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Yiru Peng - One of the best experts on this subject based on the ideXlab platform.

  • Synthesis and Photophysical Property of Polyion Complex Micelle Incorporating Phthalocyanine Zinc(II) Bearing Benzyl Ether Dendritic Substituents with Nitro-Terminal Group
    Advanced Materials Research, 2015
    Co-Authors: Xiao Dong Zhu, Zhen Zhen Chen, Jun Ri Wen, Xiong Wei Wang, Yiru Peng
    Abstract:

    A new Phthalocyanine Zinc(II) bearing benzyl ether dendritic substituents with nitro-terminal group: tetra-{3,5-[di-(4-nitro benzyloxy) benzyloxy]} Phthalocyanine Zinc(II) (ZnPc(NO2)8), was synthesis and characterized by IR, 1HNMR, MALDI-TOF-MS and UV/Vis. UV/Vis spectra of ZnPc(NO2)8 exhibited characteristic absorption peaks at 290, 350 and 680 nm, and fluorescence emission peak was at 692 nm with a quantum yield at 0.20 in dimethylsulfoxide (DMSO). The polymeric nanoparticle ZnPc(NO2)8@MPEG-PLGA was formed between the amphiphilic block copolymer poly(ethylene glycol)-polylactic and polyglyctic acids (PEG-PLGA) and ZnPc(NO2)8, ZnPc(NO2)8@MPEG-PLGA formed a core-shell-type nanoparticle with diameter about 70 nm. UV/Vis spectra and fluorescence emission spectra of ZnPc(NO2)8@MPEG-PLGA were obviously lower than that of free ZnPc(NO2)8 in buffer solution, and with varying degrees of redshift. ZnPc(NO2)8@MPEG-PLGA would be a promising third-generation photosensitizer for PDT.

  • tetra sulfonate Phthalocyanine Zinc bovine serum albumin conjugate mediated photodynamic therapy of human glioma
    Journal of Biomaterials Applications, 2014
    Co-Authors: Dianshuang Xu, Keen Chen, Yingxin Li, Yiru Peng, Xiangyu Chen, Yiquan Ke
    Abstract:

    BackgroundGlioma is the most common brain malignancy with poor prognosis. The current treatments for gliomas are mainly based on surgery, chemotherapy, and radiotherapy, which exhibit limited efficacy. Photodynamic therapy (PDT) using photosensitizers has been applied to glioma therapy. However, different photosensitizers usually lead to different therapeutic effects and adverse reactions.ObjectiveThis study investigates the anti-tumor effect of photosensitizer ZnPcS4-BSA in xenograft glioma tumors.MethodsThe xenograft glioma tumor model was established by inoculating nude mice with U251 cells. Tumor growth was evaluated by tumor volume, weight, and inhibition rate. Cell apoptosis was evaluated using TUNEL staining. Vascular endothelial growth factor (VEGF) expression and microvessel density were measured by immunohistochemistry.ResultsSignificant decreases in tumor volume and weight as well as significant increases in tumor inhibition rate, cell apoptosis, VEGF expression, and microvessel density were ob...

  • Photoinduced intra-molecular energy transfer of a novel Phthalocyanine Zinc(II) bearing poly (aryl benzyl ether) dendritic substitutents with carboxylic terminal
    Guang pu xue yu guang pu fen xi = Guang pu, 2014
    Co-Authors: Si-ning Zheng, Wan-ling Chen, Yiru Peng
    Abstract:

    The photoinduced intra-molecular energy transfer in Phthalocyanine Zinc(II) bearing poly (aryl benzyl ether) dendritic substituents with carboxylic terminal was studied by steady-state, time-resolved fluorescence and UV/Vis spectroscopic methods. The result shows that the complexes mainly existed as monomers in dimethyl sulfoxide. The light-harvesting ability of this series of dendritic Phthalocyanines increased with the dendron generation under 270 nm. The effects of the dendron generation on the fluorescence characteristics of Phthalocyanine cores was significantly, and the fluorescence lifetime and fluorescent quantum yield decreased with the increase of the dendron generation. Intra-molecular energy could be transferred from peripheral dendron acting as an energy hydrazine to the Phthalocyanine core during a photo-induced process. With the dendrimer increasing, the intra-molecular energy transfer quantum yield increased. These results obviously indicated that this series of dendritic Phthalocyanines is a king of novel compound with light-harvesting structure.

