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Carlos Simon - One of the best experts on this subject based on the ideXlab platform.
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clinical factors affecting endometrial receptiveness in Oocyte Donation cycles
Fertility and Sterility, 2008Co-Authors: Sergio Reis Soares, Juan Garcia A Velasco, Manuel Fernandez, Ernesto Bosch, J Remohi, Antonio Pellicer, Carlos SimonAbstract:Objective To provide a summary of the actual knowledge about the clinical factors affecting the Oocyte recipient (other than those associated with uterine cavity abnormalities) on the outcome of Oocyte Donation cycles. Design Review of the literature. Setting Information regarding the association between age, body mass index (BMI), endometrial priming, tobacco consumption, hydrosalpinx, and endometriosis/adenomyosis in Oocyte recipients and the results of Oocyte Donation cycles. Result(s) Recipient age and the presence of hydrosalpinx are clearly associated with a poorer outcome in Oocyte Donation cycles. The negative impact of tobacco consumption has recently been confirmed. The exact relevance of an elevated BMI is under debate but it is likely that it determines a lower ongoing pregnancy rate (PR). Endometriosis may be significant for endometrial receptiveness in the context of a natural cycle, but no negative impact is detected when standard endometrial priming protocols are used in Oocyte Donation. The same may be true for adenomyosis, although its relevance to endometrial receptiveness is less clear. Conclusion(s) Accumulated knowledge in the field of Oocyte Donation has led to the recognition of clinical variables that affect cycle outcome by impairing endometrial receptiveness. Many studies are being carried out on endometrial molecular and gene expression changes taking place in these circumstances. In the near future a comprehensive understanding of these processes should be achieved, from a genetic, molecular, and clinical perspective. These advances in the collective knowledge will lead to an improvement in the diagnosis and treatment of infertile patients.
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Oocyte and embryo quality after coasting the experience from Oocyte Donation
Human Reproduction, 2002Co-Authors: Veronica Isaza, J Remohi, Carlos Simon, J A Garciavelasco, M Aragones, A PellicerAbstract:BACKGROUND: Oocyte Donation provides us with an opportunity to study the clinical outcome of Oocytes, retrieved from women undergoing coasting, in recipients in whom endometrial receptivity is unaltered by the coasting procedure. Thus, our aim was to describe Oocyte Donation outcome in donors undergoing coasting, the Oocyte and embryo quality obtained from these cycles, and to determine the influence of coasting duration in the cycle outcome. METHODS: Matched-paired analysis included 15 Oocyte donors with high response to ovarian stimulation and submitted to coasting and 15 Oocyte donors with normal response to ovarian stimulation and not undergoing coasting. There were 38 Oocyte recipients who shared Oocytes from the donors under coasting and 37 from donors not undergoing coasting. RESULTS: Both groups of donors were comparable in terms of days and dose of ovarian stimulation, Oocytes retrieved, metaphase II Oocytes obtained, and in the appearance of ovarian hyperstimulation syndrome. Both groups of Oocyte recipients were comparable in male-associated factor, pregnancy and implantation rates, as well as in embryo quality. Recipients from donors with coasting for >4 days had significantly lower implantation and pregnancy rates. CONCLUSIONS: the outcome of Oocyte Donation from donors undergoing coasting is not impaired, as good implantation and pregnancy rates are achieved. Embryo quality, according to our current standards, does not seem to be compromised by coasting itself. However, if coasting in Oocyte donors is prolonged for >4 days there is a significant decrease in both implantation and pregnancy rates.
