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Reiko Tanaka - One of the best experts on this subject based on the ideXlab platform.
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new class azaphilone produced by a marine fish derived chaetomium globosum the stereochemistry and biological activities
Bioorganic & Medicinal Chemistry, 2011Co-Authors: Takeshi Yamada, Yasuhide Muroga, Atsushi Numata, Masaaki Jinno, Tetsuya Kajimoto, Yoshihide Usami, Reiko TanakaAbstract:Four new metabolites, chaetoMugilins P–R and 11-epi-chaetoMugilin I, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and various chemical transformations. Particularly, the skeleton of chaetoMugilin P is different from that of other azaphilones isolated from this fungal strain to date. In addition, these compounds significantly inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines.
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chaetoMugilins i o new potent cytotoxic metabolites from a marine fish derived chaetomium species stereochemistry and biological activities
Tetrahedron, 2009Co-Authors: Yasuhide Muroga, Takeshi Yamada, Atsushi Numata, Reiko TanakaAbstract:Abstract ChaetoMugilins I–O were isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, as well as chemical transformations. These compounds exhibited significant growth inhibition of cultured P388, HL-60, L1210, and KB cell lines. In addition, chaetoMugilin I showed selective cytotoxic activity against 39 human cancer cell lines.
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Absolute stereostructures of chaetoMugilins G and H produced by a marine-fish-derived Chaetomium species
The Journal of Antibiotics, 2009Co-Authors: Takeshi Yamada, Hirohumi Shigeta, Atsushi Numata, Muroga Yasuhide, Reiko TanakaAbstract:ChaetoMugilins G and H were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish, Mugil cephalus , and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and chemical transformation. In addition, the absolute configuration of chaetoviridin C was established by derivatization from chaetoMugilin A. These compounds exhibited a growth inhibitory activity against cultured P388, HL-60, L1210 and KB cells.
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chaetoMugilins new selectively cytotoxic metabolites produced by a marine fish derived chaetomium species
The Journal of Antibiotics, 2008Co-Authors: Muroga Yasuhide, Takeshi Yamada, Atsushi Numata, Reiko TanakaAbstract:ChaetoMugilins A∼F have been isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, some chemical transformations and an X-ray analysis. These compounds exhibited significant growth inhibition against cultured P388 cells and HL-60 cells. In addition, chaetoMugilins A, C and F showed selective cytotoxic activities against 39 human cancer cell lines.
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absolute stereostructures of cytotoxic metabolites chaetoMugilins a c produced by a chaetomium species separated from a marine fish
Tetrahedron Letters, 2008Co-Authors: Takeshi Yamada, M Doi, Hirohumi Shigeta, Yasuhide Muroga, Saki Hosoe, Atsushi Numata, Reiko TanakaAbstract:ChaetoMugilins A–C were isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques, some chemical transformations, and an X-ray analysis. This compound exhibited significant cytotoxicity against cultured P388 cells and HL-60 cells.
Assem M Elshazly - One of the best experts on this subject based on the ideXlab platform.
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Preliminary observations on infection of brackish and fresh water fish by heterophyid encysted metacercariae in Egypt
Parasitology Research, 2008Co-Authors: Hany M Elsheikha, Assem M ElshazlyAbstract:The infection status with heterophyids in the second intermediate host fish obtained from brackish and fresh water resources in Dakahlia governorate, northern Egypt was investigated. Encysted metacercariae (EMC) in the fish species Mugil cephalus , Mugil capito , Mugil auratus , Tilapia nilotica , and Tilapia zilli from brackish water and T. nilotica and T. zilli from fresh water were isolated by artificial digestion method and identified by microscopic examination. Morphometric analysis of EMC isolated from these fishes identified seven phenotypically distinct groups. No significant morphologic differences were detected between EMC of the same group obtained from different fish species. The adult flukes recovered from seven groups of puppies separately infected with distinct EMC groups were compatible with seven species belong to six genera of Heterophyidae namely Heterophyes heterophyes , Heterophyes aequalis , Pygidiopsis genata , Haplorchis yokogawi , Prohemostomum vivax , Phagicola ascolonga , and Stictodora tridactyla . EMC of these seven heterophyid species were detected in all examined brackish water fishes. On the other hand, only EMC of P. genata , H. yokogawi , and P. ascolonga were detected in fresh water fishes, T. nilotica and T. zilli . These results indicate that heterophyid infections occur in brackish and fresh water fishes in northern Egypt, where the parasites are indigenous.
