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Rone Roubenoff - One of the best experts on this subject based on the ideXlab platform.
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skeletal muscle cutpoints associated with elevated Physical Disability risk in older men and women
American Journal of Epidemiology, 2004Co-Authors: Ian Janssen, Irwi H Rosenberg, Richard N Baumgartner, Robert Ross, Rone RoubenoffAbstract:The purpose of this study was to determine skeletal muscle cutpoints for identifying elevated Physical Disability risk in older adults. Subjects included 4,449 older (> or = 60 years) participants from the Third National Health and Nutrition Examination Survey during 1988-1994. Physical Disability was assessed by questionnaire, and bioimpedance was used to estimate skeletal muscle, which was normalized for height. Receiver operating characteristics were used to develop the skeletal muscle cutpoints associated with a high likelihood of Physical Disability. Odds for Physical Disability were compared in subjects whose measures fell above and below these cutpoints. Skeletal muscle cutpoints of 5.76-6.75 and < or =5.75 kg/m2 were selected to denote moderate and high Physical Disability risk in women. The corresponding values in men were 8.51-10.75 and < or =8.50 kg/m2. Compared with women with low-risk skeletal muscle values, women with moderate- and high-risk skeletal muscle values had odds for Physical Disability of 1.41 (95% confidence interval (CI): 0.97, 2.04) and 3.31 (95% CI: 1.91, 5.73), respectively. The corresponding odds in men were 3.65 (95% CI: 1.92, 6.94) and 4.71 (95% CI: 2.28, 9.74). This study presents skeletal muscle cutpoints for Physical Disability risk in older adults. Future applications of these cutpoints include the comparison of morbidity risk in older persons with normal muscle mass and those with sarcopenia, the determination and comparison of sarcopenia prevalences, and the estimation of health-care costs attributable to sarcopenia.
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skeletal muscle cutpoints associated with elevated Physical Disability risk in older men and women
American Journal of Epidemiology, 2004Co-Authors: Ia Jansse, Robe Ross, Richard N Aumgartne, Irwi H Rosenberg, Rone RoubenoffAbstract:The purpose of this study was to determine skeletal muscle cutpoints for identifying elevated Physical Disability risk in older adults. Subjects included 4,449 older (≥60 years) participants from the Third National Health and Nutrition Examination Survey during 1988–1994. Physical Disability was assessed by questionnaire, and bioimpedance was used to estimate skeletal muscle, which was normalized for height. Receiver operating characteristics were used to develop the skeletal muscle cutpoints associated with a high likelihood of Physical Disability. Odds for Physical Disability were compared in subjects whose measures fell above and below these cutpoints. Skeletal muscle cutpoints of 5.76–6.75 and ≤5.75 kg/m 2 were selected to denote moderate and high Physical Disability risk in women. The corresponding values in men were 8.51–10.75 and ≤8.50 kg/m 2 . Compared with women with low-risk skeletal muscle values, women with moderate- and high-risk skeletal muscle values had odds for Physical Disability of 1.41 (95% confidence interval (CI): 0.97, 2.04) and 3.31 (95% CI: 1.91, 5.73), respectively. The corresponding odds in men were 3.65 (95% CI: 1.92, 6.94) and 4.71 (95% CI: 2.28, 9.74). This study presents skeletal muscle cutpoints for Physical Disability risk in older adults. Future applications of these cutpoints include the comparison of morbidity risk in older persons with normal muscle mass and those with sarcopenia, the determination and comparison of sarcopenia prevalences, and the estimation of health-care costs attributable to sarcopenia. activities of daily living; aging; Disability evaluation; men; muscle, skeletal; risk; women
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body fat and skeletal muscle mass in relation to Physical Disability in very old men and women of the framingham heart study
Journals of Gerontology Series A-biological Sciences and Medical Sciences, 1998Co-Authors: Marjolei Visse, Jea A Langlois, Maria T Hanna, Rone Roubenoff, David T Felso, Pete W F Wilso, Tamara Harris, Douglas P KielAbstract:Background. Low muscle mass has been assumed to be associated with Disability, but no studies confirming this association have been published. High body weight and high body mass index, both rough indicators of body fatness, have been shown to increase the risk for Disability; however, the specific role of body fatness has not been studied. Methods. The relations of skeletal muscle mass and percent body fat with self-reported Physical Disability were studied in 753 men and women aged 72 to 95 years. Cross-sectional data from biennial examination 22 (1992-1993) of the Framingham Heart Study were used. Body composition was assessed