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E H Huizing - One of the best experts on this subject based on the ideXlab platform.
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histological structure of the Nasal Cartilages and their perichondrial envelope ii the perichondrial envelope of the septal and lobular cartilage
Rhinology, 2007Co-Authors: Ronald L A W Bleys, Mariola Popko, Janwillem De Groot, E H HuizingAbstract:: The perichondrial envelopes of the septal cartilage and the lateral crus of the lobular cartilage were studied in serial coronal sections of five human noses. To differentiate between the various tissue components, the sections were stained according to Mallory-Cason, Azan, Herovici, Verhoeff-van Gieson, and Lawson. Collagen types I and II were immunohistochemically stained. The results demonstrated that the perichondrium of the septal cartilage and the lateral crus of the lobular cartilage consists of a homogeneous layer of type I collagen fibers and elastic fibers. The elastic fibers have a network-like arrangement and are most numerous in the perichondrium of the lateral crus of the lobular cartilage. Clearly distinguishable zones in the perichondrial envelopes could not be observed. The perichondrium on the outside of the lateral crus of the lobular cartilage and the triangular cartilage is significantly thicker than the inner perichondrium. It is speculated that these morphological characteristics of the perichondrial envelopes are related to functional differences between the Cartilages. The mobility of the lateral crus of the lobular cartilage requires a higher content of elastic fibers in its perichondrium than the more rigid septal cartilage. A thicker outer perichondrium of the lateral crus of the lobular cartilage and the triangular cartilage may be related to muscular forces that are exerted on the outer side of the Cartilages only.
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histological structure of the Nasal Cartilages and their perichondrial envelope i the septal and lobular cartilage
Rhinology, 2007Co-Authors: Mariola Popko, Ronald L A W Bleys, Janwillem De Groot, E H HuizingAbstract:The cellular elements and extracellular matrix of the Nasal septal cartilage and the lateral crus of the lobular cartilage were studied in serial coronal sections of five human cadaver noses. To discern the various tissue components, the sections were stained according to the methods of Mallory-Cason, Azan, Herovici, Verhoeff-van Gieson, and Lawson as well as by immunohistochemistry to demonstrate the presence of collagen type I and II. A characteristic gradual transition of the chondrocytes was observed in both septal and lobular cartilage: from numerous small flat cells oriented parallel to the surface of the cartilage to less numerous larger ovaloid cells oriented perpendicular to the surface. This difference between the peripheral and central zones of the cartilage was particularly marked in lobular cartilage. Both septal and lobular cartilage have a high density of type II collagen but almost none of type I. The peripheral zones of the matrix showed a higher density of collagen than the central zone. This difference was more pronounced in septal than lobular cartilage. The high density of type II collagen in septal cartilage, particularly in the peripheral zones, suggests that one of the primary tasks of the septum is providing stiffness to the external nose. That idea is consistent with findings from our study of the perichondrial envelope. SUMMARY
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a functional anatomic study of the relationship of the Nasal Cartilages and muscles to the Nasal valve area
Laryngoscope, 1998Co-Authors: Tjasse D Bruintjes, Adriaan F Van Olphen, Berend Hillen, E H HuizingAbstract:The functioning of the Nasal valve area is largely determined by the stability and the mobility of the lateral Nasal wall. To gain insight into the kinematics of the lateral Nasal wall, we studied the functional anatomy of the Nasal muscles and the intercartilaginous and osseous-cartilaginous junctions. We performed gross and microscopic Nasal dissection and serial sectioning in 15 human cadaveric noses. In addition, two noses were used for three-dimensional reconstruction of the Nasal Cartilages. We conclude that the lateral Nasal wall can be seen as made up of three parts. At the level of the osseous-cartilaginous chain of bone, lateral Nasal cartilage, and lateral crus, the lateral Nasal wall is relatively stable, limited mobility being allowed by translation and rotation in the intercartilaginous joint and a coupled distortion of the Cartilages. At the level of the hinge area the lateral Nasal wall is supported by one or more accessory Cartilages, embedded in soft tissue, and therefore much more compliant. The alar part of the Nasalis muscle, which originates from the maxilla and inserts on these Cartilages, may dilate the valve area by drawing this hinge area laterally. The third and most compliant part of the lateral Nasal wall is the part that is not supported by cartilage, the ala. The dilatator naris muscle largely occupies the ala and is attached to the lateral crus; it opens the vestibule and nostril. The third Nasal muscle that influences the lateral Nasal wall is the transverse part of the Nasalis muscle. It overlies the nose but is not attached to it. This muscle stabilizes the lateral Nasal wall, in particular, the lateral Nasal cartilage, the intercartilaginous junction, and the hinge area, by moving the Nasal skin.
