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Meng Tang - One of the best experts on this subject based on the ideXlab platform.

  • mechanisms underlying Nickel Nanoparticle induced reproductive toxicity and chemo protective effects of vitamin c in male rats
    Chemosphere, 2019
    Co-Authors: Lu Kong, Keping Cheng, Meng Tang
    Abstract:

    The purpose of this research is to go a step further study on the reproductive toxicities and the underlying mechanisms induced by Nickel Nanoparticles (NiNPs), and the possible protective action of vitamin C. Animal experiment was designed according to the one-generation reproductive toxicity standard, and rats were exposed to NiNPs through gavage. Ultrastructural, reactive oxygen species (ROS), oxidant and antioxidant enzymes, and cell apoptosis-related factors in the testicular tissue were analyzed. In contrast with the control group, the activity of surperoxide dismutase (SOD), catalase (CAT) and gonad-stimulating hormone (GSH) was reduced, while the content of nitric oxide (NO), malondialdehyde (MDA) and ROS was increased in the NiNPs treated animals. As the doses of NiNPs increase, the mRNA of apoptotic related factor Caspase-9, Caspase-8 and Caspase-3 showed an obviously upregulation. Protein expression of Bcl-2-associated X Protein (Bax) and apoptosis inducing factor (AIF) was significantly unregulated. After addition of antioxidants-vitamin C, the toxicity was reduced. Injured testicular tissue indicated that NiNPs exposure could damage the reproductive system. Our results suggest that NiNPs induce significant reproductive toxicities. The cellular apoptosis might be induced by caspase family proteinases, but the regulator factor (factor associated suicide (Fas), B-cell lymphoma-2 (Bcl-2), Bax, BH3-interacting domain death agonist (Bid) and AIF protein) might not be involved in this process. Thus, the mechanism of reproductive toxicity of NiNPs on rat testes involves in the induction of oxidative stress, which further results in cell apoptosis. Antioxidants-vitamin C shows a significant inhibition on the reproductive toxicities induced by NiNPs.

  • Nickel Nanoparticles Exposure and Reproductive Toxicity in Healthy Adult Rats
    International journal of molecular sciences, 2014
    Co-Authors: Lu Kong, Ting Zhang, Meng Tang, Dayong Wang, Chao Wei, Geyu Liang
    Abstract:

    Nickel is associated with reproductive toxicity. However, the reproductive toxicity of Nickel Nanoparticles (Ni NPs) is unclear. Our goal was to determine the association between Nickel Nanoparticle exposure and reproductive toxicity. According to the one-generation reproductive toxicity standard, rats were exposed to Nickel Nanoparticles by gavage and we selected indicators including sex hormone levels, sperm motility, histopathology, and reproductive outcome etc. Experimental results showed Nickel Nanoparticles increased follicle stimulating hormone (FSH) and luteinizing hormone (LH), and lowered etradiol (E2) serum levels at a dose of 15 and 45 mg/kg in female rats. Ovarian lymphocytosis, vascular dilatation and congestion, inflammatory cell infiltration, and increase in apoptotic cells were found in ovary tissues in exposure groups. For male rats, the weights decreased gradually, the ratio of epididymis weight over body weight increased, the motility of rat sperm changed, and the levels of FSH and testosterone (T) diminished. Pathological results showed the shedding of epithelial cells of raw seminiferous tubule, disordered arrangement of cells in the tube, and the appearance of cell apoptosis and death in the exposure group. At the same time, Ni NPs resulted in a change of the reproductive index and the offspring development of rats. Further research is needed to elucidate exposure to human populations and mechanism of actions.

Lu Kong - One of the best experts on this subject based on the ideXlab platform.

  • mechanisms underlying Nickel Nanoparticle induced reproductive toxicity and chemo protective effects of vitamin c in male rats
    Chemosphere, 2019
    Co-Authors: Lu Kong, Keping Cheng, Meng Tang
    Abstract:

