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Johan G. Eriksson - One of the best experts on this subject based on the ideXlab platform.
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Prenatal Growth and ckd in older adults longitudinal findings from the helsinki birth cohort study 1924 1944
American Journal of Kidney Diseases, 2018Co-Authors: Eero Kajantie, Johan G. Eriksson, Minna K Salonen, Clive OsmondAbstract:Background According to the Developmental Origins of Health and Disease (DOHaD) hypothesis, several noncommunicable diseases, including hypertension, type 2 diabetes, and coronary heart disease, have their origins in early life. Chronic kidney disease (CKD) has traditionally been assumed to develop as the result of an interaction between genetic and environmental factors, although more recently, the importance of factors present early in life has been recognized. Study Design Longitudinal birth cohort study. Setting & Participants 20,431 people born in 1924 to 1944 in Helsinki, Finland, who were part of the Helsinki Birth Cohort Study were followed up through their life course from birth until death or age 86 years. Predictor Prenatal Growth and socioeconomic factors. Outcomes Death or hospitalization for CKD. Results Smaller body size at birth was associated with increased risk for developing CKD. Each standard deviation higher birth weight was associated with an HR for CKD of 0.82 (95% CI, 0.74-0.91; P Limitations The study was restricted to people who were born in Helsinki in 1924 to 1944. Conclusions Smaller body size at birth was associated with increased risk for developing CKD in men. Prematurity was also associated with increased risk for CKD in women. These findings in the Helsinki Birth Cohort Study support the importance of early life factors in the development of CKD.
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trajectories of Growth and symptoms of attention deficit hyperactivity disorder in children a longitudinal study
BMC Pediatrics, 2011Co-Authors: Kati Heinonen, Katri Raikkonen, Anu-katriina Pesonen, Johan G. Eriksson, Eero Kajantie, Sture Andersson, Timo Vartia, Dieter Wolke, Aulikki LanoAbstract:Background Empirical evidence suggests that Prenatal Growth is associated with attention deficit/hyperactivity disorder (ADHD) and its symptoms. Data on the importance of postnatal Growth is, however scanty. We studied whether pre- and postnatal Growth up to 56 months is associated with symptoms of ADHD in children.
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Prenatal Growth postnatal Growth and trait anxiety in late adulthood the helsinki birth cohort study
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jari Lahti, Katri Raikkonen, Anu-katriina Pesonen, Clive Osmond, David J P Barker, Kati Heinonen, Tom Forsen, Eero Kajantie, Johan G. ErikssonAbstract:Lahti J, Raikkonen K, Pesonen A-K, Heinonen K, Kajantie E, Forsen T, Osmond C, Barker DJP, Eriksson JG. Prenatal Growth, postnatal Growth and trait anxiety in late adulthood – the Helsinki Birth Cohort Study. Objective: Trait anxiety may predispose to anxiety disorders and cardiovascular events. We tested whether Prenatal Growth or postnatal Growth from birth to 11 years of age and in adulthood predict trait anxiety in late adulthood. Method: Women (n = 951) and men (n = 753) reported trait anxiety using the Spielberger Trait Anxiety Scale at an average age of 63.4 years and Growth was estimated from records. Results: Higher trait anxiety was predicted by smaller body size at birth, in infancy and in adulthood. Moreover, faster Growth particularly from seven to 11 years of age and slower Growth between 11 and 63 years predicted higher trait anxiety. Conclusion: We found a pattern of pre- and postnatal Growth that predisposed to higher trait anxiety in late adulthood. This pattern resembles that found to increase the risk of cardiovascular events and, thus, points to a shared common origin in a suboptimal Prenatal and childhood developmental milieu.
Eero Kajantie - One of the best experts on this subject based on the ideXlab platform.