by dual-energy x-ray absorptiometry. Disability was scored as any versus none on a 9-item questionnaire. Results. Total body and lower extremity muscle mass were not associated with Disability in either men or women. However, a strong positive association between percent body fat and Disability was observed. The odds ratio for Disability in those in the highest tertile of body fatness was 2.69 (95% confidence interval 1.45-5.00) for women and 3.08 (1.22-7.81) for men compared to those in the lowest tertile. The increased risk could not be explained by age, education, Physical activity, smoking, alcohol use, estrogen use (women only), muscle mass, and health status. Analyses restricting Disability to mobility items gave similar results. Conclusions. In contrast to current assumptions, low skeletal muscle mass was not associated with self-reported Physical Disability. Persons with a high percent body fat had high levels of Disability. Because it cannot be ruled out that persons with low skeletal muscle mass dropped out earlier in the study, prospective studies are needed to further assess the relationship between body composition and Physical Disability.
Ian Janssen - One of the best experts on this subject based on the ideXlab platform.
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influence of sarcopenia on the development of Physical Disability the cardiovascular health study
Journal of the American Geriatrics Society, 2006Co-Authors: Ian JanssenAbstract:OBJECTIVES: To examine the temporal relationship between sarcopenia and Disability in elderly men and women. DESIGN: Cardiovascular Health Study, a longitudinal study of cardiovascular disease and its risk factors in older people. SETTING: Four U.S. communities. PARTICIPANTS: Five thousand thirty-six men and women aged 65 and older. MEASUREMENTS: Whole-body skeletal muscle mass was measured at baseline, and subjects were classified as having normal muscle mass, moderate sarcopenia, or severe sarcopenia based on previously established thresholds. Disability was measured via questionnaire at baseline in up to eight annual follow-up examinations. The cross-sectional relationship between sarcopenia and prevalent Disability at baseline was examined using logistic regression models. The longitudinal relation between sarcopenia and incident Disability over 8 years of follow-up was examined using Cox proportional hazards models. RESULTS: At baseline, the likelihood of Disability was 79% greater in those with severe sarcopenia (P<.001) but was not significantly greater in those with moderate sarcopenia (P=.38) than in those with normal muscle mass. During the 8-year follow-up, the risk of developing Disability was 27% greater in those with severe sarcopenia (P=.006) but was not statistically greater in those with moderate sarcopenia (P=.23) than in those with normal muscle mass. CONCLUSION: Severe sarcopenia was a modest independent risk factor for the development of Physical Disability. The effect of sarcopenia on Disability was considerably smaller in the longitudinal analysis than in the cross-sectional analysis.
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skeletal muscle cutpoints associated with elevated Physical Disability risk in older men and women
American Journal of Epidemiology, 2004Co-Authors: Ian Janssen, Irwi H Rosenberg, Richard N Baumgartner, Robert Ross, Rone RoubenoffAbstract:The purpose of this study was to determine skeletal muscle cutpoints for identifying elevated Physical Disability risk in older adults. Subjects included 4,449 older (> or = 60 years) participants from the Third National Health and Nutrition Examination Survey during 1988-1994. Physical Disability was assessed by questionnaire, and bioimpedance was used to estimate skeletal muscle, which was normalized for height. Receiver operating characteristics were used to develop the skeletal muscle cutpoints associated with a high likelihood of Physical Disability. Odds for Physical Disability were compared in subjects whose measures fell above and below these cutpoints. Skeletal muscle cutpoints of 5.76-6.75 and < or =5.75 kg/m2 were selected to denote moderate and high Physical Disability risk in women. The corresponding values in men were 8.51-10.75 and < or =8.50 kg/m2. Compared with women with low-risk skeletal muscle values, women with moderate- and high-risk skeletal muscle values had odds for Physical Disability of 1.41 (95% confidence interval (CI): 0.97, 2.04) and 3.31 (95% CI: 1.91, 5.73), respectively. The corresponding odds in men were 3.65 (95% CI: 1.92, 6.94) and 4.71 (95% CI: 2.28, 9.74). This study presents skeletal muscle cutpoints for Physical Disability risk in older adults. Future applications of these cutpoints include the comparison of morbidity risk in older persons with normal muscle mass and those with sarcopenia, the determination and comparison of sarcopenia prevalences, and the estimation of health-care costs attributable to sarcopenia.
