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Ki Ho Park - One of the best experts on this subject based on the ideXlab platform.
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Association Between Platelet Function and Disc Hemorrhage in Patients With Normal-Tension Glaucoma: A Prospective Cross-Sectional Study.
American Journal of Ophthalmology, 2015Co-Authors: Seong Hee Shim, Joon Mo Kim, Hee-yeon Woo, Ko Un Shin, Jae Woong Koh, Ki Ho ParkAbstract:Purpose To evaluate the association between platelet function and disc hemorrhage in patients with Normal-Tension Glaucoma. Design Prospective, cross-sectional study. Methods Study involved a total of 315 subjects, including patients with Normal-Tension Glaucoma and disc hemorrhage (n = 120), patients with Normal-Tension Glaucoma without disc hemorrhage (n = 75), and healthy individuals (control group, n = 120). A detailed eye examination including visual field testing, color disc photography, optical coherence tomography scanning, and measurement of collagen/epinephrine closure time using a platelet function analyzer were performed for all subjects. Results The collagen/epinephrine closure time (s) as measured by the platelet function analyzer was approximately 14%–24% longer in the Normal-Tension Glaucoma and disc hemorrhage group compared with the other groups (141.92 ± 53.44 [with Normal-Tension Glaucoma and disc hemorrhage] vs 124.60 ± 46.72 [with Normal-Tension Glaucoma without disc hemorrhage] vs 114.84 ± 34.84 [healthy individuals], 1-way analysis of variance test, P Conclusions Our results suggest that platelet function is significantly associated with disc hemorrhage in patients with Normal-Tension Glaucoma. Delayed absorption resulted from prolonged bleeding due to delayed platelet aggregation may have an effect on the detectability of disc hemorrhage in patients with Normal-Tension Glaucoma.
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Association Between Platelet Function and Disc Hemorrhage in Patients With Normal-Tension Glaucoma: A Prospective Cross-Sectional Study.
American journal of ophthalmology, 2015Co-Authors: Seong Hee Shim, Joon Mo Kim, Hee-yeon Woo, Ko Un Shin, Jae Woong Koh, Ki Ho ParkAbstract:To evaluate the association between platelet function and disc hemorrhage in patients with Normal-Tension Glaucoma. Prospective, cross-sectional study. Study involved a total of 315 subjects, including patients with Normal-Tension Glaucoma and disc hemorrhage (n = 120), patients with Normal-Tension Glaucoma without disc hemorrhage (n = 75), and healthy individuals (control group, n = 120). A detailed eye examination including visual field testing, color disc photography, optical coherence tomography scanning, and measurement of collagen/epinephrine closure time using a platelet function analyzer were performed for all subjects. The collagen/epinephrine closure time (s) as measured by the platelet function analyzer was approximately 14%-24% longer in the Normal-Tension Glaucoma and disc hemorrhage group compared with the other groups (141.92 ± 53.44 [with Normal-Tension Glaucoma and disc hemorrhage] vs 124.60 ± 46.72 [with Normal-Tension Glaucoma without disc hemorrhage] vs 114.84 ± 34.84 [healthy individuals], 1-way analysis of variance test, P < .001). The activated partial thromboplastin time (s) value of the Normal-Tension Glaucoma with disc hemorrhage group was also higher than the control group. Stepwise multiple logistic regression analysis revealed that only a longer collagen/epinephrine closure time (OR adjusted for age, sex, prothrombin time, activated partial thromboplastin time, diabetes mellitus, hyperTension, hypoTension, heart disease, hypothyroidism, migraine, stroke, hypercholesterolemia: 2.94; 95% CI: 1.40-6.17) was independently associated with disc hemorrhage. A similar trend was observed when platelet function was compared among the 3 groups with respect to age. Our results suggest that platelet function is significantly associated with disc hemorrhage in patients with Normal-Tension Glaucoma. Delayed absorption resulted from prolonged bleeding due to delayed platelet aggregation may have an effect on the detectability of disc hemorrhage in patients with Normal-Tension Glaucoma. Copyright © 2015 Elsevier Inc. All rights reserved.
