The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Roland Zell - One of the best experts on this subject based on the ideXlab platform.
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Picornaviridae—the ever-growing virus family
Archives of Virology, 2018Co-Authors: Roland ZellAbstract:Picornaviruses are small, nonenveloped, icosahedral RNA viruses with positive-strand polarity. Although the vast majority of picornavirus infections remain asymptomatic, many picornaviruses are important human and animal pathogens and cause diseases that affect the central nervous system, the respiratory and gastrointestinal tracts, heart, liver, pancreas, skin and eye. A stunning increase in the number of newly identified picornaviruses in the past decade has shown that picornaviruses are globally distributed and infect vertebrates of all classes. Moreover, picornaviruses exhibit a surprising diversity of both genome sequences and genome layouts, sometimes challenging the definition of taxonomic relevant criteria. At present, 35 genera comprising 80 species and more than 500 types are acknowledged. Fifteen species within five new and three existing genera have been proposed in 2017, but more than 50 picornaviruses still remain unassigned.
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Picornaviridae-the ever-growing virus family.
Archives of virology, 2017Co-Authors: Roland ZellAbstract:Picornaviruses are small, nonenveloped, icosahedral RNA viruses with positive-strand polarity. Although the vast majority of picornavirus infections remain asymptomatic, many picornaviruses are important human and animal pathogens and cause diseases that affect the central nervous system, the respiratory and gastrointestinal tracts, heart, liver, pancreas, skin and eye. A stunning increase in the number of newly identified picornaviruses in the past decade has shown that picornaviruses are globally distributed and infect vertebrates of all classes. Moreover, picornaviruses exhibit a surprising diversity of both genome sequences and genome layouts, sometimes challenging the definition of taxonomic relevant criteria. At present, 35 genera comprising 80 species and more than 500 types are acknowledged. Fifteen species within five new and three existing genera have been proposed in 2017, but more than 50 picornaviruses still remain unassigned.
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ICTV Virus Taxonomy Profile : Picornaviridae
The Journal of general virology, 2017Co-Authors: Roland Zell, Eric Delwart, Alexander E. Gorbalenya, Tapani Hovi, A. M. Q. King, Nick J. Knowles, A. M. Lindberg, Mark A. Pallansch, Ann C. Palmenberg, Gábor ReuterAbstract:The family Picornaviridae comprises small non-enveloped viruses with RNA genomes of 6.7 to 10.1 kb, and contains >30 genera and >75 species. Most of the known picornaviruses infect mammals and birds, but some have also been detected in reptiles, amphibians and fish. Many picornaviruses are important human and veterinary pathogens and may cause diseases of the central nervous system, heart, liver, skin, gastrointestinal tract or upper respiratory tract. Most picornaviruses are transmitted by the faecal-oral or respiratory routes. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Picornaviridae, which is available at www.ictv.global/report/Picornaviridae.
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Taxonomy of the Picornaviridae: Expanding the Family Beyond 12 Genera
2010Co-Authors: Nick J. Knowles, Timo Hyypiä, A. Michael Lindberg, Tapani Hovi, Mark A. Pallansch, Ann C. Palmenberg, Tim Skern, Glyn Stanway, Teruo Yamashita, Roland ZellAbstract:(1) Inst. for Anim. Hlth., Pirbright, UK; (2) Natl. Inst. for Health and Welfare (THL), Helsinki, Finland; (3) Univ. of Turku, Finland; (4) Linnaeus University, Kalmar, Sweden; (5) CDC, Atlanta, USA; (6) Inst. for Molecular Virology, Madison, WI, USA; (7) Max F. Perutz Labs., Medical Univ. of Vienna, Austria; (8) Univ. of Essex, UK; (9) Aichi Prefectural Inst. of Public Hlth., Aichi, Japan; (10) Inst. fur Virologie und Antivirale Therapie, Jena, Germany.
