The Experts below are selected from a list of 19863 Experts worldwide ranked by ideXlab platform
Gunter G C Kuhnle - One of the best experts on this subject based on the ideXlab platform.
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phytoestrogen consumption and association with breast prostate and colorectal cancer in epic norfolk
Archives of Biochemistry and Biophysics, 2010Co-Authors: Heather Ward, Gunter G C KuhnleAbstract:Phytoestrogens are polyphenolic secondary plant metabolites that have structural and functional similarities to 17β-oestradiol and have been associated with a protective effect against hormone-related cancers. Most foods in the UK only contain small amounts of Phytoestrogens (median content 21 μg/100 g) and the highest content is found in soya and soya-containing foods. The highest phytoestrogen content in commonly consumed foods is found in breads (average content 450 μg/100 g), the main source of isoflavones in the UK diet. The phytoestrogen consumption in cases and controls was considerably lower than in Asian countries. No significant associations between phytoestrogen intake and breast cancer risk in a nested case-control study in EPIC Norfolk were found. Conversely, colorectal cancer risk was inversely associated with enterolignan intake in women but not in men. Prostate cancer risk was positively associated with enterolignan intake, however this association became non-significant when adjusting for dairy intake, suggesting that enterolignans can act as a surrogate marker for dairy or calcium intake.
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phytoestrogen content of fruits and vegetables commonly consumed in the uk based on lc ms and 13c labelled standards
Food Chemistry, 2009Co-Authors: Gunter G C Kuhnle, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Caterina Dellaquila, Annemiek M C P Joosen, Sheila BinghamAbstract:Abstract Phytoestrogens are a group of non-steroidal secondary plant metabolites with structural and functional similarity to 17β-oestradiol. Urinary and plasma Phytoestrogens have been used as biomarkers for dietary intake, however, this is often not possible in large epidemiological studies or to assess general exposure in free-living individuals. Accurate information about dietary Phytoestrogens is therefore important but there is very limited data concerning food contents. In this study, we analysed the phytoestrogen (isoflavone, lignan and coumestrol) content in more than 240 different foods based on fresh and processed fruits and vegetables using a newly developed sensitive method based on LC–MS incorporating 13C3-labelled standards. Phytoestrogens were detected in all foods analysed with a median content of 20 μg/100 g wet weight (isoflavones: 2 μg/100 g; lignans 12 μg/100 g). Most foods contained less than 100 μg/100 g, however, 5% of foods analysed contained more than 400 μg/100 g, in particular soya-based foods and other legumes. The results published here will contribute to databases of dietary phytoestrogen content and allow the more accurate determination of phytoestrogen exposure in free-living individuals.
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Phytoestrogen content of cereals and cereal-based foods consumed in the UK.
Nutrition and Cancer, 2009Co-Authors: Gunter G C Kuhnle, Caterina Dell’aquila, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Sheila BinghamAbstract:Dietary Phytoestrogens may be involved in the occurrence of chronic diseases. Reliable information on the phytoestrogen content in foods is required to assess dietary exposure and disease risk in epidemiological studies. However, there is little information on isoflavone, lignan, and coumestrol content of cereals and cereal-based foods, leading to an underestimation of intake. This is the first study of Phytoestrogens (isoflavones: biochanin A, daidzein, formononetin, genistein, glycitein; lignans: matairesinol, secoisplariciresinol; coumestrol) in a comprehensive selection of 101 cereals and cereal-based foods—including breads, breakfast cereals, biscuits, pasta and rice—consumed in the UK using a sensitive LCMS technique with 13 C-labelled internal standards. Phytoestrogens were detected in all foods analyzed; bread contained the highest amount of Phytoestrogens—many as isoflavones—with an average content of 375 ± 67 μ g/100 g wet weight (excluding soya-linseed bread with 12,000 μ g/100 g). Most other f...
