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Anna Bassols - One of the best experts on this subject based on the ideXlab platform.
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serum acute phase proteins as biomarkers of pleuritis and cranio ventral Pulmonary Consolidation in slaughter aged pigs
Research in Veterinary Science, 2011Co-Authors: Yolanda Saco, Lorenzo Fraile, R Lopezjimenez, Joaquim Segales, Mercè Giménez, Ana Alegre, Martí Cortey, Anna BassolsAbstract:The purpose of this study was to investigate the relationship between the existence of lung lesions in pigs at slaughter and the concentration of the serum acute phase proteins (APP), haptoglobin (Hp), pig-major acute protein (Pig-MAP) and C-reactive protein (CRP). A total of 24 pig farms were selected out of a larger farm database previously screened to study risk factors associated with pleuritis and cranio-ventral Pulmonary Consolidation (CVPC) lesions at slaughter-aged pigs in Spain. The farms were classified as "pleuritis negative (P-) or positive (P+)" and as "CVPC negative (M-) or positive (M+)" and divided into four groups according to a 2X2 factorial design (P-M-, P-M+, P+M-, P+M+). Also at slaughter, blood from 20 randomly selected pigs from each farm was collected. Obtained serum samples were used to measure acute phase proteins. All APP concentrations were significantly higher for M+ farms than for M- ones. However, only Hp and Pig-MAP showed significantly higher concentrations for P+ farms than for P- ones. Pig-MAP was the most sensitive biomarker since it was able to clearly discriminate between P-/P+ and M-/M+ groups (p<0.001 in both cases). Hp was an excellent marker for pleuritis and good for CVPC lesions. CRP was able to discriminate for CVPC lesions but not for pleuritis. The present results indicate that Pig-MAP and, possibly Hp, may be used as potential markers to characterise and discriminate respiratory lesions in swine herds at slaughter.
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Serum acute phase proteins as biomarkers of pleuritis and cranio-ventral Pulmonary Consolidation in slaughter-aged pigs.
Research in veterinary science, 2010Co-Authors: Yolanda Saco, Lorenzo Fraile, Joaquim Segales, R. López-jiménez, Mercè Giménez, Ana Alegre, Martí Cortey, Anna BassolsAbstract:The purpose of this study was to investigate the relationship between the existence of lung lesions in pigs at slaughter and the concentration of the serum acute phase proteins (APP), haptoglobin (Hp), pig-major acute protein (Pig-MAP) and C-reactive protein (CRP). A total of 24 pig farms were selected out of a larger farm database previously screened to study risk factors associated with pleuritis and cranio-ventral Pulmonary Consolidation (CVPC) lesions at slaughter-aged pigs in Spain. The farms were classified as "pleuritis negative (P-) or positive (P+)" and as "CVPC negative (M-) or positive (M+)" and divided into four groups according to a 2X2 factorial design (P-M-, P-M+, P+M-, P+M+). Also at slaughter, blood from 20 randomly selected pigs from each farm was collected. Obtained serum samples were used to measure acute phase proteins. All APP concentrations were significantly higher for M+ farms than for M- ones. However, only Hp and Pig-MAP showed significantly higher concentrations for P+ farms than for P- ones. Pig-MAP was the most sensitive biomarker since it was able to clearly discriminate between P-/P+ and M-/M+ groups (p
Amita Sharma - One of the best experts on this subject based on the ideXlab platform.
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clinical role safety and diagnostic accuracy of percutaneous transthoracic needle biopsy in the evaluation of Pulmonary Consolidation
Respiratory Research, 2019Co-Authors: Nantaka Kiranantawat, Shaunagh Mcdermott, Florian J. Fintelmann, Sydney B. Montesi, Melissa C. Price, Subba R. Digumarthy, Amita SharmaAbstract:Background To determine the clinical role, safety, and diagnostic accuracy of percutaneous transthoracic needle biopsy in the evaluation of Pulmonary Consolidation.