  • Synthesis, separation and characterization of amphiphilic 2,10-di-sulfonato-18,26-di-phthalimidomethyl Phthalocyanine Zinc di-potassium salt by template reaction
    Dyes and Pigments, 2005
    Co-Authors: Yiru Peng, Jinling Huang, Zhipeng Lin, Naisheng Chen
    Abstract:

    Abstract An amphiphilic 2,10-di-sulfonato-18,26-di-phthalimidomethyl Phthalocyanine Zinc di-potassium salt ( 3 ) was synthesized by first direct condensation of hydrophilic precursor 4-sulfonic phthalic acid mono-potassium salt ( 1 ) with hydrophobic precursor 4-phthalimidomethyl phthalic acid ( 2 ). Then the condensed mixture was separated by reverse HPLC method and further purified by a membrane separation method. The composition of the title compound was characterized by elemental analysis, UV, 1 H NMR, 13 C NMR as well as TG and DTA, and its C 4 h -structure was identified according to the 1 H NMR signal of submethyl protons of the phthalimidomethyl groups in the Phthalocyanine ring, polarity and synthetic mechanism. In vivo antitumor activity of the title compound as photosensitizer showed that its inhibitory rate was up to 90.3%. This amphiphilic photosensitizer has a potential application in the photodynamic therapy of cancer.

Wei Chen - One of the best experts on this subject based on the ideXlab platform.

  • Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-α-(4-carboxyphenoxy) Phthalocyanine Zinc photodynamic therapy in LoVo cells.
    Oncology reports, 2017
    Co-Authors: Yu Wang, Chunhui Xia, Zhiqiang Lun, Wei Chen
    Abstract:

    Photodynamic therapy (PDT) is considered to be an advancing antitumor technology. PDT using hydrophilic/lipophilic tetra‑α-(4-carboxyphenoxy) Phthalocyanine Zinc (TαPcZn-PDT) has exhibited antitumor activity in Bel-7402 hepatocellular cancer cells. However, the manner in which p38 MAPK and caspase-9 are involved in the regulation of mitochondria-mediated apoptosis in the TαPcZn-PDT-treated LoVo human colon carcinoma cells remains unclear. Therefore, in the present study, a siRNA targeting p38 MAPK (siRNA-p38 MAPK) and the caspase‑9 specific inhibitor z-LEHD-fmk were used to examine the crosstalk between p38 MAPK and caspase-9 during mitochondria-mediated apoptosis in the TαPcZn-PDT‑treated LoVo cells. The findings revealed that the TαPcZn-PDT treatment of LoVo cells resulted in the induction of apoptosis, the formation of p38 MAPK/caspase-9 complexes, the activation of p38 MAPK, caspase-9, caspase-3 and Bid, the downregulation of Bcl-2, the reduction of mitochondrial membrane potential (ΔΨm), the upregulation of Bax and the release of apoptosis-inducing factor (AIF) and cytochrome c (Cyto c). By contrast, siRNA‑p38 MAPK or z-LEHD-fmk both attenuated the effects of TαPcZn-PDT in the LoVo cells. Furthermore, the results revealed that siRNA-p38 MAPK had more significant inhibitory effects on apoptosis and mitochondria compared with the effects of z-LEHD-fmk in TαPcZn-PDT-treated LoVo cells. These findings indicated that p38 MAPK plays the major regulatory role in the crosstalk between p38 MAPK and caspase-9 and that direct interaction between p38 MAPK and caspase-9 may regulate mitochondria-mediated apoptosis in the TαPcZn-PDT-treated LoVo cells.

  • Autoregulatory Feedback Mechanism of P38MAPK/Caspase-8 in Photodynamic Therapy-Hydrophilic/Lipophilic Tetra--(4-carboxyphenoxy) Phthalocyanine Zinc-Induced Apoptosis of Human Hepatocellular Carcinoma Bel-7402 Cells
    International Journal of Photoenergy, 2014
    Co-Authors: Yu Wang, Chunhui Xia, Wei Chen, Yuhang Chen, Yiyi Wang
    Abstract:

    Photodynamic therapy (PDT) is a novel and promising antitumor treatment. Our previous study showed that hydrophilic/lipophilic tetra-α-(4-carboxyphenoxy) Phthalocyanine Zinc- (TαPcZn-) mediated PDT (TαPcZn-PDT) inhibits the proliferation of human hepatocellular carcinoma Bel-7402 cells by triggering apoptosis and arresting cell cycle. However, mechanisms of TαPcZn-PDT-induced apoptosis of Bel-7402 cells have not been fully clarified. In the present study, therefore, effect of TαPcZn-PDT on apoptosis, P38MAPK, p-P38MAPK, Caspase-8, Caspase-3, Bcl-2, Bid, Cytochrome c, and mitochondria membrane potential in Bel-7402 cells without or with P38MAPK inhibitor SB203580 or Caspase-8 inhibitor Ac-IEFD-CHO was investigated by haematoxylin and eosin (HE) staining assay, flow cytometry analysis of annexin V-FITC/propidium iodide (PI) double staining cells and 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide (JC-1), and immunoblot assay. We found that TαPcZn-PDT resulted in apoptosis induction, activation of P38MAPK, Caspase-8, Caspase-3, and Bid, downregulation of Bcl-2, release of Cytochrome c from mitochondria, and disruption of mitochondrial membrane potential in TαPcZn-PDT-treated Bel-7402 cells. In contrast, SB203580 or Ac-IEFD-CHO attenuated induction of apoptosis, activation of P38MAPK, Caspase-8, Caspase-3, and Bid, downregulation of Bcl-2, release of Cytochrome c from mitochondria, and disruption of mitochondrial membrane potential in TαPcZn-PDT-treated Bel-7402 cells. Taken together, we conclude that Caspase-3, Bcl-2, Bid, and mitochondria are involved in autoregulatory feedback of P38MAPK/Caspase-8 during TαPcZn-PDT-induced apoptosis of Bel-7402 cells.

  • New hydrophilic/lipophilic tetra-α-(4-carboxyphenoxy) Phthalocyanine Zinc-mediated photodynamic therapy inhibits the proliferation of human hepatocellular carcinoma Bel-7402 cells by triggering apoptosis and arresting cell cycle.
    Molecules (Basel Switzerland), 2011
    Co-Authors: Chunhui Xia, Yu Wang, Wei Chen, Baiqi Wang
    Abstract:

    Photodynamic therapy (PDT) is a novel and promising antitumor treatment. Phthalocyanine-mediated PDT has shown antitumor activity in some tumor cells, but the effect of new hydrophilic/lipophilic tetra-α-(4-carboxyphenoxy)Phthalocyanine Zinc (TαPcZn)-mediated PDT (TαPcZn-PDT) on human hepatocellular carcinoma Bel-7402 cells and underlying mechanisms have not been clarified. In the present study, therefore, the ultraviolet-visible (UV-vis) absorption spectrum and cellular localization of TαPcZn, and effect of TαPcZn-PDT on the proliferation, apoptosis, cell cycle, Bcl-2 and Fas in Bel-7402 cells were investigated by spectrophotometry, inverted microscope, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay, electron microscopy, annexinV-FITC/propidium iodide double staining, DNA content and immunoblot assay, respectively. We found that an intense absorption in UV-vis absorption spectrum of TαPcZn was in the red visible region at 650–680 nm, where light penetration in tissue is efficient, that green TαPcZn localized to both plasma membrane and nuclear membrane of Bel-7402 cells, signifying that there was a selective uptake of TαPcZn in Bel-7402 cells and TαPcZn-PDT would be expected to directly damage DNA, and that TαPcZn-PDT significantly resulted in the proliferation inhibition, apoptosis induction, S cell cycle arrest, and down-regulation of Bcl-2 and Fas. Taken together, we conclude that TαPcZn-PDT inhibits the proliferation of Bel-7402 cells by triggering apoptosis and arresting the cell cycle.

  • BMEI - Photodynamic Therapy of New Amphiphilic Phthalocyanine Zinc Inhibits the Proliferation of Human Hepatoma Bel-7402 Cells through the Induction of Apoptosis
    2009 2nd International Conference on Biomedical Engineering and Informatics, 2009
    Co-Authors: Chunhui Xia, Yu Wang, Yin Gao, Cuixiang Zhang, Yuchun Wang, Wei Chen, Liming Bai
    Abstract:

    Photodynamic therapy of Phthalocyanines has been shown to have antitumor activity in some tumor cells. However, the photodynamic therapy mechanism of amphiphilic Phthalocyanine Zinc in Human Hepatoma Bel-7402 cells has not been clarified. In the present study, therefore, the photodynamic therapy effect of amphiphilic Phthalocyanine Zinc on the proliferation and apoptosis in Bel-7402 cells was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide, AnnexinV-FITC/ Propidium Iodide double staining, electron microscopy and inverted microscope assay, respectively. We found that photodynamic therapy of amphiphilic Phthalocyanine Zinc significantly led to inhibition of proliferation and induction of apoptosis in Bel-7402 cells. Therefore, we conclude that photodynamic therapy of amphiphilic Phthalocyanine Zinc inhibits the proliferation of Bel-7402 cells through the induction of apoptosis. Keywords-Human Hepatoma Bel-7402 cells; Photodynamic therapy; Apoptosis; Proliferation; Amphiphilic Phthalocyanine Zinc

  • Spectral study of monoisothiocyanato-substituted 3:1 asymmetrical Phthalocyanine Zinc(II)
    Guang pu xue yu guang pu fen xi = Guang pu, 2007
    Co-Authors: Wei Chen, Wubiao Duan, Xia Zuo
    Abstract:

    Electronic absorption spectra of three monoisothiocyanato-substituted asymmetrical Phthalocyanine Zinc(II), 2-isothiocyanato-9,10,16,17,23,24-alkyloxyPhthalocyanine Zinc(II) [(RO)6 (NCS)PcZn(II)] (R = n-C4H9, n-C5H11, n-C10H21), were measured in five organic solvents. The effect and order of the substitute groups and solvents were studied by electronic absorption spectra. The changes of lamda(max) data are very small between monoamino- and monoisothiocyanato-substituted asymmetrical Phthalocyanines. The order of lamda(max), data is listed here, CHCl3>CH2Cl2>toluene in non-coordination solvents; DMF>THF in O-coordination solvents. The fluorescence spectra of these complexes were measured in organic solvents at the same time. The effect and order of the substitute groups, solvents and concentrations were studied on the maximum wavelength of emission and fluorescence intensity. The lamda(em,max) data of fluorescence emission are among 690-700 nm. The order of lamda(em,max) data is listed here, DMF>THF in O-coordination solvents and almost the same in non-coordination solvents. The fluorescence intensity is very strong in DMF and THF. The order of fluorescence intensity is listed here, DMF>THF in O-coordination solvents; toluene> CH2Clz > CHCl3 in non-coordination solvents. They have special fluorescent effect and should be expected to become a photosensitizer of photodynamic therapy in future.

Ángela Sastre-santos - One of the best experts on this subject based on the ideXlab platform.

  • Supramolecular complex of a fused Zinc Phthalocyanine-Zinc porphyrin dyad assembled by two imidazole-C60 units: ultrafast photoevents.
    Physical chemistry chemical physics : PCCP, 2018
    Co-Authors: Jorge Follana-berná, Sairaman Seetharaman, Luis Martín-gomis, Georgios Charalambidis, Adelais Trapali, Paul A. Karr, Athanassios G. Coutsolelos, Fernando Fernández-lázaro, Francis D'souza, Ángela Sastre-santos
    Abstract:

    A new Zinc Phthalocyanine-Zinc porphyrin dyad (ZnPc-ZnP) fused through a pyrazine ring has been synthesized as a receptor for imidazole-substituted C60 (C60Im) electron acceptor. Self-assembly via metal-ligand axial coordination and the pertinent association constants in solution were determined by 1H-NMR, UV-Vis and fluorescence titration experiments at room temperature. The designed host was able to bind up to two C60Im electron acceptor guest molecules to yield C60Im:ZnPc-ZnP:ImC60 donor-acceptor supramolecular complex. The spectral data showed that the two binding sites behave independently with binding constants similar in magnitude. Steady-state fluorescence studies were indicative of an efficient singlet-singlet energy transfer from Zinc porphyrin to Zinc Phthalocyanine within the fused dyad. Accordingly, the transient absorption studies covering a wide timescale of femto-to-milli seconds revealed ultrafast energy transfer from 1ZnP* to ZnPc (kEnT ∼ 1012 s-1) in the fused dyad. Further, a photo induced electron transfer was observed in the supramolecularly assembled C60Im:ZnPc-ZnP:ImC60 donor-acceptor complex leading to charge separated states, which persisted for about 200 ns.

Fuxi Gan - One of the best experts on this subject based on the ideXlab platform.

