The Experts below are selected from a list of 25533 Experts worldwide ranked by ideXlab platform
Lawrence A. Yannuzzi - One of the best experts on this subject based on the ideXlab platform.
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Multimodal Imaging of multifocal chorioretinitis secondary to endogenous candida infection
International Ophthalmology, 2019Co-Authors: Chiara Veronese, Chiara Maiolo, Annalisa Gurreri, Mariachiara Morara, Antonio P Ciardella, Lawrence A. YannuzziAbstract:To present Multimodal Imaging of multifocal chorioretinitis secondary to endogenous candida infection in a young adult. A 49-year-old woman who presented for evaluation of bilateral endogenous candida chorioretinitis underwent complete ophthalmic examination, in addition to fundus photography (FP), enhanced depth Imaging optical coherence tomography, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA). Multimodal Imaging of both eyes of the patient affected by endogenous candida chorioretinitis was performed. FP showed multiple white chorioretinal lesions at the posterior pole, FAF showed dark dot at the posterior pole surrounded by hyperautofluorescence area, FA showed early hyperfluorescence round perifoveal lesion at the posterior pole and small hyperfluorescence dots under the inferior retinal vessels. Early ICGA showed hypofluorescence dots at the posterior pole. Late ICGA showed dark hypofluorescence dots at the posterior pole surrounded by faint hyperautofluorescent ring. OCTA showed dark areas corresponded to hypoperfusion areas seen with early ICGA. We reported Multimodal Imaging of an unusual occurrence of multifocal chorioretinitis due to immunosuppression. These findings suggested that the infection resulted from choroidal infiltration via the short posterior ciliary arteries with resultant breakthrough into the retina, rather than via the central retinal artery. By comparing findings on OCTA with data obtained from traditional systems, we are gaining essential information on the pathogenesis of endogenous candida chorioretinitis.
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acute zonal occult outer retinopathy a classification based on Multimodal Imaging
JAMA Ophthalmology, 2014Co-Authors: Sarah Mrejen, Lee M. Jampol, Samira Khan, Roberto Gallegopinazo, Lawrence A. YannuzziAbstract:Importance We describe the Multimodal Imaging in a group of patients showing a distinct clinical entity that best represents acute zonal occult outer retinopathy (AZOOR). Objective To propose a classification of AZOOR based on clinical fundus and Multimodal Imaging. Design, Setting and Participants A retrospective review of patients diagnosed as having AZOOR at 2 centers. After reviewing more than 400 cases diagnosed or referred to us as AZOOR or AZOOR complex, we assembled 30 cases that fit our current definition; (48 eyes) with a median age at diagnosis of 47 years (age range, 17-86 years) and a mean follow-up period of 39 months. Twenty patients were female. Eighteen patients had initially been seen with bilateral lesions, mostly asymmetric (4 cases were symmetric). Most patients had no remarkable medical or ocular history. The median visual acuity at the time of presentation was 20/25 (range, 20/20 to 20/400). Main Outcomes and Measures Multimodal Imaging, including fundus photography, fluorescein and indocyanine green angiography, fundus autofluorescence Imaging, and corresponding eye-tracked spectral-domain coherence tomography Imaging. Results Each patient was initially seen with visual symptoms of photopsia and scotoma, and most had a detectable lesion in the fundus evident clinically or detected on Multimodal Imaging. The clinical appearance of the AZOOR lesions varied depending on their duration and location, but some features were characteristic, including a demarcating line of the progression at the level of the outer retina and a trizonal pattern of sequential involvement of the outer retina, retinal pigment epithelium, and choroid, as well as frequent zonal progression. Advanced cases of AZOOR demonstrated disruption of the inner and outer retina and severe damage or loss of the retinal pigment epithelium and the choroid. Conclusions and Relevance A specific definition of AZOOR based on Multimodal Imaging is proposed to help physicians distinguish it from other diseases of the posterior fundus, including white spot syndromes and autoimmune, hereditary, paraneoplastic, toxic, and other inflammatory retinopathies.