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Clinical role, safety and diagnostic accuracy of percutaneous transthoracic needle biopsy in the evaluation of Pulmonary Consolidation
BMC, 2019Co-Authors: Nantaka Kiranantawat, Shaunagh Mcdermott, Florian J. Fintelmann, Sydney B. Montesi, Melissa C. Price, Subba R. Digumarthy, Amita SharmaAbstract:Abstract Background To determine the clinical role, safety, and diagnostic accuracy of percutaneous transthoracic needle biopsy in the evaluation of Pulmonary Consolidation. Methods A retrospective review of all computed tomography (CT)-guided percutaneous transthoracic needle biopsies (PTNB) at a tertiary care hospital over a 4-year period was performed to identify all cases of PTNB performed for Pulmonary Consolidation. For each case, CT Chest images were reviewed by two thoracic radiologists. Histopathologic and microbiologic results were obtained and clinical follow-up was performed. Results Thirty of 1090 (M:F 17:30, mean age 67 years) patients underwent PTNB for Pulmonary Consolidation (2.8% of all biopsies). A final diagnosis was confirmed in 29 patients through surgical resection, microbiology, or clinicoradiologic follow-up for at least 18 months after biopsy. PTNB had an overall diagnostic accuracy of 83%. A final diagnosis of malignancy was made in 20/29 patients, of which 19 were correctly diagnosed by PTNB, resulting in a sensitivity of 95% and specificity of 100% for malignancy. In all cases of primary lung cancer, adequate tissue for molecular testing was obtained. A benign final diagnosis was made in 9 patients, infection in 5 cases and non-infectious benign etiology in 4 cases. PTNB correctly diagnosed all cases of infection. Minor complications occurred in 13% (4/30) of patients. Conclusions Pulmonary Consolidation can be safely evaluated with CT-guided percutaneous needle biopsy. Diagnostic yield is high, especially for malignancy. PTNB of Pulmonary Consolidation should be considered following non-diagnostic bronchoscopy
Pan-chyr Yang - One of the best experts on this subject based on the ideXlab platform.
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Reactive Pulmonary artery vasoconstriction in Pulmonary Consolidation evaluated by color Doppler ultrasonography.
Ultrasound in medicine & biology, 2000Co-Authors: Ang Yuan, Pan-chyr Yang, Li-na Lee, Sow-hsong Kuo, Kwen-tay Luh, Wen-jone Chen, Fang-yue LinAbstract:A total of 122 patients with Pulmonary Consolidation on chest radiographs underwent color Doppler ultrasonography to evaluate hemodynamic change in regional Pulmonary artery in Pulmonary Consolidation due to various causes. The diseases underlying Pulmonary Consolidation included 66 simple pneumonia, 37 obstructive pneumonia, 13 tumor Consolidation and 6 Pulmonary infarctions. Blood flow signals in Consolidation were detected by color-flow mapping. The degree of reactive vasoconstriction was evaluated from analysis of the spectral waveform of the blood flow in the segmental Pulmonary artery by several vessel resistance-indicating Doppler ultrasound (US) indices, including pulsativity index (PI), resistive index (RI), and acceleration time (AT). The results showed that reactive vasoconstriction was most marked in obstructive pneumonia, followed by simple pneumonia, and least in tumor Consolidation (p < 0.001, Kruskal-Wallis test and p < 0.001, Dunn's test for comparison of PI, RI and AT values between different groups of Pulmonary Consolidation). No flow was detected in Pulmonary infarction. We conclude that color Doppler US is a useful tool for evaluating reactive vasoconstriction in Pulmonary Consolidation. The different degrees of reactive vasoconstriction may be helpful in exploring the possible etiology of Pulmonary Consolidation.
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Color doppler ultrasound of Pulmonary Consolidation
European Journal of Ultrasound, 1996Co-Authors: Pan-chyr YangAbstract:Abstract Color Doppler ultrasound (US) is a very powerful imaging tool that can simultaneously display blood flow information and Doppler spectral analysis. This imaging modality, for the first time, provides an opporturnity to assess Pulmonary blood flow and perfusion noninvasively. Color Doppler US has many potential applications in diseases of the chest. Color Doppler imaging is useful in assisting the diagnosis of Pulmonary arterio-venous malformation and Pulmonary sequestration. The ‘fluid color sign’ can be used to detect minimal effusion amenable to thoracentesis. Color Doppler US can be utilized to assess the angiogenesis of a lung tumor and is helpful in differentiating a malignant tumor from a benign one. Color Doppler US can be used to guide a transthoracic needle biopsy and improve the safety of this invasive procedure. Color Doppler US can demonstrate the vascular patterns and assess the regional hemodynamic changes of a Pulmonary Consolidation. The information of spectral wave analysis is helpful for understanding the underlying etiology of a Pulmonary Consolidation. Color Doppler US is useful in assessing the perfusion and reperfusion status of a Pulmonary infarction. There are still other potential applications of this new technique in chest diseases that may need further exploration.
