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Connie M Weaver - One of the best experts on this subject based on the ideXlab platform.
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short term rct of increased dietary Potassium from potato or Potassium Gluconate effect on blood pressure microcirculation and Potassium and sodium retention in pre hypertensive to hypertensive adults
Nutrients, 2021Co-Authors: Michael S Stone, Berdine R Martin, Connie M WeaverAbstract:Increased Potassium intake has been linked to improvements in cardiovascular and other health outcomes. We assessed increasing Potassium intake through food or supplements as part of a controlled diet on blood pressure (BP), microcirculation (endothelial function), and Potassium and sodium retention in thirty pre-hypertensive-to-hypertensive men and women. Participants were randomly assigned to a sequence of four 17 day dietary Potassium treatments: a basal diet (control) of 60 mmol/d and three phases of 85 mmol/d added as potatoes, French fries, or a Potassium Gluconate supplement. Blood pressure was measured by manual auscultation, cutaneous microvascular and endothelial function by thermal hyperemia, utilizing laser Doppler flowmetry, and mineral retention by metabolic balance. There were no significant differences among treatments for end-of-treatment BP, change in BP over time, or endothelial function using a mixed-model ANOVA. However, there was a greater change in systolic blood pressure (SBP) over time by feeding baked/boiled potatoes compared with control (−6.0 mmHg vs. −2.6 mmHg; p = 0.011) using contrast analysis. Potassium retention was highest with supplements. Individuals with a higher cardiometabolic risk may benefit by increasing Potassium intake. This trial was registered at ClinicalTrials.gov as NCT02697708.
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abstract p091 short term increased dietary Potassium from potato and Potassium Gluconate has no effect on blood pressure and microcirculation in pre hypertensive to hypertensive adults
Circulation, 2019Co-Authors: Michael S Stone, Berdine R Martin, George P Mccabe, Linda D Mccabe, Connie M WeaverAbstract:Potassium is an essential nutrient of concern according to recent Dietary Guidelines for Americans Advisory Committees, with less than 3% of the population meeting the current adequate intake (AI) ...
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bioavailability of Potassium from potatoes and Potassium Gluconate a randomized dose response trial
The American Journal of Clinical Nutrition, 2016Co-Authors: Claire J Macdonaldclarke, Berdine R Martin, George P Mccabe, Linda D Mccabe, Pamela J. Lachcik, Meryl E Wastney, Connie M WeaverAbstract:BACKGROUND: The bioavailability of Potassium should be considered in setting requirements, but to our knowledge, the bioavailability from individual foods has not been determined. Potatoes provide 19-20% of Potassium in the American diet. OBJECTIVE: We compared the bioavailability and dose response of Potassium from nonfried white potatoes with skin [targeted at 20, 40, and 60 milliequivalents (mEq) K] and French fries (40 mEq K) with Potassium Gluconate at the same doses when added to a basal diet that contained ∼60 mEq K. DESIGN: Thirty-five healthy, normotensive men and women with a mean ± SD age of 29.7 ± 11.2 y and body mass index (in kg/m(2)) of 24.3 ± 4.4 were enrolled in a single-blind, crossover, randomized controlled trial. Participants were partially randomly assigned to the order of testing for nine 5-d interventions of additional Potassium as follows: 0 (control; repeated at phases 1 and 5), 20, 40, and 60 mEq K/d consumed as a Potassium Gluconate supplement or as unfried potato or 40 mEq K from French fries completed at phase 9. The bioavailability of Potassium was determined from the area under the curve (AUC) of serial blood draws and cumulative urinary excretion during a 24-h period and from a kinetic analysis. The effects of the Potassium source and dose on the change in blood pressure and augmentation index (AIx) were determined. RESULTS: The serum Potassium AUC increased with the dose (P 94% ± 12%). There were no significant differences in the change in blood pressure or AIx with the treatment source or dose. CONCLUSIONS: The bioavailability of Potassium is as high from potatoes as from Potassium Gluconate supplements. Future studies that measure the effect of dietary Potassium on blood pressure will need to evaluate the effect of various dietary sources on Potassium retention and in both normal and hypertensive populations. This trial was registered at clinicaltrials.gov as NCT01881295.