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Multimodal Imaging findings in retinal deep capillary ischemia
Retina-the Journal of Retinal and Vitreous Diseases, 2014Co-Authors: Suqin Yu, Claudine E. Pang, Lawrence A. Yannuzzi, Fenghua Wang, K. FreundAbstract:Purposes:To evaluate the Multimodal Imaging findings in retinal deep capillary ischemia (DCI).Methods:This was a retrospective review of 5 eyes of 4 patients with sudden onset of paracentral scotomas caused by DCI. Multimodal Imaging techniques, including color and red-free photographs, near-infrare
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idiopathic multifocal choroiditis with peripapillary zonal inflammation a Multimodal Imaging analysis
Retinal Cases & Brief Reports, 2014Co-Authors: Jesse J Jung, Bailey K Freund, Sarah Mrejen, Lawrence A. YannuzziAbstract:PURPOSE To report a case of idiopathic multifocal choroiditis with transient peripapillary zonal inflammation that was followed with Multimodal Imaging and explain the mechanism by which chorioretinal atrophy may occur. METHODS Observational case report. Review of the clinical examination, ocular Imaging, and progression of idiopathic multifocal choroiditis. RESULTS A 30-year-old white myopic man presented with complaints of worsening vision and a loss of visual field for 1 month in his left eye. Using Multimodal Imaging, including wide-field Imaging with fluorescein angiography, fundus autofluorescence, and high-definition spectral-domain optical coherence tomography, he was found to have a macula involving peripapillary zonal inflammation consistent with acute idiopathic multifocal choroiditis involving the outer photoreceptor layer, ellipsoid layer, retinal pigment epithelium, and choroid. This area of inflammation was monitored with Multimodal Imaging over 7 months and slowly improved along with the patient's vision. Imaging allowed us to view the development of chorioretinal scars from several, but not all, acute inflammatory white spots. CONCLUSION Multifocal choroiditis is an inflammatory disorder affecting the outer photoreceptors, ellipsoid layer, retinal pigment epithelium, and choroid; and areas of acute inflammation may improve over time but can also leave permanent chorioretinal atrophy including focal lesions or peripapillary zonal atrophy.
Sarah Mrejen - One of the best experts on this subject based on the ideXlab platform.
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cuticular drusen clinical phenotypes and natural history defined using Multimodal Imaging
Ophthalmology, 2018Co-Authors: Chandrakumar Balaratnasingam, Svetlana Cherepanoff, Rosa Dolzmarco, Murray C Killingsworth, Fred K Chen, Randev Mendis, Sarah MrejenAbstract:Purpose To define the range and life cycles of cuticular drusen phenotypes using Multimodal Imaging and to review the histologic characteristics of cuticular drusen. Design Retrospective, observational cohort study and experimental laboratory study. Participants Two hundred forty eyes of 120 clinic patients with a cuticular drusen phenotype and 4 human donor eyes with cuticular drusen (n = 2), soft drusen (n = 1), and hard drusen (n = 1). Methods We performed a retrospective review of clinical and Multimodal Imaging data of patients with a cuticular drusen phenotype. Patients had undergone Imaging with various combinations of color photography, fluorescein angiography, indocyanine green angiography, near-infrared reflectance, fundus autofluorescence, high-resolution OCT, and ultrawide-field Imaging. Human donor eyes underwent processing for high-resolution light and electron microscopy. Main Outcome Measures Appearance of cuticular drusen in Multimodal Imaging and the topography of a cuticular drusen distribution; age-dependent variations in cuticular drusen phenotypes, including the occurrence of retinal pigment epithelium (RPE) abnormalities, choroidal neovascularization, acquired vitelliform lesions (AVLs), and geographic atrophy (GA); and ultrastructural and staining characteristics of druse subtypes. Results The mean age of patients at the first visit was 57.9±13.4 years. Drusen and RPE changes were seen in the peripheral retina, anterior to the vortex veins, in 21.8% of eyes. Of eyes with more than 5 years of follow-up, cuticular drusen disappeared from view in 58.3% of eyes, drusen coalescence was seen in 70.8% of eyes, and new RPE pigmentary changes developed in 56.2% of eyes. Retinal pigment epithelium abnormalities, AVLs, neovascularization, and GA occurred at a frequency of 47.5%, 24.2%, 12.5%, and 25%, respectively, and were significantly more common in patients older than 60 years of age (all P P Conclusions Although the ultrastructural characteristics of cuticular drusen appear more similar to those of hard drusen, their lifecycle and macular complications are more comparable with those of soft drusen. Cuticular drusen phenotype may confer a unique risk for the development of GA and neovascularization.
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EXPANDED CLINICAL SPECTRUM OF MULTIPLE EVANESCENT WHITE DOT SYNDROME WITH Multimodal Imaging.