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Ultrasound guided percutaneous cutting biopsy for the diagnosis of Pulmonary Consolidations of unknown aetiology.
Thorax, 1992Co-Authors: Pan-chyr Yang, Sow-hsong Kuo, Dun-bing Chang, Yung-chie Lee, Kwen-tay LuhAbstract:BACKGROUND: Ultrasound has been used to guide percutaneous aspiration biopsy of thoracic tumours with high diagnostic yield. This study assessed the diagnostic value of ultrasound guided percutaneous cutting biopsy for Pulmonary Consolidation of unknown aetiology. METHODS: Thirty patients with undiagnosed lobar or segmental Consolidation underwent ultrasound guided percutaneous needle aspiration and large bore cutting biopsy. The needle aspirates and biopsy specimens were sent for cytological, microbiological, and histopathological examination. RESULTS: Percutaneous needle aspiration provided a diagnosis in nine of 30 patients (30%), whereas cutting biopsy obtained a satisfactory specimen for histological diagnosis in 28 patients (93%) and provided a definite aetiological diagnosis in 17 patients (57%). The combination of needle aspiration with Trucut biopsy provided a diagnostic rate of 63%. The underlying diagnoses were fungal pneumonia (five patients), tuberculosis (five), bacterial pneumonia (one), bronchioloalveolar carcinoma (three), lymphoma (two), adenocarcinoma (one), vasculitis (one), acute pneumonia of unknown aetiology (one), and chronic non-specific pneumonia (nine). Two patients, who had necrotic tissue only in the biopsy specimen, were found at thoracotomy to have an adenocarcinoma and aspergillosis. Two patients had complications from the technique, a small pneumothorax in one and a small haemoptysis in another. CONCLUSIONS: Ultrasound guided percutaneous cutting biopsy is a valuable method for diagnosing Pulmonary Consolidation of unknown aetiology. The diagnostic yield is high and the procedure appears to be relatively safe.
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Ultrasonographic evaluation of Pulmonary Consolidation.
The American review of respiratory disease, 1992Co-Authors: Pan-chyr Yang, Kwen-tay Luh, Dun-bing Chang, Sow-hsong KuoAbstract:A total of 161 patients with lobar or segmental Consolidation were examined by realtime ultrasound and Doppler ultrasound. Air bronchograms were detected in 141 patients, fluid bronchograms in 27 patients, and parapneumonic effusion in 74 patients. In 36 patients with necrotizing pneumonia, ultrasound detected microabscesses in 33 (91.7%) compared with the air-fluid levels detected by standard chest radiographs in 20 patients (55.6%; p < 0.05). Of 31 patients with tumors causing obstructive pneumonitis, 29 (93.5%) had tumors detected by chest ultrasound, whereas only 11 patients (35.5%) had chest radiographs that suggested a tumor was causing the obstructive pneumonitis (p < 0.05). Chest ultrasound was used to guide thoracentesis for parapneumonic effusion in 65 patients, with a 100% success rate. Twenty-six patients with necrotizing pneumonia underwent ultrasound-guided needle aspiration of microabscesses. The procedure was successful in 24 patients (92.3%), and 21 patients (80.8%) had microbiologic conf...
Joaquim Segales - One of the best experts on this subject based on the ideXlab platform.
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serum acute phase proteins as biomarkers of pleuritis and cranio ventral Pulmonary Consolidation in slaughter aged pigs
Research in Veterinary Science, 2011Co-Authors: Yolanda Saco, Lorenzo Fraile, R Lopezjimenez, Joaquim Segales, Mercè Giménez, Ana Alegre, Martí Cortey, Anna BassolsAbstract:The purpose of this study was to investigate the relationship between the existence of lung lesions in pigs at slaughter and the concentration of the serum acute phase proteins (APP), haptoglobin (Hp), pig-major acute protein (Pig-MAP) and C-reactive protein (CRP). A total of 24 pig farms were selected out of a larger farm database previously screened to study risk factors associated with pleuritis and cranio-ventral Pulmonary Consolidation (CVPC) lesions at slaughter-aged pigs in Spain. The farms were classified as "pleuritis negative (P-) or positive (P+)" and as "CVPC negative (M-) or positive (M+)" and divided into four groups according to a 2X2 factorial design (P-M-, P-M+, P+M-, P+M+). Also at slaughter, blood from 20 randomly selected pigs from each farm was collected. Obtained serum samples were used to measure acute phase proteins. All APP concentrations were significantly higher for M+ farms than for M- ones. However, only Hp and Pig-MAP showed significantly higher concentrations for P+ farms than for P- ones. Pig-MAP was the most sensitive biomarker since it was able to clearly discriminate between P-/P+ and M-/M+ groups (p<0.001 in both cases). Hp was an excellent marker for pleuritis and good for CVPC lesions. CRP was able to discriminate for CVPC lesions but not for pleuritis. The present results indicate that Pig-MAP and, possibly Hp, may be used as potential markers to characterise and discriminate respiratory lesions in swine herds at slaughter.