Takeshi Yamada - One of the best experts on this subject based on the ideXlab platform.
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new class azaphilone produced by a marine fish derived chaetomium globosum the stereochemistry and biological activities
Bioorganic & Medicinal Chemistry, 2011Co-Authors: Takeshi Yamada, Yasuhide Muroga, Atsushi Numata, Masaaki Jinno, Tetsuya Kajimoto, Yoshihide Usami, Reiko TanakaAbstract:Four new metabolites, chaetoMugilins P–R and 11-epi-chaetoMugilin I, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and various chemical transformations. Particularly, the skeleton of chaetoMugilin P is different from that of other azaphilones isolated from this fungal strain to date. In addition, these compounds significantly inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines.
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chaetoMugilins i o new potent cytotoxic metabolites from a marine fish derived chaetomium species stereochemistry and biological activities
Tetrahedron, 2009Co-Authors: Yasuhide Muroga, Takeshi Yamada, Atsushi Numata, Reiko TanakaAbstract:Abstract ChaetoMugilins I–O were isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, as well as chemical transformations. These compounds exhibited significant growth inhibition of cultured P388, HL-60, L1210, and KB cell lines. In addition, chaetoMugilin I showed selective cytotoxic activity against 39 human cancer cell lines.
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Absolute stereostructures of chaetoMugilins G and H produced by a marine-fish-derived Chaetomium species
The Journal of Antibiotics, 2009Co-Authors: Takeshi Yamada, Hirohumi Shigeta, Atsushi Numata, Muroga Yasuhide, Reiko TanakaAbstract:ChaetoMugilins G and H were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish, Mugil cephalus , and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and chemical transformation. In addition, the absolute configuration of chaetoviridin C was established by derivatization from chaetoMugilin A. These compounds exhibited a growth inhibitory activity against cultured P388, HL-60, L1210 and KB cells.
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chaetoMugilins new selectively cytotoxic metabolites produced by a marine fish derived chaetomium species
The Journal of Antibiotics, 2008Co-Authors: Muroga Yasuhide, Takeshi Yamada, Atsushi Numata, Reiko TanakaAbstract:ChaetoMugilins A∼F have been isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, some chemical transformations and an X-ray analysis. These compounds exhibited significant growth inhibition against cultured P388 cells and HL-60 cells. In addition, chaetoMugilins A, C and F showed selective cytotoxic activities against 39 human cancer cell lines.
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absolute stereostructures of cytotoxic metabolites chaetoMugilins a c produced by a chaetomium species separated from a marine fish
Tetrahedron Letters, 2008Co-Authors: Takeshi Yamada, M Doi, Hirohumi Shigeta, Yasuhide Muroga, Saki Hosoe, Atsushi Numata, Reiko TanakaAbstract:ChaetoMugilins A–C were isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques, some chemical transformations, and an X-ray analysis. This compound exhibited significant cytotoxicity against cultured P388 cells and HL-60 cells.
Francesco Fazio - One of the best experts on this subject based on the ideXlab platform.
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haematological and biochemical response of Mugil cephalus after acclimation to captivity
2014Co-Authors: Caterina Faggio, Francesca Arfuso, Michele Panzera, Grazia Fedele, Francesco FazioAbstract:In this study the effect of acclimation to captivity on haematological and biochemical parameters of Mugil cephalus was investigated. A total of fifteen fish (21.93 ± 2.03 cm fork length; 80.28 ± 21.32 g weight) was harvested from a Reservoir-Faro Lake, Messina (Italy). Immediately after capture blood samples was collected on all fish to evaluate haematological parameters, glucose and lactate levels. Then, all animals were transferred in tank and acclimated for a period of 15 days. After this acclimate period, on all fish blood samples were collected and the blood parameter were assessed again. Paired t-test, used to determine significant differences between blood parameters measured before and after acclimation, showed that after acclimation to captivity, there was significant reduction (P < 0.001) in red blood cell (RBC), Haematocrit (Hct), Haemoglobin concentration (Hgb), White Blood Cell Count (WBC). Lactate and total proteins values increased significantly after acclimation (P < 0.001 and P < 0.05, respectively), while glucose blood concentration decreased significantly (P < 0.001). The results of this study showed how haematological and biochemical parameters of the mullet change after acclimation to captivity. Resume : Reponse hematologique et biochimique de Mugil cephalus apres acclimatation a la captivite. Cette etude implique les repercussions de l'acclimatation a la captivite sur les parametres hematologiques et biochimiques du Mugil cephalus. Quinze poissons (longueur a la fourche: 21,93 ± 2,03 cm ; poids: 80,28 ± 21,32 g) ont ete preleves dans le lac Faro, Messine (Italie). Tout de suite apres la capture, des prelevements de sang ont ete recueillis de chaque poisson pour evaluer les parametres hematologiques et les niveaux de glucose et lactate. Ensuite, les animaux ont ete transferes dans des citernes et acclimates pendant 15 jours. Apres cette periode d'acclimatation, des prelevements de sang de chaque poisson ont ete recueillis pour evaluer les parametres hematologiques. Un test t apparie, utilise pour comparer les parametres hematologiques mesures avant et apres l'acclimatation, a montre qu'apres l'acclimatation a la captivite, s'il existe une reduction significative (P < 0,001) des globules rouges, de l'hematocrite, de la concentration en hemoglobine et du nombre des globules blancs, les valeurs de lactate et des proteines totales etaient significativement augmentees apres l'acclimatation (P < 0,001 and P < 0,05, respectivement), bien que la concentration de glucose dans le sang etait significativement diminuee (P < 0,001). Les resultats de cette etude ont montre comment les parametres hematologiques et biochimiques des mulets changent apres l'acclimatation a la captivite.
