The Experts below are selected from a list of 14256 Experts worldwide ranked by ideXlab platform

Shuming Nie - One of the best experts on this subject based on the ideXlab platform.

  • development of Multifunctional Nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effect
    Current Drug Discovery Technologies, 2009
    Co-Authors: Hari Krishna Sajja, Hui Mao, Shuming Nie, Michael P East, Andrew Y Wang, Lily Yang
    Abstract:

    Nanotechnology is a multidisciplinary scientific field undergoing explosive development. Nanometer-sized particles offer novel structural, optical and electronic properties that are not attainable with individual molecules or bulk solids. Advances in nanomedicine can be made by engineering biodegradable Nanoparticles such as magnetic iron oxide Nanoparticles, polymers, dendrimers and liposomes that are capable of targeted delivery of both imaging agents and anticancer drugs. This leads toward the concept and possibility of personalized medicine for the potential of early detection of cancer lesions, determination of molecular signatures of the tumor by non-invasive imaging and, most importantly, molecular targeted cancer therapy. Increasing evidence suggests that the Nanoparticles, whose surface contains a targeting molecule that binds to receptors highly expressed in tumor cells, can serve as cancer image contrast agents to increase sensitivity and specificity in tumor detection. In comparison with other small molecule contrast agents, the advantage of using Nanoparticles is their large surface area and the possibility of surface modifications for further conjugation or encapsulation of large amounts of therapeutic agents. Targeted Nanoparticles ferry large doses of therapeutic agents into malignant cells while sparing the normal healthy cells. Such Multifunctional nanodevices hold the promise of significant improvement of current clinical management of cancer patients. This review explores the development of Nanoparticles for enabling and improving the targeted delivery of therapeutic agents, the potential of nanomedicine, and the development of novel and more effective diagnostic and screening techniques to extend the limits of molecular diagnostics providing point-of-care diagnosis and more personalized medicine.

  • proton sponge coated quantum dots for sirna delivery and intracellular imaging
    Journal of the American Chemical Society, 2008
    Co-Authors: Maksym Yezhelyev, Shuming Nie, Ruth M Oregan, Xiaohu Gao
    Abstract:

    We report the rational design of Multifunctional Nanoparticles for short-interfering RNA (siRNA) delivery and imaging based on the use of semiconductor quantum dots (QDs) and proton-absorbing polymeric coatings (proton sponges). With a balanced composition of tertiary amine and carboxylic acid groups, these Nanoparticles are specifically designed to address longstanding barriers in siRNA delivery such as cellular penetration, endosomal release, carrier unpacking, and intracellular transport. The results demonstrate dramatic improvement in gene silencing efficiency by 10-20 fold and simultaneous reduction in cellular toxicity by 5-6 fold, when compared directly with existing transfection agents for MDA-MB-231 cells. The QD-siRNA Nanoparticles are also dual-modality optical and electron-microscopy probes, allowing real-time tracking and ultrastructural localization of QDs during delivery and transfection. These new insights and capabilities represent a major step towards nanoparticle engineering for imaging and therapeutic applications.

  • quantum dots and Multifunctional Nanoparticles new contrast agents for tumor imaging
    Nanomedicine: Nanotechnology Biology and Medicine, 2006
    Co-Authors: Matthew N Rhyner, Andrew M. Smith, Xiaohu Gao, Hui Mao, Lily Yang, Shuming Nie
    Abstract:

    Nanometer-sized particles, such as semiconductor quantum dots and iron oxide nanocrystals, have novel optical, electronic, magnetic or structural properties that are not available from either molecules or bulk solids. When linked with tumor-targeting ligands, such as monoclonal antibodies, peptide fragments of tumor-specific proteins or small molecules, these Nanoparticles can be used to target tumor antigens (biomarkers) and tumor vasculatures with high affinity and specificity. In the mesoscopic size range of 5-100 nm diameter, quantum dots and related Nanoparticles have large surface areas and functional groups that can be linked to multiple diagnostic (e.g., optical, radioisotopic or magnetic) and therapeutic (e.g., anticancer) agents. In this review, recent advances in the development and applications of bioconjugated quantum dots and Multifunctional Nanoparticles for in vivo tumor imaging and targeting are discussed.