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Phytoestrogen Content of Cereals and Cereal-Based Foods Consumed in the UK
Nutrition and Cancer, 2009Co-Authors: Gunter G C Kuhnle, Caterina Dell’aquila, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Sheila BinghamAbstract:Dietary Phytoestrogens may be involved in the occurrence of chronic diseases. Reliable information on the phytoestrogen content in foods is required to assess dietary exposure and disease risk in epidemiological studies. However, there is little information on isoflavone, lignan, and coumestrol content of cereals and cereal-based foods, leading to an underestimation of intake. This is the first study of Phytoestrogens (isoflavones: biochanin A, daidzein, formononetin, genistein, glycitein; lignans: matairesinol, secoisplariciresinol; coumestrol) in a comprehensive selection of 101 cereals and cereal-based foods-including breads, breakfast cereals, biscuits, pasta and rice-consumed in the UK using a sensitive LCMS technique with 13C-labelled internal standards. Phytoestrogens were detected in all foods analyzed; bread contained the highest amount of Phytoestrogens-many as isoflavones-with an average content of 375 +/- 67 microg/100 g wet weight (excluding soya-linseed bread with 12,000 microg/100 g). Most other foods contained less than 100 microg/100 g, many as lignans. Our study shows that all foods analyzed contained Phytoestrogens, with the highest amount found in breads, making them one of the main sources of dietary Phytoestrogens in the UK. These results will allow a more accurate estimation of exposure to dietary Phytoestrogens.
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phytoestrogen content of foods of animal origin dairy products eggs meat fish and seafood
Journal of Agricultural and Food Chemistry, 2008Co-Authors: Gunter G C Kuhnle, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Caterina Dellaquila, Sheila BinghamAbstract:Dietary Phytoestrogens may be involved in the occurrence of chronic diseases. Reliable information on the phytoestrogen content in foods is required to assess dietary exposure and disease risk in epidemiological studies. However, existing analyses have focused on only one class of these compounds in plant-based foods, and there is only little information on foods of animal origin, leading to an underestimation of intake. This is the first comprehensive study of phytoestrogen content in animal food. We have determined the phytoestrogen content (isoflavones: biochanin A, daidzein, formononetin, genistein, and glycitein; lignans: secoisolariciresinol and matairesinol; coumestrol; equol; enterolactone; and enterodiol) in 115 foods of animal origin (including milk and milk-products, eggs, meat, fish, and seafood) and vegetarian substitutes using liquid chromatography−mass spectrometry (LC−MS) with 13C-labeled internal standards. Phytoestrogens were detected in all foods analyzed; the average content was 20 μg/...
Sheila Bingham - One of the best experts on this subject based on the ideXlab platform.
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phytoestrogen content of fruits and vegetables commonly consumed in the uk based on lc ms and 13c labelled standards
Food Chemistry, 2009Co-Authors: Gunter G C Kuhnle, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Caterina Dellaquila, Annemiek M C P Joosen, Sheila BinghamAbstract:Abstract Phytoestrogens are a group of non-steroidal secondary plant metabolites with structural and functional similarity to 17β-oestradiol. Urinary and plasma Phytoestrogens have been used as biomarkers for dietary intake, however, this is often not possible in large epidemiological studies or to assess general exposure in free-living individuals. Accurate information about dietary Phytoestrogens is therefore important but there is very limited data concerning food contents. In this study, we analysed the phytoestrogen (isoflavone, lignan and coumestrol) content in more than 240 different foods based on fresh and processed fruits and vegetables using a newly developed sensitive method based on LC–MS incorporating 13C3-labelled standards. Phytoestrogens were detected in all foods analysed with a median content of 20 μg/100 g wet weight (isoflavones: 2 μg/100 g; lignans 12 μg/100 g). Most foods contained less than 100 μg/100 g, however, 5% of foods analysed contained more than 400 μg/100 g, in particular soya-based foods and other legumes. The results published here will contribute to databases of dietary phytoestrogen content and allow the more accurate determination of phytoestrogen exposure in free-living individuals.
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Phytoestrogen content of cereals and cereal-based foods consumed in the UK.
