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Pulok K. Mukherjee - One of the best experts on this subject based on the ideXlab platform.
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antioxidant activity of Nelumbo nucifera sacred lotus seeds
Journal of Ethnopharmacology, 2006Co-Authors: Sujay Rai, Atul Wahile, Kakali Mukherjee, B P Saha, Pulok K. MukherjeeAbstract:Antioxidant activity of hydro alcoholic extract of Nelumbo nucifera seeds (HANN) was studied using in vitro and in vivo models. Total phenolic content in HANN was found to be 7.61 ± 0.04% (w/w). Characteristic HPTLC fingerprints of HANN were also made using different solvent systems. The HANN exhibited strong free radical scavenging activity as evidenced by the low IC50 values in both DPPH (1,1-diphenyl-2-picryl hydrazyl) (6.12 ± 0.41 μg/ml) and nitric oxide (84.86 ± 3.56 μg/ml) methods. The values were found to be less than those of rutin, the standard used. Acute toxicity of HANN was evaluated in Swiss Albino mice, no signs of toxicity were observed up to the oral dose of 1000 mg/kg body weight. Administration of HANN to Wistar rats at 100 and 200 mg/kg body weight for 4 days prior to carbon tetrachloride (CCl4) treatment caused a significant dose dependent increase (p < 0.05 to p < 0.001) in the level of superoxide dismutase (SOD) and catalase and a significant decrease (p < 0.05 to p < 0.001) in the level of thiobarbituric acid reactive substances (TBARS), when compared to CCl4 treated control in both liver and kidney. These changes observed at 100 mg/kg body weight treatment were comparable to those observed for standard Vitamin E at 50 mg/kg treatment. Nelumbo nucifera seeds contain alkaloids, saponins, phenolics and carbohydrates. The results support significant antioxidant nature of HANN.
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Pharmacognostical profile of rhizome of Nelumbo nucifera gaertn.
Ancient Science of Life, 1998Co-Authors: Pulok K. Mukherjee, Kakali Saha, B. P. SahaAbstract:: The rhizome of Nelumbo nucifera Gaertn (fam. Nymphaeaceae) was studied to fix the parameters for pharmacognostical standards. The present investigation deals with the macro and microscopically characters of rhizome along with studies on some physical constants, behavior of powdered rhizomes on treatment with different chemical reagents and florescence characteristics on exposure to U.V light, which would help in identification of the drug.
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effect of Nelumbo nucifera rhizome extract on blood sugar level in rats
Journal of Ethnopharmacology, 1997Co-Authors: Pulok K. Mukherjee, M. Pal, Kakali Saha, B P SahaAbstract:Oral administration of the ethanolic extract of rhizomes of Nelumbo nucifera markedly reduced the blood sugar level of normal, glucose-fed hyperglycemic and streptozotocin-induced diabetic rats, when compared with control animals. The extract improved glucose tolerance and potentiated the action of exogenously injected insulin in normal rats. When compared with tolbutamide, the extract exhibited activity of 73 and 67% of that of tolbutamide in normal and diabetic rats, respectively.
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diuretic activity of extract of the rhizomes of Nelumbo nucifera gaertn fam nymphaeaceae
Phytotherapy Research, 1996Co-Authors: Pulok K. Mukherjee, M. Pal, Kakali Saha, B P Saha, J DasAbstract:The diuretic efficacy of the rhizomes of Nelumbo nucifera was studied on albino rats. The methanol extract of the rhizomes induced significant diuresis in rats. Dose dependent effects were observed in urine volume and electrolyte excretion. There was a significant increase in natriuretic and chloruretic activity but kaliuresis was less than natriuresis.
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Studies on psychopharmacological effects of Nelumbo nucifera Gaertn. rhizome extract
Journal of Ethnopharmacology, 1996Co-Authors: Pulok K. Mukherjee, Ramjee Balasubramanian, M. Pal, Kakali Saha, B. P. SahaAbstract:Methanolic extract of rhizomes of Nelumbo nucifera (NNRE) was investigated for different psychopharmacological actions in rats and mice. The extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip and Y-maze test, reduction in muscle relaxant activity by rotarod, 30° inclined screen and traction test and potentiated the pentobarbitone induced sleeping time in mice significantly.
Kakali Saha - One of the best experts on this subject based on the ideXlab platform.
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Pharmacognostical profile of rhizome of Nelumbo nucifera gaertn.
Ancient Science of Life, 1998Co-Authors: Pulok K. Mukherjee, Kakali Saha, B. P. SahaAbstract:: The rhizome of Nelumbo nucifera Gaertn (fam. Nymphaeaceae) was studied to fix the parameters for pharmacognostical standards. The present investigation deals with the macro and microscopically characters of rhizome along with studies on some physical constants, behavior of powdered rhizomes on treatment with different chemical reagents and florescence characteristics on exposure to U.V light, which would help in identification of the drug.
