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Revathy B Iyer - One of the best experts on this subject based on the ideXlab platform.

  • consensus guidelines for delineation of clinical target volume for intensity modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer
    International Journal of Radiation Oncology Biology Physics, 2008
    Co-Authors: William Small, Loren K Mell, Penny R Anderson, Carien L Creutzberg, Jennifer F De Los Santos, David K Gaffney, Anuja Jhingran, L Portelance, Tracey E Schefter, Revathy B Iyer
    Abstract:

    Purpose: To develop an atlas of the clinical target volume (CTV) definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy. Methods and Materials: The RadiationTherapy Oncology Groupledan internationalcollaberation of cooperative groups in the development of the atlas. The groups included the Radiation Therapy Oncology Group, Gynecologic Oncology Group,National Cancer Institute of Canada, European Societyof Therapeutic Radiology and Oncology, and American College of Radiology Imaging Network. The members of the group were asked by questionnaire to define the areas that were to be included in the CTVand to outline theses areas on individual computed tomography images. The initial formulation of the group began in late 2004 and culminated with a formal consensus conference in June 2005. Results: The committee achieved a consensus CTV definition for postoperative therapy for endometrial and cervical cancer. The CTV should include the common, external, and internal iliac lymph Node Regions. The upper 3.0 cm of the vagina and paravaginal soft tissue lateral to the vagina should also be included. For patients with cervical cancer, orendometrial cancer with cervical stromal invasion, it is also recommended that the CTVinclude the presacral lymph Node Region. Conclusion: This report serves as an international template for the definition of the CTV for postoperative intensity-modulated radiotherapy for endometrial and cervical cancer. 2008 Elsevier Inc. Intensity-modulated radiotherapy, Adjuvant therapy, Pelvic radiotherapy, Endometrial cancer, Cervical cancer.

  • consensus guidelines for delineation of clinical target volume for intensity modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer
    International Journal of Radiation Oncology Biology Physics, 2008
    Co-Authors: William Small, Loren K Mell, Penny R Anderson, Carien L Creutzberg, David K Gaffney, Anuja Jhingran, L Portelance, Tracey E Schefter, Jennifer F De Los Santos, Revathy B Iyer
    Abstract:

    Purpose: To develop an atlas of the clinical target volume (CTV) definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy. Methods and Materials: The RadiationTherapy Oncology Groupledan internationalcollaberation of cooperative groups in the development of the atlas. The groups included the Radiation Therapy Oncology Group, Gynecologic Oncology Group,National Cancer Institute of Canada, European Societyof Therapeutic Radiology and Oncology, and American College of Radiology Imaging Network. The members of the group were asked by questionnaire to define the areas that were to be included in the CTVand to outline theses areas on individual computed tomography images. The initial formulation of the group began in late 2004 and culminated with a formal consensus conference in June 2005. Results: The committee achieved a consensus CTV definition for postoperative therapy for endometrial and cervical cancer. The CTV should include the common, external, and internal iliac lymph Node Regions. The upper 3.0 cm of the vagina and paravaginal soft tissue lateral to the vagina should also be included. For patients with cervical cancer, orendometrial cancer with cervical stromal invasion, it is also recommended that the CTVinclude the presacral lymph Node Region. Conclusion: This report serves as an international template for the definition of the CTV for postoperative intensity-modulated radiotherapy for endometrial and cervical cancer. 2008 Elsevier Inc. Intensity-modulated radiotherapy, Adjuvant therapy, Pelvic radiotherapy, Endometrial cancer, Cervical cancer.

Jelle O Barentsz - One of the best experts on this subject based on the ideXlab platform.