Xiaohu Gao - One of the best experts on this subject based on the ideXlab platform.

  • Multifunctional Nanoparticles as coupled contrast agents
    Nature Communications, 2010
    Co-Authors: Yongdong Jin, Congxian Jia, Sheng Wen Huang, Matthew Odonnell, Xiaohu Gao
    Abstract:

    Engineering compact imaging probes with highly integrated modalities is a key focus in bionanotechnology and will have profound impact on molecular diagnostics, imaging and therapeutics. However, combining multiple components on a nanometre scale to create new imaging modalities unavailable from individual components has proven to be challenging. In this paper, we demonstrate iron oxide and gold-coupled core-shell Nanoparticles (NPs) with well-defined structural characteristics (for example, size, shell thickness and core-shell separation) and physical properties (for example, electronic, magnetic, optical, thermal and acoustic). The resulting Multifunctional nanoprobes not only offer contrast for electron microscopy, magnetic resonance imaging and scattering-based imaging but, more importantly, enable a new imaging mode, magnetomotive photoacoustic imaging, with remarkable contrast enhancement compared with photoacoustic images using conventional NP contrast agents.

  • proton sponge coated quantum dots for sirna delivery and intracellular imaging
    Journal of the American Chemical Society, 2008
    Co-Authors: Maksym Yezhelyev, Shuming Nie, Ruth M Oregan, Xiaohu Gao
    Abstract:

    We report the rational design of Multifunctional Nanoparticles for short-interfering RNA (siRNA) delivery and imaging based on the use of semiconductor quantum dots (QDs) and proton-absorbing polymeric coatings (proton sponges). With a balanced composition of tertiary amine and carboxylic acid groups, these Nanoparticles are specifically designed to address longstanding barriers in siRNA delivery such as cellular penetration, endosomal release, carrier unpacking, and intracellular transport. The results demonstrate dramatic improvement in gene silencing efficiency by 10-20 fold and simultaneous reduction in cellular toxicity by 5-6 fold, when compared directly with existing transfection agents for MDA-MB-231 cells. The QD-siRNA Nanoparticles are also dual-modality optical and electron-microscopy probes, allowing real-time tracking and ultrastructural localization of QDs during delivery and transfection. These new insights and capabilities represent a major step towards nanoparticle engineering for imaging and therapeutic applications.

  • quantum dots and Multifunctional Nanoparticles new contrast agents for tumor imaging
    Nanomedicine: Nanotechnology Biology and Medicine, 2006
    Co-Authors: Matthew N Rhyner, Andrew M. Smith, Xiaohu Gao, Hui Mao, Lily Yang, Shuming Nie
    Abstract:

    Nanometer-sized particles, such as semiconductor quantum dots and iron oxide nanocrystals, have novel optical, electronic, magnetic or structural properties that are not available from either molecules or bulk solids. When linked with tumor-targeting ligands, such as monoclonal antibodies, peptide fragments of tumor-specific proteins or small molecules, these Nanoparticles can be used to target tumor antigens (biomarkers) and tumor vasculatures with high affinity and specificity. In the mesoscopic size range of 5-100 nm diameter, quantum dots and related Nanoparticles have large surface areas and functional groups that can be linked to multiple diagnostic (e.g., optical, radioisotopic or magnetic) and therapeutic (e.g., anticancer) agents. In this review, recent advances in the development and applications of bioconjugated quantum dots and Multifunctional Nanoparticles for in vivo tumor imaging and targeting are discussed.

Hongjie Zhang - One of the best experts on this subject based on the ideXlab platform.