Nutrition and Cancer, 2009Co-Authors: Gunter G C Kuhnle, Caterina Dell’aquila, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Sheila BinghamAbstract:Dietary Phytoestrogens may be involved in the occurrence of chronic diseases. Reliable information on the phytoestrogen content in foods is required to assess dietary exposure and disease risk in epidemiological studies. However, there is little information on isoflavone, lignan, and coumestrol content of cereals and cereal-based foods, leading to an underestimation of intake. This is the first study of Phytoestrogens (isoflavones: biochanin A, daidzein, formononetin, genistein, glycitein; lignans: matairesinol, secoisplariciresinol; coumestrol) in a comprehensive selection of 101 cereals and cereal-based foods—including breads, breakfast cereals, biscuits, pasta and rice—consumed in the UK using a sensitive LCMS technique with 13 C-labelled internal standards. Phytoestrogens were detected in all foods analyzed; bread contained the highest amount of Phytoestrogens—many as isoflavones—with an average content of 375 ± 67 μ g/100 g wet weight (excluding soya-linseed bread with 12,000 μ g/100 g). Most other f...
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Phytoestrogen Content of Cereals and Cereal-Based Foods Consumed in the UK
Nutrition and Cancer, 2009Co-Authors: Gunter G C Kuhnle, Caterina Dell’aquila, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Sheila BinghamAbstract:Dietary Phytoestrogens may be involved in the occurrence of chronic diseases. Reliable information on the phytoestrogen content in foods is required to assess dietary exposure and disease risk in epidemiological studies. However, there is little information on isoflavone, lignan, and coumestrol content of cereals and cereal-based foods, leading to an underestimation of intake. This is the first study of Phytoestrogens (isoflavones: biochanin A, daidzein, formononetin, genistein, glycitein; lignans: matairesinol, secoisplariciresinol; coumestrol) in a comprehensive selection of 101 cereals and cereal-based foods-including breads, breakfast cereals, biscuits, pasta and rice-consumed in the UK using a sensitive LCMS technique with 13C-labelled internal standards. Phytoestrogens were detected in all foods analyzed; bread contained the highest amount of Phytoestrogens-many as isoflavones-with an average content of 375 +/- 67 microg/100 g wet weight (excluding soya-linseed bread with 12,000 microg/100 g). Most other foods contained less than 100 microg/100 g, many as lignans. Our study shows that all foods analyzed contained Phytoestrogens, with the highest amount found in breads, making them one of the main sources of dietary Phytoestrogens in the UK. These results will allow a more accurate estimation of exposure to dietary Phytoestrogens.
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phytoestrogen content of foods of animal origin dairy products eggs meat fish and seafood
Journal of Agricultural and Food Chemistry, 2008Co-Authors: Gunter G C Kuhnle, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Caterina Dellaquila, Sheila BinghamAbstract:Dietary Phytoestrogens may be involved in the occurrence of chronic diseases. Reliable information on the phytoestrogen content in foods is required to assess dietary exposure and disease risk in epidemiological studies. However, existing analyses have focused on only one class of these compounds in plant-based foods, and there is only little information on foods of animal origin, leading to an underestimation of intake. This is the first comprehensive study of phytoestrogen content in animal food. We have determined the phytoestrogen content (isoflavones: biochanin A, daidzein, formononetin, genistein, and glycitein; lignans: secoisolariciresinol and matairesinol; coumestrol; equol; enterolactone; and enterodiol) in 115 foods of animal origin (including milk and milk-products, eggs, meat, fish, and seafood) and vegetarian substitutes using liquid chromatography−mass spectrometry (LC−MS) with 13C-labeled internal standards. Phytoestrogens were detected in all foods analyzed; the average content was 20 μg/...
