The Experts below are selected from a list of 1305 Experts worldwide ranked by ideXlab platform
Jarunee Wonglimpiyarat - One of the best experts on this subject based on the ideXlab platform.
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Towards the Sixth Kondratieff Cycle of Nano Revolution
International Journal of Nanotechnology and Molecular Computation, 2011Co-Authors: Jarunee WonglimpiyaratAbstract:Nanotechnology is currently seen as a paradigm shift towards scientific Revolution or ‘Nano Revolution. This article discusses the Nano Revolution within the global context. It is interesting to see that the governments around the world have formulated policies to manage the research and development (R&D) efforts and exploit the potential of Nanotechnology to increase industry's ability in the global economy. The article analyses the successive waves of technological change based on Kuhn's model of scientific change and Schumpeter's model of Kondratieff cycles. As Nanotechnology would have significant impacts on virtually every commercial sector, many countries commit to foster Nanotechnology developments. This article will focus on Nanotechnology framework policy recommendations. The policies and research activities of the most preeminent nations discussed in this article represent global research trend towards Nano Revolution in the next decades.
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The Nano-Revolution of Schumpeter's Kondratieff cycle
Technovation, 2005Co-Authors: Jarunee WonglimpiyaratAbstract:Abstract This paper is concerned with the scientific change of Nano-Revolution with an aim to discuss and evaluate the scientific progress of Nanotechnology in some Asian countries. Nanotechnology is now a science and technology (S&T) priority area for many Asian countries with the governments' efforts to put the results of Nanotechnology development to commercialisation. The national policy for Nanotechnology is to change the existing technology system and bring about an industrial Revolution. Under the pressure of competition, the key to a success would lie in how each country could find the right application to focus on in order to survive through international competitions. This paper reviews specific targeted research activities of Nanotechnology in some Asian countries—Thailand, Malaysia, Singapore, China, South Korea, Taiwan, and Japan. The paper finally recommends policy implications to encourage national innovativeness and effective commercialisation.
Nathalie Tufenkji - One of the best experts on this subject based on the ideXlab platform.
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An improved experimental methodology to evaluate the effectiveness of protective gloves against Nanoparticles in suspension.
Journal of occupational and environmental hygiene, 2017Co-Authors: Ludwig Vinches, Mohamed Zemzem, Stéphane Hallé, Caroline Peyrot, Kevin J. Wilkinson, Nathalie TufenkjiAbstract:ABSTRACTRecent studies underline the potential health risks associated to the “Nano” Revolution, particularly for the workers who handle engineered Nanoparticles (ENPs) that can be found in the formulation of several commercial products. Although many Health & Safety agencies recommend the use of protective gloves against chemicals, few studies have investigated the effectiveness of these gloves towards Nanoparticle suspensions. Moreover, the data that are available are often contradictory. This study was designed to evaluate the effectiveness of protective gloves against Nanoparticles in suspension. For this purpose, a new methodology was developed in order to take into account parameters encountered in the workplace such as mechanical deformations (MD) that simulate hand flexion and sweat. The effects of the precise experimental protocol on the concentrations of Nanoparticles that were detected in the sampling suspension were assessed. Several samples of nitrile rubber gloves (73 µm thick), taken from d...
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Influence of Solution Chemistry on the Deposition and Detachment Kinetics of a CdTe Quantum Dot Examined Using a Quartz Crystal Microbalance
Environmental science & technology, 2009Co-Authors: Ivan R. Quevedo, Nathalie TufenkjiAbstract:Recent reports underline the potential environmental and public health risks linked to the “Nano” Revolution, yet little is known regarding the environmental fate and impacts of most Nanomaterials following release in natural soils and groundwaters. Quantum dots (QDs) are one example of engineered Nanomaterials that have been demonstrated to exhibit cytotoxic effects; hence the fate of this material in aqueous environments is of particular interest. In this study, a quartz crystal microbalance (QCM) was used to examine the interaction of a commercially available carboxyl terminated CdTe QD with a model sand (i.e., silica) surface. The deposition kinetics of the QD onto clean silica coated QCM crystals were measured over a wide range of solution conditions, in the presence of either monovalent (K+) or divalent cations (Ca2+). QD deposition rates onto silica were significantly greater in the presence of calcium versus potassium. Solution pH also influenced QD deposition behavior, with increased deposition o...