    The purpose of this research is to go a step further study on the reproductive toxicities and the underlying mechanisms induced by Nickel Nanoparticles (NiNPs), and the possible protective action of vitamin C. Animal experiment was designed according to the one-generation reproductive toxicity standard, and rats were exposed to NiNPs through gavage. Ultrastructural, reactive oxygen species (ROS), oxidant and antioxidant enzymes, and cell apoptosis-related factors in the testicular tissue were analyzed. In contrast with the control group, the activity of surperoxide dismutase (SOD), catalase (CAT) and gonad-stimulating hormone (GSH) was reduced, while the content of nitric oxide (NO), malondialdehyde (MDA) and ROS was increased in the NiNPs treated animals. As the doses of NiNPs increase, the mRNA of apoptotic related factor Caspase-9, Caspase-8 and Caspase-3 showed an obviously upregulation. Protein expression of Bcl-2-associated X Protein (Bax) and apoptosis inducing factor (AIF) was significantly unregulated. After addition of antioxidants-vitamin C, the toxicity was reduced. Injured testicular tissue indicated that NiNPs exposure could damage the reproductive system. Our results suggest that NiNPs induce significant reproductive toxicities. The cellular apoptosis might be induced by caspase family proteinases, but the regulator factor (factor associated suicide (Fas), B-cell lymphoma-2 (Bcl-2), Bax, BH3-interacting domain death agonist (Bid) and AIF protein) might not be involved in this process. Thus, the mechanism of reproductive toxicity of NiNPs on rat testes involves in the induction of oxidative stress, which further results in cell apoptosis. Antioxidants-vitamin C shows a significant inhibition on the reproductive toxicities induced by NiNPs.

  • Nickel Nanoparticles Exposure and Reproductive Toxicity in Healthy Adult Rats
    International journal of molecular sciences, 2014
    Co-Authors: Lu Kong, Ting Zhang, Meng Tang, Dayong Wang, Chao Wei, Geyu Liang
    Abstract:

    Nickel is associated with reproductive toxicity. However, the reproductive toxicity of Nickel Nanoparticles (Ni NPs) is unclear. Our goal was to determine the association between Nickel Nanoparticle exposure and reproductive toxicity. According to the one-generation reproductive toxicity standard, rats were exposed to Nickel Nanoparticles by gavage and we selected indicators including sex hormone levels, sperm motility, histopathology, and reproductive outcome etc. Experimental results showed Nickel Nanoparticles increased follicle stimulating hormone (FSH) and luteinizing hormone (LH), and lowered etradiol (E2) serum levels at a dose of 15 and 45 mg/kg in female rats. Ovarian lymphocytosis, vascular dilatation and congestion, inflammatory cell infiltration, and increase in apoptotic cells were found in ovary tissues in exposure groups. For male rats, the weights decreased gradually, the ratio of epididymis weight over body weight increased, the motility of rat sperm changed, and the levels of FSH and testosterone (T) diminished. Pathological results showed the shedding of epithelial cells of raw seminiferous tubule, disordered arrangement of cells in the tube, and the appearance of cell apoptosis and death in the exposure group. At the same time, Ni NPs resulted in a change of the reproductive index and the offspring development of rats. Further research is needed to elucidate exposure to human populations and mechanism of actions.

Sun Zhi - One of the best experts on this subject based on the ideXlab platform.

  • Optimization of biohydrogen production using acid pretreated corn stover hydrolysate followed by Nickel Nanoparticle addition
    'Wiley', 2020
    Co-Authors: Sun Yong, Wang Yunshan, Yang Gang, Sun Zhi
    Abstract:

    The dilute acid hydrolysis using corn stover (CS) to produce reducible sugars was optimized by the response surface methodology. The electron-equivalent balances of the main metabolites during the dark fermentation (DF) using acid hydrolysate were investigated to identify the evolutions of the electron sinks over the course of DF. The additions of Nickel ion and Ni0 Nanoparticles (NPs) were found to effectively enhance the hydrogen production at experimental conditions. The optimal condition (HCl 2.5 wt%, hydrolyzing duration 105 minutes, pH=5, S/B=3.5, Ni0 NPs=10 mg/L-1) was achieved with YH2/S reaching 1.18 (mol.mol-1-glucose). The YH2/S increased from 0.7 (mol.mol-1-glucose) to 1.18 (mol.mol-1-glucose) reaching 40% hydrogen yield increase when Ni0 NPs was added to the fermentation broth. Among the investigated significant soluble metabolites, the butyric acid was found to serve as the largest e-sink in the electron-equivalent balance. The additions of Ni0 NPs at low level (below 10 mg/L) were found to appreciably increase the hydrogen production. The increased pH and substrate to biomass ratio were found to skew the metabolic balance from hydrogen production to the biosynthesis (an increase of biomass). The proposed anaerobic digestion model with consideration of the inhibitory factors model presents a good agreement with the experimental data. The chemical addition such as Nickel ions, Ni0 NPs was found to be a practical approach in enhancing biohydrogen production using CS acid hydrolysate as cultivation broth. © 2019 John Wiley & Sons, Ltd

