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Sirichai Chayasirisobhon - One of the best experts on this subject based on the ideXlab platform.
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psychopathology in pediatric complex partial and Primary Generalized Epilepsy
Developmental Medicine & Child Neurology, 2008Co-Authors: Rochelle Caplan, Shoshana Arbelle, Wagdan Magharious, Donald Guthrie, Scott Komo, Donald W Shields, Sirichai Chayasirisobhon, Rebecca HansenAbstract:Structured psychiatric interviews were administered to 60 children with complex partial seizure disorder (CPS). 40 children with Primary Generalized Epilepsy with absences (PGE), and 48 control children, aged 5 to 16 years. Significantly more patients with Epilepsy had psychiatric diagnoses compared with the control children. There were no statistically significant differences, however, in the number of patients with CPS and PGE with psychiatric diagnoses. Other than a schizophrenia-like psychosis found only in the patients with CPS, the two groups of patients had similar psychiatric diagnoses. The presence of psychopathology was related to significantly lower IQ scores and socioeconomic status, but not to seizure-related factors. These findings suggest that the psychopathology of children with CPS and PGE reflects different subtle neuropsychological deficits.
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measures of psychopathology in children with complex partial seizures and Primary Generalized Epilepsy with absence
Journal of the American Academy of Child and Adolescent Psychiatry, 2001Co-Authors: Rochelle Caplan, Donald Guthrie, Scott Komo, Donald W Shields, Prahba Siddarth, Raman Sankar, Harley I Kornblum, Sirichai ChayasirisobhonAbstract:ABSTRACT Objective This investigation examined psychopathology in 48 children with complex partial seizures (CPS), 39 children with Primary Generalized Epilepsy with absence (PGE), and 59 nonepileptic children, aged 5 to 16 years, by comparing the Child Behavior Checklist (CBCL) and the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS). Method The CBCL was completed by parents and the K-SADS was administered to both parent and child. Results The CBCL identified psychopathology in 26% and the K-SADS in 51% of the CPS and PGE patients (κ = 0.32). The CPS and PGE groups had significantly higher mean CBCL scores, as well as higher rates of psychiatric diagnoses and symptoms of psychopathology, compared with the nonepileptic group. However, the CPS and PGE groups did not differ in these measures. Within each patient group, Full Scale IQ, but not seizure control, was associated with these measures of psychopathology. Conclusion These findings suggest that the K-SADS identifies more children with psychopathology than the CBCL in children with CPS and PGE.
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formal thought disorder and psychopathology in pediatric Primary Generalized and complex partial Epilepsy
Journal of the American Academy of Child and Adolescent Psychiatry, 1997Co-Authors: Rochelle Caplan, Shoshana Arbelle, Donald Guthrie, Scott Komo, Donald W Shields, Rebecca Hansen, Sirichai ChayasirisobhonAbstract:ABSTRACT Objective To examine whether formal thought disorder and psychopathology occurred in children with complex partial seizures (CPS) rather than children with Primary Generalized Epilepsy with absences (PGE) or nonepileptic children. Method Formal thought disorder was coded in 30 children with CPS, 24 children with PGE, and 61 nonepileptic children, and structured interview—based psychiatric diagnoses were obtained for the epileptic subjects. Results The CPS subjects had significantly more illogical thinking than the PGE and nonepileptic children. The severity of their illogical thinking was related to global cognitive dysfunction and a schizophrenia-like psychosis. Age of onset and seizure control, however, were significantly associated with the severity of illogical thinking in the PGE group. One or more psychiatric diagnoses were found in 63% of the CPS and 54% of the PGE patients, particularly if they had global cognitive deficits. Conclusions Illogical thinking, associated with cognitive dysfunction or schizophrenia-like symptoms, might be a feature of pediatric CPS. Psychopathology might be related to global cognitive dysfunction in pediatric CPS and PGE.
Rochelle Caplan - One of the best experts on this subject based on the ideXlab platform.