Gábor Reuter - One of the best experts on this subject based on the ideXlab platform.
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A humán parechovírusok klinikai jelentősége súlyos újszülött- és csecsemőkori fertőzésekben hazánkban
Orvosi hetilap, 2019Co-Authors: Akos Boros, Péter Pankovics, Zsófia Hamarics, Hajnalka Fenyvesi, Zoltán Liptai, Zoltán Nyul, Gábor ReuterAbstract:Absztrakt: Bevezetes: A human parechovirus (HPeV, Picornaviridae viruscsalad) okozta fertőzesek tobbsege tunetmentes, de gyermekeknel hasmenessel jarhatnak. Ujabb megfigyeles, hogy a HPeV-ok a csec...
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Dicipivirus (family Picornaviridae) in wild Northern white-breasted hedgehog (Erinaceus roumanicus)
Archives of Virology, 2018Co-Authors: Gábor Reuter, Akos Boros, Eric Delwart, Gábor Földvári, Sándor Szekeres, Róbert Mátics, Beatrix Kapusinszky, Péter PankovicsAbstract:Using random amplification and high-throughput sequencing technology a novel picornavirus with dicistronic genome organization and genetically related to canine picodicistrovirus (genus Dicipivirus , family Picornaviridae ) was identified and characterized in Northern white-breasted hedgehogs. Hedgehog dicipivirus (hedgehog/H14/2015/HUN, MF188967) was detected in 15 (75%) of 20 faecal specimens by RT-PCR with high viral loads (up to 8.2x10^8 genomic copies/ml faeces). Hedgehog dicipivirus RNA was also identified in blood, ear skin, abdominal muscle and liver tissues. While the general dicistronic genome organization of hedgehog/H14/2015/HUN is similar to canine picodicistrovirus (5’UTR-P1-IGR-P2/P3-3UTR) there are some unique genome characteristics within the untranslated regions, especially in the functional IRES elements. This study reports the putative second member of the genus Dicipivirus , in a novel host species.
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ICTV Virus Taxonomy Profile : Picornaviridae
The Journal of general virology, 2017Co-Authors: Roland Zell, Eric Delwart, Alexander E. Gorbalenya, Tapani Hovi, A. M. Q. King, Nick J. Knowles, A. M. Lindberg, Mark A. Pallansch, Ann C. Palmenberg, Gábor ReuterAbstract:The family Picornaviridae comprises small non-enveloped viruses with RNA genomes of 6.7 to 10.1 kb, and contains >30 genera and >75 species. Most of the known picornaviruses infect mammals and birds, but some have also been detected in reptiles, amphibians and fish. Many picornaviruses are important human and veterinary pathogens and may cause diseases of the central nervous system, heart, liver, skin, gastrointestinal tract or upper respiratory tract. Most picornaviruses are transmitted by the faecal-oral or respiratory routes. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Picornaviridae, which is available at www.ictv.global/report/Picornaviridae.
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a highly divergent picornavirus in an amphibian the smooth newt lissotriton vulgaris
Journal of General Virology, 2015Co-Authors: Akos Boros, Gábor Reuter, Tung Gia Phan, Eric Delwart, Zoltán Tóth, Péter PankovicsAbstract:Genetically highly divergent picornavirus (Newt/2013/HUN, KP770140) was detected using viral metagenomics in faecal samples of free-living smooth newts (Lissotriton vulgaris). Newt picornavirus was identified by reverse transcription-polymerase chain reaction (RT-PCR) in six (25 %) of the 24 samples originating from individuals caught in two out of the six investigated natural ponds in Hungary. The first picornavirus in amphibians expands the host range of members of the Picornaviridae, and opens a new research field in picornavirus evolution in lower vertebrates. Newt picornavirus represents a novel species in a novel genus within the family Picornaviridae, provisionally named genus Ampivirus (amphibian picornavirus).