  • Optimization of biohydrogen production using acid pretreated corn stover hydrolysate followed by Nickel Nanoparticle addition
    'Wiley', 2020
    Co-Authors: Sun Yong, Wang Yunshan, Yang Gang, Sun Zhi
    Abstract:

    The dilute acid hydrolysis using corn stover (CS) to produce reducible sugars was optimized by the response surface methodology. The electron-equivalent balances of the main metabolites during the dark fermentation (DF) using acid hydrolysate were investigated to identify the evolutions of the electron sinks over the course of DF. The additions of Nickel ion and Ni-0 Nanoparticles (NPs) were found to effectively enhance the hydrogen production at experimental conditions. The optimal condition (HCl 2.5 wt%, hydrolyzing duration 105 minutes, pH=5, S/B=3.5, Ni-0 NPs=10 mg/L-1) was achieved with Y-H2/S reaching 1.18 (mol.mol(-1)-glucose). The Y-H2/S increased from 0.7 (mol.mol(-1)-glucose) to 1.18 (mol.mol(-1)-glucose) reaching 40% hydrogen yield increase when Ni-0 NPs was added to the fermentation broth. Among the investigated significant soluble metabolites, the butyric acid was found to serve as the largest e-sink in the electron-equivalent balance. The additions of Ni-0 NPs at low level (below 10 mg/L) were found to appreciably increase the hydrogen production. The increased pH and substrate to biomass ratio were found to skew the metabolic balance from hydrogen production to the biosynthesis (an increase of biomass). The proposed anaerobic digestion model with consideration of the inhibitory factors model presents a good agreement with the experimental data. The chemical addition such as Nickel ions, Ni-0 NPs was found to be a practical approach in enhancing biohydrogen production using CS acid hydrolysate as cultivation broth

  • Optimization and kinetic modeling of an enhanced bio-hydrogen fermentation with the addition of synergistic biochar and Nickel Nanoparticle
    'Wiley', 2019
    Co-Authors: Sun Yong, Yang Gang, Zhang Jinping, Wen Chao, Sun Zhi
    Abstract:

    The improvement of hydrogen production was achieved by the addition of biochar (BC) and metal co-factor Nanoparticle Ni-0 during the dark fermentation. A new hybrid approach by combing the artificial neural networks with the response surface methodology was applied to optimize the hydrogen production. The effects of operating conditions, ie, BC, metal cofactor Ni-0, pH, and dosage of microbes, upon the hydrogen production together with the concentrations of other metabolites such as the acetic acid, propionic acid, butyric acid, and ethanol were extensively investigated. From kinetic study of the major metabolites, the acetate pathway was found to be apparently enhanced by the addition of synergistic factors. The modified anaerobic digestion model with the consideration of inhabitation factor was found to best represent the kinetics of hydrogen production and the formation of major metabolites

Yujin Chen - One of the best experts on this subject based on the ideXlab platform.

  • Nickel Nanoparticle encapsulated in few layer nitrogen doped graphene supported by nitrogen doped graphite sheets as a high performance electromagnetic wave absorbing material
    ACS Applied Materials & Interfaces, 2018
    Co-Authors: Haoran Yuan, Feng Yan, Chunling Zhu, Xitian Zhang, Yujin Chen
    Abstract:

    Herein we develop a facile strategy for fabricating Nickel particle encapsulated in few-layer nitrogen-doped graphene supported by graphite carbon sheets as a high-performance electromagnetic wave (EMW) absorbing material. The obtained material exhibits sheetlike morphology with a lateral length ranging from a hundred nanometers to 2 μm and a thickness of about 23 nm. Nickel Nanoparticles with a diameter of approximately 20 nm were encapsulated in about six layers of nitrogen-doped graphene. As applied for electromagnetic absorbing material, the heteronanostructures exhibit excellent electromagnetic wave absorption property, comparable to most EMW absorbing materials previously reported. Typically, the effective absorption bandwidth (the frequency region falls within the reflection loss below −10 dB) is up to 8.5 GHz at the thicknesses of 3.0 mm for the heteronanostructures with the optimized Ni content. Furthermore, two processes, carbonization at a high temperature and subsequent treatment in hot acid s...

Jianping Lang - One of the best experts on this subject based on the ideXlab platform.