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pregnancy and birth rates after Oocyte Donation
Fertility and Sterility, 1997Co-Authors: Jose Remohi, Carlos Simon, Bernard Gartner, Ernesto Gallardo, Sonia Yalil, Antonio PellicerAbstract:Abstract Objective: To determine accumulated conception and live birth rates in ovum Donation. Design: Retrospective study from a computer database. Pregnancies with one gestational sac observed by ultrasound have been included as conceptional cycles and pregnancies that resulted in one live child were recorded for the analysis of the live birth rates. Life table analysis was applied. Setting: Oocyte Donation program at the Instituto Valenciano de Infertilidad. Patient(s): Three hundred ninety-seven recipients undergoing a total of 627 ETs were analyzed. Intervention(s): Ovarian stimulation and ovum pick-up in donors. Uterine ET in recipients after appropriate exogenous steroid replacement. Main Outcome Measurement(s): Accumulated and estimated (95% confidence intervals [CI]) conception and live birth rates in the Oocyte Donation program as well as considering age and cause of infertility of the recipients. Result(s): Pregnancy rate after one cycle was 53.4% (CI 50.9% to 55.9%), with a delivery rate of 42.6% (CI 40.1% to 45.1%). Accumulated pregnancy rate increased up to 94.8% (CI 90.6% to 99.0%) after four transfers. Similarly, live birth rates reached 88.7% (CI 88.1% to 89.3%) after four attempts of ET by ovum Donation. Cycle fecundity rates were maintained at approximately 50% after each attempt. Implantation rate was 18.3% (430/2,340 replaced embryos). Age and cause of entering the program did not influence the overall results of ovum Donation. Conclusion(s): Oocyte Donation is a successful treatment modality for infertile couples that offers even higher success rates than natural conception. No difference in cumulative pregnancy rate was observed regardless of recipient age, indication for Oocyte Donation, or number of cycles attempted.
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effect of age on sperm fertility potential Oocyte Donation as a model
Fertility and Sterility, 1996Co-Authors: Ernesto Gallardo, Carlos Simon, Jose Remohi, M Levy, Pedro P Guanes, Antonio PellicerAbstract:Objective To determine the effect of age on sperm fecundability using Oocyte Donation as an in vivo model. Setting Oocyte Donation and IVF programs at the Instituto Valenciano de Infertilidad. Patients Two-hundred forty couples undergoing 345 cycles of ovum Donation, who were recipients of 298 donors. Design Retrospective study in which four groups of Oocyte Donation cycles were established according to age of the male providing the semen sample: group 1 (n = 31) 51 years, the oldest being 64 years. All donated Oocytes were obtained from patients Main Outcome Measurements Male age, sperm characteristics (volume, concentration, motility, morphology), fertilization, embryo quality, pregnancy, implantation, and abortion rates among recipients. Results Similar sperm characteristics in fresh as well as after preparation for IVF were observed among males of different ages. Fertilization, embryo quality, pregnancy, and implantation were similar among the established groups. The mean age of the females included in each group significantly increased from group 1 to group 4. Conclusions Age (up to 64 years) does not affect sperm characteristics or its ability to fertilize human eggs. Similarly, embryo development in vitro as well as implantation in recipient uteri are not affected by age of the male providing the semen sample.
O B A Van Den Akker - One of the best experts on this subject based on the ideXlab platform.
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Attitudes and intentions towards volunteer Oocyte Donation.
Reproductive biomedicine online, 2020Co-Authors: S Purewal, O B A Van Den AkkerAbstract:There is an acute shortage of donated Oocytes in the UK and clinics are largely relying on shared Donation. Shared Donation of Oocytes is not without its ethical and moral concerns. The aims of this study were therefore to investigate non-patient population attitudes towards Oocyte Donation and examine the link between Oocyte Donation intentions and reasons for parenthood using structural equation modelling (SEM). The survey population consisted of 349 women aged 27.8 +/- 4.7 years. Results revealed that approximately one-third of woman would consider donating their Oocytes as identifiable donors. SEM analyses indicated a significant direct effect of positive attitudes towards Oocyte Donation, high levels of social support and endorsement of less conventional reasons for parenthood to intentions to donate. Age, education and attitudes towards less conventional perceptions of parenthood coincided with their positive beliefs about the importance of parenthood and children. Thus, results indicated that attitudes towards parenthood are an important factor underpinning the motivation for potential Oocyte Donation.