  • Optical writing and erasing properties of Phthalocyanine Zinc spin-coated films
    Fifth International Symposium on Optical Storage (ISOS 2000), 2001
    Co-Authors: Jinlong Yin, Fuxi Gan
    Abstract:

    Thin films of tetra-neopentoxy Phthalocyanine Zinc (TNPPcZn) were prepared from its toluene solution by spin-coating technique. Their structural changes due to heat treatment were characterized by the change in optical absorption. The static rewritable optical storage performance of these thin films with recording wavelength at 632.8 nm was investigated. Under the selected writing and erasing conditions, 35 cycles was realized in the static measurement. The reflectivity contrast was in the range of -20% to approximately 20%.© (2001) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

  • Comparison of two types of Phthalocyanine thin films
    Optical Storage Technology, 1998
    Co-Authors: Jinlong Yin, Fulong Tang, Xiaodong Tang, Fuxi Gan
    Abstract:

    Thin films of TNPPcZn (tetra-neopentoxy Phthalocyanine Zinc) were prepared by methods of spin-coating and vacuum evaporation. The absorption spectra and X-ray diffraction of both types of thin films were measured at various temperature or after annealing at various temperature. Phase changes were found in the TNPPcZn spin-coating film while the evaporating thin film hardly showed any changes.© (1998) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

  • Optical properties and recording characteristics of Phthalocyanine-derivative LB films
    Optical Storage (ISOS '92), 1993
    Co-Authors: Fuxi Gan, Tao Luo
    Abstract:

    Langmuir-Blodgett (LB) films of tetra-neopentoxy Phthalocyanine Zinc and tetra-nonyl Phthalocyanine copper are prepared. Their structures, optical properties, and temperature dependencies are investigated. Static optical recording tests by He-Ne laser are done in these LB films and the experimental results demonstrate that Phthalocyanine derivates are useful for phase change type erasable data storage media.© (1993) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

  • Structural change of Langmuir-Blodgett film of tetra-neopentoxy Phthalocyanine Zinc during heat treatment
    Optical Materials, 1992
    Co-Authors: Tao Luo, Weiqing Zhang, Fuxi Gan
    Abstract:

    Abstract Langmuir-Blodgett (LB) films of tetra-neopentaxy Phthalocyanine Zinc (TNPPcZn) were prepared and annealed at a selected temperature. Their optical spectra and optical constants were measured and the structural changes of the films were studied by X-ray diffraction. The arrangement of molecules in the TNPPcZn LB film is changed from disorder to order due to increase of the dimer when the films are annealed at the temperature range of 363 to 433 K. When the annealing temperature is increased further from 433 K to the 573 K, the film undergoes a reorganization in which the orientation of Phthalocyanine rings are transformed formed from perpendicular to the substrate surface into parallel to the substrate surface, because the dimers are destroyed owing to the segregation of the neopentoxy and the monomers are recovered.

Jinling Huang - One of the best experts on this subject based on the ideXlab platform.

  • Isomeric separation and identification of tetra-, tri-, and di-β-sulphonic Phthalocyanine Zinc complexes
    Journal of Porphyrins and Phthalocyanines, 2011
    Co-Authors: Zhou Jiang, Naisheng Chen, Jian Wang, Huisheng Yao, Jinling Huang
    Abstract:

    The synthesis, isomeric separation, and identification of β-sulphonic Phthalocyanine Zinc complexes were reported. While the sulphonic Phthalocyanines have been studied extensively, the development of separation technology may enable deeper insights into their isomeric constitution. An ion-pair reversed-phase high performance liquid chromatography (IP-RP-HPLC) method was developed to separate the sulphonic Phthalocyanine isomers. The results showed that the product of the condensation reaction is a mixture of all possible isomers with statistical distribution. Several isomers were obtained and structural determination was undertaken by NMR. Based on the IP-RP-HPLC elution sequence of these well-identified isomers, a relationship between the structure and efficiency was deduced: closely spaced intervals of sulphonic groups lead to higher hydrophobicity and shorter retention times on HPLC. Based on this relationship, each HPLC peak was assigned to the corresponding isomeric structure.

