The Experts below are selected from a list of 3051 Experts worldwide ranked by ideXlab platform
Amirhossein Sahebkar - One of the best experts on this subject based on the ideXlab platform.
-
Effect of Purslane on blood lipids and glucose: A systematic review and meta-analysis of randomized controlled trials.
Phytotherapy research : PTR, 2018Co-Authors: Amir Hadi, Makan Pourmasoumi, Ameneh Najafgholizadeh, Marziyeh Kafeshani, Amirhossein SahebkarAbstract:Despite a history of Purslane usage as a herbal treatment for dyslipidemia and hyperglycemia management, existing evidence from clinical trials is controversial. The aim for the current study was to evaluate the efficacy of Purslane supplementation on lipid parameters and glycemic status in adult populations. A systematic review was conducted in PubMed, Scopus, ISI Web of Science, and Google Scholar up to January 15, 2018, searching for randomized controlled trials that assessed the impact of Purslane on fasting blood glucose (FBG), triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Based on the detected heterogeneity between studies, a random- or fixed-effect model was applied in the meta-analysis. The findings from six randomized controlled trials, comprising 352 participants, indicated that Purslane can reduce FBG (-4.54 mg/dl, 95% CI [-7.54, -1.53]; I2 = 0.53%) and triglycerides (-19.16 mg/dl, 95% CI [-38.17, -0.15]; I2 = 0%) levels. Changes in TC, LDL-C, and HDL-C concentrations did not reach a statistically significant level. Subgroup analysis showed a favorable effects of Purslane on FBG, triglycerides, TC, and LDL-C in a subset of studies in which Purslane was administered >1.5 g/day. Categorization based on gender showed that Purslane was more effective in improving FBG, TC and LDL-C in females compared with males. This systematic review and meta-analysis suggested that the Purslane might be effective on the improvement of blood lipid and glucose levels. Further robust studies with sufficient durations and dosages of supplementation are needed to confirm these results.
-
The effect of Portulaca oleracea (Purslane) seeds on hemoglobin levels in adolescent girls with iron deficiency anemia: a randomized comparative trial
Comparative Clinical Pathology, 2017Co-Authors: Ali Mokhtarifar, Fatemeh Asadi Zeydabadi, Javad Asili, Mohammad Mahdi Kooshyar, Amirhossein SahebkarAbstract:Iron deficiency anemia (IDA) is the most severe and the latest stage of iron deficiency. Consumption of Purslane seeds is a traditional medicine approach for the treatment of anemia. We aimed to compare the effect of Purslane seeds and ferrous sulfate (FS) on the hemoglobin (Hb) level of adolescent girls suffering from IDA. In this single-blind randomized comparative clinical trial, the effect of Purslane seeds was compared with a FS tablet in 53 adolescent girls. Included subjects were within the age range of 15–18 years; with Hb levels of 10–12 g/dL and serum ferritin levels lower than 12 ng/L. The experimental group received 0.3 g/kg of Purslane seeds and control group received 3 mg/kg of elemental iron as a standard control per day for a period of 4 weeks. There were significant increases in hemoglobin (Hb), hematocrit (Hct), and mean corpuscular volume in both Purslane and FS groups; however, the mean elevation was significantly greater with the latter. FS also caused a significantly greater increase in red cell distribution width compared with Purslane. Purslane seed consumption increases Hb and Hct levels but is less effective than FS. Purslane seeds may be used for the prevention of IDA and treatment of its mild form.
Mohammad Ali Azarbayjani - One of the best experts on this subject based on the ideXlab platform.
-
Purslane portulaca oleracea seed consumption and aerobic training improves biomarkers associated with atherosclerosis in women with type 2 diabetes t2d
Scientific Reports, 2016Co-Authors: Firouzeh Dehghan, Sara Heidarzadeh, Parvin Farzanegi, Rahman Soori, Khadijeh Gholami, Mitra Abolmaesoomi, Ashril Yusof, Sekaran Muniandy, Mohammad Ali AzarbayjaniAbstract:The aim of this study was to investigate the responses of atherosclerosis plaque biomarkers to Purslane seed consumption and aerobic training in women with T2D. 196 women with T2D were assigned into; (1) placebo (PL), (2) aerobic training+placebo (AT + PL), 3) Purslane seeds (PS), aerobic training+Purslane seeds (AT + PS). The training program and Purslane seeds consumption (2.5 g lunch and 5 g dinner) were carried out for 16 weeks. The components of Purslane seed were identified and quantified by GC–MS. Blood samples were withdrawn via venipuncture to examine blood glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, triglycerides (TG), creatinine, urea, uric acid, NF-κB, GLP1, GLP1R, TIMP-1, MMP2, MMP9, CRP, CST3, and CTSS expressions. Blood glucose, LDL, cholesterol, TG, creatinine, urea, and uric acid levels in the (P), (AT), and (AT + PS) groups were significantly decreased compared to the pre-experimental levels or the placebo group, while HDL, significantly increased. Furthermore, the protein and mRNA levels of NF-κB, TIMP-1, MMP2 &9, CRP, CST3, and CTSS in the (P), (AT), (AT + PS) significantly decreased compared to pre-experimental or the placebo group, while level of GLP1 and GLP1-R increased drastically. Findings suggest that Purslane seed consumption alongside exercising could improve atherosclerosis plaque biomarkers through synergistically mechanisms in T2D.