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Changes in corneal endothelial cell density in patients with Normal-Tension Glaucoma.
Japanese journal of ophthalmology, 2009Co-Authors: Sung Woo Cho, Chul Young Choi, Joon Mo Kim, Ki Ho ParkAbstract:To study the changes in corneal endothelial cell density in eyes with Normal-Tension Glaucoma compared with those in controls. A total of 227 subjects in three groups, one each of Normal-Tension Glaucoma and primary open-angle Glaucoma patients and one of Normal controls, were studied from January 2008 to July 2008 in the Ophthalmology Department of Kangbuk Samsung Hospital. The Glaucoma (Normal-Tension Glaucoma and primary open-angle Glaucoma) patients included monocular and binocular Glaucoma patients. Corneal endothelial cells were examined using a noncontact specular microscope. The mean endothelial cell densities in the three groups were as follows: Normal-Tension Glaucoma group, 2696.7 ± 303.9 cell/mm2; primary open-angle Glaucoma group, 2370.5 ± 392.3 cell/mm2; and Normal group, 2723.6 ± 300.6 cell/mm2. The endothelial cell count was not significantly different between Normal-Tension Glaucoma and Normal groups (P = 1.000). Primary open-angle Glaucoma patients had significantly lower endothelial cell counts (P < 0.001) than the Normal group. The endothelial cell count was also significantly lower in eyes with primary open-angle Glaucoma than in Normal-Tension Glaucoma eyes (P < 0.001). There was a significant decrease in corneal endothelial cell density in eyes with primary open-angle Glaucoma, but not in eyes with Normal-Tension Glaucoma. Elevated intraocular pressure likely affected the decrease of corneal endothelial cell density in eyes with Glaucoma.
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Changes in corneal endothelial cell density in patients with Normal-Tension Glaucoma
Japanese Journal of Ophthalmology, 2009Co-Authors: Chul Young Choi, Ki Ho ParkAbstract:Purpose To study the changes in corneal endothelial cell density in eyes with Normal-Tension Glaucoma compared with those in controls. Methods A total of 227 subjects in three groups, one each of Normal-Tension Glaucoma and primary open-angle Glaucoma patients and one of Normal controls, were studied from January 2008 to July 2008 in the Ophthalmology Department of Kangbuk Samsung Hospital. The Glaucoma (Normal-Tension Glaucoma and primary open-angle Glaucoma) patients included monocular and binocular Glaucoma patients. Corneal endothelial cells were examined using a noncontact specular microscope. Results The mean endothelial cell densities in the three groups were as follows: Normal-Tension Glaucoma group, 2696.7 ± 303.9 cell/mm^2; primary open-angle Glaucoma group, 2370.5 ± 392.3 cell/mm^2; and Normal group, 2723.6 ± 300.6 cell/mm^2. The endothelial cell count was not significantly different between Normal-Tension Glaucoma and Normal groups ( P = 1.000). Primary open-angle Glaucoma patients had significantly lower endothelial cell counts ( P < 0.001) than the Normal group. The endothelial cell count was also significantly lower in eyes with primary open-angle Glaucoma than in Normal-Tension Glaucoma eyes ( P < 0.001). Conclusions There was a significant decrease in corneal endothelial cell density in eyes with primary open-angle Glaucoma, but not in eyes with Normal-Tension Glaucoma. Elevated intraocular pressure likely affected the decrease of corneal endothelial cell density in eyes with Glaucoma.
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Four cases of Normal-Tension Glaucoma with disk hemorrhage combined with branch retinal vein occlusion in the contralateral eye.