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Attitudes and intentions towards volunteer Oocyte Donation
Reproductive Biomedicine Online, 2020Co-Authors: S Purewal, O B A Van Den AkkerAbstract:There is an acute shortage of donated Oocytes in the UK and clinics are largely relying on shared Donation. Shared Donation of Oocytes is not without its ethical and moral concerns. The aims of this study were therefore to investigate non-patient population attitudes towards Oocyte Donation and examine the link between Oocyte Donation intentions and reasons for parenthood using structural equation modelling (SEM). The survey population consisted of 349 women aged 27.8 ± 4.7 years. Results revealed that approximately one-third of women would consider donating their Oocytes as identifiable donors. SEM analyses indicated a significant direct effect of positive attitudes towards Oocyte Donation, high levels of social support and endorsement of less conventional reasons for parenthood to intentions to donate. Age, education and attitudes towards the importance of a genetic link between parent and child indirectly influenced intentions to donate Oocytes. Intenders' less conventional perceptions of parenthood coincided with their positive beliefs about the importance of parenthood and children. Thus, results indicated that attitudes towards parenthood are an important factor underpinning the motivation for potential Oocyte Donation.
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A study of the effect of message framing on Oocyte Donation
Human Reproduction, 2009Co-Authors: S Purewal, O B A Van Den AkkerAbstract:BACKGROUND: The aims of this study were to examine the effect of gain- and loss-framed messages on British and South East Asian women's intentions towards Oocyte Donation and to examine whether the components of the theory of planned behaviour influenced the relationship between framing and intentions. METHODS: A total of 406 women participated in this study (mean age = 22, SD = 2.9). There were 211 participants in the gain condition and 195 in the loss condition. RESULTS: An analysis of covariance found a main effect for framing (F(1, 402) = 6.3; P < 0.01) after controlling for existing attitudes towards Oocyte Donation and pre-message intentions to donate. Specifically, participants in the gain-framed condition were significantly more likely to report higher post-message intentions to donate Oocytes than participants in the loss condition. However, the framing effect was only observed with British populations and not with women from South East Asia. Further, structural equation modelling analyses revealed lower levels of ‘perceived behavioural control’ (β = –0.420, P < 0.03) and positive attitudes towards ‘the importance of genetic ties between parent and child’ (β = 0.70, P < 0.001) were direct predictors of post-message intentions in the gain (but not loss) frame condition. CONCLUSION: Findings obtained from this study indicate that Oocyte Donation campaigns should consider using gain-framed messages in recruitment appeals and message frames should be matched to the target populations’ perceived level of behavioural control.
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systematic review of Oocyte Donation investigating attitudes motivations and experiences
Human Reproduction Update, 2009Co-Authors: S Purewal, O B A Van Den AkkerAbstract:BACKGROUND: The social and psychological factors determining intentions to donate gametes are important for clinics, policy-makers and recruitment campaigns. The aims of this systematic review were therefore to integrate the research findings regarding the psychosocial determinants of Oocyte Donation and extrapolate women's experiences of Donation. METHODS: A bibliographic search of English language publications of four computerized databases was undertaken with no time restriction set for publications. RESULTS: A total of 64 studies met the inclusion criteria and were included in the review. The research syntheses revealed there were distinct differences between patient and non-patient (known, commercial, volunteer and potential) donors on demographic characteristics, motives for Donation, and issues relating to disclosure and attitudes towards the resultant offspring. Further, studies have found that a significant proportion of Oocyte donors and women from the general population were prepared to donate their Oocytes as identifiable donors. Studies which have examined the experiences of donors report positive experiences of Oocyte Donation. However, a number of methodological limitations relating to the Oocyte Donation research literature have been identified in this systematic review. CONCLUSION: Differences between donor groups on a range of factors highlight the need for tailored psychosocial evaluation and counselling. The review has demonstrated that it is not useful to generalize across donor groups on various factors relating to Oocyte Donation.