Elzbieta Menaszek - One of the best experts on this subject based on the ideXlab platform.
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layered gelatin plla scaffolds fabricated by electrospinning and 3d printing for Nasal Cartilages and subchondral bone reconstruction
Materials & Design, 2018Co-Authors: I Rajzer, Anna Kurowska, Adam Jablonski, Samuel Jatteau, Mateusz śliwka, Magdalena Ziąbka, Elzbieta MenaszekAbstract:Abstract In the present work the advantages of two kinds of different, well known and applicable, biomaterials (PLLA and gelatin) and two kinds of scaffold fabrication techniques (3D printing - FDM and electrospinning) were combined in order to create a novel multifunctional layered scaffold for Nasal Cartilages and subchondral bone reconstruction. The pore size of scaffolds produced by 3D printing technology was designed to solve the problem that otolaryngologists currently have with fixing the Nasal cartilage implant with needle and threads. The effect of the solution concentration for the electrospinning process on the microstructure and mechanical properties of gelatin nanofibers produced as well as the influence of drug concentration on the mechanical properties of membranes were investigated. The commercially available FDM – 3D printing system was used. 3D scaffolds varying in structure and geometry were designed and printed. The influence of the internal architecture of 3D printed scaffolds on their mechanical properties was tested. Hybrid layered scaffolds consisting of a top gelatin nanofibrous layer and a bottom 3D printed porous PLLA material were developed. The mineralization ability of a scaffold was determined in simulated body fluid. The cytotoxicity, proliferation and morphology of Murine fibroblasts L929 cultured on obtained biomaterials were evaluated.
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Layered gelatin/PLLA scaffolds fabricated by electrospinning and 3D printing- for Nasal Cartilages and subchondral bone reconstruction
Materials & Design, 2018Co-Authors: I Rajzer, Anna Kurowska, Samuel Jatteau, Magdalena Ziąbka, Adam Jabłoński, Mateusz Śliwka, Elzbieta MenaszekAbstract:Abstract In the present work the advantages of two kinds of different, well known and applicable, biomaterials (PLLA and gelatin) and two kinds of scaffold fabrication techniques (3D printing - FDM and electrospinning) were combined in order to create a novel multifunctional layered scaffold for Nasal Cartilages and subchondral bone reconstruction. The pore size of scaffolds produced by 3D printing technology was designed to solve the problem that otolaryngologists currently have with fixing the Nasal cartilage implant with needle and threads. The effect of the solution concentration for the electrospinning process on the microstructure and mechanical properties of gelatin nanofibers produced as well as the influence of drug concentration on the mechanical properties of membranes were investigated. The commercially available FDM – 3D printing system was used. 3D scaffolds varying in structure and geometry were designed and printed. The influence of the internal architecture of 3D printed scaffolds on their mechanical properties was tested. Hybrid layered scaffolds consisting of a top gelatin nanofibrous layer and a bottom 3D printed porous PLLA material were developed. The mineralization ability of a scaffold was determined in simulated body fluid. The cytotoxicity, proliferation and morphology of Murine fibroblasts L929 cultured on obtained biomaterials were evaluated.
I Rajzer - One of the best experts on this subject based on the ideXlab platform.