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Prenatal Growth and ckd in older adults longitudinal findings from the helsinki birth cohort study 1924 1944
American Journal of Kidney Diseases, 2018Co-Authors: Eero Kajantie, Johan G. Eriksson, Minna K Salonen, Clive OsmondAbstract:Background According to the Developmental Origins of Health and Disease (DOHaD) hypothesis, several noncommunicable diseases, including hypertension, type 2 diabetes, and coronary heart disease, have their origins in early life. Chronic kidney disease (CKD) has traditionally been assumed to develop as the result of an interaction between genetic and environmental factors, although more recently, the importance of factors present early in life has been recognized. Study Design Longitudinal birth cohort study. Setting & Participants 20,431 people born in 1924 to 1944 in Helsinki, Finland, who were part of the Helsinki Birth Cohort Study were followed up through their life course from birth until death or age 86 years. Predictor Prenatal Growth and socioeconomic factors. Outcomes Death or hospitalization for CKD. Results Smaller body size at birth was associated with increased risk for developing CKD. Each standard deviation higher birth weight was associated with an HR for CKD of 0.82 (95% CI, 0.74-0.91; P Limitations The study was restricted to people who were born in Helsinki in 1924 to 1944. Conclusions Smaller body size at birth was associated with increased risk for developing CKD in men. Prematurity was also associated with increased risk for CKD in women. These findings in the Helsinki Birth Cohort Study support the importance of early life factors in the development of CKD.
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trajectories of Growth and symptoms of attention deficit hyperactivity disorder in children a longitudinal study
BMC Pediatrics, 2011Co-Authors: Kati Heinonen, Katri Raikkonen, Anu-katriina Pesonen, Johan G. Eriksson, Eero Kajantie, Sture Andersson, Timo Vartia, Dieter Wolke, Aulikki LanoAbstract:Background Empirical evidence suggests that Prenatal Growth is associated with attention deficit/hyperactivity disorder (ADHD) and its symptoms. Data on the importance of postnatal Growth is, however scanty. We studied whether pre- and postnatal Growth up to 56 months is associated with symptoms of ADHD in children.
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Prenatal Growth postnatal Growth and trait anxiety in late adulthood the helsinki birth cohort study
Acta Psychiatrica Scandinavica, 2010Co-Authors: Jari Lahti, Katri Raikkonen, Anu-katriina Pesonen, Clive Osmond, David J P Barker, Kati Heinonen, Tom Forsen, Eero Kajantie, Johan G. ErikssonAbstract:Lahti J, Raikkonen K, Pesonen A-K, Heinonen K, Kajantie E, Forsen T, Osmond C, Barker DJP, Eriksson JG. Prenatal Growth, postnatal Growth and trait anxiety in late adulthood – the Helsinki Birth Cohort Study. Objective: Trait anxiety may predispose to anxiety disorders and cardiovascular events. We tested whether Prenatal Growth or postnatal Growth from birth to 11 years of age and in adulthood predict trait anxiety in late adulthood. Method: Women (n = 951) and men (n = 753) reported trait anxiety using the Spielberger Trait Anxiety Scale at an average age of 63.4 years and Growth was estimated from records. Results: Higher trait anxiety was predicted by smaller body size at birth, in infancy and in adulthood. Moreover, faster Growth particularly from seven to 11 years of age and slower Growth between 11 and 63 years predicted higher trait anxiety. Conclusion: We found a pattern of pre- and postnatal Growth that predisposed to higher trait anxiety in late adulthood. This pattern resembles that found to increase the risk of cardiovascular events and, thus, points to a shared common origin in a suboptimal Prenatal and childhood developmental milieu.
Tara Cominski - One of the best experts on this subject based on the ideXlab platform.