Retina (Philadelphia Pa.), 2016Co-Authors: Marcela Marsiglia, Sarah Mrejen, Naomi Goldberg, Roberto Gallego-pinazo, Eduardo Cunha De Souza, Marion R. Munk, Emmett T. Cunningham, Brandon J. Lujan, Thomas A. AlbiniAbstract:PURPOSE: To evaluate and characterize multiple evanescent white dot syndrome abnormalities with modern Multimodal Imaging modalities. METHODS: This retrospective cohort study evaluated fundus photography, fluorescein angiography, indocyanine green angiography, optical coherence tomography, enhanced depth Imaging optical coherence tomography, short-wavelength autofluorescence, and near-infrared autofluorescence. RESULTS: Thirty-four multiple evanescent white dot syndrome patients with mean age of 28.7 years were studied (range, 14-49 years). Twenty-six patients were women, and eight were men. Initial mean visual acuity was 0.41 logMAR. Final mean visual acuity was 0.03 logMAR. Fluorescein angiography shows a variable number of mid retinal early fluorescent dots distributed in a wreathlike pattern, which correlate to fundus photography, fundus autofluorescence, and indocyanine green angiography. Indocyanine green angiography Imaging shows the dots and also hypofluorescent, deeper, and larger spots, which are occasionally confluent, demonstrating a large plaque of deep retinal hypofluorescence. Optical coherence tomography Imaging shows multifocal debris centered at and around the ellipsoid layer, corresponding to the location of spots seen with photography, indocyanine green angiography, and fluorescein angiography. Protrusions of the hyperreflectant material from the ellipsoid layer toward the outer nuclear layer correspond to the location of dots seen with photography, indocyanine green angiography, and fluorescein angiography. CONCLUSION: Multimodal Imaging analysis of the retina in patients with multiple evanescent white dot syndrome shows additional features that may help in the diagnosis of the disease and in further understanding its etiology. Multiple evanescent white dot syndrome is predominantly a disease of the outer retina, centered at the ellipsoid zone, but also involving the interdigitation zone and the outer nuclear layer.
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acute zonal occult outer retinopathy a classification based on Multimodal Imaging
JAMA Ophthalmology, 2014Co-Authors: Sarah Mrejen, Lee M. Jampol, Samira Khan, Roberto Gallegopinazo, Lawrence A. YannuzziAbstract:Importance We describe the Multimodal Imaging in a group of patients showing a distinct clinical entity that best represents acute zonal occult outer retinopathy (AZOOR). Objective To propose a classification of AZOOR based on clinical fundus and Multimodal Imaging. Design, Setting and Participants A retrospective review of patients diagnosed as having AZOOR at 2 centers. After reviewing more than 400 cases diagnosed or referred to us as AZOOR or AZOOR complex, we assembled 30 cases that fit our current definition; (48 eyes) with a median age at diagnosis of 47 years (age range, 17-86 years) and a mean follow-up period of 39 months. Twenty patients were female. Eighteen patients had initially been seen with bilateral lesions, mostly asymmetric (4 cases were symmetric). Most patients had no remarkable medical or ocular history. The median visual acuity at the time of presentation was 20/25 (range, 20/20 to 20/400). Main Outcomes and Measures Multimodal Imaging, including fundus photography, fluorescein and indocyanine green angiography, fundus autofluorescence Imaging, and corresponding eye-tracked spectral-domain coherence tomography Imaging. Results Each patient was initially seen with visual symptoms of photopsia and scotoma, and most had a detectable lesion in the fundus evident clinically or detected on Multimodal Imaging. The clinical appearance of the AZOOR lesions varied depending on their duration and location, but some features were characteristic, including a demarcating line of the progression at the level of the outer retina and a trizonal pattern of sequential involvement of the outer retina, retinal pigment epithelium, and choroid, as well as frequent zonal progression. Advanced cases of AZOOR demonstrated disruption of the inner and outer retina and severe damage or loss of the retinal pigment epithelium and the choroid. Conclusions and Relevance A specific definition of AZOOR based on Multimodal Imaging is proposed to help physicians distinguish it from other diseases of the posterior fundus, including white spot syndromes and autoimmune, hereditary, paraneoplastic, toxic, and other inflammatory retinopathies.