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british women s attitudes towards Oocyte Donation ethnic differences and altruism
Patient Education and Counseling, 2006Co-Authors: S Purewal, O B A Van Den AkkerAbstract:Abstract Objective This study assessed the importance of altruism and willingness to donate Oocytes in British Asian and Caucasian samples. The Theory of Planned Behaviour (TPB) was used to test the importance of attitudes towards Oocyte Donation, normative and control beliefs to attitudes to donate Oocytes. Method One hundred and one participants (55% Asian, 45% Caucasian) completed questionnaires measuring altruism and attitudes to Oocyte Donation. There were no socio-demographic differences between ethnic groups. Results Few women were willing to donate Oocytes, Asian women were least likely to donate Oocytes, and altruism was not related to willingness to donate. Forty-one participants considered themselves ‘possible’ Oocyte donors and 54 as definite ‘non’ donors. Possible donors reported significantly more positive attitudes towards egg Donation; asking women to donate under various circumstances; to the consequences of donating their eggs; positively experiencing egg Donation and to factors that would induce women to donate. Subjective norms and behavioural control also influenced intention to donate. Conclusion A number of components of the TPB were able to predict possible Oocyte Donation, and non-Oocyte Donation. Practice implications: This study provides some empirical support for specific factors influencing cultural differences in gamete Donation in the UK. A future culturally appropriate targeted approach to Donation education could redress the present imbalance in supply and demand of gametes in infertility treatment.
Antonio Pellicer - One of the best experts on this subject based on the ideXlab platform.
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Oocyte Donation and endometriosis: What are the lessons?
Seminars in Reproductive Medicine, 2013Co-Authors: Erik Hauzman, Juan A. Garcia-velasco, Antonio PellicerAbstract:Outcomes of in vitro fertilization cycles in women with endometriosis are significantly worse than in patients without this condition. The impact of endometriosis on ovarian reserve and the quality of retrieved Oocytes seems evident. Lower implantation rates, however, raise the question whether this finding is purely the consequence of lower number and poorer quality of embryos, or whether it also reflects compromised endometrial receptivity. Oocyte Donation provides an interesting model to investigate reproductive outcome because factors affecting the Oocytes are excluded, especially if cycles using Oocytes derived from the same donor are analyzed. These studies have shown lower implantation rates in nonendometriotic patients who received Oocytes from women with endometriosis, whereas healthy donated Oocytes have proven to contribute to a pregnancy with similar chances in women without the disease. The question still to be answered is whether this situation applies for natural cycles or whether it is the use of gonadotropin-releasing hormone analogs and hormonal replacement therapy used for endometrial priming in Oocyte recipients that reestablishes an adequate uterine environment. Using a genomic tool based on microarray technology (endometrial receptivity array), the study of differential gene expression in the eutopic endometrium of endometriosis patients undergoing Oocyte Donation treatment is still underway.
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clinical factors affecting endometrial receptiveness in Oocyte Donation cycles
Fertility and Sterility, 2008Co-Authors: Sergio Reis Soares, Juan Garcia A Velasco, Manuel Fernandez, Ernesto Bosch, J Remohi, Antonio Pellicer, Carlos SimonAbstract:Objective To provide a summary of the actual knowledge about the clinical factors affecting the Oocyte recipient (other than those associated with uterine cavity abnormalities) on the outcome of Oocyte Donation cycles. Design Review of the literature. Setting Information regarding the association between age, body mass index (BMI), endometrial priming, tobacco consumption, hydrosalpinx, and endometriosis/adenomyosis in Oocyte recipients and the results of Oocyte Donation cycles. Result(s) Recipient age and the presence of hydrosalpinx are clearly associated with a poorer outcome in Oocyte Donation cycles. The negative impact of tobacco consumption has recently been confirmed. The exact relevance of an elevated BMI is under debate but it is likely that it determines a lower ongoing pregnancy rate (PR). Endometriosis may be significant for endometrial receptiveness in the context of a natural cycle, but no negative impact is detected when standard endometrial priming protocols are used in Oocyte Donation. The same may be true for adenomyosis, although its relevance to endometrial receptiveness is less clear. Conclusion(s) Accumulated knowledge in the field of Oocyte Donation has led to the recognition of clinical variables that affect cycle outcome by impairing endometrial receptiveness. Many studies are being carried out on endometrial molecular and gene expression changes taking place in these circumstances. In the near future a comprehensive understanding of these processes should be achieved, from a genetic, molecular, and clinical perspective. These advances in the collective knowledge will lead to an improvement in the diagnosis and treatment of infertile patients.