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influence of different salinity on haematological and biochemical parameters of the widely cultured mullet Mugil cephalus
Marine and Freshwater Behaviour and Physiology, 2013Co-Authors: Francesco Fazio, Simona Marafioti, Francesca Arfuso, Giuseppe Piccione, Caterina FaggioAbstract:This study investigates and reports on the effects of salinity levels on haematological and biochemical parameters of the widely cultured mullet, Mugil cephalus. For this purpose, 45 mullet caught in Faro Lake (Italy) were acclimated and fed with commercial diet for 20 days prior to the start of experiments that lasted for 20 days. After acclimation, fish were divided into three equal groups and subjected to 25‰ (Group A), 45‰ (Group B) and 35‰ of salinity (Group C), respectively. Statistical analysis and linear regression showed a significant influence of salinity levels on erythrocyte, haemoglobin, haematocrit, leucocytes and trombocytes and on all biochemical parameters except on osmolarity. These results add to our understanding of the effects of salinity levels on the physiological and biochemical parameters of Mugil cephalus and, in particular, improve our ability to select salinity levels for optimal growth for aquaculture and breeding of this species.
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effect of storage time on haematological parameters in mullet Mugil cephalus
Cell Biochemistry and Function, 2013Co-Authors: Caterina Faggio, Simona Marafioti, Francesca Arfuso, Giuseppe Piccione, Stefania Casella, Francesco FazioAbstract:The aim of the present study was to assess the effect of storage time at +4 � C on red blood cell count (RBC), haematocrit (Hct), haemoglobin (Hb), white blood cell count (WBC), thrombocyte count (TC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) in mullet (Mugil cephalus) using an automatic method. After blood collection (T0), all samples were analyzed using both the manual and automatic method. To test the validation of the automatic method, a paired t-test was applied, and no statistical difference was observed. The samples were successively divided into four different aliquots and stored at +4 � Ct o assess the haematological parameters using the automatic method. The first aliquot was refrigerated for 6 h, the second one for 24 h, the third one for 48 h and the last one at for 72 h. One-way repeated-measures ANOVA showed a significant effect of storage time (P<0.05) on Hb, WBC, TC, MCH and MCHC. These results suggest that haematological parameters can be assessed within 6 h from blood collection when samples are stored at +4 � C because long-term storage modifies the results of the analyses. Further studies on these parameters could be still needed in various fish species to validate an appropriate method for haematological analysis useful not only for the evaluation of the health status of animal living in captivity and in aquaculture but also to have reliability environmental haematological biomarkers. Copyright © 2012 John Wiley & Sons, Ltd. key words—haematological automatic analysis; haematological parameters; Mugil cephalus; storage time; teleost
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haematological and serum protein profiles of Mugil cephalus effect of two different habitats
Ichthyological Research, 2013Co-Authors: Francesco Fazio, Simona Marafioti, Agata Torre, Marilena Sanfilippo, Michele Panzera, Caterina FaggioAbstract:The aim of this study was to assess the influence of two different habitats, Faro Lake (group A) and Tyrrhenian Sea (group B), on the haematological and serum protein profiles of Mugil cephalus. Our results showed significant differences of white blood cells, total proteins, prealbumin, albumin and α-globulins between groups A and B. These findings suggest that changes in haematological and serum protein profiles are important indices in monitoring the effects of aquatic habitat changes, representing an adaptive physiological response to different habitats of M. cephalus.