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idiopathic multifocal choroiditis with peripapillary zonal inflammation a Multimodal Imaging analysis
Retinal Cases & Brief Reports, 2014Co-Authors: Jesse J Jung, Bailey K Freund, Sarah Mrejen, Lawrence A. YannuzziAbstract:PURPOSE To report a case of idiopathic multifocal choroiditis with transient peripapillary zonal inflammation that was followed with Multimodal Imaging and explain the mechanism by which chorioretinal atrophy may occur. METHODS Observational case report. Review of the clinical examination, ocular Imaging, and progression of idiopathic multifocal choroiditis. RESULTS A 30-year-old white myopic man presented with complaints of worsening vision and a loss of visual field for 1 month in his left eye. Using Multimodal Imaging, including wide-field Imaging with fluorescein angiography, fundus autofluorescence, and high-definition spectral-domain optical coherence tomography, he was found to have a macula involving peripapillary zonal inflammation consistent with acute idiopathic multifocal choroiditis involving the outer photoreceptor layer, ellipsoid layer, retinal pigment epithelium, and choroid. This area of inflammation was monitored with Multimodal Imaging over 7 months and slowly improved along with the patient's vision. Imaging allowed us to view the development of chorioretinal scars from several, but not all, acute inflammatory white spots. CONCLUSION Multifocal choroiditis is an inflammatory disorder affecting the outer photoreceptors, ellipsoid layer, retinal pigment epithelium, and choroid; and areas of acute inflammation may improve over time but can also leave permanent chorioretinal atrophy including focal lesions or peripapillary zonal atrophy.
Bailey K Freund - One of the best experts on this subject based on the ideXlab platform.
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Multimodal Imaging of igg4 related papillitis and retinal disease
Retinal Cases & Brief Reports, 2019Co-Authors: Edmund Tsui, Bailey K Freund, Naomi Goldberg, Cinthi Pillai, Lediana GoduniAbstract:Purpose To report a case of IgG4-related ophthalmic disease, which presented with papillitis and subretinal deposits. Methods Observational case report with Multimodal Imaging. Results A 52-year-old man with a history of persistent lymphadenopathy presented with decreased vision in his left eye. Funduscopic examination demonstrated cuticular drusen in both eyes and florid edema of the left optic nerve, along with scattered circumscribed grey-yellow subretinal deposits that were distinct from the cuticular drusen. Swept-source optical coherence tomography demonstrated a hyper-reflective subretinal material corresponding to the grey-yellow subretinal deposits on clinical examination along with diffuse outer retinal disruption. Fundus autofluorescence revealed scattered hypoautofluorescence corresponding to cuticular drusen and also larger patches of hypoautofluorescence corresponding to the grey-yellow subretinal deposits. Fluorescein angiography demonstrated hypofluorescence corresponding to the large subretinal deposits and leakage at the optic nerve. Lymph node biopsy demonstrated IgG4-positive plasma cells and elevated serum IgG4 levels leading to a diagnosis of IgG4-related ophthalmic disease. The patient was treated with oral prednisone with subsequent resolution of the optic nerve edema. Conclusion We describe Multimodal Imaging of unique retinal and optic nerve findings associated with IgG4-related ophthalmic disease. Our report broadens the spectrum of ocular involvement associated with IgG4-related disease.
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Multimodal Imaging adds new insights into acute syphilitic posterior placoid chorioretinitis
Retinal Cases & Brief Reports, 2017Co-Authors: Edmund Tsui, Orly Galor, Quraish Ghadiali, Bailey K FreundAbstract:Purpose:Acute syphilitic posterior placoid chorioretinitis (ASPPC) is an uncommon manifestation of ocular syphilis with distinct clinical features. We describe new Multimodal Imaging findings in a patient with ASPPC.Methods:Observational case report with Multimodal Imaging.Results:A 44-year-old woma
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idiopathic multifocal choroiditis with peripapillary zonal inflammation a Multimodal Imaging analysis
Retinal Cases & Brief Reports, 2014Co-Authors: Jesse J Jung, Bailey K Freund, Sarah Mrejen, Lawrence A. YannuzziAbstract:PURPOSE To report a case of idiopathic multifocal choroiditis with transient peripapillary zonal inflammation that was followed with Multimodal Imaging and explain the mechanism by which chorioretinal atrophy may occur. METHODS Observational case report. Review of the clinical examination, ocular Imaging, and progression of idiopathic multifocal choroiditis. RESULTS A 30-year-old white myopic man presented with complaints of worsening vision and a loss of visual field for 1 month in his left eye. Using Multimodal Imaging, including wide-field Imaging with fluorescein angiography, fundus autofluorescence, and high-definition spectral-domain optical coherence tomography, he was found to have a macula involving peripapillary zonal inflammation consistent with acute idiopathic multifocal choroiditis involving the outer photoreceptor layer, ellipsoid layer, retinal pigment epithelium, and choroid. This area of inflammation was monitored with Multimodal Imaging over 7 months and slowly improved along with the patient's vision. Imaging allowed us to view the development of chorioretinal scars from several, but not all, acute inflammatory white spots. CONCLUSION Multifocal choroiditis is an inflammatory disorder affecting the outer photoreceptors, ellipsoid layer, retinal pigment epithelium, and choroid; and areas of acute inflammation may improve over time but can also leave permanent chorioretinal atrophy including focal lesions or peripapillary zonal atrophy.