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The `vanishing embryo' phenomenon in an Oocyte Donation programme
Human Reproduction, 2002Co-Authors: Manuel Rodríguez-gonzález, Antonio Pellicer, Vicente Serra, Juan A. Garcia-velasco, Jose RemohiAbstract:BACKGROUND: We studied the incidence of vanishing embryos (VE) in pregnancies achieved by Oocyte Donation and evaluated the obstetric and perinatal complications. METHOD: A retrospective study was carried out based on a chart review of 399 patients with multiple pregnancies from our Oocyte Donation programme. We defined vanishing phenomenon as the early resorption, in the first trimester, of one or more embryos in a multiple gestation, after confirming embryonic heart activity by transvaginal ultrasound. RESULTS: Vanishing embryo was observed in 75 patients (18.8%). In 60 patients (80%) this phenomenon occurred before the ninth gestational week. A higher incidence of VE was observed in patients who initially showed a higher number of gestational sacs (P < 0.03). Vaginal bleeding in the first trimester was significantly higher in patients with VE (P < 0.005). Miscarriage rate was similar in pregnancies with and without VE (P NS). The incidence of pregnancy induced hypertension was decreased in the group with VE (P < 0.03). Preterm spontaneous rupture of membranes occurred more frequently in pregnancies with VE (P < 0.05). However, gestational age at delivery was similar in the group with VE and the controls. CONCLUSIONS: The high incidence of VE in pregnancies achieved by Oocyte Donation should be considered when counselling patients with high order multiple gestations.
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pregnancy and birth rates after Oocyte Donation
Fertility and Sterility, 1997Co-Authors: Jose Remohi, Carlos Simon, Bernard Gartner, Ernesto Gallardo, Sonia Yalil, Antonio PellicerAbstract:Abstract Objective: To determine accumulated conception and live birth rates in ovum Donation. Design: Retrospective study from a computer database. Pregnancies with one gestational sac observed by ultrasound have been included as conceptional cycles and pregnancies that resulted in one live child were recorded for the analysis of the live birth rates. Life table analysis was applied. Setting: Oocyte Donation program at the Instituto Valenciano de Infertilidad. Patient(s): Three hundred ninety-seven recipients undergoing a total of 627 ETs were analyzed. Intervention(s): Ovarian stimulation and ovum pick-up in donors. Uterine ET in recipients after appropriate exogenous steroid replacement. Main Outcome Measurement(s): Accumulated and estimated (95% confidence intervals [CI]) conception and live birth rates in the Oocyte Donation program as well as considering age and cause of infertility of the recipients. Result(s): Pregnancy rate after one cycle was 53.4% (CI 50.9% to 55.9%), with a delivery rate of 42.6% (CI 40.1% to 45.1%). Accumulated pregnancy rate increased up to 94.8% (CI 90.6% to 99.0%) after four transfers. Similarly, live birth rates reached 88.7% (CI 88.1% to 89.3%) after four attempts of ET by ovum Donation. Cycle fecundity rates were maintained at approximately 50% after each attempt. Implantation rate was 18.3% (430/2,340 replaced embryos). Age and cause of entering the program did not influence the overall results of ovum Donation. Conclusion(s): Oocyte Donation is a successful treatment modality for infertile couples that offers even higher success rates than natural conception. No difference in cumulative pregnancy rate was observed regardless of recipient age, indication for Oocyte Donation, or number of cycles attempted.