  • rational design of nd3 sensitized Multifunctional Nanoparticles with highly dominant red emission
    Dalton Transactions, 2016
    Co-Authors: Pengpeng Lei, Lile Dong, Xiuling Liu, Shuyan Song, Jing Feng, Hongjie Zhang
    Abstract:

    Controlling excitation and emission wavelengths on demand is very significant in bioimaging. Up-conversion Nanoparticles (UCNPs) emit visible light upon near-infrared (NIR) light excitation and are well studied in bioimaging. Red emission is usually preferred to green due to its higher tissue penetration depth in bioimaging. Herein, dominant red emission has been achieved under 808 nm excitation based on the designed α-NaYbF4:Mn2+/Er3+@NaLuF4:Mn2+/Yb3+@NaNdF4:Yb3+@NaGdF4 (C@S1@S2@S3) nanostructure. The rationally designed interlayer shell NaLuF4:Mn2+/Yb3+ could efficiently filter unwanted energy back-transfer from Er3+ to Nd3+ and the outmost shell NaGdF4 could prevent excitation energy from surface-related quenching. The lifetime of 4F9/2 → 4I15/2 transition of Er3+ could be as high as 0.7 ms. Moreover, C@S1@S2@S3 UCNPs also possess effective contrast efficiency for both X-ray computed tomography (CT) and magnetic resonance (MR) imaging. The designed Multifunctional UCNPs could be used as a potential multimodal bioprobe in bioimaging applications.

  • rational design of nd 3 sensitized Multifunctional Nanoparticles with highly dominant red emission
    Dalton Transactions, 2016
    Co-Authors: Pengpeng Lei, Lile Dong, Xiuling Liu, Shuyan Song, Jing Feng, Hongjie Zhang
    Abstract:

    Controlling excitation and emission wavelengths on demand is very significant in bioimaging. Up-conversion Nanoparticles (UCNPs) emit visible light upon near-infrared (NIR) light excitation and are well studied in bioimaging. Red emission is usually preferred to green due to its higher tissue penetration depth in bioimaging. Herein, dominant red emission has been achieved under 808 nm excitation based on the designed α-NaYbF4:Mn(2+)/Er(3+)@NaLuF4:Mn(2+)/Yb(3+)@NaNdF4:Yb(3+)@NaGdF4 (C@S1@S2@S3) nanostructure. The rationally designed interlayer shell NaLuF4:Mn(2+)/Yb(3+) could efficiently filter unwanted energy back-transfer from Er(3+) to Nd(3+) and the outmost shell NaGdF4 could prevent excitation energy from surface-related quenching. The lifetime of (4)F9/2→(4)I15/2 transition of Er(3+) could be as high as 0.7 ms. Moreover, C@S1@S2@S3 UCNPs also possess effective contrast efficiency for both X-ray computed tomography (CT) and magnetic resonance (MR) imaging. The designed Multifunctional UCNPs could be used as a potential multimodal bioprobe in bioimaging applications.

Mukhles Sowwan - One of the best experts on this subject based on the ideXlab platform.

  • nanoparticle design by gas phase synthesis
    Advances in Physics: X, 2016
    Co-Authors: Panagiotis Grammatikopoulos, Stephan Steinhauer, Jerome Vernieres, Vidyadhar Singh, Mukhles Sowwan
    Abstract:

    AbstractGas-phase synthesis characterizes a class of bottom-up methods for producing Multifunctional Nanoparticles (NPs) from individual atoms or molecules. This review aims to summarize recent achievements using this approach, and compare its potential to other physical or chemical NP fabrication techniques. More specifically, emphasis is given to magnetron-sputter gas-phase condensation, since it allows for flexible growth of complex, sophisticated NPs, owing to the fast kinetics and non-equilibrium processes it entails. Nanoparticle synthesis is decomposed into four stages, i.e. aggregation, shell-coating, mass-filtration, and deposition. We present the formation of NPs of various functionalities for different applications, such as magnetic, plasmonic, catalytic and, gas-sensing, emphasizing on the primary dependence of each type on a different stage of the fabrication process, and their resultant physical and chemical properties.