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effect of Nelumbo nucifera rhizome extract on blood sugar level in rats
Journal of Ethnopharmacology, 1997Co-Authors: Pulok K. Mukherjee, M. Pal, Kakali Saha, B P SahaAbstract:Oral administration of the ethanolic extract of rhizomes of Nelumbo nucifera markedly reduced the blood sugar level of normal, glucose-fed hyperglycemic and streptozotocin-induced diabetic rats, when compared with control animals. The extract improved glucose tolerance and potentiated the action of exogenously injected insulin in normal rats. When compared with tolbutamide, the extract exhibited activity of 73 and 67% of that of tolbutamide in normal and diabetic rats, respectively.
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diuretic activity of extract of the rhizomes of Nelumbo nucifera gaertn fam nymphaeaceae
Phytotherapy Research, 1996Co-Authors: Pulok K. Mukherjee, M. Pal, Kakali Saha, B P Saha, J DasAbstract:The diuretic efficacy of the rhizomes of Nelumbo nucifera was studied on albino rats. The methanol extract of the rhizomes induced significant diuresis in rats. Dose dependent effects were observed in urine volume and electrolyte excretion. There was a significant increase in natriuretic and chloruretic activity but kaliuresis was less than natriuresis.
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Studies on psychopharmacological effects of Nelumbo nucifera Gaertn. rhizome extract
Journal of Ethnopharmacology, 1996Co-Authors: Pulok K. Mukherjee, Ramjee Balasubramanian, M. Pal, Kakali Saha, B. P. SahaAbstract:Methanolic extract of rhizomes of Nelumbo nucifera (NNRE) was investigated for different psychopharmacological actions in rats and mice. The extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip and Y-maze test, reduction in muscle relaxant activity by rotarod, 30° inclined screen and traction test and potentiated the pentobarbitone induced sleeping time in mice significantly.
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A review on Nelumbo nucifera gaertn.
Ancient science of life, 1996Co-Authors: Pulok K. Mukherjee, Ramjee Balasubramanian, Kakali Saha, B. P. Saha, M. PalAbstract:Nelumbo nucifera Gaertn (Family- Nymphaeaceae) is a well known plant in ancient medical sciences, Much research have been done on the leaves, flowers, seeds and rhizomes of the plant, Our present aim is to review all the work performed on the plant to get a clear idea to evaluate its various medicinal principles relating to phytochemical pharmacological microbiological and allied approaches.
B P Saha - One of the best experts on this subject based on the ideXlab platform.
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antioxidant activity of Nelumbo nucifera sacred lotus seeds
Journal of Ethnopharmacology, 2006Co-Authors: Sujay Rai, Atul Wahile, Kakali Mukherjee, B P Saha, Pulok K. MukherjeeAbstract:Antioxidant activity of hydro alcoholic extract of Nelumbo nucifera seeds (HANN) was studied using in vitro and in vivo models. Total phenolic content in HANN was found to be 7.61 ± 0.04% (w/w). Characteristic HPTLC fingerprints of HANN were also made using different solvent systems. The HANN exhibited strong free radical scavenging activity as evidenced by the low IC50 values in both DPPH (1,1-diphenyl-2-picryl hydrazyl) (6.12 ± 0.41 μg/ml) and nitric oxide (84.86 ± 3.56 μg/ml) methods. The values were found to be less than those of rutin, the standard used. Acute toxicity of HANN was evaluated in Swiss Albino mice, no signs of toxicity were observed up to the oral dose of 1000 mg/kg body weight. Administration of HANN to Wistar rats at 100 and 200 mg/kg body weight for 4 days prior to carbon tetrachloride (CCl4) treatment caused a significant dose dependent increase (p < 0.05 to p < 0.001) in the level of superoxide dismutase (SOD) and catalase and a significant decrease (p < 0.05 to p < 0.001) in the level of thiobarbituric acid reactive substances (TBARS), when compared to CCl4 treated control in both liver and kidney. These changes observed at 100 mg/kg body weight treatment were comparable to those observed for standard Vitamin E at 50 mg/kg treatment. Nelumbo nucifera seeds contain alkaloids, saponins, phenolics and carbohydrates. The results support significant antioxidant nature of HANN.
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effect of Nelumbo nucifera rhizome extract on blood sugar level in rats
Journal of Ethnopharmacology, 1997Co-Authors: Pulok K. Mukherjee, M. Pal, Kakali Saha, B P SahaAbstract:Oral administration of the ethanolic extract of rhizomes of Nelumbo nucifera markedly reduced the blood sugar level of normal, glucose-fed hyperglycemic and streptozotocin-induced diabetic rats, when compared with control animals. The extract improved glucose tolerance and potentiated the action of exogenously injected insulin in normal rats. When compared with tolbutamide, the extract exhibited activity of 73 and 67% of that of tolbutamide in normal and diabetic rats, respectively.
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diuretic activity of extract of the rhizomes of Nelumbo nucifera gaertn fam nymphaeaceae
Phytotherapy Research, 1996Co-Authors: Pulok K. Mukherjee, M. Pal, Kakali Saha, B P Saha, J DasAbstract:The diuretic efficacy of the rhizomes of Nelumbo nucifera was studied on albino rats. The methanol extract of the rhizomes induced significant diuresis in rats. Dose dependent effects were observed in urine volume and electrolyte excretion. There was a significant increase in natriuretic and chloruretic activity but kaliuresis was less than natriuresis.