  • Investigation on the antioxidation of the flavonoids based on the photoinduced chemiluminescence of lucigenin by a new Zinc(II) Phthalocyanine compound
    Free radical research, 2008
    Co-Authors: Jian Wang, Jinling Huang, Zhou Jiang, Liyan Huang, Guonan Chen
    Abstract:

    A Zinc(II) Phthalocyanine compound, tetra-α-(2,2,4-tirmethyl-3-pentoxy) Phthalocyanine Zinc (ZnPc(OR)4) was synthesized in this paper and this Zinc (II) Phthalocyanine compound was used as the photosensitizer in the photoinduced chemiluminescence (PCL) of lucigenin in N,N-dimethylformamide (DMF). The photoexcited ZnPc(OR)4 would produce singlet molecular oxygen (1O2), which would further react with DMF to form corresponding DMF radicals, such as CH3 and CH2N(CH3)CHO, or corresponding alkylperoxyl radicals. Then the carbon centred radical would react with lucigenin to initiate the chemiluminescence. These results would provide useful data to establish a method for evaluation of the ability of 1O2 generation of Phthalocyanine. It was also found in this paper that the flavonoids could effectively inhibit this PCL system, which parallelled very well to flavonoids’ radical-scavenging capacity. The mechanism of this PCL system and the relationship between the molecular structure of flavonoids and their radical-...

  • derivatizable Phthalocyanine with single carboxyl group synthesis and purification
    Inorganic Chemistry Communications, 2006
    Co-Authors: Jincan Chen, Naisheng Chen, Jinling Huang, Jundong Wang, Mingdong Huang
    Abstract:

    Abstract Phthalocyanine Zinc (ZnPc) is an important class of photosensitizers. Derivatization of Phthalocyanine ring with chemical functional groups provides anchor points for covalent attachment of biological targeting agents, thus increasing the selectivity of the photosensitizers. ZnPc with symmetric and multiple functional groups, e.g., tetracarboxyPhthalocyanine Zinc, is easy to be prepared but is unfavorable for linking targeting agents due to many reasons. On the other hand, single-substituted ZnPc, is more challenging to synthesize and, especially, to purify. Here we report the synthesis of an unsymmetrical Phthalocyanine, 2-carboxyPhthalocyanine Zinc 1 , with a single carboxylic group on Phthalocyanine ring, and the design of its chromatographic purification.

  • Investigation of Photoinduced Sensitized Chemiluminescence by Sulfonated Phthalocyanines Using Flow Injection Technology
    Mikrochimica Acta, 2005
    Co-Authors: Jian Wang, Naisheng Chen, Zhou Jiang, Jinling Huang
    Abstract:

    This paper reports the photoinduced chemiluminescence (PCL) of a methyl cypridina luciferin analogue (MCLA) in a flow injection system using Phthalocyanine derivatives as photosensitizers. The photoexcited Phthalocyanine produces singlet molecular oxygen (1O2) in air-saturated solutions. Subsequently 1O2 reacts with MCLA to initiate chemiluminescence. The MCLA-dependent chemiluminescence method would thus potentially provide an easy way for determination of 1O2. Under the optimum conditions, the increase in PCL intensity was proportional to the MCLA concentration ranging from 0.1 to 1.0 µM. The assay was sensitive and reproducible (the relative standard deviation was 6.3%, n = 10). The method has successfully been applied to compare the ability of 1O2 generation of tetra(potassium) salt and tetra(tetrabutylammonium) salt of tetra sulfonated Phthalocyanine Zinc, which have similar structures and spectra.

  • Synthesis, separation and characterization of amphiphilic 2,10-di-sulfonato-18,26-di-phthalimidomethyl Phthalocyanine Zinc di-potassium salt by template reaction
    Dyes and Pigments, 2005
    Co-Authors: Yiru Peng, Jinling Huang, Zhipeng Lin, Naisheng Chen
    Abstract:

    Abstract An amphiphilic 2,10-di-sulfonato-18,26-di-phthalimidomethyl Phthalocyanine Zinc di-potassium salt ( 3 ) was synthesized by first direct condensation of hydrophilic precursor 4-sulfonic phthalic acid mono-potassium salt ( 1 ) with hydrophobic precursor 4-phthalimidomethyl phthalic acid ( 2 ). Then the condensed mixture was separated by reverse HPLC method and further purified by a membrane separation method. The composition of the title compound was characterized by elemental analysis, UV, 1 H NMR, 13 C NMR as well as TG and DTA, and its C 4 h -structure was identified according to the 1 H NMR signal of submethyl protons of the phthalimidomethyl groups in the Phthalocyanine ring, polarity and synthetic mechanism. In vivo antitumor activity of the title compound as photosensitizer showed that its inhibitory rate was up to 90.3%. This amphiphilic photosensitizer has a potential application in the photodynamic therapy of cancer.