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lack of prospective associations between plasma and urinary Phytoestrogens and risk of prostate or colorectal cancer in the european prospective into cancer norfolk study
Cancer Epidemiology Biomarkers & Prevention, 2008Co-Authors: Heather Ward, Gunter G C Kuhnle, Gaelle Chapelais, Robert Luben, Kaytee Khaw, Sheila BinghamAbstract:Dietary Phytoestrogens are suggested to reduce the risk of prostate and colorectal cancer, but the results of epidemiologic studies have not yielded consistent support for this proposed effect, possibly due to inadequate databases of phytoestrogen levels in foods. Biomarkers of phytoestrogen intakes may provide a clearer insight into the relationship between phytoestrogen exposure and the risk of prostate or colorectal cancer risks. From the European Prospective into Cancer-Norfolk cohort (ages 45-75), serum and urine samples were analyzed for seven Phytoestrogens [daidzein, enterodiol, enterolactone, genistein, glycitein, O-desmethylangolensin (O-DMA), and equol] among 193 cases of prostate cancer and 828 controls, and 221 cases of colorectal cancer with 889 controls. Summary variables of total lignans (enterodiol and enterolactone) and total isoflavones (daidzein, genistein, O-DMA, equol, and glycitein) were created and analyzed in conjunction with individual Phytoestrogens. Logistic regression analyses revealed that there was no significant association between prostate cancer risk and total serum isoflavones [odds ratio (OR), 1.01; 95% confidence interval (CI), 0.93-1.10] or total serum lignans (OR, 0.94; 95% CI, 0.86-1.04) or between colorectal cancer risk and total serum isoflavones (OR, 1.01; 95% CI, 0.94-1.08) or total serum lignans (OR, 1.03; 95% CI, 0.94-1.12). Similarly, null associations were observed for individual serum Phytoestrogens and for all urinary phytoestrogen biomarkers. In conclusion, we have found no evidence to support an inverse association between phytoestrogen exposure and prostate or colorectal cancer risk.
R Tumino - One of the best experts on this subject based on the ideXlab platform.
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Dietary intakes and food sources of Phytoestrogens in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24-hour dietary recall cohort
European Journal of Clinical Nutrition, 2012Co-Authors: R Zamora-ros, V Knaze, L Luján-barroso, G G C Kuhnle, A A Mulligan, M Touillaud, N Slimani, I Romieu, N Powell, R TuminoAbstract:BACKGROUND/OBJECTIVES: Phytoestrogens are estradiol-like natural compounds found in plants that have been associated with protective effects against chronic diseases, including some cancers, cardiovascular diseases and osteoporosis. The purpose of this study was to estimate the dietary intake of Phytoestrogens, identify their food sources and their association with lifestyle factors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. SUBJECTS/METHODS: Single 24-hour dietary recalls were collected from 36 037 individuals from 10 European countries, aged 35–74 years using a standardized computerized interview programe (EPIC-Soft). An ad hoc food composition database on Phytoestrogens (isoflavones, lignans, coumestans, enterolignans and equol) was compiled using data from available databases, in order to obtain and describe phytoestrogen intakes and their food sources across 27 redefined EPIC centres. RESULTS: Mean total phytoestrogen intake was the highest in the UK health-conscious group (24.9 mg/day in men and 21.1 mg/day in women) whereas lowest in Greece (1.3 mg/day) in men and Spain-Granada (1.0 mg/day) in women. Northern European countries had higher intakes than southern countries. The main phytoestrogen contributors were isoflavones in both UK centres and lignans in the other EPIC cohorts. Age, body mass index, educational level, smoking status and physical activity were related to increased intakes of lignans, enterolignans and equol, but not to total phytoestrogen, isoflavone or coumestan intakes. In the UK cohorts, the major food sources of Phytoestrogens were soy products. In the other EPIC cohorts the dietary sources were more distributed, among fruits, vegetables, soy products, cereal products, non-alcoholic and alcoholic beverages. CONCLUSIONS: There was a high variability in the dietary intake of total and phytoestrogen subclasses and their food sources across European regions.
R Zamora-ros - One of the best experts on this subject based on the ideXlab platform.