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Bioavailability of Potassium from Potato and Potassium Gluconate
The FASEB Journal, 2015Co-Authors: Claire Macdonald Clarke, Berdine R Martin, George P Mccabe, Linda D Mccabe, Pamela J. Lachcik, Connie M WeaverAbstract:Potassium is a shortfall nutrient according to the 2010 Dietary Guidelines for Americans. Only 3% of Americans meet the recommended Adequate Intake of 4700 mg/d for Potassium. Bioavailability of Potassium has not been considered in setting requirements as no food has been tested. Among adult potato consumers potatoes provide 19-20% of Potassium in the diet. The aim of this study was to compare bioavailability and dose response of Potassium from non-fried white potatoes with skin with Potassium Gluconate. Thirty five healthy, normotensive men and women with a mean age of 29.7 (+/- 11.2) years and BMI of 24.3 (+/- 4.4) kg/m2 (mean +/- (SD)) were enrolled in this single-blind, cross-over, randomized controlled trial. Participants were randomized to 1 of 8 interventions of Potassium: 0 (control repeated twice), 720 (~18.5), 1440 (~37), 2160 (~55.5) mg/day (mEq/day) consumed as a Potassium Gluconate supplement or white potato with skin added to the basal diet containing ~2300 mg/day (~60 mEq/day) Potassium. Bi...
Berdine R Martin - One of the best experts on this subject based on the ideXlab platform.
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short term rct of increased dietary Potassium from potato or Potassium Gluconate effect on blood pressure microcirculation and Potassium and sodium retention in pre hypertensive to hypertensive adults
Nutrients, 2021Co-Authors: Michael S Stone, Berdine R Martin, Connie M WeaverAbstract:Increased Potassium intake has been linked to improvements in cardiovascular and other health outcomes. We assessed increasing Potassium intake through food or supplements as part of a controlled diet on blood pressure (BP), microcirculation (endothelial function), and Potassium and sodium retention in thirty pre-hypertensive-to-hypertensive men and women. Participants were randomly assigned to a sequence of four 17 day dietary Potassium treatments: a basal diet (control) of 60 mmol/d and three phases of 85 mmol/d added as potatoes, French fries, or a Potassium Gluconate supplement. Blood pressure was measured by manual auscultation, cutaneous microvascular and endothelial function by thermal hyperemia, utilizing laser Doppler flowmetry, and mineral retention by metabolic balance. There were no significant differences among treatments for end-of-treatment BP, change in BP over time, or endothelial function using a mixed-model ANOVA. However, there was a greater change in systolic blood pressure (SBP) over time by feeding baked/boiled potatoes compared with control (−6.0 mmHg vs. −2.6 mmHg; p = 0.011) using contrast analysis. Potassium retention was highest with supplements. Individuals with a higher cardiometabolic risk may benefit by increasing Potassium intake. This trial was registered at ClinicalTrials.gov as NCT02697708.
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abstract p091 short term increased dietary Potassium from potato and Potassium Gluconate has no effect on blood pressure and microcirculation in pre hypertensive to hypertensive adults
Circulation, 2019Co-Authors: Michael S Stone, Berdine R Martin, George P Mccabe, Linda D Mccabe, Connie M WeaverAbstract:Potassium is an essential nutrient of concern according to recent Dietary Guidelines for Americans Advisory Committees, with less than 3% of the population meeting the current adequate intake (AI) ...
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bioavailability of Potassium from potatoes and Potassium Gluconate a randomized dose response trial
The American Journal of Clinical Nutrition, 2016Co-Authors: Claire J Macdonaldclarke, Berdine R Martin, George P Mccabe, Linda D Mccabe, Pamela J. Lachcik, Meryl E Wastney, Connie M WeaverAbstract:BACKGROUND: The bioavailability of Potassium should be considered in setting requirements, but to our knowledge, the bioavailability from individual foods has not been determined. Potatoes provide 19-20% of Potassium in the American diet. OBJECTIVE: We compared the bioavailability and dose response of Potassium from nonfried white potatoes with skin [targeted at 20, 40, and 60 milliequivalents (mEq) K] and French fries (40 mEq K) with Potassium Gluconate at the same doses when added to a basal diet that contained ∼60 mEq K. DESIGN: Thirty-five healthy, normotensive men and women with a mean ± SD age of 29.7 ± 11.2 y and body mass index (in kg/m(2)) of 24.3 ± 4.4 were enrolled in a single-blind, crossover, randomized controlled trial. Participants were partially randomly assigned to the order of testing for nine 5-d interventions of additional Potassium as follows: 0 (control; repeated at phases 1 and 5), 20, 40, and 60 mEq K/d consumed as a Potassium Gluconate supplement or as unfried potato or 40 mEq K from French fries completed at phase 9. The bioavailability of Potassium was determined from the area under the curve (AUC) of serial blood draws and cumulative urinary excretion during a 24-h period and from a kinetic analysis. The effects of the Potassium source and dose on the change in blood pressure and augmentation index (AIx) were determined. RESULTS: The serum Potassium AUC increased with the dose (P 94% ± 12%). There were no significant differences in the change in blood pressure or AIx with the treatment source or dose. CONCLUSIONS: The bioavailability of Potassium is as high from potatoes as from Potassium Gluconate supplements. Future studies that measure the effect of dietary Potassium on blood pressure will need to evaluate the effect of various dietary sources on Potassium retention and in both normal and hypertensive populations. This trial was registered at clinicaltrials.gov as NCT01881295.
