmonary System -- 142.Auscultation and Physical Diagnosis -- 143.Cardiovascular Radiography -- 144.Electrocardiography -- 145.Disorders of Cardiac Rhythm -- 146.Drugs for Treatment of Cardiovascular Diseases -- 147.Syncope -- 148.Heart Failure -- 149.Valvular Heart Disease -- 150.Cardiomyopathy -- 151.Pericardial Diseases and Cardiac Neoplasia -- 152.Heartworm Disease -- 153.Vascular Diseases -- 154.Congenital Heart Disease -- 155.Surgical Correction of Patent Ductus Arteriosus -- 156.Shock -- 157.Cardiopulmonary Cerebral Resuscitation -- 158.Diagnostic Methods in Respiratory Disease -- 159.Diagnostic Imaging in Respiratory Disease -- 160.Surgery of the Nasal Cavity and Sinuses -- 161.Obstructive Upper Airway Disorders -- 162.Bronchopulmonary Disease -- 163.Respiratory Infections -- 164.Pleural Effusion -- 165.Respiratory Neoplasia -- 166.Thoracic Trauma -- 167.Principles of Thoracic Surgery -- Section 12 Diseases of Avian and Exotic Pets -- 168.Avian Techniques -- 169.Avian Infectious Diseases -- 170.Avian Dermatology -- 171.Disorders of the Avian Respiratory System -- 172.Disorders of the Avian Digestive System -- 173.Avian Obstetric Medicine -- 174.Disorders of the Avian Nervous System -- 175.Ferrets -- 176.Rabbits -- 177.Pet Rodents -- 178.Basic Husbandry and Medicine of Pet Reptiles.
Claude Favrot - One of the best experts on this subject based on the ideXlab platform.
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Clinical symptomps, diagnosis and therapy of feline allergic Dermatitis
Schweizer Archiv Fur Tierheilkunde, 2014Co-Authors: Claude Favrot, Ana Rostaher, Nina M. FischerAbstract:Allergies are often suspected in cats and they are mainly hypersensitivity reactions against insect bites, food- or environmental allergens. Cats, with non flea induced atopic Dermatitis, normally present with one oft he following reaction patterns: Miliary Dermatitis, eosinophilic Dermatitis, selfinduced alopecia or head and neck excoriations. None of these reaction patterns is nevertheless pathognomonic for allergic Dermatitis, therefore the diagnosis is based on the one hand on the exclusion of similar diseases on the other hand on the successful response on a certain therapy. Recently a study on the clinical presentation of cats with non flea induced atopic Dermatitis was published. In this study certain criteria for diagnosing atopy in cats were proposed. For therapy of allergic cats cyclosporin, glucocorticoids, antihistamines, hypoallergenic diets and allergen specific immunotherapy are used. This article should provide a recent overview on the clinical symptoms, diagnosis and therapy of feline allergic Dermatitis.
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Feline non-flea induced hypersensitivity Dermatitis: clinical features, diagnosis and treatment.
Journal of Feline Medicine and Surgery, 2013Co-Authors: Claude FavrotAbstract:Practical relevance:Hypersensitivity Dermatitis (HD) is often suspected in cats and is mostly caused by insect bites, food or environmental allergens. Cats with non-flea induced HD are reported to present frequently with one or more of the following cutaneous reaction patterns: Miliary Dermatitis, eosinophilic Dermatitis, self-induced symmetrical alopecia or head and neck excoriations/pruritus.Clinical challenges:None of the above patterns are, however, pathognomonic for non-flea induced HD and the diagnosis of this condition is based on exclusion of diseases presenting similarly and an adequate response to treatment. Therapeutic approaches to affected cats include use of immunomodulatory drugs (ciclosporin, glucocorticoids, antihistamines), hypoallergenic diets and allergen-specific immunotherapy.Evidence base:This review provides an update on the clinical signs, diagnosis and treatment of feline non-flea induced HD. It draws on the findings of a recent large-scale study that described the clinical signs...