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A tortoise-infecting picornavirus expands the host range of the family Picornaviridae
Archives of Virology, 2015Co-Authors: James F. X. Wellehan, Gábor Reuter, Nick J. Knowles, James K. Coleman, Nikola O. Kondov, Xutao Deng, Thomas B. Waltzek, Eric DelwartAbstract:While picornaviruses can cause diseases in many mammals, little is known of their host range for replication in non-mammalian vertebrates. Here, a picornavirus in liver and kidney tissues from diseased Sulawesi tortoises ( Indotestudo forsteni ) was genetically characterized. Tortoise rafivirus A (ToRaV-A, KJ415177) represents a potential new genus in the family Picornaviridae , for which we propose the name “ Rafivirus ”. Our finding confirms the susceptibility of reptiles to picornaviruses.
A. Michael Lindberg - One of the best experts on this subject based on the ideXlab platform.
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Structure of Aichi Virus 1 and Its Empty Particle: Clues to Kobuvirus Genome Release Mechanism.
Journal of virology, 2016Co-Authors: Charles David Sabin, A. Michael Lindberg, Tibor Füzik, Karel Škubník, Lenka Pálková, Pavel PlevkaAbstract:Aichi virus 1 (AiV-1) is a human pathogen from the Kobuvirus genus of the Picornaviridae family. Worldwide, 80 to 95% of adults have antibodies against the virus. AiV-1 infections are associated wi ...
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Taxonomy of the Picornaviridae: Expanding the Family Beyond 12 Genera
2010Co-Authors: Nick J. Knowles, Timo Hyypiä, A. Michael Lindberg, Tapani Hovi, Mark A. Pallansch, Ann C. Palmenberg, Tim Skern, Glyn Stanway, Teruo Yamashita, Roland ZellAbstract:(1) Inst. for Anim. Hlth., Pirbright, UK; (2) Natl. Inst. for Health and Welfare (THL), Helsinki, Finland; (3) Univ. of Turku, Finland; (4) Linnaeus University, Kalmar, Sweden; (5) CDC, Atlanta, USA; (6) Inst. for Molecular Virology, Madison, WI, USA; (7) Max F. Perutz Labs., Medical Univ. of Vienna, Austria; (8) Univ. of Essex, UK; (9) Aichi Prefectural Inst. of Public Hlth., Aichi, Japan; (10) Inst. fur Virologie und Antivirale Therapie, Jena, Germany.
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Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype.
Journal of General Virology, 2003Co-Authors: E. Susanne Johansson, Bo Niklasson, Robert B. Tesh, Darren R. Shafren, Amelia P. A. Travassos Da Rosa, A. Michael LindbergAbstract:Ljungan virus (LV) is a suspected human pathogen recently isolated from bank voles in Sweden. This study describes the genetic characterization of a virus, M1146, which was isolated in 1962 from another vole species (Microtus montanus), trapped in Oregon, USA. Based on antigenic properties, M1146 was postulated previously as a putative member of the family Picornaviridae. The near complete genomic sequence verifies that M1146 is a member of the Picornaviridae, most closely related to LVs isolated in Sweden. The strain M1146 possesses typical LV genomic organization, including a cluster of two 2A homologues. There are significant differences throughout the capsid protein region, while the non-structural region of M1146 is closely related to the Swedish LV genomes. Genetic and phylogenetic analyses show that M1146 represents a new genotype within the distinct LV cluster. Isolation of LV from both Swedish and American voles trapped over a period of 30 years suggests a continuous worldwide presence.
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Molecular Analysis of Three Ljungan Virus Isolates Reveals a New, Close-to-Root Lineage of the Picornaviridae with a Cluster of Two Unrelated 2A Proteins
Journal of virology, 2002Co-Authors: Susanne Johansson, Bo Niklasson, Alexander E. Gorbalenya, Jacob Maizel, A. Michael LindbergAbstract:Molecular analysis of three Ljungan virus isolates reveals a new, close-to-root lineage of the Picornaviridae with a cluster of two unrelated 2A proteins
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Phylogenetic analysis of Ljungan virus and A-2 plaque virus, new members of the Picornaviridae.