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Bioavailability of Potassium from Potato and Potassium Gluconate
The FASEB Journal, 2015Co-Authors: Claire Macdonald Clarke, Berdine R Martin, George P Mccabe, Linda D Mccabe, Pamela J. Lachcik, Connie M WeaverAbstract:Potassium is a shortfall nutrient according to the 2010 Dietary Guidelines for Americans. Only 3% of Americans meet the recommended Adequate Intake of 4700 mg/d for Potassium. Bioavailability of Potassium has not been considered in setting requirements as no food has been tested. Among adult potato consumers potatoes provide 19-20% of Potassium in the diet. The aim of this study was to compare bioavailability and dose response of Potassium from non-fried white potatoes with skin with Potassium Gluconate. Thirty five healthy, normotensive men and women with a mean age of 29.7 (+/- 11.2) years and BMI of 24.3 (+/- 4.4) kg/m2 (mean +/- (SD)) were enrolled in this single-blind, cross-over, randomized controlled trial. Participants were randomized to 1 of 8 interventions of Potassium: 0 (control repeated twice), 720 (~18.5), 1440 (~37), 2160 (~55.5) mg/day (mEq/day) consumed as a Potassium Gluconate supplement or white potato with skin added to the basal diet containing ~2300 mg/day (~60 mEq/day) Potassium. Bi...
Francisco Javier Gutierrezmanero - One of the best experts on this subject based on the ideXlab platform.
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pseudomonas palmensis sp nov a novel bacterium isolated from nicotiana glauca microbiome draft genome analysis and biological potential for agriculture
Frontiers in Microbiology, 2021Co-Authors: Enrique Gutierrezalbanchez, Ana Garciavillaraco, Jose Antonio Lucas, Ignacio Horche, Beatriz Ramossolano, Francisco Javier GutierrezmaneroAbstract:A novel Pseudomonas, designated strain BBB001T, an aerobic, rod-shaped bacterium was isolated from the rhizosphere of Nicotiana Glauca in Las Palmas Gran Canaria, Spain. Genomic analysis revealed that it could not be assigned to any known species of Pseudomonas, so the name Pseudomonas palmensis sp. nov. was proposed. A 16S rRNA gene phylogenetic analysis suggested affiliation to the Pseudomonas brassicae group being P. brassicae MAFF212427 T the closest related type strain. Upon genomic comparisons of both strains, all values were below thresholds established for differentiation: average nucleotide identity (ANI, 88.29 %), average amino acid identity (AAI, 84.53 %), digital DNA-DNA hybridisation (dDDH, 35.4 %), TETRA values (0.98). When comparing complete genomes, a total of 96 genes present exclusively in BBB001T were identified, 80 of which appear associated with specific subsystems. Phenotypic analysis has shown its ability to assimilate glucose, Potassium Gluconate, capric acid malate, trisodium citrate and phenylacetic acid; it was oxidase positive. It is able to produce auxins and siderophores in vitro; its metabolic profile based on BIOLOG Eco has shown a high catabolic capacity. The major fatty acids accounting for 81.17 % of the total fatty acids were: C16:0 (33.29 %), summed feature 3 (22.80 %) comprising C16:17c and C 16:16c, summed feature 8 (13.66 %), comprising C18:17c and C18:16c and C17:0 cyclo (11.42 %). The ability of this strain to improve plant fitness was tested on tomato and olive trees, demonstrating a great potential for agriculture as it is able to trigger herbaceous and woody species. First, it was able to improve iron nutrition and growth on iron-starved tomatoes, demonstrating its nutrient mobilization capacity; this effect is related to its unique genes related to iron metabolism. Secondly, it increased olive and oil yield up to 30 % on intensive olive orchards under water limiting conditions, demonstrating its capacity to improve adaptation to adverse conditions. Results from genomic analysis together with differences in phenotypic features and chemotaxonomic analysis support the proposal of strain BBB001T (= LMG 31775T = NCTC 14418T) as the type strain of a novel species for which the name Pseudomonas palmensis sp. nov is proposed
George P Mccabe - One of the best experts on this subject based on the ideXlab platform.