  • geographical distribution of lymph Node metastases on mr lymphography in prostate cancer patients
    Radiotherapy and Oncology, 2013
    Co-Authors: Hanneke J M Meijer, Ansje S Fortuin, Emile Th N J Van Lin, Oscar A Debats, Alfred J Witjes, Johannes H A M Kaanders, Jelle O Barentsz
    Abstract:

    Abstract Purpose To investigate the pattern of lymph Node spread on magnetic resonance lymphography (MRL) in prostate cancer patients and compare this pattern to the clinical target volume for elective pelvis irradiation as defined by the radiation therapy oncology group (RTOG-CTV). Methods and materials The charts of 60 intermediate and high risk prostate cancer patients with non-enlarged positive lymph Nodes on MRL were reviewed. Positive lymph Nodes were assigned to a lymph Node Region according to the guidelines for delineation of the RTOG-CTV. Five lymph Node Regions outside this RTOG-CTV were defined: the para-aortal, proximal common iliac, pararectal, paravesical and inguinal Region. Results Fifty-three percent of the patients had an MRL-positive lymph Node in a lymph Node Region outside the RTOG-CTV. The most frequently involved aberrant sites were the proximal common iliac, the pararectal and para-aortal Region, which were affected in 30%, 25% and 18% respectively. Conclusion More than half of the patients had an MRL-positive lymph Node outside the RTOG-CTV. To reduce geographical miss while minimizing the toxicity of radiotherapy, image based definition of an individual target volume seems to be necessary.

  • high occurrence of aberrant lymph Node spread on magnetic resonance lymphography in prostate cancer patients with a biochemical recurrence after radical prostatectomy
    International Journal of Radiation Oncology Biology Physics, 2012
    Co-Authors: Hanneke J M Meijer, Emile Th N J Van Lin, Oscar A Debats, Alfred J Witjes, Johannes H A M Kaanders, Paul N Span, Jelle O Barentsz
    Abstract:

    Purpose To investigate the pattern of lymph Node spread in prostate cancer patients with a biochemical recurrence after radical prostatectomy, eligible for salvage radiotherapy; and to determine whether the clinical target volume (CTV) for elective pelvic irradiation in the primary setting can be applied in the salvage setting for patients with (a high risk of) lymph Node metastases. Methods and Materials The charts of 47 prostate cancer patients with PSA recurrence after prostatectomy who had positive lymph Nodes on magnetic resonance lymphography (MRL) were reviewed. Positive lymph Nodes were assigned to a lymph Node Region according to the guidelines of the Radiation Therapy Oncology Group (RTOG) for delineation of the CTV for pelvic irradiation (RTOG-CTV). We defined four lymph Node Regions for positive Nodes outside this RTOG-CTV: the para-aortal, proximal common iliac, pararectal, and paravesical Regions. They were referred to as aberrant lymph Node Regions. For each patient, clinical and pathologic features were recorded, and their association with aberrant lymph drainage was investigated. The distribution of positive lymph Nodes was analyzed separately for patients with a prostate-specific antigen (PSA) Results MRL detected positive aberrant lymph Nodes in 37 patients (79%). In 20 patients (43%) a positive lymph Node was found in the pararectal Region. Higher PSA at the time of MRL was associated with the presence of positive lymph Nodes in the para-aortic Region (2.49 vs. 0.82 ng/mL; p  = 0.007) and in the proximal common iliac Region (1.95 vs. 0.59 ng/mL; p  = 0.009). There were 18 patients with a PSA Conclusion Seventy-nine percent of the PSA-recurrent patients had at least one aberrant positive lymph Node. Application of the standard RTOG-CTV for pelvic irradiation in the salvage setting therefore seems to be inappropriate.

William Small - One of the best experts on this subject based on the ideXlab platform.

  • consensus guidelines for delineation of clinical target volume for intensity modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer
    International Journal of Radiation Oncology Biology Physics, 2008
    Co-Authors: William Small, Loren K Mell, Penny R Anderson, Carien L Creutzberg, Jennifer F De Los Santos, David K Gaffney, Anuja Jhingran, L Portelance, Tracey E Schefter, Revathy B Iyer
    Abstract:

    Purpose: To develop an atlas of the clinical target volume (CTV) definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy. Methods and Materials: The RadiationTherapy Oncology Groupledan internationalcollaberation of cooperative groups in the development of the atlas. The groups included the Radiation Therapy Oncology Group, Gynecologic Oncology Group,National Cancer Institute of Canada, European Societyof Therapeutic Radiology and Oncology, and American College of Radiology Imaging Network. The members of the group were asked by questionnaire to define the areas that were to be included in the CTVand to outline theses areas on individual computed tomography images. The initial formulation of the group began in late 2004 and culminated with a formal consensus conference in June 2005. Results: The committee achieved a consensus CTV definition for postoperative therapy for endometrial and cervical cancer. The CTV should include the common, external, and internal iliac lymph Node Regions. The upper 3.0 cm of the vagina and paravaginal soft tissue lateral to the vagina should also be included. For patients with cervical cancer, orendometrial cancer with cervical stromal invasion, it is also recommended that the CTVinclude the presacral lymph Node Region. Conclusion: This report serves as an international template for the definition of the CTV for postoperative intensity-modulated radiotherapy for endometrial and cervical cancer. 2008 Elsevier Inc. Intensity-modulated radiotherapy, Adjuvant therapy, Pelvic radiotherapy, Endometrial cancer, Cervical cancer.

  • consensus guidelines for delineation of clinical target volume for intensity modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer
    International Journal of Radiation Oncology Biology Physics, 2008
    Co-Authors: William Small, Loren K Mell, Penny R Anderson, Carien L Creutzberg, David K Gaffney, Anuja Jhingran, L Portelance, Tracey E Schefter, Jennifer F De Los Santos, Revathy B Iyer
    Abstract:

    Purpose: To develop an atlas of the clinical target volume (CTV) definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy. Methods and Materials: The RadiationTherapy Oncology Groupledan internationalcollaberation of cooperative groups in the development of the atlas. The groups included the Radiation Therapy Oncology Group, Gynecologic Oncology Group,National Cancer Institute of Canada, European Societyof Therapeutic Radiology and Oncology, and American College of Radiology Imaging Network. The members of the group were asked by questionnaire to define the areas that were to be included in the CTVand to outline theses areas on individual computed tomography images. The initial formulation of the group began in late 2004 and culminated with a formal consensus conference in June 2005. Results: The committee achieved a consensus CTV definition for postoperative therapy for endometrial and cervical cancer. The CTV should include the common, external, and internal iliac lymph Node Regions. The upper 3.0 cm of the vagina and paravaginal soft tissue lateral to the vagina should also be included. For patients with cervical cancer, orendometrial cancer with cervical stromal invasion, it is also recommended that the CTVinclude the presacral lymph Node Region. Conclusion: This report serves as an international template for the definition of the CTV for postoperative intensity-modulated radiotherapy for endometrial and cervical cancer. 2008 Elsevier Inc. Intensity-modulated radiotherapy, Adjuvant therapy, Pelvic radiotherapy, Endometrial cancer, Cervical cancer.

Masahiro Hiraoka - One of the best experts on this subject based on the ideXlab platform.

  • a consensus based guideline defining the clinical target volume for pelvic lymph Nodes in external beam radiotherapy for uterine cervical cancer
    Japanese Journal of Clinical Oncology, 2010
    Co-Authors: Takafumi Toita, Tatsuya Ohno, Yuko Kaneyasu, Ryouichi Yoshimura, Takeshi Kodaira, Kazuhisa Furutani, Goro Kasuya, Satoshi Ishikura, Toshiharu Kamura, Masahiro Hiraoka
    Abstract:

    Objective: To develop a consensus-based guideline as well as an atlas defining pelvic nodal clinical target volumes in external beam radiotherapy for uterine cervical cancer. Methods: A working subgroup to establish the consensus-based guideline on clinical target volumes for uterine cervical cancer was formulated by the Radiation Therapy Study Group of the Japan Clinical Oncology Group in July 2008. The working subgroup consisted of seven radiation oncologists. The process resulting in the consensus included a comparison of contouring on CT images among the members, reviewing of published textbooks and the relevant literature and a distribution analysis of metastatic Nodes on computed tomography/ magnetic resonance imaging of actual patients. Results: The working subgroup defined the pelvic nodal clinical target volumes for cervical cancer and developed an associated atlas. As a basic criterion, the lymph Node clinical target volume was defined as the area encompassed by a 7 mm margin around the applicable pelvic vessels. Modifications were made in each nodal area to cover adjacent adipose tissues at risk of microscopic nodal metastases. Although the bones and muscles were excluded, the bowel was not routinely excluded in the definition. Each of the following pelvic Node Regions was defined: common iliac, external iliac, internal iliac, obturator and presacral. Anatomical structures bordering each lymph Node Region were defined for six directions; anterior, posterior, lateral, medial, cranial and caudal. Drafts of the definition and the atlas were reviewed by members of the JCOG Gynecologic Cancer Study Group (GCSG). Conclusions: We developed a consensus-based guideline defining the pelvic Node clinical target volumes that included an atlas. The guideline will be continuously updated to reflect the ongoing changes in the field.

