The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Chuanwen Sun - One of the best experts on this subject based on the ideXlab platform.
-
synthesis crystal structure and insecticidal activity of z Nitenpyram derivatives with optical activity
ChemInform, 2014Co-Authors: Chuanwen Sun, Jing Wang, Wanggeng Zhang, Yanxia ChenAbstract:Introducing a bulky group into Nitenpyram leads to a series consisting of fourteen novel title derivatives.
-
synthesis crystal structure and insecticidal activity of z Nitenpyram derivatives with optical activity
Journal of Heterocyclic Chemistry, 2014Co-Authors: Chuanwen Sun, Jing Wang, Wanggeng Zhang, Yanxia ChenAbstract:Fourteen novel Nitenpyram derivatives (Z)-4-substituted-3-acetyl-6-methylamino −6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-5-nitno-2-oxa-5-hexene were synthesized, and their structures were confirmed by 1H NMR, IR, and elemental analysis. The stereostructure of was determined by the single-crystal X-ray analysis. The preliminary bioassay tests showed that most of the title compounds exhibited good insecticide activities against Nilaparvata lugens as well as Aphis medicaginis at 500 mg/L, whereas compound afforded the best activity, with 100% mortality against A. medicaginis at 100 mg/L.
-
synthesis and insecticidal activities of cis configuration Nitenpyram analogues with benzoyl hydrazines
ChemInform, 2013Co-Authors: Chuanwen Sun, Dingrong Yang, Jing WangAbstract:The novel Nitenpyram analogues are designed by introducing benzoyl hydrazines into Nitenpyram as well as a cis-configured tetrahydropyrimidine ring.
-
synthesis and insecticidal activity of Nitenpyram analogs with tetrahydropyrimidine fixed z configuration
Journal of Heterocyclic Chemistry, 2013Co-Authors: Chuanwen Sun, Ting Fang, Zhibing Hao, Chuncheng Pang, Huajia XinAbstract:Two series of novel (Z)-Nitenpyram analogs 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 3a, 3b, 3c, 3d were synthesized by introducing various amino acids benzyl ester or amino acids tetrahydrofurfur-2-yl ester into Nitenpyram and forming a tetrahydropyrimidine ring to fix (Z)-configuration. The structures of the target compounds were characterized by 1HNMR, MS, IR, and elemental analysis. Preliminary bioassays against Nilaparvata lugens indicated that all the Nitenpyram analogs exhibited good insecticidal activity at 100 mg/L, whereas the compounds 3b and 3d afforded the best in vitro inhibitory activities that had ≥ 90% mortality at 20 mg/L.
-
synthesis and insecticidal activities of cis configuration Nitenpyram analogues with benzoyl hydrazines
Journal of Heterocyclic Chemistry, 2013Co-Authors: Chuanwen Sun, Dingrong Yang, Jing WangAbstract:To research on the structure–activity relationships of our designed neonicotinoid compounds, a series of novel cis-configuration Nitenpyram analogues with benzoyl hydrazines were designed and synthesized. The structures of all compounds were confirmed by IR, 1H NMR, MS, and elemental analysis. Preliminary bioassays indicated that all the analogues exhibited good insecticidal activities against Nilaparvata legen and Aphis medicagini at 500 mg L−1.
Xue Tian - One of the best experts on this subject based on the ideXlab platform.