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effect of age on sperm fertility potential Oocyte Donation as a model
Fertility and Sterility, 1996Co-Authors: Ernesto Gallardo, Carlos Simon, Jose Remohi, M Levy, Pedro P Guanes, Antonio PellicerAbstract:Objective To determine the effect of age on sperm fecundability using Oocyte Donation as an in vivo model. Setting Oocyte Donation and IVF programs at the Instituto Valenciano de Infertilidad. Patients Two-hundred forty couples undergoing 345 cycles of ovum Donation, who were recipients of 298 donors. Design Retrospective study in which four groups of Oocyte Donation cycles were established according to age of the male providing the semen sample: group 1 (n = 31) 51 years, the oldest being 64 years. All donated Oocytes were obtained from patients Main Outcome Measurements Male age, sperm characteristics (volume, concentration, motility, morphology), fertilization, embryo quality, pregnancy, implantation, and abortion rates among recipients. Results Similar sperm characteristics in fresh as well as after preparation for IVF were observed among males of different ages. Fertilization, embryo quality, pregnancy, and implantation were similar among the established groups. The mean age of the females included in each group significantly increased from group 1 to group 4. Conclusions Age (up to 64 years) does not affect sperm characteristics or its ability to fertilize human eggs. Similarly, embryo development in vitro as well as implantation in recipient uteri are not affected by age of the male providing the semen sample.
S Purewal - One of the best experts on this subject based on the ideXlab platform.
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Attitudes and intentions towards volunteer Oocyte Donation.
Reproductive biomedicine online, 2020Co-Authors: S Purewal, O B A Van Den AkkerAbstract:There is an acute shortage of donated Oocytes in the UK and clinics are largely relying on shared Donation. Shared Donation of Oocytes is not without its ethical and moral concerns. The aims of this study were therefore to investigate non-patient population attitudes towards Oocyte Donation and examine the link between Oocyte Donation intentions and reasons for parenthood using structural equation modelling (SEM). The survey population consisted of 349 women aged 27.8 +/- 4.7 years. Results revealed that approximately one-third of woman would consider donating their Oocytes as identifiable donors. SEM analyses indicated a significant direct effect of positive attitudes towards Oocyte Donation, high levels of social support and endorsement of less conventional reasons for parenthood to intentions to donate. Age, education and attitudes towards less conventional perceptions of parenthood coincided with their positive beliefs about the importance of parenthood and children. Thus, results indicated that attitudes towards parenthood are an important factor underpinning the motivation for potential Oocyte Donation.
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Attitudes and intentions towards volunteer Oocyte Donation
Reproductive Biomedicine Online, 2020Co-Authors: S Purewal, O B A Van Den AkkerAbstract:There is an acute shortage of donated Oocytes in the UK and clinics are largely relying on shared Donation. Shared Donation of Oocytes is not without its ethical and moral concerns. The aims of this study were therefore to investigate non-patient population attitudes towards Oocyte Donation and examine the link between Oocyte Donation intentions and reasons for parenthood using structural equation modelling (SEM). The survey population consisted of 349 women aged 27.8 ± 4.7 years. Results revealed that approximately one-third of women would consider donating their Oocytes as identifiable donors. SEM analyses indicated a significant direct effect of positive attitudes towards Oocyte Donation, high levels of social support and endorsement of less conventional reasons for parenthood to intentions to donate. Age, education and attitudes towards the importance of a genetic link between parent and child indirectly influenced intentions to donate Oocytes. Intenders' less conventional perceptions of parenthood coincided with their positive beliefs about the importance of parenthood and children. Thus, results indicated that attitudes towards parenthood are an important factor underpinning the motivation for potential Oocyte Donation.