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insulin like Growth factor ii an essential adult stem cell niche constituent in brain and intestine
Stem cell reports, 2019Co-Authors: Amber N. Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M. Testai, Ekta Kumari, Deborah E. Rothbard, Miguel Constancia, Ionel Sandovici, Tara CominskiAbstract:Summary Tissue-specific stem cells have unique properties and Growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like Growth factor II (IGF-II) is necessary for Prenatal Growth, its role in adult stem cell physiology is largely unknown. We show that loss of Igf2 in adult mice resulted in a ∼50% reduction in slowly dividing, label-retaining cells in the two regions of the brain that harbor neural stem cells. Concordantly, induced Igf2 deletion increased newly generated neurons in the olfactory bulb accompanied by hyposmia, and caused impairments in learning and memory and increased anxiety. Induced Igf2 deletion also resulted in rapid loss of stem and progenitor cells in the crypts of Lieberkuhn, leading to body-weight loss and lethality and the inability to produce organoids in vitro. These data demonstrate that IGF-II is critical for multiple adult stem cell niches.
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Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine
Elsevier, 2019Co-Authors: Amber N. Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M. Testai, Ekta Kumari, Deborah E. Rothbard, Miguel Constancia, Ionel Sandovici, Tara Cominski, Kevin PangAbstract:Summary: Tissue-specific stem cells have unique properties and Growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like Growth factor II (IGF-II) is necessary for Prenatal Growth, its role in adult stem cell physiology is largely unknown. We show that loss of Igf2 in adult mice resulted in a ∼50% reduction in slowly dividing, label-retaining cells in the two regions of the brain that harbor neural stem cells. Concordantly, induced Igf2 deletion increased newly generated neurons in the olfactory bulb accompanied by hyposmia, and caused impairments in learning and memory and increased anxiety. Induced Igf2 deletion also resulted in rapid loss of stem and progenitor cells in the crypts of Lieberkühn, leading to body-weight loss and lethality and the inability to produce organoids in vitro. These data demonstrate that IGF-II is critical for multiple adult stem cell niches. : In this article, Levison, Wood and colleagues demonstrate that IGF-II expression in the adult mouse is necessary for maintaining multiple adult stem cell niches including in the subventricular and subgranular zones of the brain and in the crypts of Lieberkühn of the gut. Keywords: neural stem cell, IGF-II, intestinal stem cell, subventricular zone, subgranular zone, crypt of Lieberkühn, neurogenesi
Miguel Constancia - One of the best experts on this subject based on the ideXlab platform.
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insulin like Growth factor ii an essential adult stem cell niche constituent in brain and intestine
Stem cell reports, 2019Co-Authors: Amber N. Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M. Testai, Ekta Kumari, Deborah E. Rothbard, Miguel Constancia, Ionel Sandovici, Tara CominskiAbstract:Summary Tissue-specific stem cells have unique properties and Growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like Growth factor II (IGF-II) is necessary for Prenatal Growth, its role in adult stem cell physiology is largely unknown. We show that loss of Igf2 in adult mice resulted in a ∼50% reduction in slowly dividing, label-retaining cells in the two regions of the brain that harbor neural stem cells. Concordantly, induced Igf2 deletion increased newly generated neurons in the olfactory bulb accompanied by hyposmia, and caused impairments in learning and memory and increased anxiety. Induced Igf2 deletion also resulted in rapid loss of stem and progenitor cells in the crypts of Lieberkuhn, leading to body-weight loss and lethality and the inability to produce organoids in vitro. These data demonstrate that IGF-II is critical for multiple adult stem cell niches.
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Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine
Elsevier, 2019Co-Authors: Amber N. Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M. Testai, Ekta Kumari, Deborah E. Rothbard, Miguel Constancia, Ionel Sandovici, Tara Cominski, Kevin PangAbstract:Summary: Tissue-specific stem cells have unique properties and Growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like Growth factor II (IGF-II) is necessary for Prenatal Growth, its role in adult stem cell physiology is largely unknown. We show that loss of Igf2 in adult mice resulted in a ∼50% reduction in slowly dividing, label-retaining cells in the two regions of the brain that harbor neural stem cells. Concordantly, induced Igf2 deletion increased newly generated neurons in the olfactory bulb accompanied by hyposmia, and caused impairments in learning and memory and increased anxiety. Induced Igf2 deletion also resulted in rapid loss of stem and progenitor cells in the crypts of Lieberkühn, leading to body-weight loss and lethality and the inability to produce organoids in vitro. These data demonstrate that IGF-II is critical for multiple adult stem cell niches. : In this article, Levison, Wood and colleagues demonstrate that IGF-II expression in the adult mouse is necessary for maintaining multiple adult stem cell niches including in the subventricular and subgranular zones of the brain and in the crypts of Lieberkühn of the gut. Keywords: neural stem cell, IGF-II, intestinal stem cell, subventricular zone, subgranular zone, crypt of Lieberkühn, neurogenesi
Francis De Zegher - One of the best experts on this subject based on the ideXlab platform.