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Dietary intakes and food sources of Phytoestrogens in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24-hour dietary recall cohort
European Journal of Clinical Nutrition, 2012Co-Authors: R Zamora-ros, V Knaze, L Luján-barroso, G G C Kuhnle, A A Mulligan, M Touillaud, N Slimani, I Romieu, N Powell, R TuminoAbstract:BACKGROUND/OBJECTIVES: Phytoestrogens are estradiol-like natural compounds found in plants that have been associated with protective effects against chronic diseases, including some cancers, cardiovascular diseases and osteoporosis. The purpose of this study was to estimate the dietary intake of Phytoestrogens, identify their food sources and their association with lifestyle factors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. SUBJECTS/METHODS: Single 24-hour dietary recalls were collected from 36 037 individuals from 10 European countries, aged 35–74 years using a standardized computerized interview programe (EPIC-Soft). An ad hoc food composition database on Phytoestrogens (isoflavones, lignans, coumestans, enterolignans and equol) was compiled using data from available databases, in order to obtain and describe phytoestrogen intakes and their food sources across 27 redefined EPIC centres. RESULTS: Mean total phytoestrogen intake was the highest in the UK health-conscious group (24.9 mg/day in men and 21.1 mg/day in women) whereas lowest in Greece (1.3 mg/day) in men and Spain-Granada (1.0 mg/day) in women. Northern European countries had higher intakes than southern countries. The main phytoestrogen contributors were isoflavones in both UK centres and lignans in the other EPIC cohorts. Age, body mass index, educational level, smoking status and physical activity were related to increased intakes of lignans, enterolignans and equol, but not to total phytoestrogen, isoflavone or coumestan intakes. In the UK cohorts, the major food sources of Phytoestrogens were soy products. In the other EPIC cohorts the dietary sources were more distributed, among fruits, vegetables, soy products, cereal products, non-alcoholic and alcoholic beverages. CONCLUSIONS: There was a high variability in the dietary intake of total and phytoestrogen subclasses and their food sources across European regions.
Sue M. Aspinall - One of the best experts on this subject based on the ideXlab platform.
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phytoestrogen content of fruits and vegetables commonly consumed in the uk based on lc ms and 13c labelled standards
Food Chemistry, 2009Co-Authors: Gunter G C Kuhnle, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Caterina Dellaquila, Annemiek M C P Joosen, Sheila BinghamAbstract:Abstract Phytoestrogens are a group of non-steroidal secondary plant metabolites with structural and functional similarity to 17β-oestradiol. Urinary and plasma Phytoestrogens have been used as biomarkers for dietary intake, however, this is often not possible in large epidemiological studies or to assess general exposure in free-living individuals. Accurate information about dietary Phytoestrogens is therefore important but there is very limited data concerning food contents. In this study, we analysed the phytoestrogen (isoflavone, lignan and coumestrol) content in more than 240 different foods based on fresh and processed fruits and vegetables using a newly developed sensitive method based on LC–MS incorporating 13C3-labelled standards. Phytoestrogens were detected in all foods analysed with a median content of 20 μg/100 g wet weight (isoflavones: 2 μg/100 g; lignans 12 μg/100 g). Most foods contained less than 100 μg/100 g, however, 5% of foods analysed contained more than 400 μg/100 g, in particular soya-based foods and other legumes. The results published here will contribute to databases of dietary phytoestrogen content and allow the more accurate determination of phytoestrogen exposure in free-living individuals.
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Phytoestrogen content of cereals and cereal-based foods consumed in the UK.
Nutrition and Cancer, 2009Co-Authors: Gunter G C Kuhnle, Caterina Dell’aquila, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Sheila BinghamAbstract:Dietary Phytoestrogens may be involved in the occurrence of chronic diseases. Reliable information on the phytoestrogen content in foods is required to assess dietary exposure and disease risk in epidemiological studies. However, there is little information on isoflavone, lignan, and coumestrol content of cereals and cereal-based foods, leading to an underestimation of intake. This is the first study of Phytoestrogens (isoflavones: biochanin A, daidzein, formononetin, genistein, glycitein; lignans: matairesinol, secoisplariciresinol; coumestrol) in a comprehensive selection of 101 cereals and cereal-based foods—including breads, breakfast cereals, biscuits, pasta and rice—consumed in the UK using a sensitive LCMS technique with 13 C-labelled internal standards. Phytoestrogens were detected in all foods analyzed; bread contained the highest amount of Phytoestrogens—many as isoflavones—with an average content of 375 ± 67 μ g/100 g wet weight (excluding soya-linseed bread with 12,000 μ g/100 g). Most other f...