Tufenkji Nathalie - One of the best experts on this subject based on the ideXlab platform.
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An improved experimental methodology to evaluate the effectiveness of protective gloves against Nanoparticles in suspension
Taylor & Francis, 2018Co-Authors: Vinches Ludwig, Zemzem Mohamed, Hallé Stéphane, Peyrot Caroline, Wilkinson, Kevin J., Tufenkji NathalieAbstract:Recent studies underline the potential health risks associated to the “Nano” Revolution, particularly for the workers who handle engineered Nanoparticles (ENPs) that can be found in the formulation of several commercial products. Although many Health & Safety agencies recommend the use of protective gloves against chemicals, few studies have investigated the effectiveness of these gloves towards Nanoparticle suspensions. Moreover, the data that are available are often contradictory. This study was designed to evaluate the effectiveness of protective gloves against Nanoparticles in suspension. For this purpose, a new methodology was developed in order to take into account parameters encountered in the workplace such as mechanical deformations (MD) that simulate hand flexion and sweat. The effects of the precise experimental protocol on the concentrations of Nanoparticles that were detected in the sampling suspension were assessed. Several samples of nitrile rubber gloves (73 µm thick), taken from different boxes, were brought into contact with gold Nanoparticles (5 nm) in water. During their exposure to ENPs, the glove samples submitted systematic mechanical deformations and were placed in contact with a physiological solution simulating human sweat. [...
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Influence of Solution Chemistry on the Deposition and Detachment Kinetics of a CdTe Quantum Dot Examined Using a Quartz Crystal Microbalance
American Chemical Society, 2018Co-Authors: Quevedo, Ivan R., Tufenkji NathalieAbstract:Recent reports underline the potential environmental and public health risks linked to the “Nano” Revolution, yet little is known regarding the environmental fate and impacts of most Nanomaterials following release in natural soils and groundwaters. Quantum dots (QDs) are one example of engineered Nanomaterials that have been demonstrated to exhibit cytotoxic effects; hence the fate of this material in aqueous environments is of particular interest. In this study, a quartz crystal microbalance (QCM) was used to examine the interaction of a commercially available carboxyl terminated CdTe QD with a model sand (i.e., silica) surface. The deposition kinetics of the QD onto clean silica coated QCM crystals were measured over a wide range of solution conditions, in the presence of either monovalent (K+) or divalent cations (Ca2+). QD deposition rates onto silica were significantly greater in the presence of calcium versus potassium. Solution pH also influenced QD deposition behavior, with increased deposition observed at a lower pH value. The rate of QD release from the silica surface was also monitored using QCM measurements and found to be comparable to the rate of particle deposition when the monovalent salt was used. In contrast, the rate of QD release was considerably lower than the rate of deposition when particles were deposited in the presence of Ca2+. Physicochemical characterization of the QD suspended in varying electrolytes provided insights into the role of solution chemistry on particle size and electrophoretic mobility (surface charge). Measurements of QD size using dynamic light scattering (DLS) and transmission electron microscopy (TEM) were used to interpret the QD deposition behavior in different solution chemistries. Lower particle deposition rates observed at high ionic strengths were attributed to aggregation of the QDs resulting in decreased convective-diffusive transport to the silica surface
Kevin J. Wilkinson - One of the best experts on this subject based on the ideXlab platform.
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An improved experimental methodology to evaluate the effectiveness of protective gloves against Nanoparticles in suspension.