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layered gelatin plla scaffolds fabricated by electrospinning and 3d printing for Nasal Cartilages and subchondral bone reconstruction
Materials & Design, 2018Co-Authors: I Rajzer, Anna Kurowska, Adam Jablonski, Samuel Jatteau, Mateusz śliwka, Magdalena Ziąbka, Elzbieta MenaszekAbstract:Abstract In the present work the advantages of two kinds of different, well known and applicable, biomaterials (PLLA and gelatin) and two kinds of scaffold fabrication techniques (3D printing - FDM and electrospinning) were combined in order to create a novel multifunctional layered scaffold for Nasal Cartilages and subchondral bone reconstruction. The pore size of scaffolds produced by 3D printing technology was designed to solve the problem that otolaryngologists currently have with fixing the Nasal cartilage implant with needle and threads. The effect of the solution concentration for the electrospinning process on the microstructure and mechanical properties of gelatin nanofibers produced as well as the influence of drug concentration on the mechanical properties of membranes were investigated. The commercially available FDM – 3D printing system was used. 3D scaffolds varying in structure and geometry were designed and printed. The influence of the internal architecture of 3D printed scaffolds on their mechanical properties was tested. Hybrid layered scaffolds consisting of a top gelatin nanofibrous layer and a bottom 3D printed porous PLLA material were developed. The mineralization ability of a scaffold was determined in simulated body fluid. The cytotoxicity, proliferation and morphology of Murine fibroblasts L929 cultured on obtained biomaterials were evaluated.
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Layered gelatin/PLLA scaffolds fabricated by electrospinning and 3D printing- for Nasal Cartilages and subchondral bone reconstruction
Materials & Design, 2018Co-Authors: I Rajzer, Anna Kurowska, Samuel Jatteau, Magdalena Ziąbka, Adam Jabłoński, Mateusz Śliwka, Elzbieta MenaszekAbstract:Abstract In the present work the advantages of two kinds of different, well known and applicable, biomaterials (PLLA and gelatin) and two kinds of scaffold fabrication techniques (3D printing - FDM and electrospinning) were combined in order to create a novel multifunctional layered scaffold for Nasal Cartilages and subchondral bone reconstruction. The pore size of scaffolds produced by 3D printing technology was designed to solve the problem that otolaryngologists currently have with fixing the Nasal cartilage implant with needle and threads. The effect of the solution concentration for the electrospinning process on the microstructure and mechanical properties of gelatin nanofibers produced as well as the influence of drug concentration on the mechanical properties of membranes were investigated. The commercially available FDM – 3D printing system was used. 3D scaffolds varying in structure and geometry were designed and printed. The influence of the internal architecture of 3D printed scaffolds on their mechanical properties was tested. Hybrid layered scaffolds consisting of a top gelatin nanofibrous layer and a bottom 3D printed porous PLLA material were developed. The mineralization ability of a scaffold was determined in simulated body fluid. The cytotoxicity, proliferation and morphology of Murine fibroblasts L929 cultured on obtained biomaterials were evaluated.
Gary D Friedman - One of the best experts on this subject based on the ideXlab platform.
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Changing the convexity and concavity of Nasal Cartilages and cartilage grafts with horizontal mattress sutures: part II. Clinical results.
Plastic and reconstructive surgery, 2020Co-Authors: Ronald P Gruber, Farzad Nahai, Michael A Bogdan, Gary D FriedmanAbstract:Horizontal mattress sutures have previously been shown to remove unwanted bulbosity and convexity of Nasal tip Cartilages. The purpose of this study was to extend that concept by investigating the universal applicability of the horizontal mattress suture to change and control the curvature (e.g., convexity or concavity) of a wide variety of Nasal Cartilages and warped cartilage grafts. The horizontal mattress suture was applied to a variety of clinical situations, including Nasal tip bulbosity caused by convex lateral crura, collapsed external Nasal valves, warped grafts and struts, crooked L-shaped septal struts, and collapsed internal Nasal valves. Twenty-nine cases were studied over a period of 10 to 23 months. The horizontal mattress suture proved to be a simple, effective means of achieving satisfactory control of the curvature of various Cartilages of the nose (including external valves, internal valves, and septum) and warped cartilage grafts. Curvature control was obtained in all cases where the cartilage was supple. Moreover, the resultant strength was increased above normal. Partial recurrence of the curvature was seen in only two cases. Clinical results indicated that the horizontal mattress suture is universally applicable to a variety of situations in which the curvature of Nasal cartilage and cartilage grafts needs to be removed or modified. The mattress suture drastically reduces the need for scoring (with its inherent problems of weakness) and the need for cartilage grafting.