-
neonicotinoids caused oxidative stress and dna damage in juvenile chinese rare minnows gobiocypris rarus
Ecotoxicology and Environmental Safety, 2020Co-Authors: Xue Tian, Aijun Lin, Saihong Yan, Xiangsheng Hong, Wenjie YangAbstract:Abstract To assess the effects of neonicotinoid insecticides on fish, juvenile Chinese rare minnows (Gobiocypris rarus) were exposed to 0.1, 0.5, or 2.0 mg/L neonicotinoid insecticides (imidacloprid, Nitenpyram, and dinotefuran) for 60 days. The endpoints, including oxidative stress and DNA damage, were determined. The results of oxidative stress assays showed that SOD activities were significantly increased in the 2.0 mg/L imidacloprid and 0.5 mg/L Nitenpyram and dinotefuran treatments (p
-
chronic brain toxicity response of juvenile chinese rare minnows gobiocypris rarus to the neonicotinoid insecticides imidacloprid and Nitenpyram
Chemosphere, 2018Co-Authors: Xue Tian, Dong Wang, Wenjie Yang, Yue Zhao, Ruihua Yao, Zeyu Huang, Wentao Jiao, Aijun LinAbstract:Abstract Imidacloprid and Nitenpyram are widely used neonicotinoid pesticides worldwide and were observed to adversely affect non-target aquatic organisms. In this study, the toxic effect of imidacloprid and Nitenpyram on the brain of juvenile Chinese rare minnows (Gobiocypris rarus) was investigated by determining the oxidative stress, 8-hydroxy-2-deoxyguanosine (8-OHdG) content and acetylcholinesterase (AChE) activity. The superoxide dismutase (SOD) activities did not significantly change after long-term exposure to imidacloprid and Nitenpyram. A noticeable increase of catalase (CAT) activities was observed on the brain tissues under 0.1 mg/L imidacloprid and under all Nitenpyram treatments (p
-
changes of hematological and biochemical parameters revealed genotoxicity and immunotoxicity of neonicotinoids on chinese rare minnows gobiocypris rarus
Environmental Pollution, 2018Co-Authors: Xiangsheng Hong, Xue Tian, Xu Zhao, Jinmiao ZhaAbstract:Abstract Adverse impacts of immunity in terrestrial non-target organisms exposed to neonicotinoid insecticides have been reported, but the causal link between insecticide exposure and possible immune alterations in fish remains limited. In the present study, the potential genotoxicity and immunotoxicity of three neonicotinoids (imidacloprid, Nitenpyram, and dinotefuran) were assessed in Chinese rare minnows by using a 60-day chronic toxicity test. The hematological and biochemical parameters of juvenile Chinese rare minnows and changes in the transcription of six inflammation-related genes were determined after exposure to neonicotinoids at 0.1, 0.5, or 2.0 mg/L. A clear difference in the frequency of erythrocytes with micronuclei (MN) was observed after treatment with 2.0 mg/L imidacloprid (p
Wenjie Yang - One of the best experts on this subject based on the ideXlab platform.
-
neonicotinoids caused oxidative stress and dna damage in juvenile chinese rare minnows gobiocypris rarus
Ecotoxicology and Environmental Safety, 2020Co-Authors: Xue Tian, Aijun Lin, Saihong Yan, Xiangsheng Hong, Wenjie YangAbstract:Abstract To assess the effects of neonicotinoid insecticides on fish, juvenile Chinese rare minnows (Gobiocypris rarus) were exposed to 0.1, 0.5, or 2.0 mg/L neonicotinoid insecticides (imidacloprid, Nitenpyram, and dinotefuran) for 60 days. The endpoints, including oxidative stress and DNA damage, were determined. The results of oxidative stress assays showed that SOD activities were significantly increased in the 2.0 mg/L imidacloprid and 0.5 mg/L Nitenpyram and dinotefuran treatments (p
-
chronic brain toxicity response of juvenile chinese rare minnows gobiocypris rarus to the neonicotinoid insecticides imidacloprid and Nitenpyram
Chemosphere, 2018Co-Authors: Xue Tian, Dong Wang, Wenjie Yang, Yue Zhao, Ruihua Yao, Zeyu Huang, Wentao Jiao, Aijun LinAbstract:Abstract Imidacloprid and Nitenpyram are widely used neonicotinoid pesticides worldwide and were observed to adversely affect non-target aquatic organisms. In this study, the toxic effect of imidacloprid and Nitenpyram on the brain of juvenile Chinese rare minnows (Gobiocypris rarus) was investigated by determining the oxidative stress, 8-hydroxy-2-deoxyguanosine (8-OHdG) content and acetylcholinesterase (AChE) activity. The superoxide dismutase (SOD) activities did not significantly change after long-term exposure to imidacloprid and Nitenpyram. A noticeable increase of catalase (CAT) activities was observed on the brain tissues under 0.1 mg/L imidacloprid and under all Nitenpyram treatments (p
Aijun Lin - One of the best experts on this subject based on the ideXlab platform.