  • heterogeneous gas phase synthesis and molecular dynamics modeling of janus and core satellite si ag Nanoparticles
    Journal of Physical Chemistry C, 2014
    Co-Authors: Vidyadhar Singh, Panagiotis Grammatikopoulos, Mukhles Sowwan, K Nordlund, Flyura Djurabekova, Cathal Cassidy
    Abstract:

    Heterogeneous gas-phase condensation is a promising method of producing hybrid Multifunctional Nanoparticles with tailored composition and microstructure but also intrinsically introduces greater complexity to the nucleation process and growth kinetics. Herein, we report on the synthesis and growth modeling of silicon–silver (Si–Ag) hybrid Nanoparticles using gas-aggregated cosputtering from elemental Si and Ag source targets. The final Si–Ag ensemble size was manipulated in the range 5–15 nm by appropriate tuning of the deposition parameters, while variations in the Si–Ag sputtering power ratio, from 1.8 to 2.25, allowed distinctive Janus and core–satellite structures, respectively, to be produced. Molecular dynamics simulations indicate that the individual species first form independent clusters of Si and Ag without significant intermixing. Collisions between unlike species are unstable in the early stages of growth (<100 ns), with large temperature differences resulting in rapid energy exchange and sep...

Xinyuan Zhu - One of the best experts on this subject based on the ideXlab platform.

  • a molecular recognition approach to synthesize nucleoside analogue based Multifunctional Nanoparticles for targeted cancer therapy
    Journal of the American Chemical Society, 2017
    Co-Authors: Dali Wang, Deyue Yan, Bing Liu, Quanbing Mou, Hongping Deng, Ruibin Wang, Chuan Zhang, Xinyuan Zhu
    Abstract:

    Tumor-targeted drug delivery with simultaneous cancer imaging is highly desirable for personalized medicine. Herein, we report a supramolecular approach to design a promising class of Multifunctional Nanoparticles based on molecular recognition of nucleobases, which combine excellent tumor-targeting capability via aptamer, controlled drug release, and efficient fluorescent imaging for cancer-specific therapy. First, an amphiphilic prodrug dioleoyl clofarabine was self-assembled into micellar Nanoparticles with hydrophilic nucleoside analogue clofarabine on their surface. Thereafter, two types of single-stranded DNAs that contain the aptamer motif and fluorescent probe Cy5.5, respectively, were introduced onto the surface of the Nanoparticles via molecular recognition between the clofarabine and the thymine on DNA. These drug-containing Multifunctional Nanoparticles exhibit good capabilities of targeted clofarabine delivery to the tumor site and intracellular controlled drug release, leading to a robust an...

  • A Molecular Recognition Approach To Synthesize Nucleoside Analogue Based Multifunctional Nanoparticles for Targeted Cancer Therapy
    2017
    Co-Authors: Dali Wang, Deyue Yan, Bing Liu, Quanbing Mou, Hongping Deng, Ruibin Wang, Chuan Zhang, Xinyuan Zhu
    Abstract:

    Tumor-targeted drug delivery with simultaneous cancer imaging is highly desirable for personalized medicine. Herein, we report a supramolecular approach to design a promising class of Multifunctional Nanoparticles based on molecular recognition of nucleobases, which combine excellent tumor-targeting capability via aptamer, controlled drug release, and efficient fluorescent imaging for cancer-specific therapy. First, an amphiphilic prodrug dioleoyl clofarabine was self-assembled into micellar Nanoparticles with hydrophilic nucleoside analogue clofarabine on their surface. Thereafter, two types of single-stranded DNAs that contain the aptamer motif and fluorescent probe Cy5.5, respectively, were introduced onto the surface of the Nanoparticles via molecular recognition between the clofarabine and the thymine on DNA. These drug-containing Multifunctional Nanoparticles exhibit good capabilities of targeted clofarabine delivery to the tumor site and intracellular controlled drug release, leading to a robust and effective antitumor effect in vivo