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Serum acute phase proteins as biomarkers of pleuritis and cranio-ventral Pulmonary Consolidation in slaughter-aged pigs.
Research in veterinary science, 2010Co-Authors: Yolanda Saco, Lorenzo Fraile, Joaquim Segales, R. López-jiménez, Mercè Giménez, Ana Alegre, Martí Cortey, Anna BassolsAbstract:The purpose of this study was to investigate the relationship between the existence of lung lesions in pigs at slaughter and the concentration of the serum acute phase proteins (APP), haptoglobin (Hp), pig-major acute protein (Pig-MAP) and C-reactive protein (CRP). A total of 24 pig farms were selected out of a larger farm database previously screened to study risk factors associated with pleuritis and cranio-ventral Pulmonary Consolidation (CVPC) lesions at slaughter-aged pigs in Spain. The farms were classified as "pleuritis negative (P-) or positive (P+)" and as "CVPC negative (M-) or positive (M+)" and divided into four groups according to a 2X2 factorial design (P-M-, P-M+, P+M-, P+M+). Also at slaughter, blood from 20 randomly selected pigs from each farm was collected. Obtained serum samples were used to measure acute phase proteins. All APP concentrations were significantly higher for M+ farms than for M- ones. However, only Hp and Pig-MAP showed significantly higher concentrations for P+ farms than for P- ones. Pig-MAP was the most sensitive biomarker since it was able to clearly discriminate between P-/P+ and M-/M+ groups (p
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risk factors associated with pleuritis and cranio ventral Pulmonary Consolidation in slaughter aged pigs
Veterinary Journal, 2010Co-Authors: Lorenzo Fraile, A Alegre, R Lopezjimenez, Miquel Nofrarias, Joaquim SegalesAbstract:Abstract Examination of lung lesions at the slaughterhouse is a useful tool to estimate the importance of respiratory disease at farm, regional or national level. The objective of the present work was to describe the prevalence of gross lung lesions at slaughter, with a special focus on pleuritis and cranio-ventral Pulmonary Consolidation, and to identify major risk factors for these lesions. Data from 107 farms involving approximately 11,000 pigs enabled gross lung lesions to be correlated with serology to different swine respiratory pathogens as well as with production system characteristics and vaccination schedules. Pleuritis and cranio-ventral Pulmonary Consolidation lesions were recorded in 26.8% and 55.7% of slaughter-aged pigs, respectively. Among lungs with pleuritis, 50.1% had lesions compatible with Actinobacillus pleuropneumoniae (App) infection. Antibodies to porcine reproductive and respiratory syndrome (PRRSV), three subtypes (H1N1, H1N2 and H3N2) of swine influenza virus (SIV), App and Mycoplasma hyopneumoniae (Mhyo) were highly prevalent (>82%) in most of the farms. In a multivariable analysis, it was estimated (R2 = 0.40) that the percentage of animals with pleuritis compatible with App infection depended on the existence of an all in-all out by room management system and App and PRRSV herd seroprevalence. Moreover, it was possible to foresee (R2 = 0.59) that cranio-ventral Pulmonary Consolidation lesions (EP-like lesions) were affected by the type of farm ventilation, the presence of respiratory symptoms during the fattening period and Mhyo and SIV H1N2 herd seroprevalence.
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Risk factors associated with pleuritis and cranio-ventral Pulmonary Consolidation in slaughter-aged pigs.