Journal of occupational and environmental hygiene, 2017Co-Authors: Ludwig Vinches, Mohamed Zemzem, Stéphane Hallé, Caroline Peyrot, Kevin J. Wilkinson, Nathalie TufenkjiAbstract:ABSTRACTRecent studies underline the potential health risks associated to the “Nano” Revolution, particularly for the workers who handle engineered Nanoparticles (ENPs) that can be found in the formulation of several commercial products. Although many Health & Safety agencies recommend the use of protective gloves against chemicals, few studies have investigated the effectiveness of these gloves towards Nanoparticle suspensions. Moreover, the data that are available are often contradictory. This study was designed to evaluate the effectiveness of protective gloves against Nanoparticles in suspension. For this purpose, a new methodology was developed in order to take into account parameters encountered in the workplace such as mechanical deformations (MD) that simulate hand flexion and sweat. The effects of the precise experimental protocol on the concentrations of Nanoparticles that were detected in the sampling suspension were assessed. Several samples of nitrile rubber gloves (73 µm thick), taken from d...
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Which gloves are efficient to protect against titanium dioxide Nanoparticles in work conditions
International Journal of Theoretical and Applied Nanotechnology, 2014Co-Authors: Ludwig Vinches, Stéphane Hallé, Caroline Peyrot, Kevin J. WilkinsonAbstract:Recent articles underline the potential health risks associated to the “Nano” Revolution. Titanium dioxide Nanoparticles (nTiO2) are one of these engineered Nanoparticles (ENP) that have been cautioned about their likely harmful effects on health. In occupational use, to handle ENP, many Health & Safety agencies have recommended the application of the precautionary principle namely the recommendation of the use of protective gloves against chemicals. However, at the best of our knowledge, no study about the penetration of ENP through protective gloves in working conditions was performed. This study was designed to evaluate the efficiency of several models of protective gloves against nTiO2. Two types of nitrile rubber gloves (100 μm and 200μm), latex and butyl rubber gloves were brought into contact with nTiO2 in water, in propylene glycol (PG) or in powder. Mechanical biaxial deformations (BD), simulating the flexing of the hand, were applied to the samples during their exposure to ENP. Depending the model of gloves and the mode of application of the NP, the results obtained by ICP-MS (Inductively Coupled Plasma – Mass Spectrometry) are different. For nTiO2 in water, the passage is highlighted for nitrile rubber gloves (100 μm) after only 60 deformations and the nTiO2 concentration reaches its maximum for 180 DB. Regarding the nTiO2 in powder, nitrile rubber gloves (100 μm) and butyl rubber, the values achieved are significant but less than the solutions.
Celia N. Cruz - One of the best experts on this subject based on the ideXlab platform.
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How Has CDER Prepared for the Nano Revolution? A Review of Risk Assessment, Regulatory Research, and Guidance Activities
The AAPS Journal, 2017Co-Authors: Katherine M. Tyner, Changning Guo, Peng Zou, Wenlei Jiang, Xiaoming Xu, Stephanie Choi, Nan Zheng, Celia N. CruzAbstract:The Nanotechnology Risk Assessment Working Group in the Center for Drug Evaluation and Research (CDER) within the United States Food and Drug Administration (FDA) was established to assess the potential impact of Nanotechnology on drug products. One of the working group’s major initiatives has been to conduct a comprehensive risk management exercise regarding the potential impact of Nanomaterial pharmaceutical ingredients and excipients on drug product quality, safety, and efficacy. This exercise concluded that current review practices and regulatory guidance are capable of detecting and managing the potential risks to quality, safety, and efficacy when a drug product incorporates a Nanomaterial. However, three risk management areas were identified for continued focus during the review of drug products containing Nanomaterials: (1) the understanding of how to perform the characterization of Nanomaterial properties and the analytical methods used for this characterization, (2) the adequacy of in vitro tests to evaluate drug product performance for drug products containing Nanomaterials, and (3) the understanding of properties arising from Nanomaterials that may result in different toxicity and biodistribution profiles for drug products containing Nanomaterials. CDER continues to actively track the incorporation of Nanomaterials in drug products and the methodologies used to characterize them, in order to continuously improve the readiness of our science- and risk-based review approaches. In parallel to the risk management exercise, CDER has also been supporting regulatory research in the area of Nanotechnology, specifically focused on characterization, safety, and equivalence (between reference and new product) considerations. This article provides a comprehensive summary of regulatory and research efforts supported by CDER in the area of drug products containing Nanomaterials and other activities supporting the development of this emerging technology.