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psychopathology in pediatric complex partial and Primary Generalized Epilepsy
Developmental Medicine & Child Neurology, 2008Co-Authors: Rochelle Caplan, Shoshana Arbelle, Wagdan Magharious, Donald Guthrie, Scott Komo, Donald W Shields, Sirichai Chayasirisobhon, Rebecca HansenAbstract:Structured psychiatric interviews were administered to 60 children with complex partial seizure disorder (CPS). 40 children with Primary Generalized Epilepsy with absences (PGE), and 48 control children, aged 5 to 16 years. Significantly more patients with Epilepsy had psychiatric diagnoses compared with the control children. There were no statistically significant differences, however, in the number of patients with CPS and PGE with psychiatric diagnoses. Other than a schizophrenia-like psychosis found only in the patients with CPS, the two groups of patients had similar psychiatric diagnoses. The presence of psychopathology was related to significantly lower IQ scores and socioeconomic status, but not to seizure-related factors. These findings suggest that the psychopathology of children with CPS and PGE reflects different subtle neuropsychological deficits.
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measures of psychopathology in children with complex partial seizures and Primary Generalized Epilepsy with absence
Journal of the American Academy of Child and Adolescent Psychiatry, 2001Co-Authors: Rochelle Caplan, Donald Guthrie, Scott Komo, Donald W Shields, Prahba Siddarth, Raman Sankar, Harley I Kornblum, Sirichai ChayasirisobhonAbstract:ABSTRACT Objective This investigation examined psychopathology in 48 children with complex partial seizures (CPS), 39 children with Primary Generalized Epilepsy with absence (PGE), and 59 nonepileptic children, aged 5 to 16 years, by comparing the Child Behavior Checklist (CBCL) and the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS). Method The CBCL was completed by parents and the K-SADS was administered to both parent and child. Results The CBCL identified psychopathology in 26% and the K-SADS in 51% of the CPS and PGE patients (κ = 0.32). The CPS and PGE groups had significantly higher mean CBCL scores, as well as higher rates of psychiatric diagnoses and symptoms of psychopathology, compared with the nonepileptic group. However, the CPS and PGE groups did not differ in these measures. Within each patient group, Full Scale IQ, but not seizure control, was associated with these measures of psychopathology. Conclusion These findings suggest that the K-SADS identifies more children with psychopathology than the CBCL in children with CPS and PGE.
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formal thought disorder and psychopathology in pediatric Primary Generalized and complex partial Epilepsy
Journal of the American Academy of Child and Adolescent Psychiatry, 1997Co-Authors: Rochelle Caplan, Shoshana Arbelle, Donald Guthrie, Scott Komo, Donald W Shields, Rebecca Hansen, Sirichai ChayasirisobhonAbstract:ABSTRACT Objective To examine whether formal thought disorder and psychopathology occurred in children with complex partial seizures (CPS) rather than children with Primary Generalized Epilepsy with absences (PGE) or nonepileptic children. Method Formal thought disorder was coded in 30 children with CPS, 24 children with PGE, and 61 nonepileptic children, and structured interview—based psychiatric diagnoses were obtained for the epileptic subjects. Results The CPS subjects had significantly more illogical thinking than the PGE and nonepileptic children. The severity of their illogical thinking was related to global cognitive dysfunction and a schizophrenia-like psychosis. Age of onset and seizure control, however, were significantly associated with the severity of illogical thinking in the PGE group. One or more psychiatric diagnoses were found in 63% of the CPS and 54% of the PGE patients, particularly if they had global cognitive deficits. Conclusions Illogical thinking, associated with cognitive dysfunction or schizophrenia-like symptoms, might be a feature of pediatric CPS. Psychopathology might be related to global cognitive dysfunction in pediatric CPS and PGE.
Suleyman Aydin - One of the best experts on this subject based on the ideXlab platform.