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redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through Multimodal Imaging
Retina-the Journal of Retinal and Vitreous Diseases, 2013Co-Authors: Richard F Spaide, Naomi Goldberg, Bailey K FreundAbstract:PURPOSE To evaluate the characteristics of multifocal choroiditis and panuveitis (MCP) and punctate inner choroidopathy (PIC) using Multimodal Imaging. METHODS This is a retrospective, consecutive, observational case series of 38 eyes of 22 patients. Each eye of patients with multiple yellow-white idiopathic inflammatory lesions in the fundus was classified as having MCP or PIC using standard diagnostic criteria in a masked fashion. The features of these eyes as determined from color fundus photography, spectral-domain optical coherence tomography, fundus autofluorescence, and angiography were compared across diagnostic categories. The main outcome measures were the features of both MCP and PIC as evidenced by Multimodal Imaging. RESULTS Of the 38 eyes, 23 eyes had MCP, 15 had PIC; and 7 patients had a discordant pairing of one diagnosis in 1 eye with the other diagnosis in the fellow eye. Acute lesions appeared as nodular collections under the retinal pigment epithelium. These solid retinal pigment epithelium detachments appeared to rupture leading to inflammatory infiltration of the subretinal space and outer retina, often with a widespread loss of the outer retinal architecture beyond the confines of the inflammatory exudate. Treatment with corticosteroids caused a rapid regression of this material with a slower resolution of the abnormalities of the outer retinal architecture. The pattern of inflammatory involvement seen by Multimodal Imaging did not vary between PIC and MCP. No consistent abnormalities were seen in the choroid in either condition, although there was slight thickening of the choroid underlying some acute lesions. CONCLUSION Despite the names of these diseases, the principle sites involved appears to be the subretinal pigment epithelium and outer retinal spaces. Because both MCP and PIC target the same essential structures in the same phenotypic manner and, when active, are treated the same way, there seems to be limited clinical utility in trying to differentiate them. Based on Multimodal Imaging results, a reappraisal of pathogenic features and naming conventions of these diseases seems indicated.
Shuliang Jiao - One of the best experts on this subject based on the ideXlab platform.
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integrating photoacoustic microscopy optical coherence tomography oct angiography and fluorescence microscopy for Multimodal Imaging
Experimental Biology and Medicine, 2020Co-Authors: Arash Dadkhah, Shuliang JiaoAbstract:We have developed a Multimodal Imaging system, which integrated optical resolution photoacoustic microscopy, optical coherence tomography, optical coherence tomography angiography, and confocal flu...
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simultaneous Multimodal Imaging with integrated photoacoustic microscopy and optical coherence tomography
Optics Letters, 2009Co-Authors: Shuliang Jiao, Hao Zhang, Zhixing Xie, Carmen A PuliafitoAbstract:We have developed a Multimodal Imaging technique by integrating photoacoustic microscopy and spectral-domain optical coherence tomography to provide simultaneous volumetric microscopic Imaging of both optical absorption and scattering contrasts in biological tissues. In the integrated system, the two Imaging modalities share the same optical scanning and delivery mechanisms after their probing and illumination light beams are combined. By further synchronizing the image acquisitions, the images from the two modalities are intrinsically registered. The capabilities of this novel technique were demonstrated by Imaging both the microanatomy and microvasculature in mouse ears in vivo.
Peng Huang - One of the best experts on this subject based on the ideXlab platform.
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cobalt carbide based theranostic agents for in vivo Multimodal Imaging guided photothermal therapy
Nanoscale, 2020Co-Authors: Dongyang Zhang, Jing Lin, Muhammad Rizwan Younis, Leli Zeng, Hengke Liu, Chao Jiang, Peng HuangAbstract:Development of multifunctional theranostics is of great significance for cancer management. Herein, we develop polyethylene glycol (PEG) modified cobalt carbide nanoparticles (Co2C-PEG NPs) as cancer photothermal theranostic agents for Multimodal Imaging and photothermal therapy (PTT). Co2C NPs are synthesized by a high-temperature thermal decomposition method. Afterwards, the morphology, photothermal effect, Multimodal Imaging capacities, biocompatibility, and PTT efficacy of Co2C-PEG NPs are carefully investigated. The as-prepared Co2C-PEG NPs exhibit high photothermal conversion efficiency (PCE, η = 35.7%) and good photostability. Through photoacoustic (PA), magnetic resonance (MR), and photothermal (PT) tri-modal Imaging, in vivo pharmacokinetics and tumor temperature elevation could be monitored during the PTT process. Meanwhile, the Co2C-PEG NPs also show good PTT efficacy both in vitro and in vivo. Our findings suggest that Co2C-PEG NPs are effective for cancer photothermal theranostics.