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Establishment of diagnostic criteria for feline nonflea‐induced hypersensitivity Dermatitis
Veterinary Dermatology, 2011Co-Authors: Claude Favrot, Jean Steffan, Thierry Olivry, Wolfgang Seewald, Stefan Hobi, Monika Linek, Geneviève Marignac, Luc Beco, Claudia Nett, Jacques FontaineAbstract:Hypersensitivity dermatitides (HD) are commonly seen in cats, and they are usually caused by environmental, food and/or flea allergens. Affected cats normally present with one of the following clinical reaction patterns: head and neck excoriations, usually symmetrical self-induced alopecia, eosinophilic skin lesions or Miliary Dermatitis. Importantly, none of these clinical presentations is considered to be pathognomonic for HD skin diseases, and the diagnosis of HD is usually based on the exclusion of other pruritic diseases and on a positive response to therapy. The objectives of this study were to propose sets of criteria for the diagnosis of nonflea-induced HD (NFHD). We recruited 501 cats with pruritus and skin lesions and compared clinical parameters between cats with NFHD (encompassing those with nonflea, nonfood HD and those with food HD), flea HD and other pruritic conditions. Using simulated annealing techniques, we established two sets of proposed criteria for the following two different clinical situations: (i) the diagnosis of NFHD in a population of pruritic cats; and (ii) the diagnosis of NFHD after exclusion of cats with flea HD. These criteria sets were associated with good sensitivity and specificity and may be useful for homogeneity of enrolment in clinical trials and to evaluate the probability of diagnosis of NFHD in clinical practice. Finally, these criteria were not useful to differentiate cats with NFHD from those with food HD.
F. Scarampella - One of the best experts on this subject based on the ideXlab platform.
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Prospective open pilot study on the use of ciclosporin for feline allergic skin disease.
Journal of Small Animal Practice, 2006Co-Authors: C. Noli, F. ScarampellaAbstract:Objectives: To evaluate the efficacy of ciclosporin in cats with allergic skin disease. Methods: Ten cats with signs of allergic skin disease were administered ciclosporin daily at a dose of 3·6 to 8·3 mg/kg for one month. None of these cats had previously responded to a hypoallergenic diet trial, and all animals had previously been treated with endectoparasiticidal drugs, with no improvement two weeks before entering the trial. On days 0 and 30, owners assessed pruritus with a visual analogue scale, and veterinarians evaluated cutaneous lesions. Results: All the cats had pruritus and erythema, five had alopecia, two had an eosinophilic plaque, one had Miliary Dermatitis and two had both alopecia and an eosinophilic plaque. Good or excellent improvement was observed in 40 per cent of cats for pruritus, 57 per cent of cats for alopecia and 60 per cent of cats for erythema. A significant decrease in mean scores was observed for pruritus only, while for erythema and alopecia, it was close to being significant (P
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FC-41 A prospective pilot study on the use of cyclosporin on feline allergic diseases
Veterinary Dermatology, 2004Co-Authors: C. Noli, F. ScarampellaAbstract:The efficacy of cyclosporin in canine atopic Dermatitis has been well documented, but reports on its use in feline allergic dermatoses are scarce. The aim of this study was to evaluate the efficacy of cyclosporin in cats affected by pruritus and eosinophilic dermatoses. Ten otherwise healthy cats were selected. All cats had no response to a hypoallergenic diet trial, had not been treated with short-acting corticosteroids or antihistamines for at least 2 weeks, had not been treated with long-acting steroids for 2 months, and had been treated with endo- and ectoparasiticidal drugs with no improvement 2 weeks before entering the study. All cats were pruritic and had erythema, seven had alopecia, five had an eosinophilic plaque, three had facial pruritus, one had Miliary Dermatitis, and one had an eosinophilic granuloma. Cyclosporin was administered daily at the dosage of 5 mg/kg for 1 month. Owners assessed pruritus by means of a visual analogue scale, and veterinarians evaluated cutaneous lesions on days 0 and 30 by a newly developed index called Feline Eosinophilic Granuloma, Eosinophilic Plaque, Extension and Severity Index (FEGEPESI), similar to the Canine Atopic Dermatitis Extension and Severity Index (CADESI). Fifty percent of the cats had a reduction of pruritus ≥ 50%, and in 50% of the animals, the lesions improved or disappeared completely. However, overall pruritus and FEGEPESI scores did not improve significantly. In conclusion, cyclosporin was helpful in symptomatically treating about half of the cases of feline pruritus and eosinophilic dermatitides. Funding: Novartis.