Veterinary journal (London England : 1997), 2009Co-Authors: Lorenzo Fraile, A Alegre, Miquel Nofrarias, R. López-jiménez, Joaquim SegalesAbstract:Abstract Examination of lung lesions at the slaughterhouse is a useful tool to estimate the importance of respiratory disease at farm, regional or national level. The objective of the present work was to describe the prevalence of gross lung lesions at slaughter, with a special focus on pleuritis and cranio-ventral Pulmonary Consolidation, and to identify major risk factors for these lesions. Data from 107 farms involving approximately 11,000 pigs enabled gross lung lesions to be correlated with serology to different swine respiratory pathogens as well as with production system characteristics and vaccination schedules. Pleuritis and cranio-ventral Pulmonary Consolidation lesions were recorded in 26.8% and 55.7% of slaughter-aged pigs, respectively. Among lungs with pleuritis, 50.1% had lesions compatible with Actinobacillus pleuropneumoniae (App) infection. Antibodies to porcine reproductive and respiratory syndrome (PRRSV), three subtypes (H1N1, H1N2 and H3N2) of swine influenza virus (SIV), App and Mycoplasma hyopneumoniae (Mhyo) were highly prevalent (>82%) in most of the farms. In a multivariable analysis, it was estimated (R2 = 0.40) that the percentage of animals with pleuritis compatible with App infection depended on the existence of an all in-all out by room management system and App and PRRSV herd seroprevalence. Moreover, it was possible to foresee (R2 = 0.59) that cranio-ventral Pulmonary Consolidation lesions (EP-like lesions) were affected by the type of farm ventilation, the presence of respiratory symptoms during the fattening period and Mhyo and SIV H1N2 herd seroprevalence.
Yolanda Saco - One of the best experts on this subject based on the ideXlab platform.
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serum acute phase proteins as biomarkers of pleuritis and cranio ventral Pulmonary Consolidation in slaughter aged pigs
Research in Veterinary Science, 2011Co-Authors: Yolanda Saco, Lorenzo Fraile, R Lopezjimenez, Joaquim Segales, Mercè Giménez, Ana Alegre, Martí Cortey, Anna BassolsAbstract:The purpose of this study was to investigate the relationship between the existence of lung lesions in pigs at slaughter and the concentration of the serum acute phase proteins (APP), haptoglobin (Hp), pig-major acute protein (Pig-MAP) and C-reactive protein (CRP). A total of 24 pig farms were selected out of a larger farm database previously screened to study risk factors associated with pleuritis and cranio-ventral Pulmonary Consolidation (CVPC) lesions at slaughter-aged pigs in Spain. The farms were classified as "pleuritis negative (P-) or positive (P+)" and as "CVPC negative (M-) or positive (M+)" and divided into four groups according to a 2X2 factorial design (P-M-, P-M+, P+M-, P+M+). Also at slaughter, blood from 20 randomly selected pigs from each farm was collected. Obtained serum samples were used to measure acute phase proteins. All APP concentrations were significantly higher for M+ farms than for M- ones. However, only Hp and Pig-MAP showed significantly higher concentrations for P+ farms than for P- ones. Pig-MAP was the most sensitive biomarker since it was able to clearly discriminate between P-/P+ and M-/M+ groups (p<0.001 in both cases). Hp was an excellent marker for pleuritis and good for CVPC lesions. CRP was able to discriminate for CVPC lesions but not for pleuritis. The present results indicate that Pig-MAP and, possibly Hp, may be used as potential markers to characterise and discriminate respiratory lesions in swine herds at slaughter.
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Serum acute phase proteins as biomarkers of pleuritis and cranio-ventral Pulmonary Consolidation in slaughter-aged pigs.
Research in veterinary science, 2010Co-Authors: Yolanda Saco, Lorenzo Fraile, Joaquim Segales, R. López-jiménez, Mercè Giménez, Ana Alegre, Martí Cortey, Anna BassolsAbstract:The purpose of this study was to investigate the relationship between the existence of lung lesions in pigs at slaughter and the concentration of the serum acute phase proteins (APP), haptoglobin (Hp), pig-major acute protein (Pig-MAP) and C-reactive protein (CRP). A total of 24 pig farms were selected out of a larger farm database previously screened to study risk factors associated with pleuritis and cranio-ventral Pulmonary Consolidation (CVPC) lesions at slaughter-aged pigs in Spain. The farms were classified as "pleuritis negative (P-) or positive (P+)" and as "CVPC negative (M-) or positive (M+)" and divided into four groups according to a 2X2 factorial design (P-M-, P-M+, P+M-, P+M+). Also at slaughter, blood from 20 randomly selected pigs from each farm was collected. Obtained serum samples were used to measure acute phase proteins. All APP concentrations were significantly higher for M+ farms than for M- ones. However, only Hp and Pig-MAP showed significantly higher concentrations for P+ farms than for P- ones. Pig-MAP was the most sensitive biomarker since it was able to clearly discriminate between P-/P+ and M-/M+ groups (p