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Body Composition and Circulating High-Molecular- Weight Adiponectin and IGF-I in Infants Born Small for Gestational Age Breast- Versus Formula-Feeding
2016Co-Authors: Francis De Zegher, Marta Díaz, Abel López-bermejo, Giorgia Sebastiani, David Sánchez-infantes, Lourdes IbáñezAbstract:Prenatal Growth restraint, if followed by postnatal overweight, confers risk for adult disease including diabetes. The mecha-nisms whereby neonatal nutrition may modulate such risk are poorly understood. We studied the effects of nutrition (breast-feeding [BRF] vs. formula-feeding [FOF]) on weight partitioning and endocrine state (as judged by high-molecular-weight [HMW] adiponectin and IGF-I) of infants born small for gestational age (SGA). Body composition (by absorptiometry), HMW adiponectin, and IGF-I were assessed at birth and 4 months in BRF infants born appropriate for gestational age (AGA; n = 72) and SGA infants receiving BRF (n = 46) or FOF (n = 56), the latter being randomized to receive a standard (FOF1) or protein-rich formula (FOF2). Compared with AGA-BRF infants, the catchup Growth of SGA infants was confined to lean mass, independently of nutri-tion. Compared with AGA-BRF infants, SGA-BRF infants had nor
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Gender specificity of body adiposity and circulating adiponectin, visfatin, insulin, and insulin Growth factor-I at term birth: relation to Prenatal Growth.
The Journal of clinical endocrinology and metabolism, 2008Co-Authors: Lourdes Ibáñez, Marta Díaz, Abel López-bermejo, Giorgia Sebastiani, Maria Dolores Gomez-roig, Francis De ZegherAbstract:Context: Fetal development is thought to be gender specific for adiposity and circulating insulin and IGF-I but not adipokinemia, as judged by serum visfatin and adiponectin at term birth. We studied the potential relationship between these gender specificities and fetal Growth. Setting: The study was conducted at a university hospital. Study Population: Subjects included 96 strictly matched neonates born appropriate for gestational age (AGA; 24 girls, 24 boys) or small for gestational age (SGA; 24 girls, 24 boys). Main Outcomes: Outcomes included serum insulin, IGF-I, visfatin, total and high-molecular-weight (HMW) adiponectin, osteocalcin at term birth, and neonatal body composition by absorptiometry. Results: Cord insulin and IGF-I levels were higher in girls than boys (P ≤ 0.01), in both the AGA and SGA subpopulation. In AGA newborns, fat and lean mass were each gender specific (P < 0.0001), whereas visfatin and total and HMW adiponectin were not. Conversely, in SGA newborns, visfatin and HMW adiponec...