American journal of ophthalmology, 2004Co-Authors: Sang Jin Kim, Ki Ho ParkAbstract:Abstract Purpose To report four cases of Normal-Tension Glaucoma with disk hemorrhage in one eye and branch retinal vein occlusion in the contralateral eye. Design Observational case series. Methods Four cases of Normal-Tension Glaucoma with disk hemorrhage in one eye and branch retinal vein occlusion in the contralateral eye were detected within a 1-year period. Results Mean patient age was 57 ± 10 years. Three patients had systemic hyperTension, two bilateral Normal-Tension Glaucoma, and all four bilateral peripapillary atrophy. There was no significant difference in intraocular pressure between the disk hemorrhage eyes and the contralateral eyes with branch retinal vein occlusion. Conclusion Some Normal-Tension Glaucoma patients with disk hemorrhage may have a pathogenic mechanism in combination with branch retinal vein occlusion.
Kazuyuki Hirooka - One of the best experts on this subject based on the ideXlab platform.
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evaluation of peripapillary choroidal thickness in patients with Normal Tension Glaucoma
BMC Ophthalmology, 2012Co-Authors: Kazuyuki Hirooka, Kaori Tenkumo, Atsushi Fujiwara, Tetsuya Baba, Shino Sato, Fumio ShiragaAbstract:Background To compare peripapillary choroidal thickness measurements between Normal and Normal-Tension Glaucoma eyes.
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Relationship between progression of visual field damage and choroidal thickness in eyes with Normal-Tension Glaucoma.
Clinical & experimental ophthalmology, 2012Co-Authors: Kazuyuki Hirooka, Atsushi Fujiwara, Tetsuya Baba, Chieko Shiragami, Fumio ShiragaAbstract:Background: To measure choroidal thickness in Normal eyes and in patients with Normal-Tension Glaucoma using enhanced depth imaging optical coherence tomography and evaluate the association between choroidal thickness and progression of visual field damage. Design: Cross-sectional comparative study. Participants: A total of 62 eyes of 62 Normal subjects and 45 eyes of 45 Normal-Tension Glaucoma patients were examined. Methods: The choroid was measured at the fovea and 3 mm nasal and temporal from the fovea. In the separate study, both eyes of the patients with Normal-Tension Glaucoma were included in the analyses. Visual fields were measured with automated perimetry. Changes in mean deviation per year (dB/year), that is, mean deviation slope, were calculated. Main Outcome Measures: Difference in the choroidal thickness between the Normal subjects and the patients with Normal-Tension Glaucoma. The relationship between mean deviation slope and the choroidal thickness in eyes with Normal-Tension Glaucoma was analysed. Results: Compared with Normal subjects, the choroidal thickness was significantly thinner in eyes with Normal-Tension Glaucoma at 3 mm nasal from the fovea (P = 0.02). There was a significant correlation between the choroidal thickness at 3 mm nasal from the fovea and the mean deviation slope (Pearson's r = 0.413; P
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Bradykinin sensitivity in primary open-angle Glaucoma and Normal-Tension Glaucoma patients.
American journal of ophthalmology, 2002Co-Authors: Kazuyuki Hirooka, Fumio Shiraga, Eiichi HasegawaAbstract:Abstract Purpose To report the reaction after intradermal injection of bradykinin in nonGlaucoma, primary open-angle Glaucoma, and Normal-Tension Glaucoma subjects. Design Prospective comparative study. Methods The study participants were 14 healthy control subjects, 16 patients with primary open-angle Glaucoma, and 15 patients with Normal-Tension Glaucoma. In each participant, the wheal response to intradermal injection of 10 μg bradykinin in the volar forearm was measured by a masked observer. Results There was no significant difference in the wheal response to bradykinin between control subjects and primary open-angle Glaucoma patients ( P = .73) and between primary open-angle Glaucoma patients and Normal-Tension Glaucoma patients ( P = .09). However, there was a significant difference in the wheal response to bradykinin between control subjects and Normal-Tension Glaucoma patients ( P = .04). Conclusions These in vivo structure-activity studies may suggest abNormalities of the tissue kallikrein-kinin system in Normal-Tension Glaucoma.