Virus research, 2002Co-Authors: A. Michael Lindberg, Susanne JohanssonAbstract:In addition to the viruses belonging to the nine proposed genera of the Picornaviridae, Enterovirus, Rhinovirus, Cardiovirus, Aphtovirus, Hepatovirus, Parechovirus, Kobuvirus, Erbovirus and Teschovirus, two new members of this family have recently been discovered. Three strains of Ljungan virus (LV) were isolated from bank voles (Clethrionomys glareolus) and A-2 plaque virus (A-2) was isolated from human sera. To study the genetic relationship between these recently discovered viruses and the members of the family Picornaviridae, an evolutionary analysis has been carried out using the amino acid sequences of the two nonstructural proteins 2C and 3D. Phylogenetic analysis using prime members of the nine genera support the division of picornaviruses into the proposed genera. The study also supports a previous suggestion based on analysis of partial sequences of the structural proteins that LV is more related to the genus of Parechovirus than to other picornaviruses, but also shows that the three LV strains used in the comparison constitute a distinct monophyletic group, clearly separated from the parechoviruses. The analyses using the 2C and 3D sequences clearly showed that A-2 was related to the genera of Rhinovirus and Enterovirus, but it was not possible to group the A-2 with high confidence into one of the genera. Comparison using the VP1 protein sequences of Enterovirus and Rhinovirus showed that although the A-2 virus is positioned between the two genera, the virus is more related to the genus of Enterovirus than to Rhinovirus. Our analysis of the three LV strains based on the phylogenetic analysis of the 2C and 3D proteins suggests that the strains used in this study constitute a monophyletic group clearly related to Parechovirus of Picornaviridae. The taxonomic position of the A-2 virus is presently uncertain but available data indicate that this virus may be classified as a member of the genus of Enterovirus.
Mark A. Pallansch - One of the best experts on this subject based on the ideXlab platform.
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ICTV Virus Taxonomy Profile : Picornaviridae
The Journal of general virology, 2017Co-Authors: Roland Zell, Eric Delwart, Alexander E. Gorbalenya, Tapani Hovi, A. M. Q. King, Nick J. Knowles, A. M. Lindberg, Mark A. Pallansch, Ann C. Palmenberg, Gábor ReuterAbstract:The family Picornaviridae comprises small non-enveloped viruses with RNA genomes of 6.7 to 10.1 kb, and contains >30 genera and >75 species. Most of the known picornaviruses infect mammals and birds, but some have also been detected in reptiles, amphibians and fish. Many picornaviruses are important human and veterinary pathogens and may cause diseases of the central nervous system, heart, liver, skin, gastrointestinal tract or upper respiratory tract. Most picornaviruses are transmitted by the faecal-oral or respiratory routes. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Picornaviridae, which is available at www.ictv.global/report/Picornaviridae.
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Taxonomy of the Picornaviridae: Expanding the Family Beyond 12 Genera
2010Co-Authors: Nick J. Knowles, Timo Hyypiä, A. Michael Lindberg, Tapani Hovi, Mark A. Pallansch, Ann C. Palmenberg, Tim Skern, Glyn Stanway, Teruo Yamashita, Roland ZellAbstract:(1) Inst. for Anim. Hlth., Pirbright, UK; (2) Natl. Inst. for Health and Welfare (THL), Helsinki, Finland; (3) Univ. of Turku, Finland; (4) Linnaeus University, Kalmar, Sweden; (5) CDC, Atlanta, USA; (6) Inst. for Molecular Virology, Madison, WI, USA; (7) Max F. Perutz Labs., Medical Univ. of Vienna, Austria; (8) Univ. of Essex, UK; (9) Aichi Prefectural Inst. of Public Hlth., Aichi, Japan; (10) Inst. fur Virologie und Antivirale Therapie, Jena, Germany.
