The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform
Yu Xue - One of the best experts on this subject based on the ideXlab platform.
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Using RD、Hep-2、L20B cell for Poliomyelitis Virus isolation and identification
Journal of Xinjiang Medical University, 2003Co-Authors: Yu XueAbstract:Objective: A study to increase Poliomyelitis Virus (PV) isolation rate, the RD\, Hep 2 and L20B cell were used for identification. Methods: By cell cultivation. Results: The sensitivity and specificity of L20B cell was stronger. Since some non polio enteroViruses (NPEV) can only be isolated with Hep 2 cell line, NPEV isolation rate may be decrease do Conclusion: We suggest that RD\, Hep 2 and L20B cell can be used as routine procedure for PV isdation.
Hana M. El Sahly - One of the best experts on this subject based on the ideXlab platform.
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Oral Poliomyelitis Virus Type 2 Vaccines for the Posteradication Era
NEJM Journal Watch, 2021Co-Authors: Hana M. El SahlyAbstract:Poliomyelitis Virus type 2 was declared eradicated in 2015, but the number of vaccine-derived Poliomyelitis cases has risen since then. The novel oral
Am Hilda Kurtz - One of the best experts on this subject based on the ideXlab platform.
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OBSERVATIONS CONCERNING A PERSISTING INFECTION OF HELA CELLS WITH Poliomyelitis Virus*
2013Co-Authors: B Wilbur W. Ackermann, Am Hilda KurtzAbstract:In nature degrees of interaction between cells and Viruses must occur and, depending upon the integration achieved, a variety of reactions result, which are the usual phenomena associated with Virus infections (1). This is most apparent from considerations of comparative virology. Compare for example, the various combinations of influenza Virus with the cells of the chorionic membrane (2), the allantois (3), with the muscle fibroblasts of the chick (4), of the monkey kidney (5), HeLa ceils (6), and mouse brain (7). This range of host ceils can support viral multiplication with or without marked cytopathogenic effect, induce infection and cytopathology without viral increase, or establish infection and multiplication without viral release. Recent findings suggest further that a single complex host-Virus system could exhibit its multiple associated phenomena autonomously. Under certain metabolic influences, it is possible to observe the infection of HeLa cells by Poliomyelitis Virus with an accompanying cytopathogenic effect but without viral multiplication (8). This implies that a single host and Virus are capable of varying degrees of integration
B E Raupov - One of the best experts on this subject based on the ideXlab platform.
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an outbreak of Poliomyelitis in tajikistan in 1991 caused by the Poliomyelitis Virus type 1 in concomitant echoVirus 19 infection
Voprosy virusologii, 1993Co-Authors: G A Koroleva, V A Lashkevich, I N Martynenko, S I Nazarenko, B E RaupovAbstract:In 1991 in Tajikistan 36 cases of acute Poliomyelitis were recorded (spinal form 27, bulbospinal 3, pontospinal 6 cases) in children ranging in ages from 6 months to 6 years. The outcome of the disease was fatal in 4 cases and with crude residual effects in 32 children. Out of 23 children examined, Poliomyelitis Virus type I was isolated from 13, antibodies to polioVirus type I in titres 1:16 to 1:1024 were detected in 21 children, ECHO 19 Virus was isolated from 5 children and antibodies to this Virus in titres 1:16 to 1:8192 were demonstrated in 13 children. The fresh isolates of Poliomyelitis Virus type I had rct+, DS+ and N+ markers. The strains of ECHO 19 Virus were highly pathogenic for monkeys causing deaths of the animals within 3-4 days. It is assumed that the main causative agent of the Tajikistan outbreak of Poliomyelitis was a virulent "wild" variant of polioVirus type I. The preceding or concomitant infection with ECHO 19 Virus (considering the data from the literature and the demonstrated high virulence of this agent for monkeys) could exert an aggravating effect on the course of Poliomyelitis or, in some cases, be an independent cause of the disease and, possibly, death of the children.
V A Lashkevich - One of the best experts on this subject based on the ideXlab platform.
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100 years of studying Poliomyelitis Virus and nonPoliomyelitis enteroViruses
Voprosy virusologii, 2008Co-Authors: V A LashkevichAbstract:M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitis, Russian Academy of Medical Sciences, Moscow The paper deals with the history of discovery of Poliomyelitis Virus by K. Landsteiner and E. Popper in 1908, the identification of three immunological types of the Virus in 1949, the discovery of viral multiplication in the cultures of non-nerve cells with a cytopathogenic effect by A. Anders in 1949, the development of new diagnostic techniques, the design of inactivated polioVirus vaccine by D. Salk in 1953 and its live vaccine by A. Sabin in 1957. The advantages and disadvantages of these vaccines and the prospects for further Poliomyelitis control are discussed. The characteristics and role of nonPoliomyelitis enteroViruses are considered. The most important scientific discoveries made in the study of enteroViruses are noted.
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an outbreak of Poliomyelitis in tajikistan in 1991 caused by the Poliomyelitis Virus type 1 in concomitant echoVirus 19 infection
Voprosy virusologii, 1993Co-Authors: G A Koroleva, V A Lashkevich, I N Martynenko, S I Nazarenko, B E RaupovAbstract:In 1991 in Tajikistan 36 cases of acute Poliomyelitis were recorded (spinal form 27, bulbospinal 3, pontospinal 6 cases) in children ranging in ages from 6 months to 6 years. The outcome of the disease was fatal in 4 cases and with crude residual effects in 32 children. Out of 23 children examined, Poliomyelitis Virus type I was isolated from 13, antibodies to polioVirus type I in titres 1:16 to 1:1024 were detected in 21 children, ECHO 19 Virus was isolated from 5 children and antibodies to this Virus in titres 1:16 to 1:8192 were demonstrated in 13 children. The fresh isolates of Poliomyelitis Virus type I had rct+, DS+ and N+ markers. The strains of ECHO 19 Virus were highly pathogenic for monkeys causing deaths of the animals within 3-4 days. It is assumed that the main causative agent of the Tajikistan outbreak of Poliomyelitis was a virulent "wild" variant of polioVirus type I. The preceding or concomitant infection with ECHO 19 Virus (considering the data from the literature and the demonstrated high virulence of this agent for monkeys) could exert an aggravating effect on the course of Poliomyelitis or, in some cases, be an independent cause of the disease and, possibly, death of the children.