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A study of the effect of message framing on Oocyte Donation
Human Reproduction, 2009Co-Authors: S Purewal, O B A Van Den AkkerAbstract:BACKGROUND: The aims of this study were to examine the effect of gain- and loss-framed messages on British and South East Asian women's intentions towards Oocyte Donation and to examine whether the components of the theory of planned behaviour influenced the relationship between framing and intentions. METHODS: A total of 406 women participated in this study (mean age = 22, SD = 2.9). There were 211 participants in the gain condition and 195 in the loss condition. RESULTS: An analysis of covariance found a main effect for framing (F(1, 402) = 6.3; P < 0.01) after controlling for existing attitudes towards Oocyte Donation and pre-message intentions to donate. Specifically, participants in the gain-framed condition were significantly more likely to report higher post-message intentions to donate Oocytes than participants in the loss condition. However, the framing effect was only observed with British populations and not with women from South East Asia. Further, structural equation modelling analyses revealed lower levels of ‘perceived behavioural control’ (β = –0.420, P < 0.03) and positive attitudes towards ‘the importance of genetic ties between parent and child’ (β = 0.70, P < 0.001) were direct predictors of post-message intentions in the gain (but not loss) frame condition. CONCLUSION: Findings obtained from this study indicate that Oocyte Donation campaigns should consider using gain-framed messages in recruitment appeals and message frames should be matched to the target populations’ perceived level of behavioural control.
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systematic review of Oocyte Donation investigating attitudes motivations and experiences
Human Reproduction Update, 2009Co-Authors: S Purewal, O B A Van Den AkkerAbstract:BACKGROUND: The social and psychological factors determining intentions to donate gametes are important for clinics, policy-makers and recruitment campaigns. The aims of this systematic review were therefore to integrate the research findings regarding the psychosocial determinants of Oocyte Donation and extrapolate women's experiences of Donation. METHODS: A bibliographic search of English language publications of four computerized databases was undertaken with no time restriction set for publications. RESULTS: A total of 64 studies met the inclusion criteria and were included in the review. The research syntheses revealed there were distinct differences between patient and non-patient (known, commercial, volunteer and potential) donors on demographic characteristics, motives for Donation, and issues relating to disclosure and attitudes towards the resultant offspring. Further, studies have found that a significant proportion of Oocyte donors and women from the general population were prepared to donate their Oocytes as identifiable donors. Studies which have examined the experiences of donors report positive experiences of Oocyte Donation. However, a number of methodological limitations relating to the Oocyte Donation research literature have been identified in this systematic review. CONCLUSION: Differences between donor groups on a range of factors highlight the need for tailored psychosocial evaluation and counselling. The review has demonstrated that it is not useful to generalize across donor groups on various factors relating to Oocyte Donation.
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british women s attitudes towards Oocyte Donation ethnic differences and altruism
Patient Education and Counseling, 2006Co-Authors: S Purewal, O B A Van Den AkkerAbstract:Abstract Objective This study assessed the importance of altruism and willingness to donate Oocytes in British Asian and Caucasian samples. The Theory of Planned Behaviour (TPB) was used to test the importance of attitudes towards Oocyte Donation, normative and control beliefs to attitudes to donate Oocytes. Method One hundred and one participants (55% Asian, 45% Caucasian) completed questionnaires measuring altruism and attitudes to Oocyte Donation. There were no socio-demographic differences between ethnic groups. Results Few women were willing to donate Oocytes, Asian women were least likely to donate Oocytes, and altruism was not related to willingness to donate. Forty-one participants considered themselves ‘possible’ Oocyte donors and 54 as definite ‘non’ donors. Possible donors reported significantly more positive attitudes towards egg Donation; asking women to donate under various circumstances; to the consequences of donating their eggs; positively experiencing egg Donation and to factors that would induce women to donate. Subjective norms and behavioural control also influenced intention to donate. Conclusion A number of components of the TPB were able to predict possible Oocyte Donation, and non-Oocyte Donation. Practice implications: This study provides some empirical support for specific factors influencing cultural differences in gamete Donation in the UK. A future culturally appropriate targeted approach to Donation education could redress the present imbalance in supply and demand of gametes in infertility treatment.
Susan C. Klock - One of the best experts on this subject based on the ideXlab platform.
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Emerging Views of Kinships Created Through Oocyte Donation.