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alteration in chromogranin a obestatin and total ghrelin levels of saliva and serum in Epilepsy cases
Peptides, 2010Co-Authors: Suleyman Aydin, Yusuf Ozkan, Fazilet Erman, Adile Ferda Dagli, Mehtap GurgerAbstract:Abstract This study was designed to measure the levels of chromogranin A (CgA), ghrelin and obestatin in serum and saliva (including CgA expression in healthy tissue) in epileptic patients to determine any significant differences between these patients and healthy controls. Samples were obtained from a total of 91 subjects: 10 newly-diagnosed Primary Generalized Epilepsy (PGE) patients who had started treatment with valproic acid and phenytoin for seizure control; 18 PGE patients who were previously and currently receiving treatment with valproic acid and phenytoin for seizure control; 37 patients with partial Epilepsy (PE) (simple, n = 17 or complex, n = 20) who had been and were still being treated with carbazebime for seizures; and 26 healthy controls. CgA immunoreactivity in healthy salivary gland was analyzed by immunohistochemistry and ELISA. The levels of CgA, total ghrelin and obestatin in serum and saliva were measured by ELISA. The results revealed that normal salivary gland produces its own CgA. Before treatment, CgA levels in saliva and serum were significantly greater in patients newly-diagnosed with PGE than controls. Ghrelin and CgA concentrations were also greater in PGE patients previously or currently treated with drugs, and in patients with simple or complex partial Epilepsy (PE) previously or currently treated with drugs, than in healthy normal controls. In conclusion, salivary concentrations of CgA, ghrelin and obestatin were similar to their serum levels, so saliva might be a desirable alternative to serum for measuring these hormones because it is easy and painless to collect.
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nesfatin 1 and ghrelin levels in serum and saliva of epileptic patients hormonal changes can have a major effect on seizure disorders
Molecular and Cellular Biochemistry, 2009Co-Authors: Suleyman Aydin, Yusuf Ozkan, Fazilet Erman, Adile Ferda Dagli, Nermin Kilic, Ibrahim Sahin, Fikret Karatas, Tahir Kurtulus Yoldas, Abdullah Onder Barim, Yalcin KendirAbstract:Nesfatin-1 and ghrelin are the two recently discovered peptide hormones involved in the control of appetite. Besides its main appetite-control function, ghrelin also has anticonvulsant effects, while nesfatin-1 causes depolarization in the paraventricular nucleus (PVN). The aims of this study, therefore, were to investigate: (i) whether there are differences in the concentrations of nesfatin-1 and ghrelin in saliva and serum samples between eplilepsy patients and normal controls and (ii) whether salivary glands produce nesfatin-1. The study included a total of 73 subjects: 8 patients who were newly diagnosed with Primary Generalized seizures and had recently started antiepileptic drug therapy; 21 who had Primary Generalized seizures and were continuing with established antiepileptic drug therapy; 24 who had partial seizures (simple: n = 12 or complex: n = 12) and were continuing with established antiepileptic drug therapy; and 20 controls. Salivary gland tissue samples were analyzed for nesfatin-1 expression by immunochemistry and ELISA. Saliva and serum ghrelin levels were measured by ELISA and RIA, and nesfatin-1 levels by ELISA. Nesfatin-1 immunoreactivity was detected in the striated and interlobular parts of the salivary glands and the ducts. The nesfatin-1 level in the brain was around 12 times higher than in the salivary gland. Before antiepileptic treatment, both saliva and serum nesfatin-1 levels were around 160-fold higher in patients who are newly diagnosed with Primary Generalized Epilepsy (PGE) than in controls; these levels decreased with treatment but remained about 10 times higher than the control values. Saliva and serum nesfatin-1 levels from patients with PGE and partial epilepsies who were continuing antiepileptic drugs were also 10-fold higher than control values. Serum and saliva ghrelin levels were significantly (twofold) lower in epileptic patients before treatment than in controls; they recovered somewhat with treatment but remained below the control values. These results suggest that the low ghrelin and especially the dramatically elevated nesfatin-1 levels might contribute to the pathophyisology of Epilepsy. Therefore, serum and saliva ghrelin and especially the remarkably increased nesfatin-1 might be candidate biomarkers for the diagnosis of Epilepsy and for monitoring the response to anti-epileptic treatment.
H Assiri - One of the best experts on this subject based on the ideXlab platform.