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dual stimuli responsive bismuth nanoraspberries for Multimodal Imaging and combined cancer therapy
Nano Letters, 2018Co-Authors: Zhaohua Miao, Yan Zhao, Manli Chang, Ye Sun, Flemming Besenbacher, Peng HuangAbstract:Development of stimuli-responsive theranostics is of great importance for precise cancer diagnosis and treatment. Herein, bovine serum albumin (BSA) modified bismuth nanoraspberries (Bi-BSA NRs) are developed as cancer theranostic agents for Multimodal Imaging and chemo-photothermal combination therapy. The Bi-BSA NRs are synthesized in aqueous phase via a facile reduction method using Bi2O3 nanospheres as the sacrificial template. The morphology, biocompatibility, photothermal effect, drug loading/releasing abilities, chemotherapy effect, synergistic chemo-photothermal therapy efficacy, and Multimodal Imaging capacities of Bi-BSA NRs have been investigated. The results show that the NRs possess multiple unique features including (i) raspberry-like morphology with high specific surface area (∼52.24 m2·g–1) and large cavity (total pore volume ∼0.30 cm3·g–1), promising high drug loading capacity (∼69 wt %); (ii) dual-stimuli responsive drug release, triggered by acidic pH and NIR laser irradiation; (iii) in...
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dual stimuli responsive nanotheranostics for Multimodal Imaging guided trimodal synergistic therapy
Small, 2017Co-Authors: Peng Huang, Shan Fang, Jing Lin, Wenxiu Hou, Chunlei Zhang, Jingjing Liu, Sisi Huang, Yongxiang Luo, Wenpei FanAbstract:Multimodal Imaging guided synergistic therapy promises more accurate diagnosis than any single Imaging modality, and higher therapeutic efficiency than any single one or their simple “mechanical” combination. Herein, we report a dual-stimuli responsive nanotheranostic based on a hierarchical nanoplatform, composed of mesoporous silica-coated gold nanorods (GNR@SiO2), Indocyanine Green (ICG), and 5-fluorouracil (5-FU), for in vivo Multimodal Imaging guided synergistic therapy. The 5-FU loaded ICG-conjugated silica-coated gold nanorods (GNR@SiO2-5-FU-ICG) was able to response specifically to the two stimuli of pH change and near-infrared (NIR) light irradiation. Both the NIR light irradiation and acidic environment accelerated the 5-FU release. Meanwhile, the heat generation and singlet oxygen production can be induced by GNR@SiO2-5-FU-ICG upon light irradiation. Most intriguingly, the nanoplatform also promises Multimodal Imaging such as two-photon luminescence, fluorescence, photoacoustic, photothermal Imaging, as well as trimodal synergistic therapy such as photothermal therapy (PTT), photodynamic therapy (PDT), and chemotherapy. The cancer theranostic capability of GNR@SiO2-5-FU-ICG was evaluated both in vitro and in vivo. The trimodal synergistic therapy with the guidance of Multimodal Imaging exhibited remarkably enhanced treatment efficacy. This concept of a hierarchical nanoplatform integrates multiple diagnostic/therapeutic modalities into one platform, which can potentially be applied as personalized nanomedicine with drug delivery, diagnosis, and treatment.
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Multimodal Imaging guided cancer phototherapy by versatile biomimetic theranostics with uv and γ irradiation protection
Advanced Materials, 2016Co-Authors: Min Wang, Peng Huang, Hao Hu, Xiangyu Yang, Zhantong Wang, Orit Jacobson, Jibin Song, Guofeng Zhang, Xiaoyuan ChenAbstract:Abstract A versatile biomimetic theranostic agent based on magnetic melanin nanoparticles is developed for positron-emission tomography/magnetic resonance/photoacoustic/photothermal Multimodal-Imaging-guided cancer photothermal therapy and UV and γ-irradiation protection.