Marlene Tiduko Ueta - One of the best experts on this subject based on the ideXlab platform.
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ORIGINAL ARTICLE / ARTÍCULO ORIGINAL
2015Co-Authors: Peces Comerciales, Thales Kodi Namba, Rubens Riscala Madi, Ciudad De Iguape, Sao Paulo, Marlene Tiduko UetaAbstract:The world distribution of oriental culture and the common use of fish which is not cooked manifested problems related to parasites. There is a great incidence of Ascocotyle sp. parasites in mullet fishes, which are part of human culinary spread all over world. The aim of the present study is to estimate the presence of trematode Heterophyidae metacercariae among mullet fishes commercialized at Iguape city Sao Paulo, Brazil. Ascocotyle sp. metacercarie (Digenea: Heterophyidae) were observed and analyzed in viscera and muscles of 60 mullets Mugil liza and 60 mullets Mugil curema (Osteichthyes: Mugilidae) purchased in the fish market of the Iguape city. The extraction of metacercariae of Ascocotyle sp. from viscera and muscles was performed by homogenization in homemade processor. All mullets samples were infected. M. liza and M. curema marketed in city constitute in a potential risk to the population, because of high prevalence of infection (100%) and large numbers of metacercarie in their tissues (up to 939 to M. liza and 92 to M. curema)
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Ascocotyle sp. metacercariae (Digenea: Heterophyidae) in tissues of mullets Mugil liza and Mugil curema (Osteichthyes: Mugilidae) collected in the fish trade of the Iguape city, Sao Paulo, Brazil.
Neotropical helminthology, 2012Co-Authors: Thales Kodi Namba, Rubens Riscala Madi, Marlene Tiduko UetaAbstract:La expansion de la cultura oriental y el aumento del consumo de pescados crudos presenta algunos problemas, tales como enfermedades causadas por parasitos. Hay una gran incidencia de Ascocotyle sp. en peces lisas, muy consumidos en diversas partes del mundo. El estudio tuvo como objetivo verificar la presencia de metacercarias de trematodos Heterophyidae en peces lisas comercializados en el municipio de Iguape, Sao Paulo, Brasil. Se observaron y analizaron metacercarias de Ascocotyle sp. (Digenea: Heterophyidae) en visceras y musculatura de 60 Mugil liza y 60 Mugil curema (Osteichthyes: Mugilidae) adquiridas en el comercio de pescados del municipio de Iguape. La extraccion de metacercarias de los tejidos de los peces se realizo por homogeneizacion un procesador casero. Todas las muestras de peces estuvieron infectadas. M. liza y M. curema comercializados en la ciudad son un riesgo potencial para la poblacion ante la alta prevalencia de infeccion en los peces (100%) y el gran numero de metacercarias en sus tejidos (hasta 939 en M. lizay 92 en M. curema).
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ASCOCOTYLE SP. METACERCARIAE (DIGENEA: HETEROPHYIDAE) IN TISSUES OF MULLETS Mugil LIZA AND Mugil CUREMA (OSTEICHTHYES: MugilIDAE) COLLECTED IN THE FISH TRADE OF THE IGUAPE CITY, SAO PAULO, BRAZIL METACERCARIA DE ASCOCOTYLE SP. (DIGENEA: HETEROPHYIDAE
2012Co-Authors: Thales Kodi Namba, Rubens Riscala Madi, Marlene Tiduko UetaAbstract:The world distribution of oriental culture and the common use of fish which is not cooked manifested problems related to parasites. There is a great incidence of Ascocotyle sp. parasites in mullet fishes, which are part of human culinary spread all over world. The aim of the present study is to estimate the presence of trematode Heterophyidae metacercariae among mullet fishes commercialized at Iguape city Sao Paulo, Brazil. Ascocotyle sp. metacercarie (Digenea: Heterophyidae) were observed and analyzed in viscera and muscles of 60 mullets Mugil liza and 60 mullets Mugil curema (Osteichthyes: Mugilidae) purchased in the fish market of the Iguape city. The extraction of metacercariae of Ascocotyle sp. from viscera and muscles was performed by homogenization in homemade processor. All mullets samples were infected. M. liza and M. curema marketed in city constitute in a potential risk to the population, because of high prevalence of infection (100%) and large numbers of metacercarie in their tissues (up to 939 to M. liza and 92 to M. curema).