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Genomic evidence that simian virus 2 and six other simian picornaviruses represent a new genus in Picornaviridae
Virology, 2003Co-Authors: M. Steven Oberste, Kaija Maher, Mark A. PallanschAbstract:Analysis of the VP1 capsid protein coding region of simian virus (SV) 2, SV16, SV18, SV42, SV44, SV45, and SV49 demonstrates that they are clearly distinct from members of the Enterovirus genus and from members of other existing picornavirus genera. To further characterize this group of viruses and to clarify their classification within the Picornaviridae, we have determined the complete genomic sequence of SV2 (8126 nucleotides). The genome was typical of members of Picornaviridae, encoding a single open reading frame. The putative polyprotein contained typical picornavirus protease cleavage sites, yielding mature proteins homologous to each of the known picornavirus proteins. SV2 contained an amino-terminal extension of the reading frame, which was analogous to the leader protein of members of the Aphthovirus, Cardiovirus, Erbovirus, Kobuvirus, and Teschovirus genera, but there was no significant amino acid homology with any of these known leader proteins. The 2A protein also aligned poorly with the 2A proteins of other picornaviruses. The deduced amino acid sequences of the SV2 structural and nonstructural proteins were related to but phylogenetically distinct from those of enteroviruses and human rhinoviruses. The major distinguishing features of SV2 were the presence of a type 2 internal ribosome entry site in the 5'-NTR, a putative leader protein encoded upstream of the structural proteins, and an unusually large 2A protein. On the basis of the molecular analysis, we propose that SV2, SV16, SV18, SV42, SV44, SV45, SV49, and porcine enterovirus 8 be classified as members of a new genus in Picornaviridae and that SV2 (strain 2383) be designated as the type strain.
Shoko Okitsu - One of the best experts on this subject based on the ideXlab platform.
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Cosavirus (family Picornaviridae) in pigs in Thailand and Japan.
Archives of virology, 2015Co-Authors: Shoko Okitsu, Pattara Khamrin, Nozomu Hanaoka, Aksara Thongprachum, Sayaka Takanashi, Tsuguto Fujimoto, Masashi Mizuguchi, Hiroyuki Shimizu, Satoshi Hayakawa, Niwat ManeekarnAbstract:Cosavirus is a recently established genus in the family Picornaviridae. The present study investigated the prevalence and genetic diversity of cosaviruses in stool samples collected from piglets and pigs with and without diarrhea in Thailand and Japan. It was observed that the cosavirus-positive rate in Thailand was higher than in Japan (55.4 % vs. 18.9 %). Phylogenetic analysis of a portion of the 5’ untranslated region showed that porcine cosavirus strains clustered together in the same branch with members of the species Cosavirus A. These strains showed 97.0 to 100 % nucleotide sequence identity to each other. The virus concentration of cosavirus was very low compared with that detected in a infant with diarrhea. These results demonstrated that cosaviruses were circulating in the swine populations of both countries during the study term; however, it remains unclear whether the virus causes diarrhea in piglets and pigs.
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Isolation and Molecular Characterization of Aichi Viruses from Fecal Specimens Collected in Japan, Bangladesh, Thailand, and Vietnam
Journal of clinical microbiology, 2007Co-Authors: Ngan Thi Kim Pham, Tung Gia Phan, Pattara Khamrin, Tuan Anh Nguyen, Dey Shuvra Kanti, Shoko Okitsu, Hiroshi UshijimaAbstract:Aichi virus is a new member of the family Picornaviridae, genus Kobuvirus, and is associated with human gastroenteritis. This study detected Aichi virus in 28 of 912 fecal specimens which were negative for rotavirus, adenovirus, norovirus, sapovirus, and astrovirus and were collected in Japan, Bangladesh, Thailand, and Vietnam during 2002 to 2005.