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renal drug clearance in preterm neonates relation to Prenatal Growth
Therapeutic Drug Monitoring, 2007Co-Authors: Karel Allegaert, Brian J Anderson, John N Van Den Anker, Sophie Vanhaesebrouck, Francis De ZegherAbstract:Aminoglycosides and glycopeptides are almost exclusively eliminated by renal excretion. Postmenstrual age (PMA) is the best predictor of their clearance, presumably because it predicts the time course of development of the glomerular filtration rate (GFR). Intrauterine Growth restriction has an impact on the normalized weight of the kidney, on the number of nephrons, on GFR, and on tubular function in human perinatal life. We investigated whether Prenatal Growth also affects clearance of drugs such as aminoglycosides or glycopeptides that are eliminated through the kidney. Observations collected in two population pharmacokinetic studies involving preterm neonates and investigating amikacin and vancomycin in the first month of postnatal life were used to estimate the impact of Prenatal Growth (as judged by birth weight for gestational age) on the clearance of these drugs. Data from 1212 drug measurements (vancomycin, 648; amikacin, 564) in 531 subjects (vancomycin, 249; amikacin, 282) were available for study. Neonates born small for gestational age (SGA) were found to have a 16.2% (coefficient of variation, 12.2%) reduction in drug clearance. This effect was present from birth up to the postnatal age of 4 weeks. The covariate size (weight 0.75) explained 47.3% of drug clearance; PMA, 25.2%; coadministration of a nonselective cyclo-oxygenase inhibitor, 3.5%; renal function, 7.6%; and SGA, 1.7%. Renal drug clearance is significantly lower in preterm neonates born SGA than in appropriate-for-gestational-age (AGA) controls. This reduced clearance was observed not only at birth but also up to the postnatal age of 4 weeks.
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Metformin treatment to prevent early puberty in girls with precocious pubarche.
The Journal of clinical endocrinology and metabolism, 2006Co-Authors: Lourdes Ibáñez, Ken K. Ong, Carme Valls, Maria Victoria Marcos, David B. Dunger, Francis De ZegherAbstract:Context and Objective: Girls with precocious pubarche (PP, pubic hair at < 8 yr of age) are at high risk for early onset and rapid progression of puberty, in particular if their Prenatal Growth was restrained, i.e. low birth weight (LBW), and followed by rapid postnatal catch-up of weight gain. We postulated that insulin resistance contributes to early onset and rapid progression of puberty in LBW-PP girls and thus explored the puberty-delaying effects of insulin sensitization with metformin initiated shortly after PP diagnosis. Setting, Design, and Patients: The study population consisted of 38 prepubertal LBW girls with PP attributed to exaggerated adrenarche [mean body weight, 2.4 kg; age, 7.9 yr; body mass index (BMI), 18.4 kg/m2]. These girls were randomly assigned to remain untreated (n = 19) or to receive metformin (n = 19; 425 mg/d) for 2 yr. Main Outcome Measures: Pubertal staging, age at menarche, body composition by absorptiometry, fasting insulin, glucose, lipids, leptin, IGF-I, IGF-binding pr...
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Early Puberty-Menarche After Precocious Pubarche: Relation to Prenatal Growth
Pediatrics, 2006Co-Authors: Lourdes Ibáñez, Rafael Jiménez, Francis De ZegherAbstract:OBJECTIVE. Girls with precocious pubarche (PP; pubic hair at METHODS. We studied 187 PP girls longitudinally: (1) at birth, (2) in prepuberty, (3) at onset of puberty, (4) at menarche, and (5) on reaching adult stature. This PP cohort was divided into subgroups of higher birth weight (>0 SD), intermediate birth weight (0 to −2 SD), and lower birth weight (less than −2 SD). RESULTS. At the time of PP diagnosis, age, bone age, and BMI were similar across birth weight subgroups; circulating sex hormone–binding globulin and body height were reduced in PP girls with lower birth weight, and these remained so throughout pubertal development. Onset of puberty occurred earlier in PP girls with lower birth weight; so did menarche. Adult height differed by an average of 6.5 cm (∼1 SD) between the upper and lower birth weight subgroups; this difference was essentially achieved before puberty and even before PP. Menarche before age 12.0 years was twofold more prevalent in PP girls than in control subjects. Among PP girls, age at menarche was advanced by 8 to 10 months in lower versus higher birth weight girls. Menarche before age 12.0 years was threefold more prevalent among LBW-PP girls than in control subjects (∼75% vs ∼25%). CONCLUSIONS. The link between Prenatal Growth restraint and early menarche is herewith extended to PP girls. In particular LBW-PP girls may become a target group for interventions directed toward normalization of pubertal onset and progression.