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abstract p091 short term increased dietary Potassium from potato and Potassium Gluconate has no effect on blood pressure and microcirculation in pre hypertensive to hypertensive adults
Circulation, 2019Co-Authors: Michael S Stone, Berdine R Martin, George P Mccabe, Linda D Mccabe, Connie M WeaverAbstract:Potassium is an essential nutrient of concern according to recent Dietary Guidelines for Americans Advisory Committees, with less than 3% of the population meeting the current adequate intake (AI) ...
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bioavailability of Potassium from potatoes and Potassium Gluconate a randomized dose response trial
The American Journal of Clinical Nutrition, 2016Co-Authors: Claire J Macdonaldclarke, Berdine R Martin, George P Mccabe, Linda D Mccabe, Pamela J. Lachcik, Meryl E Wastney, Connie M WeaverAbstract:BACKGROUND: The bioavailability of Potassium should be considered in setting requirements, but to our knowledge, the bioavailability from individual foods has not been determined. Potatoes provide 19-20% of Potassium in the American diet. OBJECTIVE: We compared the bioavailability and dose response of Potassium from nonfried white potatoes with skin [targeted at 20, 40, and 60 milliequivalents (mEq) K] and French fries (40 mEq K) with Potassium Gluconate at the same doses when added to a basal diet that contained ∼60 mEq K. DESIGN: Thirty-five healthy, normotensive men and women with a mean ± SD age of 29.7 ± 11.2 y and body mass index (in kg/m(2)) of 24.3 ± 4.4 were enrolled in a single-blind, crossover, randomized controlled trial. Participants were partially randomly assigned to the order of testing for nine 5-d interventions of additional Potassium as follows: 0 (control; repeated at phases 1 and 5), 20, 40, and 60 mEq K/d consumed as a Potassium Gluconate supplement or as unfried potato or 40 mEq K from French fries completed at phase 9. The bioavailability of Potassium was determined from the area under the curve (AUC) of serial blood draws and cumulative urinary excretion during a 24-h period and from a kinetic analysis. The effects of the Potassium source and dose on the change in blood pressure and augmentation index (AIx) were determined. RESULTS: The serum Potassium AUC increased with the dose (P 94% ± 12%). There were no significant differences in the change in blood pressure or AIx with the treatment source or dose. CONCLUSIONS: The bioavailability of Potassium is as high from potatoes as from Potassium Gluconate supplements. Future studies that measure the effect of dietary Potassium on blood pressure will need to evaluate the effect of various dietary sources on Potassium retention and in both normal and hypertensive populations. This trial was registered at clinicaltrials.gov as NCT01881295.
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Bioavailability of Potassium from Potato and Potassium Gluconate
The FASEB Journal, 2015Co-Authors: Claire Macdonald Clarke, Berdine R Martin, George P Mccabe, Linda D Mccabe, Pamela J. Lachcik, Connie M WeaverAbstract:Potassium is a shortfall nutrient according to the 2010 Dietary Guidelines for Americans. Only 3% of Americans meet the recommended Adequate Intake of 4700 mg/d for Potassium. Bioavailability of Potassium has not been considered in setting requirements as no food has been tested. Among adult potato consumers potatoes provide 19-20% of Potassium in the diet. The aim of this study was to compare bioavailability and dose response of Potassium from non-fried white potatoes with skin with Potassium Gluconate. Thirty five healthy, normotensive men and women with a mean age of 29.7 (+/- 11.2) years and BMI of 24.3 (+/- 4.4) kg/m2 (mean +/- (SD)) were enrolled in this single-blind, cross-over, randomized controlled trial. Participants were randomized to 1 of 8 interventions of Potassium: 0 (control repeated twice), 720 (~18.5), 1440 (~37), 2160 (~55.5) mg/day (mEq/day) consumed as a Potassium Gluconate supplement or white potato with skin added to the basal diet containing ~2300 mg/day (~60 mEq/day) Potassium. Bi...