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the prognosis of Primary Generalized Epilepsy in patients with parental consanguinity a 1 year retrospective study
HAMDAN MEDICAL JOURNAL, 2015Co-Authors: F Babtain, H Assiri, A Bajunaid, H BhatiaAbstract:Introduction: Primary Generalized Epilepsy (PGE) is believed to be associated with a favourable prognosis but its relationship with parental consanguinity (PC) is unknown. Objectives: To assess the prognosis of PGE in patients with PC in a 1-year follow-up study. Materials and methods: Patients with PGE, seen between January 2012 and June 2013, were identified, and those with a 1-year follow-up were included in the study. Epilepsy risk factors were determined for all patients, as well as the family history of Epilepsy (FHE) and PC. Seizure control was recorded at 6- and 12-month follow-up, but predictors of seizure control were assessed during the last visit. Results: A total of 84 patients were studied, 47 of which were men (56%), and the mean age at Epilepsy onset was 14.6 years. FHE was documented in 23 patients (27.4%) and PC (first and second degree) was observed in 22 patients (26.2%). Seizure control was documented in 71 patients (84.5%). First-degree PC was observed significantly in patients who continued to have seizures in 12-month follow-up (2.8 vs. 23.1%, P =0.025), but other variables were distributed insignificantly between the two groups. Multiple regression analysis showed that first-degree PC was 17 times more likely to be associated with a less favourable prognosis in a 1-year follow-up of patients with PGE (odds ratio=17.7, P =0.027, 95% confidence interval =1.4 to 22.6). Other factors, such as age at onset, FHE and other PC, could not predict prognosis. Conclusions: Patients with PGE-lacking first-degree PC were more likely to be seizure free in a 1-year follow-up, which may indicate a genetic influence of PC that would lead to a less favourable prognosis.
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the prognosis of Primary Generalized Epilepsy in patients with parental consanguinity a one year retrospective study p2 189
Neurology, 2014Co-Authors: H Assiri, F Babtain, A Bajunaid, Muthusamy VelmuruganAbstract:Background:Studies describing the long-term prognosis of Primary Generalized Epilepsy (PGE) are rare, yet it is believed that this Epilepsy class is associated with favorable prognosis. Data on the influence of parental consanguinity (PC) on the prognosis of PGE are scant for which this study aimed to evaluate. Methods:Patients with PGE registered in our Epilepsy registry between January 2012 and June 2013 were identified, and those with a one year follow up were only included. Epilepsy risk factors were determined for all patients, as well as the presence of family history of Epilepsy (FHE) and PC. Seizure control was recorded at 6 and 12 months follow up, but predictors of seizure control were assessed at 12 months. Results: 84 patients were studied. There were 47 men (56%), mean age at Epilepsy onset was 14.6 years. FHE was documented in 23 patients (27.4%), and PC (first and second degrees) was observed in 22 patients (26.2%). At 12 months, seizure freedom was documented in 71 patients (84.5%). 23% of patients who continued to have seizure at 12 months had first degree PC, which was only documented in 2.8% of patients who were seizure free during the same period (p value = 0.025). Second degree PC and FHE were seen in no particular distribution across the two groups. Multiple regression analysis showed that first degree PC was 17 times more likely to be associated with unfavorable prognosis in one year follow up of patients with PGE (odds ratio =17.7, p values = 0.027, 95% CI = 1.4-22.6). Other factors such as gender, age at Epilepsy onset, FHE and other PC could not predict prognosis in one year. Conclusions: The presence of first degree PC was associated with unfavorable prognosis in patients with PGE. This observation may indicate a genetic influence of PC on idiopathic Epilepsy, but larger studies are recommended to support such an observation. Disclosure: Dr. Assiri has nothing to disclose. Dr. Babtain has nothing to disclose. Dr. Babtain has nothing to disclose. Dr. Velmurugan has nothing to disclose.
Christopher Skidmore - One of the best experts on this subject based on the ideXlab platform.
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Lacosamide use in refractory idiopathic Primary Generalized Epilepsy.
Epilepsy & behavior : E&B, 2011Co-Authors: Andro Zangaladze, Christopher SkidmoreAbstract:Treatment of refractory idiopathic Primary Generalized Epilepsy can be very challenging, with limited drug options, especially in young women of childbearing age. Here we describe the cases of two young women with refractory idiopathic Primary Generalized Epilepsy refractory to multiple antiepileptic drugs in monotherapy or combination before achieving a long-term remission with adjunctive lacosamide (LCS) treatment. Larger, randomized prospective studies are necessary to establish the effectiveness of lacosamide in these patients.