Roger A. Hitchings - One of the best experts on this subject based on the ideXlab platform.
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A Practical Approach to the Management of Normal Tension Glaucoma
Glaucoma, 2004Co-Authors: Roger A. HitchingsAbstract:The management of Normal Tension Glaucoma (NTG) has been a therapeutic challenge for the writer over the past 20 Years. For this period of time he has had responsibility for managing a clinic comprising entirely of patients with (possible) NTG. His views on management are based on this practical experience.
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Surgery for Normal Tension Glaucoma.
The British journal of ophthalmology, 1995Co-Authors: Roger A. Hitchings, D Poinoosawmy, Andrew I McnaughtAbstract:The long term follow up of surgery in Normal Tension Glaucoma is presented. One eye of 18 patients with bilateral progressive disease underwent fistulising surgery. Over follow up periods ranging from 2 to 7 years (50% > or = 5 years) the operated eye showed on average a 30% reduction in intraocular pressure (IOP). This was associated with a marked difference in the rate and number of retinal locations showing a progressive decline in retinal function, suggesting some protective function for lowering IOP in patients with Normal Tension Glaucoma.
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Therapeutic rationale for Normal-Tension Glaucoma.
Current opinion in ophthalmology, 1995Co-Authors: Roger A. HitchingsAbstract:Three problems exist when assessing the effectiveness of treatment for Normal-Tension Glaucoma. Firstly, it is a common type of primary open-angle Glaucoma. Secondly, the extent to which it is a pressure-sensitive disease remains to be seen. Thirdly, it is possible that Normal-Tension Glaucoma is a collection of different disease entities. This review will look at the therapeutic options available for treatment and divide them into these which attempt to moderate IOP, and those which attempt to alter blood flow.
Tetsuya Yamamoto - One of the best experts on this subject based on the ideXlab platform.
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Microsatellite analysis of the GLC1B locus on chromosome 2 points to NCK2 as a new candidate gene for Normal Tension Glaucoma.
The British journal of ophthalmology, 2008Co-Authors: M Akiyama, Tetsuya Yamamoto, Masao Ota, Kenji Kashiwagi, Fumihiko Mabuchi, Hiroyuki Iijima, Kazuhide Kawase, K Yatsu, Yoshihiko Katsuyama, Makoto NakamuraAbstract:Aims: The aim of this study was to investigate the association between Normal Tension Glaucoma and the candidate disease locus Glaucoma 1, open angle, B (GLC1B) on chromosome 2. There are many reports describing the results of association or linkage studies for primary open angle Glaucoma (POAG), with GLC1B as one of the loci associated with Normal or moderately elevated intraocular pressure. However, there are few reports about the association of genes or defined genomic regions with Normal Tension Glaucoma, which is the leading type of Glaucoma in Japan. The GLC1B locus is hypothesized to be a causative region for Normal Tension Glaucoma. Methods: Genomic DNA was extracted from whole blood of Normal Tension Glaucoma (n = 143) and healthy controls (n = 103) of Japanese origin. Results: Fifteen microsatellite markers within and/or near to the GLC1B locus were genotyped, and their association with Normal Tension Glaucoma was analysed. Two markers D2S2264 and D2S176 had significant positive associations. Conclusion: The D2S176 marker had the strongest significant association and it is located 24 kb from the nearest gene NCK2, which now becomes an important new candidate gene for future studies of its association with Normal Tension Glaucoma.
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Diurnal variation of intraocular pressure in suspected Normal-Tension Glaucoma.
Japanese journal of ophthalmology, 2006Co-Authors: Kou Hasegawa, Kazuhide Kawase, Kyoko Ishida, Akira Sawada, Tetsuya YamamotoAbstract:Purpose To assess diurnal variations of intraocular pressure (IOP) in suspected Normal-Tension Glaucoma (NTG) patients with subsequent long-term observation to detect changes that may lead to a new diagnosis.