Irwi H Rosenberg - One of the best experts on this subject based on the ideXlab platform.
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skeletal muscle cutpoints associated with elevated Physical Disability risk in older men and women
American Journal of Epidemiology, 2004Co-Authors: Ia Jansse, Robe Ross, Richard N Aumgartne, Irwi H Rosenberg, Rone RoubenoffAbstract:The purpose of this study was to determine skeletal muscle cutpoints for identifying elevated Physical Disability risk in older adults. Subjects included 4,449 older (≥60 years) participants from the Third National Health and Nutrition Examination Survey during 1988–1994. Physical Disability was assessed by questionnaire, and bioimpedance was used to estimate skeletal muscle, which was normalized for height. Receiver operating characteristics were used to develop the skeletal muscle cutpoints associated with a high likelihood of Physical Disability. Odds for Physical Disability were compared in subjects whose measures fell above and below these cutpoints. Skeletal muscle cutpoints of 5.76–6.75 and ≤5.75 kg/m 2 were selected to denote moderate and high Physical Disability risk in women. The corresponding values in men were 8.51–10.75 and ≤8.50 kg/m 2 . Compared with women with low-risk skeletal muscle values, women with moderate- and high-risk skeletal muscle values had odds for Physical Disability of 1.41 (95% confidence interval (CI): 0.97, 2.04) and 3.31 (95% CI: 1.91, 5.73), respectively. The corresponding odds in men were 3.65 (95% CI: 1.92, 6.94) and 4.71 (95% CI: 2.28, 9.74). This study presents skeletal muscle cutpoints for Physical Disability risk in older adults. Future applications of these cutpoints include the comparison of morbidity risk in older persons with normal muscle mass and those with sarcopenia, the determination and comparison of sarcopenia prevalences, and the estimation of health-care costs attributable to sarcopenia. activities of daily living; aging; Disability evaluation; men; muscle, skeletal; risk; women
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skeletal muscle cutpoints associated with elevated Physical Disability risk in older men and women
American Journal of Epidemiology, 2004Co-Authors: Ian Janssen, Irwi H Rosenberg, Richard N Baumgartner, Robert Ross, Rone RoubenoffAbstract:The purpose of this study was to determine skeletal muscle cutpoints for identifying elevated Physical Disability risk in older adults. Subjects included 4,449 older (> or = 60 years) participants from the Third National Health and Nutrition Examination Survey during 1988-1994. Physical Disability was assessed by questionnaire, and bioimpedance was used to estimate skeletal muscle, which was normalized for height. Receiver operating characteristics were used to develop the skeletal muscle cutpoints associated with a high likelihood of Physical Disability. Odds for Physical Disability were compared in subjects whose measures fell above and below these cutpoints. Skeletal muscle cutpoints of 5.76-6.75 and < or =5.75 kg/m2 were selected to denote moderate and high Physical Disability risk in women. The corresponding values in men were 8.51-10.75 and < or =8.50 kg/m2. Compared with women with low-risk skeletal muscle values, women with moderate- and high-risk skeletal muscle values had odds for Physical Disability of 1.41 (95% confidence interval (CI): 0.97, 2.04) and 3.31 (95% CI: 1.91, 5.73), respectively. The corresponding odds in men were 3.65 (95% CI: 1.92, 6.94) and 4.71 (95% CI: 2.28, 9.74). This study presents skeletal muscle cutpoints for Physical Disability risk in older adults. Future applications of these cutpoints include the comparison of morbidity risk in older persons with normal muscle mass and those with sarcopenia, the determination and comparison of sarcopenia prevalences, and the estimation of health-care costs attributable to sarcopenia.