Tracey E Schefter - One of the best experts on this subject based on the ideXlab platform.

  • consensus guidelines for delineation of clinical target volume for intensity modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer
    International Journal of Radiation Oncology Biology Physics, 2008
    Co-Authors: William Small, Loren K Mell, Penny R Anderson, Carien L Creutzberg, Jennifer F De Los Santos, David K Gaffney, Anuja Jhingran, L Portelance, Tracey E Schefter, Revathy B Iyer
    Abstract:

    Purpose: To develop an atlas of the clinical target volume (CTV) definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy. Methods and Materials: The RadiationTherapy Oncology Groupledan internationalcollaberation of cooperative groups in the development of the atlas. The groups included the Radiation Therapy Oncology Group, Gynecologic Oncology Group,National Cancer Institute of Canada, European Societyof Therapeutic Radiology and Oncology, and American College of Radiology Imaging Network. The members of the group were asked by questionnaire to define the areas that were to be included in the CTVand to outline theses areas on individual computed tomography images. The initial formulation of the group began in late 2004 and culminated with a formal consensus conference in June 2005. Results: The committee achieved a consensus CTV definition for postoperative therapy for endometrial and cervical cancer. The CTV should include the common, external, and internal iliac lymph Node Regions. The upper 3.0 cm of the vagina and paravaginal soft tissue lateral to the vagina should also be included. For patients with cervical cancer, orendometrial cancer with cervical stromal invasion, it is also recommended that the CTVinclude the presacral lymph Node Region. Conclusion: This report serves as an international template for the definition of the CTV for postoperative intensity-modulated radiotherapy for endometrial and cervical cancer. 2008 Elsevier Inc. Intensity-modulated radiotherapy, Adjuvant therapy, Pelvic radiotherapy, Endometrial cancer, Cervical cancer.

  • consensus guidelines for delineation of clinical target volume for intensity modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer
    International Journal of Radiation Oncology Biology Physics, 2008
    Co-Authors: William Small, Loren K Mell, Penny R Anderson, Carien L Creutzberg, David K Gaffney, Anuja Jhingran, L Portelance, Tracey E Schefter, Jennifer F De Los Santos, Revathy B Iyer
    Abstract:

    Purpose: To develop an atlas of the clinical target volume (CTV) definitions for postoperative radiotherapy of endometrial and cervical cancer to be used for planning pelvic intensity-modulated radiotherapy. Methods and Materials: The RadiationTherapy Oncology Groupledan internationalcollaberation of cooperative groups in the development of the atlas. The groups included the Radiation Therapy Oncology Group, Gynecologic Oncology Group,National Cancer Institute of Canada, European Societyof Therapeutic Radiology and Oncology, and American College of Radiology Imaging Network. The members of the group were asked by questionnaire to define the areas that were to be included in the CTVand to outline theses areas on individual computed tomography images. The initial formulation of the group began in late 2004 and culminated with a formal consensus conference in June 2005. Results: The committee achieved a consensus CTV definition for postoperative therapy for endometrial and cervical cancer. The CTV should include the common, external, and internal iliac lymph Node Regions. The upper 3.0 cm of the vagina and paravaginal soft tissue lateral to the vagina should also be included. For patients with cervical cancer, orendometrial cancer with cervical stromal invasion, it is also recommended that the CTVinclude the presacral lymph Node Region. Conclusion: This report serves as an international template for the definition of the CTV for postoperative intensity-modulated radiotherapy for endometrial and cervical cancer. 2008 Elsevier Inc. Intensity-modulated radiotherapy, Adjuvant therapy, Pelvic radiotherapy, Endometrial cancer, Cervical cancer.