Linda D Mccabe - One of the best experts on this subject based on the ideXlab platform.
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abstract p091 short term increased dietary Potassium from potato and Potassium Gluconate has no effect on blood pressure and microcirculation in pre hypertensive to hypertensive adults
Circulation, 2019Co-Authors: Michael S Stone, Berdine R Martin, George P Mccabe, Linda D Mccabe, Connie M WeaverAbstract:Potassium is an essential nutrient of concern according to recent Dietary Guidelines for Americans Advisory Committees, with less than 3% of the population meeting the current adequate intake (AI) ...
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bioavailability of Potassium from potatoes and Potassium Gluconate a randomized dose response trial
The American Journal of Clinical Nutrition, 2016Co-Authors: Claire J Macdonaldclarke, Berdine R Martin, George P Mccabe, Linda D Mccabe, Pamela J. Lachcik, Meryl E Wastney, Connie M WeaverAbstract:BACKGROUND: The bioavailability of Potassium should be considered in setting requirements, but to our knowledge, the bioavailability from individual foods has not been determined. Potatoes provide 19-20% of Potassium in the American diet. OBJECTIVE: We compared the bioavailability and dose response of Potassium from nonfried white potatoes with skin [targeted at 20, 40, and 60 milliequivalents (mEq) K] and French fries (40 mEq K) with Potassium Gluconate at the same doses when added to a basal diet that contained ∼60 mEq K. DESIGN: Thirty-five healthy, normotensive men and women with a mean ± SD age of 29.7 ± 11.2 y and body mass index (in kg/m(2)) of 24.3 ± 4.4 were enrolled in a single-blind, crossover, randomized controlled trial. Participants were partially randomly assigned to the order of testing for nine 5-d interventions of additional Potassium as follows: 0 (control; repeated at phases 1 and 5), 20, 40, and 60 mEq K/d consumed as a Potassium Gluconate supplement or as unfried potato or 40 mEq K from French fries completed at phase 9. The bioavailability of Potassium was determined from the area under the curve (AUC) of serial blood draws and cumulative urinary excretion during a 24-h period and from a kinetic analysis. The effects of the Potassium source and dose on the change in blood pressure and augmentation index (AIx) were determined. RESULTS: The serum Potassium AUC increased with the dose (P 94% ± 12%). There were no significant differences in the change in blood pressure or AIx with the treatment source or dose. CONCLUSIONS: The bioavailability of Potassium is as high from potatoes as from Potassium Gluconate supplements. Future studies that measure the effect of dietary Potassium on blood pressure will need to evaluate the effect of various dietary sources on Potassium retention and in both normal and hypertensive populations. This trial was registered at clinicaltrials.gov as NCT01881295.
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Bioavailability of Potassium from Potato and Potassium Gluconate
The FASEB Journal, 2015Co-Authors: Claire Macdonald Clarke, Berdine R Martin, George P Mccabe, Linda D Mccabe, Pamela J. Lachcik, Connie M WeaverAbstract:Potassium is a shortfall nutrient according to the 2010 Dietary Guidelines for Americans. Only 3% of Americans meet the recommended Adequate Intake of 4700 mg/d for Potassium. Bioavailability of Potassium has not been considered in setting requirements as no food has been tested. Among adult potato consumers potatoes provide 19-20% of Potassium in the diet. The aim of this study was to compare bioavailability and dose response of Potassium from non-fried white potatoes with skin with Potassium Gluconate. Thirty five healthy, normotensive men and women with a mean age of 29.7 (+/- 11.2) years and BMI of 24.3 (+/- 4.4) kg/m2 (mean +/- (SD)) were enrolled in this single-blind, cross-over, randomized controlled trial. Participants were randomized to 1 of 8 interventions of Potassium: 0 (control repeated twice), 720 (~18.5), 1440 (~37), 2160 (~55.5) mg/day (mEq/day) consumed as a Potassium Gluconate supplement or white potato with skin added to the basal diet containing ~2300 mg/day (~60 mEq/day) Potassium. Bi...