MCN: The American Journal of Maternal Child Nursing, 2020Co-Authors: Patricia E. Hershberger, Martha Driessnack, Karen Kavanaugh, Susan C. KlockAbstract:BACKGROUND: The United States has the highest number of Oocyte Donation cycles, which account for an estimated one-quarter of all worldwide Oocyte Donation cycles. Although there has been a steady rise in Oocyte Donation treatment, understanding the kinship views of those intimately involved is lacking. These include women Oocyte donors and parents who received donor Oocytes to establish a pregnancy. PURPOSE: To explore the views and perspectives about genetic relationships and lineages among women who were Oocyte donors and parents who received donated Oocytes 10 to 12 years after donors and parents underwent Oocyte Donation procedures to establish a pregnancy. STUDY DESIGN AND METHODS: A longitudinal cohort of pregnant women who received donor Oocytes participated in an expanded, follow-up study 12 years postpregnancy that included the women's heterosexual partners and biological fathers. Women who donated Oocytes anonymously 10 to 12 years prior also participated. Qualitative content analysis was used to analyze participants' in-depth interviews. RESULTS: Six women who received donor Oocytes and their heterosexual partners and biological fathers (n = 6), representing 12 children conceived by Oocyte Donation, and 3 women who donated Oocytes anonymously representing 3 children participated. Themes that emerged from the women Oocyte donors included a reexamination of anonymity and contact with recipient families, managing disclosure to their own children about possible half-siblings, and potential for consanguinity. For recipient parents, there was an overwhelming sense of gratitude to the women Oocyte donors, concerns about navigating genetic information gaps, and contemplating future contact with the donors and/or half-siblings. CLINICAL IMPLICATIONS: Nurses can play a vital role in supporting and educating women Oocyte donors and recipient parents about navigating complex relationship issues in donor kinships.
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Oocyte Donation: lessons from the past, directions for the future
Fertility and Sterility, 2018Co-Authors: Steven R. Lindheim, Susan C. KlockAbstract:Oocyte Donation has its origins in the clandestine use of donated sperm more than 140 years ago. Since first described in 1983, Oocyte Donation has resulted in more than 50,000 births in the United States alone and today now accounts for more than 10% of all IVF cycles performed yearly in the United States. The use of donated Oocytes has changed the human reproductive landscape, challenging the traditional norms of conception and parenthood. Oocyte Donation has also provided a unique scientific model that separates the egg from the uterus, allowing the independent study of each in normal physiologic and pathological conditions and providing insights into the fundamental aspects of reproduction, cell biology, and genetics. This Views and Reviews takes us through the historical development of Oocyte Donation, its scientific insights, and its application to daily practice and management, as well as insights into what the future may hold for this field.
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disclosure decisions among known and anonymous Oocyte Donation recipients
Fertility and Sterility, 2003Co-Authors: Dorothy A. Greenfeld, Susan C. KlockAbstract:Abstract Objective The purpose of this study was to compare anonymous and known donor mothers' demographics, knowledge about the donor, and disclosure attitudes. Design Cross-sectional survey of Oocyte Donation parents. Setting Academic medical centers. Patient(s) Women having a child through Oocyte Donation in the past 12 years. Intervention(s) Subjects completed a survey regarding their Oocyte Donation experience. Main outcome measure(s) Donor characteristics and disclosure behavior. Result(s) Questionnaires were sent to 524 individuals (262 couples); 157 (92 women and 65 men) were returned yielding a response rate of 31.4% (157/500). The average age of the women was 44.7 years and the average age of the child was 2.89 years. Seventy women used anonymous donors and 20 women used known donors. Significantly more known recipients knew their donors' religion, number of children, hobbies, profession, and photograph. Eighty percent of both groups told others about using a donor to conceive. Regarding telling the child, there were also no significant differences with approximately 10% who have told, 49% plan to tell, 31% are not telling, and 10% are unsure. Conclusion(s) Contrary to conventional wisdom we found no differences in plans to inform the child based on the use of a known or an anonymous donor.