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Disk hemorrhage is a significantly negative prognostic factor in Normal-Tension Glaucoma
American journal of ophthalmology, 2000Co-Authors: Kyoko Ishida, Tetsuya Yamamoto, Kazuhisa Sugiyama, Yoshiaki KitazawaAbstract:PURPOSE: We investigated the relationship between disk hemorrhage in Normal-Tension Glaucoma and the progression of visual field defects and, additionally, whether hemorrhage plays a role in the pathogenic process of the chronic disease. METHODS: We retrospectively reviewed the charts of 70 patients with Normal-Tension Glaucoma (mean follow-up, 5.6 years) who were not medicated for Glaucoma, and we applied a regression analysis of survival data based on the Cox proportional hazards model. Several clinical factors were investigated to find a possible association with the progression of Glaucomatous visual field defined by two different definitions: one by mean deviation change and the other by Glaucoma change probability analysis. RESULTS: Disk hemorrhage, corrected-pattern standard deviation, age, systolic blood pressure, and pulse rate had a significant influence on the visual field defect. The cumulative probability of progression of visual field loss was significantly greater for patients with disk hemorrhage than for patients without disk hemorrhage by either criterion for progression (P ≤ .0008, logrank test). All eyes that had at least two occurrences of disk hemorrhage showed progression, whereas only three of nine eyes showed progression in the nonrecurrent disk hemorrhage group by the Glaucoma change probability analysis. The difference was statistically significant (P < .0001, Fisher’s exact probability test). Furthermore, there was a significant relationship between the location of the disk hemorrhage and the area of the progression of visual field loss in 65.4% of progressive patients with disk hemorrhage. CONCLUSIONS: Several clinical factors other than intraocular pressure are significantly associated with the progression of visual field loss during the natural course of Normal-Tension Glaucoma. Among these, disk hemorrhage is a significantly negative prognostic factor in patients with Normal-Tension Glaucoma and may be a sign of progressive damage of the retinal nerve fiber layer, leading to functional deterioration of the visual field.
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Clinical Factors Associated with Progression of Normal-Tension Glaucoma
Journal of glaucoma, 1998Co-Authors: Kyoko Ishida, Tetsuya Yamamoto, Yoshiaki KitazawaAbstract:PurposeTo investigate clinical factors associated with the progression of visual field loss in Normal-Tension Glaucoma (NTG).MethodsOne hundred and ten patients with NTG whose cases were followed for more than 2 years were retrospectively analyzed with the Kaplan-Meier life table method and the Cox
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Trabeculectomy with mitomycin C for Normal-Tension Glaucoma.
Journal of glaucoma, 1995Co-Authors: Tetsuya Yamamoto, Mieko Ichien, Hiromi Suemori-matsushita, Yoshiaki KitazawaAbstract:PURPOSE A prospective investigation of the postoperative intraocular pressure level, visual function changes, and postoperative complications of trabeculectomy with adjunctive mitomycin C in Normal-Tension Glaucoma. PATIENTS AND METHODS Thirty-one patients (31 eyes) who underwent trabeculectomy with 0.4 mg/ml mitomycin C were studied. The preoperative intraocular pressure of the eyes ranged from 11 to 18 mm Hg with a mean (+/- SD) of 14.1 +/- 1.9 mm Hg. Follow-up examinations were performed at least once a month for 14-35 months (mean: 24.4 months). RESULTS Intraocular pressures decreased to between 4 and 14 mm Hg with a mean (+/- SD) of 8.4 +/- 2.4 mm Hg at the last three follow-up visits. The magnitude of the intraocular pressure reduction ranged from 1 to 10 mm Hg, with a mean of 5.8 mm Hg. Final measurements of postoperative intraocular pressure ranged between 5 and 12 mm Hg in 27 eyes (87%). Visual acuity deteriorated two lines or more in seven eyes, which was caused by cataract. The visual field deteriorated postoperatively in two eyes (6%): their respective postoperative intraocular pressures averaged 9.4 and 7.5 mm Hg. Hypotonous maculopathy developed in three eyes (10%). CONCLUSIONS Trabeculectomy with mitomycin C appears to have potential as a treatment modality of choice for Normal-Tension Glaucoma, because a large majority of the patients in the present study achieved an intraocular pressure allegedly beneficial in managing Normal-Tension Glaucoma.