-
neonicotinoids caused oxidative stress and dna damage in juvenile chinese rare minnows gobiocypris rarus
Ecotoxicology and Environmental Safety, 2020Co-Authors: Xue Tian, Aijun Lin, Saihong Yan, Xiangsheng Hong, Wenjie YangAbstract:Abstract To assess the effects of neonicotinoid insecticides on fish, juvenile Chinese rare minnows (Gobiocypris rarus) were exposed to 0.1, 0.5, or 2.0 mg/L neonicotinoid insecticides (imidacloprid, Nitenpyram, and dinotefuran) for 60 days. The endpoints, including oxidative stress and DNA damage, were determined. The results of oxidative stress assays showed that SOD activities were significantly increased in the 2.0 mg/L imidacloprid and 0.5 mg/L Nitenpyram and dinotefuran treatments (p
-
chronic brain toxicity response of juvenile chinese rare minnows gobiocypris rarus to the neonicotinoid insecticides imidacloprid and Nitenpyram
Chemosphere, 2018Co-Authors: Xue Tian, Dong Wang, Wenjie Yang, Yue Zhao, Ruihua Yao, Zeyu Huang, Wentao Jiao, Aijun LinAbstract:Abstract Imidacloprid and Nitenpyram are widely used neonicotinoid pesticides worldwide and were observed to adversely affect non-target aquatic organisms. In this study, the toxic effect of imidacloprid and Nitenpyram on the brain of juvenile Chinese rare minnows (Gobiocypris rarus) was investigated by determining the oxidative stress, 8-hydroxy-2-deoxyguanosine (8-OHdG) content and acetylcholinesterase (AChE) activity. The superoxide dismutase (SOD) activities did not significantly change after long-term exposure to imidacloprid and Nitenpyram. A noticeable increase of catalase (CAT) activities was observed on the brain tissues under 0.1 mg/L imidacloprid and under all Nitenpyram treatments (p
Jing Wang - One of the best experts on this subject based on the ideXlab platform.
-
synthesis crystal structure and insecticidal activity of z Nitenpyram derivatives with optical activity
ChemInform, 2014Co-Authors: Chuanwen Sun, Jing Wang, Wanggeng Zhang, Yanxia ChenAbstract:Introducing a bulky group into Nitenpyram leads to a series consisting of fourteen novel title derivatives.
-
synthesis crystal structure and insecticidal activity of z Nitenpyram derivatives with optical activity
Journal of Heterocyclic Chemistry, 2014Co-Authors: Chuanwen Sun, Jing Wang, Wanggeng Zhang, Yanxia ChenAbstract:Fourteen novel Nitenpyram derivatives (Z)-4-substituted-3-acetyl-6-methylamino −6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-5-nitno-2-oxa-5-hexene were synthesized, and their structures were confirmed by 1H NMR, IR, and elemental analysis. The stereostructure of was determined by the single-crystal X-ray analysis. The preliminary bioassay tests showed that most of the title compounds exhibited good insecticide activities against Nilaparvata lugens as well as Aphis medicaginis at 500 mg/L, whereas compound afforded the best activity, with 100% mortality against A. medicaginis at 100 mg/L.
-
synthesis and insecticidal activities of cis configuration Nitenpyram analogues with benzoyl hydrazines
ChemInform, 2013Co-Authors: Chuanwen Sun, Dingrong Yang, Jing WangAbstract:The novel Nitenpyram analogues are designed by introducing benzoyl hydrazines into Nitenpyram as well as a cis-configured tetrahydropyrimidine ring.
-
synthesis and insecticidal activities of cis configuration Nitenpyram analogues with benzoyl hydrazines
Journal of Heterocyclic Chemistry, 2013Co-Authors: Chuanwen Sun, Dingrong Yang, Jing WangAbstract:To research on the structure–activity relationships of our designed neonicotinoid compounds, a series of novel cis-configuration Nitenpyram analogues with benzoyl hydrazines were designed and synthesized. The structures of all compounds were confirmed by IR, 1H NMR, MS, and elemental analysis. Preliminary bioassays indicated that all the analogues exhibited good insecticidal activities against Nilaparvata legen and Aphis medicagini at 500 mg L−1.
-
synthesis and insecticidal activities cis Nitenpyram analogs with 1 4 dihydropyridine scaffold synthesis and insecticidal activities cis Nitenpyram analogs with 1 4 dihydropyridine scaffold
Journal of Heterocyclic Chemistry, 2012Co-Authors: Tianyan Liu, Yanxia Chen, Ting Fang, Sijia Xue, Jing WangAbstract:By means of multicomponent reactions, via Michael addition, nucleophilic addition, using Nitenpyram, substituted aromatic aldehydes, and cyanoacetate compounds or propanedinitrile, a new series of cis-configuration Nitenpyram analogs (1a-1k) were synthesized by introducing the 1,4-dihydropyridine scaffold pharmacophore, as shown in Scheme 1. The structures of all compounds were confirmed by IR, 1HNMR, 13C NMR, and elemental analysis. The preliminary bioassay showed that most of the target compounds exhibited good mortality against Aphis craccivora at 500 mg/L.