The Experts below are selected from a list of 32262 Experts worldwide ranked by ideXlab platform
Christine T. Chambers - One of the best experts on this subject based on the ideXlab platform.
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The development and use of facial grimace scales for Pain measurement in Animals.
Neuroscience & Biobehavioral Reviews, 2020Co-Authors: Jeffrey S. Mogil, Gabrielle Guanaes Silva Dutra, Daniel S J Pang, Christine T. ChambersAbstract:Abstract The measurement of Pain in Animals is surprisingly complex, and remains a critical issue in veterinary care and biomedical research. Based on the known utility of Pain measurement via facial expression in verbal and especially non-verbal human populations, “grimace scales” were first developed a decade ago for use in rodents and now exist for 10 different mammalian species. This review details the background context, historical development, features (including duration), psychometric properties, modulatory factors, and impact of animal grimace scales for Pain.
Paul A. Flecknell - One of the best experts on this subject based on the ideXlab platform.
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assessing Pain in Animals putting research into practice
Animal Welfare, 2004Co-Authors: Paul A. Flecknell, Johnny V RoughanAbstract:Our ability to assess Pain in Animals in clinical situations is slowly developing, but remains very limited. in order to develop appropriate Pain scoring schemes, numerous practical problems need to be overcome. in addition, we need to appraise realistically our current poor state of knowledge. Development of new scoring systems must be coupled with the increased education and training of those responsible for Pain management, so that both the assessment and the alleviation of Pain are steadily improved.
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Buprenorphine: a reappraisal of its antinociceptive effects and therapeutic use in alleviating post-operative Pain in Animals
Laboratory Animals, 2002Co-Authors: John V. Roughan, Paul A. FlecknellAbstract:Summary Buprenorphine has been widely used for post-operative analgesia in laboratory Animals. Clinical ef® cacy has been demonstrated in both subjective and objective Pain assessment schemes, however doubts have been expressed as to its value as an analgesic. initial dosage recommendations were based on analgesiometric studies. It is unlikely, however, that the Pain elicited in analgesiometric tests is comparable to post-operative Pain. This has resulted in recommendations of excessive dose rates and inappropriate clinical indications. Studies involving tests of the ef® cacy of buprenorphine for alleviating behavioural or other signs of tonic (post-surgical)Pain provide a more appropriate estimation of the analgesic capabilities of the drug. However, buprenorphine also has major effects upon the behaviour of normal (unoperated) Animals, and this makes assessments of ef® cacy dif® cult with some of the systems used for scoring clinical Pain. Nevertheless, our most recent studies of the effects of buprenorphine upon Pain-related behaviours in rats support the view that it is an effective post-operative analgesic. This short review critically reappraises the role of buprenorphine in this capacity and discusses a rational approach to the relief of Pain in laboratory Animals. We conclude that buprenorphine remains a valuable agent for Pain relief in a wide range of animal species when used in an appropriate manner.
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Pain Management in Animals
2000Co-Authors: Paul A. Flecknell, Avril Waterman-pearsonAbstract:1. introduction: Pain in Animals 2. The Physiology of Pain3. Pharmacology of Analgesics 4. Pain Recognition and Pain Assessment 5. Management of Postoperative Pain and Other Acute Pain 6. Management of Chronic Pain 7. Problems of Pain Management
Jeffrey S. Mogil - One of the best experts on this subject based on the ideXlab platform.
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The development and use of facial grimace scales for Pain measurement in Animals.
Neuroscience & Biobehavioral Reviews, 2020Co-Authors: Jeffrey S. Mogil, Gabrielle Guanaes Silva Dutra, Daniel S J Pang, Christine T. ChambersAbstract:Abstract The measurement of Pain in Animals is surprisingly complex, and remains a critical issue in veterinary care and biomedical research. Based on the known utility of Pain measurement via facial expression in verbal and especially non-verbal human populations, “grimace scales” were first developed a decade ago for use in rodents and now exist for 10 different mammalian species. This review details the background context, historical development, features (including duration), psychometric properties, modulatory factors, and impact of animal grimace scales for Pain.
M. Sharkey - One of the best experts on this subject based on the ideXlab platform.
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measurement of chronic Pain in companion Animals priorities for future research and development based on discussions from the Pain in Animals workshop paw 2017
Veterinary Journal, 2019Co-Authors: D X Lascelles, Michael G. Conzemius, Michael L. Oshinsky, M. Gill, M. SharkeyAbstract:Abstract The estimation of long-standing Pain in companion Animals through the measurement of different dimensions impacted by Pain is a fundamental requirement if Pain management, and Pain therapeutic development, are to advance. Although Pain management in veterinary medicine has advanced considerably in the last 20 years, there is much critical work to do in the area of measurement of chronic Pain. To date, most work has centered on musculoskeletal Pain, and has been focused around the measurement of limb use and the development of owner-completed questionnaires, or clinical metrology instruments (CMI). Recent areas of research have extended to developing measures of activity, sensory function (quantitative sensory testing; nociceptive withdrawal reflexes), and quality of life (QoL). Across all these areas, more data on validity are needed, and studies should be extended to other Painful disease states. By necessity, assessing measurement tools requires testing in field studies, which incur considerable time and expense. Facilitating these studies could be optimized with a collaborative (industry, academia and private practice) approach, and the utility of the information produced from all field studies would be enhanced by full and transparent reporting and data sharing, including data already generated by industry in the form of studies submitted to the regulatory authorities.
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Measurement of chronic Pain in companion Animals: Discussions from the Pain in Animals Workshop (PAW) 2017.
Veterinary Journal, 2019Co-Authors: B. Duncan X. Lascelles, Michael G. Conzemius, Michael L. Oshinsky, Dorothy Cimino Brown, M. Gill, M. SharkeyAbstract:Abstract in the face of increasing recognition and interest in treating chronic Pain in companion Animals, we struggle with a lack of therapeutic options. A significant barrier to the development of new therapeutics, or the critical evaluation of current therapies, is our inability to accurately measure chronic Pain and its impact on companion Animals. Over the last 20 years, much progress has been made in developing methods to measure chronic Pain via subjective and objective methods - particularly in owner assessment tools and measurements of limb use and activity. Most work has been focused on chronic joint Pain conditions, but there has been relatively little work in other areas of chronic Pain, such as neuropathic and cancer Pain. Although progress has been made, there is a considerable interest in improving our assessment of chronic Pain, as evidenced by the multiple disciplines across industry, academia, and clinical practice from the veterinary and human medical fields that participated in the Pain in Animals Workshop held at the National institutes of Health in 2017. This review is one product of that meeting and summarizes the current state of knowledge surrounding the measurement of chronic Pain (musculoskeletal, cancer, neuropathic), and its impact, in cats and dogs.
Gabrielle Guanaes Silva Dutra - One of the best experts on this subject based on the ideXlab platform.
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The development and use of facial grimace scales for Pain measurement in Animals.
Neuroscience & Biobehavioral Reviews, 2020Co-Authors: Jeffrey S. Mogil, Gabrielle Guanaes Silva Dutra, Daniel S J Pang, Christine T. ChambersAbstract:Abstract The measurement of Pain in Animals is surprisingly complex, and remains a critical issue in veterinary care and biomedical research. Based on the known utility of Pain measurement via facial expression in verbal and especially non-verbal human populations, “grimace scales” were first developed a decade ago for use in rodents and now exist for 10 different mammalian species. This review details the background context, historical development, features (including duration), psychometric properties, modulatory factors, and impact of animal grimace scales for Pain.