Noran Naqiah Hairi - One of the best experts on this subject based on the ideXlab platform.
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chronic pain impact of pain and pain severity with Physical Disability in older people is there a gender difference
Maturitas, 2013Co-Authors: Noran Naqiah Hairi, Robert G Cumming, Fiona M Blyth, Vasi NaganathanAbstract:Abstract Objective To establish if there is any gender difference in associations between chronic pain, impact of pain and pain severity with Physical Disability. Methods Data from the New South Wales Older People's Health Survey (OPHS), a population based survey of 8881 older people aged 65 years and above were used in the analysis. Chronic pain, pain with interference and pain severity and outcome variable of Physical Disability were all measured and determined by self report. Results Physical Disability were more frequent in respondents reporting chronic pain, pain that interferes with activities and pain that was of moderate and strong to severe severity. Chronic pain was significantly associated with Physical Disability among men with adjusted prevalence ratio (PR) 1.31 (95% CI 1.19, 1.43) and women with adjusted prevalence ratio (PR) 1.34 (95% CI 1.28, 1.42). The relationships between pain with interference and pain severity with Physical Disability were similar in older men and older women. However, adjustment for psychological distress and self-rated health led to greater reductions in prevalence ratios for older men than women for all associations. Conclusion There is no gender difference in associations between pain and Physical Disability among older people. However, psychological distress accounted for more pain-related Physical Disability in men than in women.
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loss of muscle strength mass sarcopenia and quality specific force and its relationship with functional limitation and Physical Disability the concord health and ageing in men project
Journal of the American Geriatrics Society, 2010Co-Authors: Noran Naqiah Hairi, Robert G Cumming, Vasi Naganathan, David J Handelsman, David Le G Couteur, Helen Creasey, Louise M Waite, Markus J Seibel, Philip N SambrookAbstract:OBJECTIVES: To determine the association between loss of muscle strength, mass, and quality and functional limitation and Physical Disability in older men. DESIGN: Cross-sectional study of older men participating in the Concord Health and Ageing in Men Project (CHAMP). SETTING: Elderly men living in a defined geographical region in Sydney, Australia. PARTICIPANTS: One thousand seven hundred five community-dwelling men aged 70 and older who participated in the baseline assessments of CHAMP. MEASUREMENTS: Upper and lower extremity strength were measured using dynamometers for grip and quadriceps strength. Appendicular skeletal lean mass was assessed using dual X-ray absorptiometry. Muscle quality was defined as the ratio of strength to mass in upper and lower extremities. For each parameter, subjects in the lowest 20% of the distribution were defined as below normal. Functional limitation was assessed according to self-report and objective lower extremity performance measures. Physical Disability was measured according to self-report questionnaire. RESULTS: After adjusting for important confounders, the prevalence ratio (PR) for poor quadriceps strength and self-reported functional limitation was 1.91 (95% confidence interval (CI) 51.10-2.40); for performance-based functional limitation the PR was 1.81 (95% CI = 1.45-2.24). The adjusted PR for poor grip strength and Physical Disability in instrumental activities of daily living (IADLs) was 1.37 (95% CI = 1.20-1.56). The adjusted PR for low skeletal lean mass (adjusted for fat mass) and Physical Disability in basic activities of daily living was 2.08 (95% CI = 1.37-3.15). For muscle quality, the PR for lower extremity specific force and functional limitation and Physical Disability was stronger than upper extremity specific force. CONCLUSION: Muscle strength is the single best measure of age-related muscle change and is associated with Physical Disability in IADLs and functional limitation. J Am Geriatr Soc 58:2055-2062, 2010.