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Phytoestrogen Content of Cereals and Cereal-Based Foods Consumed in the UK
Nutrition and Cancer, 2009Co-Authors: Gunter G C Kuhnle, Caterina Dell’aquila, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Sheila BinghamAbstract:Dietary Phytoestrogens may be involved in the occurrence of chronic diseases. Reliable information on the phytoestrogen content in foods is required to assess dietary exposure and disease risk in epidemiological studies. However, there is little information on isoflavone, lignan, and coumestrol content of cereals and cereal-based foods, leading to an underestimation of intake. This is the first study of Phytoestrogens (isoflavones: biochanin A, daidzein, formononetin, genistein, glycitein; lignans: matairesinol, secoisplariciresinol; coumestrol) in a comprehensive selection of 101 cereals and cereal-based foods-including breads, breakfast cereals, biscuits, pasta and rice-consumed in the UK using a sensitive LCMS technique with 13C-labelled internal standards. Phytoestrogens were detected in all foods analyzed; bread contained the highest amount of Phytoestrogens-many as isoflavones-with an average content of 375 +/- 67 microg/100 g wet weight (excluding soya-linseed bread with 12,000 microg/100 g). Most other foods contained less than 100 microg/100 g, many as lignans. Our study shows that all foods analyzed contained Phytoestrogens, with the highest amount found in breads, making them one of the main sources of dietary Phytoestrogens in the UK. These results will allow a more accurate estimation of exposure to dietary Phytoestrogens.
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phytoestrogen content of foods of animal origin dairy products eggs meat fish and seafood
Journal of Agricultural and Food Chemistry, 2008Co-Authors: Gunter G C Kuhnle, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Caterina Dellaquila, Sheila BinghamAbstract:Dietary Phytoestrogens may be involved in the occurrence of chronic diseases. Reliable information on the phytoestrogen content in foods is required to assess dietary exposure and disease risk in epidemiological studies. However, existing analyses have focused on only one class of these compounds in plant-based foods, and there is only little information on foods of animal origin, leading to an underestimation of intake. This is the first comprehensive study of phytoestrogen content in animal food. We have determined the phytoestrogen content (isoflavones: biochanin A, daidzein, formononetin, genistein, and glycitein; lignans: secoisolariciresinol and matairesinol; coumestrol; equol; enterolactone; and enterodiol) in 115 foods of animal origin (including milk and milk-products, eggs, meat, fish, and seafood) and vegetarian substitutes using liquid chromatography−mass spectrometry (LC−MS) with 13C-labeled internal standards. Phytoestrogens were detected in all foods analyzed; the average content was 20 μg/...
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Phytoestrogen content of beverages, nuts, seeds, and oils.
Journal of agricultural and food chemistry, 2008Co-Authors: Gunter G C Kuhnle, Caterina Dell’aquila, Sue M. Aspinall, Shirley A Runswick, Angela A. Mulligan, Sheila BinghamAbstract:Phytoestrogens are secondary plant metabolites that have received increasing attention for their bioactivity, in particular due to their structural and functional similarity to 17β-estradiol. Although urinary and plasma Phytoestrogens can be used as biomarkers for dietary intake, this is often not possible in large epidemiological studies or in the assessment of general exposure in free-living individuals. Accurate information about dietary Phytoestrogens is therefore important, but there are very limited data concerning food contents. In this study was analyzed a comprehensive selection of tea, coffee, alcoholic beverages, nuts, seeds, and oils for their phytoestrogen content using a newly developed sensitive method based on LC-MS incorporating 13C3-labeled standards. Phytoestrogens were detected in all foods analyzed, although the contents in gin and bitter (beer) were below the limit of quantification (1.5 μg/100 g). Lignans were the main type of Phytoestrogens detected. Tea and coffee contained up to ...