Yoshiaki Kitazawa - One of the best experts on this subject based on the ideXlab platform.
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Glaucomas: Managing Normal-Tension Glaucoma
Pearls of Glaucoma Management, 2009Co-Authors: Kazuhisa Sugiyama, Yoshiaki KitazawaAbstract:Information available in the literature on how to determine the target pressure for a Normal-Tension Glaucoma (NTG) patient is scarce. In the Collaborative Normal-Tension Glaucoma Study (CNTGS) [1, 2], there is no clearly defined single intraocular pressure (IOP) level below which an individual eye is completely safe from developing further Glaucomatous damage. In the CNTGS, progression occurred in 35% of untreated eyes (mean IOP 16.0 mmHg) vs. 12% of treated eyes (mean IOP 10.6 mmHg reduced from a mean baseline IOP of 16.9 mmHg). Probability of nonprogression (or survival) in NTG patients determined by the Kaplan Meier life table analysis is shown in Fig. 43.1 [2]. Importantly, the study also demonstrated that many patients with NTG in the untreated randomization arm did not progress. Additionally, a number of enrolled patients showed no progression while in the prerandomization observation phase and were therefore never randomly assigned to either the treatment or nontreatment arms. (The CNTGS enrolled 230 patients but did not randomize them to either arm of the study [observation arm vs. a 30% IOP reduction arm] unless they showed a visual field defect threatening fixation or had had recent Glaucomatous progression in the visual field or on the optic nerve.) It was concluded that those patients destined to be nonprogressors or only to progress slowly would derive little benefit, if any, from treatment. Moreover, it should be noted that although progression was less likely in the treated arm a number of patients’ Glaucoma continued to progress despite the 30% IOP reduction from baseline.
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Disk hemorrhage is a significantly negative prognostic factor in Normal-Tension Glaucoma
American journal of ophthalmology, 2000Co-Authors: Kyoko Ishida, Tetsuya Yamamoto, Kazuhisa Sugiyama, Yoshiaki KitazawaAbstract:PURPOSE: We investigated the relationship between disk hemorrhage in Normal-Tension Glaucoma and the progression of visual field defects and, additionally, whether hemorrhage plays a role in the pathogenic process of the chronic disease. METHODS: We retrospectively reviewed the charts of 70 patients with Normal-Tension Glaucoma (mean follow-up, 5.6 years) who were not medicated for Glaucoma, and we applied a regression analysis of survival data based on the Cox proportional hazards model. Several clinical factors were investigated to find a possible association with the progression of Glaucomatous visual field defined by two different definitions: one by mean deviation change and the other by Glaucoma change probability analysis. RESULTS: Disk hemorrhage, corrected-pattern standard deviation, age, systolic blood pressure, and pulse rate had a significant influence on the visual field defect. The cumulative probability of progression of visual field loss was significantly greater for patients with disk hemorrhage than for patients without disk hemorrhage by either criterion for progression (P ≤ .0008, logrank test). All eyes that had at least two occurrences of disk hemorrhage showed progression, whereas only three of nine eyes showed progression in the nonrecurrent disk hemorrhage group by the Glaucoma change probability analysis. The difference was statistically significant (P < .0001, Fisher’s exact probability test). Furthermore, there was a significant relationship between the location of the disk hemorrhage and the area of the progression of visual field loss in 65.4% of progressive patients with disk hemorrhage. CONCLUSIONS: Several clinical factors other than intraocular pressure are significantly associated with the progression of visual field loss during the natural course of Normal-Tension Glaucoma. Among these, disk hemorrhage is a significantly negative prognostic factor in patients with Normal-Tension Glaucoma and may be a sign of progressive damage of the retinal nerve fiber layer, leading to functional deterioration of the visual field.