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prevalence and correlates of Physical Disability and functional limitation among community dwelling older people in rural malaysia a middle income country
BMC Public Health, 2010Co-Authors: Noran Naqiah Hairi, Robert G Cumming, Vasi Naganathan, Awang Bulgiba, Izzuna MudlaAbstract:The prevalence and correlates of Physical Disability and functional limitation among older people have been studied in many developed countries but not in a middle income country such as Malaysia. The present study investigated the epidemiology of Physical Disability and functional limitation among older people in Malaysia and compares findings to other countries. A population-based cross sectional study was conducted in Alor Gajah, Malacca. Seven hundred and sixty five older people aged 60 years and above underwent tests of functional limitation (Tinetti Performance Oriented Mobility Assessment Tool). Data were also collected for self reported activities of daily living (ADL) using the Barthel Index (ten items). To compare prevalence with other studies, ADL Disability was also defined using six basic ADL's (eating, bathing, dressing, transferring, toileting and walking) and five basic ADL's (eating, bathing, dressing, transferring and toileting). Ten, six and five basic ADL Disability was reported by 24.7% (95% CI 21.6-27.9), 14.4% (95% CI 11.9-17.2) and 10.6% (95% CI 8.5-13.1), respectively. Functional limitation was found in 19.5% (95% CI 16.8-22.5) of participants. Variables independently associated with 10 item ADL Disability Physical Disability, were advanced age (≥ 75 years: prevalence ratio (PR) 7.9; 95% CI 4.8-12.9), presence of diabetes (PR 1.8; 95% CI 1.4-2.3), stroke (PR 1.5; 95% CI 1.1-2.2), depressive symptomology (PR 1.3; 95% CI 1.1-1.8) and visual impairment (blind: PR 2.0; 95% CI 1.1-3.6). Advancing age (≥ 75 years: PR 3.0; 95% CI 1.7-5.2) being female (PR 2.7; 95% CI 1.2-6.1), presence of arthritis (PR 1.6; 95% CI 1.2-2.1) and depressive symptomology (PR 2.0; 95% CI 1.5-2.7) were significantly associated with functional limitation. The prevalence of Physical Disability and functional limitation among older Malaysians appears to be much higher than in developed countries but is comparable to developing countries. Associations with socio-demographic and other health related variables were consistent with other studies.
Lauren R. Khazem - One of the best experts on this subject based on the ideXlab platform.
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Physical Disability and suicide: recent advancements in understanding and future directions for consideration.
Current opinion in psychology, 2017Co-Authors: Lauren R. KhazemAbstract:Recent research indicates a heightened risk of suicide in this population, a concern given that suicide may be more accepted for those with Physical disabilities than for those without such disabilities. The relationship between Physical Disability and suicide has begun to be examined within empirically supported frameworks of suicide and indicates that interpersonal factors (e.g. perceived burdensomeness) and pain are mechanisms contributing to this heightened risk of suicide. The suicide rate after acquiring a Physical Disability, such as a spinal cord injury, and the greater odds of suicide after reporting having a Disability further support the association between Physical Disability and suicide. The multifaceted nature of Physical Disability is reflected in its relationship with suicidal ideation and behaviors.
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Physical Disability and the Interpersonal Theory of Suicide
Death studies, 2015Co-Authors: Lauren R. Khazem, Danielle R. Jahn, Kelly C. Cukrowicz, Michael D. AnestisAbstract:Interpersonal Theory of Suicide constructs were examined in individuals with Physical disabilities, a population identified as having heightened suicidal ideation. Students (N = 184) answered online-based self-report questionnaires. Students with Physical disabilities (n = 49) were expected to endorse higher levels of constructs relative to other students (n = 133). Analyses of covariance indicated that those with disabilities reported higher perceived burdensomeness, but not thwarted belongingness, fearlessness about death, or suicidal ideation. Suicide prevention efforts, particularly in university settings, may benefit from focusing on reducing perceived burdensomeness in this population, as these individuals may be at heightened risk.