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changing the convexity and concavity of Nasal Cartilages and cartilage grafts with horizontal mattress sutures part i experimental results
Plastic and Reconstructive Surgery, 2005Co-Authors: Ronald P Gruber, Farzad Nahai, Michael A Bogdan, Gary D FriedmanAbstract:Prior studies indicated that horizontal mattress sutures can control the curvature of a convex lateral crus. This study undertook to ascertain the ideal spacing for mattress sutures, determine what effect they have on the subsequent strength of the cartilage, and compare that to the resultant streng
Ronald P Gruber - One of the best experts on this subject based on the ideXlab platform.
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Changing the convexity and concavity of Nasal Cartilages and cartilage grafts with horizontal mattress sutures: part II. Clinical results.
Plastic and reconstructive surgery, 2020Co-Authors: Ronald P Gruber, Farzad Nahai, Michael A Bogdan, Gary D FriedmanAbstract:Horizontal mattress sutures have previously been shown to remove unwanted bulbosity and convexity of Nasal tip Cartilages. The purpose of this study was to extend that concept by investigating the universal applicability of the horizontal mattress suture to change and control the curvature (e.g., convexity or concavity) of a wide variety of Nasal Cartilages and warped cartilage grafts. The horizontal mattress suture was applied to a variety of clinical situations, including Nasal tip bulbosity caused by convex lateral crura, collapsed external Nasal valves, warped grafts and struts, crooked L-shaped septal struts, and collapsed internal Nasal valves. Twenty-nine cases were studied over a period of 10 to 23 months. The horizontal mattress suture proved to be a simple, effective means of achieving satisfactory control of the curvature of various Cartilages of the nose (including external valves, internal valves, and septum) and warped cartilage grafts. Curvature control was obtained in all cases where the cartilage was supple. Moreover, the resultant strength was increased above normal. Partial recurrence of the curvature was seen in only two cases. Clinical results indicated that the horizontal mattress suture is universally applicable to a variety of situations in which the curvature of Nasal cartilage and cartilage grafts needs to be removed or modified. The mattress suture drastically reduces the need for scoring (with its inherent problems of weakness) and the need for cartilage grafting.
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commentary on anatomic and anthropometric analysis of 72 lower lateral Nasal Cartilages from fresh persian iranian cadavers
Aesthetic Surgery Journal, 2012Co-Authors: Ronald P GruberAbstract:Dr. Farahvash and his coauthors1 have provided us with a study of Persian Nasal anatomy, particularly the lower lateral Cartilages (LLC). The authors understandably wish that a distinction be made between Persian and Middle Eastern ethnicity; the umbrella term Middle Eastern commonly refers to people of Arabic, Turkish, North African, and Persian descent. Common anatomical characteristics of patients in the larger Middle Eastern group have been published by Daniel2-4 and also by Rohrich and Ghavami.5 These features often include a high dorsum, occasionally a thick skin envelope, an ill-defined or small tip (weak or small middle/medial Cartilages), and wide Nasal bones. It should not be surprising that Persian noses might be slightly different from those of patients in other Middle Eastern groups. The authors want their readers to appreciate the unique Persian anatomy in preparation for surgical maneuvers that provide better results. This is the goal of all anatomical and clinical studies of ethnic groups,6-8 with the understanding that some patients may wish to retain some or all of their ethnic characteristics.9 The study is a highly-detailed analysis of the LLC, including their relationship to certain external skin markings (eg, the rim). The authors are then able to compare Persian (Iranian) Nasal features with the parameters of other ethnic groups and …
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changing the convexity and concavity of Nasal Cartilages and cartilage grafts with horizontal mattress sutures part i experimental results
Plastic and Reconstructive Surgery, 2005Co-Authors: Ronald P Gruber, Farzad Nahai, Michael A Bogdan, Gary D FriedmanAbstract:Prior studies indicated that horizontal mattress sutures can control the curvature of a convex lateral crus. This study undertook to ascertain the ideal spacing for mattress sutures, determine what effect they have on the subsequent strength of the cartilage, and compare that to the resultant streng