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Clinical Factors Associated with Progression of Normal-Tension Glaucoma
Journal of glaucoma, 1998Co-Authors: Kyoko Ishida, Tetsuya Yamamoto, Yoshiaki KitazawaAbstract:PurposeTo investigate clinical factors associated with the progression of visual field loss in Normal-Tension Glaucoma (NTG).MethodsOne hundred and ten patients with NTG whose cases were followed for more than 2 years were retrospectively analyzed with the Kaplan-Meier life table method and the Cox
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Trabeculectomy with mitomycin C for Normal-Tension Glaucoma.
Journal of glaucoma, 1995Co-Authors: Tetsuya Yamamoto, Mieko Ichien, Hiromi Suemori-matsushita, Yoshiaki KitazawaAbstract:PURPOSE A prospective investigation of the postoperative intraocular pressure level, visual function changes, and postoperative complications of trabeculectomy with adjunctive mitomycin C in Normal-Tension Glaucoma. PATIENTS AND METHODS Thirty-one patients (31 eyes) who underwent trabeculectomy with 0.4 mg/ml mitomycin C were studied. The preoperative intraocular pressure of the eyes ranged from 11 to 18 mm Hg with a mean (+/- SD) of 14.1 +/- 1.9 mm Hg. Follow-up examinations were performed at least once a month for 14-35 months (mean: 24.4 months). RESULTS Intraocular pressures decreased to between 4 and 14 mm Hg with a mean (+/- SD) of 8.4 +/- 2.4 mm Hg at the last three follow-up visits. The magnitude of the intraocular pressure reduction ranged from 1 to 10 mm Hg, with a mean of 5.8 mm Hg. Final measurements of postoperative intraocular pressure ranged between 5 and 12 mm Hg in 27 eyes (87%). Visual acuity deteriorated two lines or more in seven eyes, which was caused by cataract. The visual field deteriorated postoperatively in two eyes (6%): their respective postoperative intraocular pressures averaged 9.4 and 7.5 mm Hg. Hypotonous maculopathy developed in three eyes (10%). CONCLUSIONS Trabeculectomy with mitomycin C appears to have potential as a treatment modality of choice for Normal-Tension Glaucoma, because a large majority of the patients in the present study achieved an intraocular pressure allegedly beneficial in managing Normal-Tension Glaucoma.
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Trabeculectomy for Normal-Tension Glaucoma
Nippon Ganka Gakkai zasshi, 1994Co-Authors: Tetsuya Yamamoto, Ichien M, Suemori-matsushita H, Yoshiaki KitazawaAbstract:We prospectively investigated the postoperative intraocular pressure (IOP) level, visual prognosis, and complications of trabeculectomy with adjunctive mitomycin C in Normal-Tension Glaucoma. The subjects were 42 eyes of 29 patients who underwent surgery with 0.2 mg mitomycin C as an adjunct and were followed for 12-30 months (mean: 20.6 months). The preoperative IOP was 11-18 mmHg with a mean (+/- standard deviation) of 13.9 +/- 1.5 mmHg. The IOP decreased to 4-16 mmHg with a mean (+/- standard deviation) of 7.9 +/- 2.6 mmHg. The magnitude of the IOP reduction ranged from -1 to 10 mmHg with a mean of 6.0 mmHg. The number of eyes receiving ocular hypotensive medication decreased remarkably from 32 eyes preoperatively to 2 eyes postoperatively. The visual field deteriorated postoperatively in 2 eyes (4.8%) whose IOP was around 8 and 9 mmHg, respectively. Cataract progressed in 8 eyes (19.0%) and hypotonous maculopathy developed in 5 eyes (11.9%). Because the postoperative IOP level is close to the IOP value that is allegedly beneficial in preserving visual function in Normal-Tension Glaucoma, the surgery is worth further consideration as a potent treatment for the disease.