M. Pal - One of the best experts on this subject based on the ideXlab platform.
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effect of Nelumbo nucifera rhizome extract on blood sugar level in rats
Journal of Ethnopharmacology, 1997Co-Authors: Pulok K. Mukherjee, M. Pal, Kakali Saha, B P SahaAbstract:Oral administration of the ethanolic extract of rhizomes of Nelumbo nucifera markedly reduced the blood sugar level of normal, glucose-fed hyperglycemic and streptozotocin-induced diabetic rats, when compared with control animals. The extract improved glucose tolerance and potentiated the action of exogenously injected insulin in normal rats. When compared with tolbutamide, the extract exhibited activity of 73 and 67% of that of tolbutamide in normal and diabetic rats, respectively.
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diuretic activity of extract of the rhizomes of Nelumbo nucifera gaertn fam nymphaeaceae
Phytotherapy Research, 1996Co-Authors: Pulok K. Mukherjee, M. Pal, Kakali Saha, B P Saha, J DasAbstract:The diuretic efficacy of the rhizomes of Nelumbo nucifera was studied on albino rats. The methanol extract of the rhizomes induced significant diuresis in rats. Dose dependent effects were observed in urine volume and electrolyte excretion. There was a significant increase in natriuretic and chloruretic activity but kaliuresis was less than natriuresis.
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Studies on psychopharmacological effects of Nelumbo nucifera Gaertn. rhizome extract
Journal of Ethnopharmacology, 1996Co-Authors: Pulok K. Mukherjee, Ramjee Balasubramanian, M. Pal, Kakali Saha, B. P. SahaAbstract:Methanolic extract of rhizomes of Nelumbo nucifera (NNRE) was investigated for different psychopharmacological actions in rats and mice. The extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip and Y-maze test, reduction in muscle relaxant activity by rotarod, 30° inclined screen and traction test and potentiated the pentobarbitone induced sleeping time in mice significantly.
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A review on Nelumbo nucifera gaertn.
Ancient science of life, 1996Co-Authors: Pulok K. Mukherjee, Ramjee Balasubramanian, Kakali Saha, B. P. Saha, M. PalAbstract:Nelumbo nucifera Gaertn (Family- Nymphaeaceae) is a well known plant in ancient medical sciences, Much research have been done on the leaves, flowers, seeds and rhizomes of the plant, Our present aim is to review all the work performed on the plant to get a clear idea to evaluate its various medicinal principles relating to phytochemical pharmacological microbiological and allied approaches.
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ANTI-DIARRHOEL EVALUATION OF Nelumbo nucifera RHIZOME EXTRACT
Indian Journal of Pharmacology, 1995Co-Authors: P K Mukerjee, Ramjee Balasubramanian, M. Pal, Kakali Saha, K Das, Bibhuti SahaAbstract:A study was undertaken to evaluate the effects of methanolic extract of rhizomes of Nelumbo nucifera Gaertn (FINN) for its antidiarrhoeal potential against several experimental models of diarrhoea in rats. RNN treated animals showed significant inhibitory activity against castor oil induced diarrhoea and inhibited significantly PGE, induced enteropooling in rats. It also showed significant reduction in gastrointestinal motility following charcoal meal in rats. The results obtained establish the efficacy of RNN as an antidiarrhoeal agent.
B. P. Saha - One of the best experts on this subject based on the ideXlab platform.
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Pharmacognostical profile of rhizome of Nelumbo nucifera gaertn.
Ancient Science of Life, 1998Co-Authors: Pulok K. Mukherjee, Kakali Saha, B. P. SahaAbstract:: The rhizome of Nelumbo nucifera Gaertn (fam. Nymphaeaceae) was studied to fix the parameters for pharmacognostical standards. The present investigation deals with the macro and microscopically characters of rhizome along with studies on some physical constants, behavior of powdered rhizomes on treatment with different chemical reagents and florescence characteristics on exposure to U.V light, which would help in identification of the drug.
-
Studies on psychopharmacological effects of Nelumbo nucifera Gaertn. rhizome extract
Journal of Ethnopharmacology, 1996Co-Authors: Pulok K. Mukherjee, Ramjee Balasubramanian, M. Pal, Kakali Saha, B. P. SahaAbstract:Methanolic extract of rhizomes of Nelumbo nucifera (NNRE) was investigated for different psychopharmacological actions in rats and mice. The extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip and Y-maze test, reduction in muscle relaxant activity by rotarod, 30° inclined screen and traction test and potentiated the pentobarbitone induced sleeping time in mice significantly.
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A review on Nelumbo nucifera gaertn.
Ancient science of life, 1996Co-Authors: Pulok K. Mukherjee, Ramjee Balasubramanian, Kakali Saha, B. P. Saha, M. PalAbstract:Nelumbo nucifera Gaertn (Family- Nymphaeaceae) is a well known plant in ancient medical sciences, Much research have been done on the leaves, flowers, seeds and rhizomes of the plant, Our present aim is to review all the work performed on the plant to get a clear idea to evaluate its various medicinal principles relating to phytochemical pharmacological microbiological and allied approaches.