-
Purslane Effect on GLP-1 and GLP-1 receptor in type 2 diabetes.
Electronic physician, 2013Co-Authors: Sara Heidarzadeh, Parvin Farzanegi, Mohammad Ali Azarbayjani, Roja DaliriAbstract:BACKGROUND The aim of this study was to examine the effect of Purslane seeds in glucagon-like peptide-1 concentration and glucagon-like peptide-1 receptor in women with diabetes. METHODS This was a quasi-experimental study. The population was consisted of the city of Sari where diabetic women with diabetes II who had no history of using Purslane seeds. All individuals used the same dose of metformin under the specialist supervision. Among these individuals, 16 were assigned at random to Purslane group and control group. The Purslane group consumed 2.5 grams Purslane with lunch and along with 5 grams of Purslane (Portulaca oleracea seeds 7.5 g daily) with dinner meals twice daily for 8 weeks. Blood sample was taken before and after 8 weeks, after 12 hours of fasting to 5 ml of the left brachial vein. RESULTS After 8 weeks using Purslane seeds in the experimental group, a significant increase was seen in glucagon-like peptide-1 concentrations (p
Amir Hadi - One of the best experts on this subject based on the ideXlab platform.
-
Effect of Purslane on blood lipids and glucose: A systematic review and meta-analysis of randomized controlled trials.
Phytotherapy research : PTR, 2018Co-Authors: Amir Hadi, Makan Pourmasoumi, Ameneh Najafgholizadeh, Marziyeh Kafeshani, Amirhossein SahebkarAbstract:Despite a history of Purslane usage as a herbal treatment for dyslipidemia and hyperglycemia management, existing evidence from clinical trials is controversial. The aim for the current study was to evaluate the efficacy of Purslane supplementation on lipid parameters and glycemic status in adult populations. A systematic review was conducted in PubMed, Scopus, ISI Web of Science, and Google Scholar up to January 15, 2018, searching for randomized controlled trials that assessed the impact of Purslane on fasting blood glucose (FBG), triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Based on the detected heterogeneity between studies, a random- or fixed-effect model was applied in the meta-analysis. The findings from six randomized controlled trials, comprising 352 participants, indicated that Purslane can reduce FBG (-4.54 mg/dl, 95% CI [-7.54, -1.53]; I2 = 0.53%) and triglycerides (-19.16 mg/dl, 95% CI [-38.17, -0.15]; I2 = 0%) levels. Changes in TC, LDL-C, and HDL-C concentrations did not reach a statistically significant level. Subgroup analysis showed a favorable effects of Purslane on FBG, triglycerides, TC, and LDL-C in a subset of studies in which Purslane was administered >1.5 g/day. Categorization based on gender showed that Purslane was more effective in improving FBG, TC and LDL-C in females compared with males. This systematic review and meta-analysis suggested that the Purslane might be effective on the improvement of blood lipid and glucose levels. Further robust studies with sufficient durations and dosages of supplementation are needed to confirm these results.
Chen Bin - One of the best experts on this subject based on the ideXlab platform.
-
Analysis of Water and Total Flavonoids Content in Purslane During Different Growth Stages
Journal of Food Science and Technology-mysore, 2013Co-Authors: Chen BinAbstract:By the pharmacopoeia method,the water and total flavonoids content of fresh Purslane at different growth stages were analyzed.Test results showed that the water content of Purslane grass,stems and leaves did not significantly decreased with the extension of growth stages.The total flavonoids content in Purslane grass,stems and leaves reduced gradually with the extension of growth stages.The total flavonoids content of Purslane leaves at the later growth stage was significantly higher than that in whole plant and stem.By the dynamic determination and distribution of the total flavonoids content at different growth stages,the appropriate harvest time of Purslane is the mid growth stage.
Zhulong Chan - One of the best experts on this subject based on the ideXlab platform.
-
physiological and metabolic changes of Purslane portulaca oleracea l in response to drought heat and combined stresses
Frontiers in Plant Science, 2016Co-Authors: Rui Jin, Yanping Wang, Ruijie Liu, Junbo Gou, Zhulong ChanAbstract:Purslane (Portulaca oleracea L.) is a fleshy herbaceous plant. So far, little information is available on the response of this plant to combined drought and heat stress. In this study, changes in physiological and metabolic levels were characterized after treatments with drought, heat and combined stresses. Both individual and combined stress treatments increased malondialdehyde (MDA), electrolyte leakage (EL), O2•− and activities of superoxide dismutase (SOD), peroxidase (POD), while declined chlorophyll content. No significant differences were found between control and treatments in leaf water content (LWC) and catalase (CAT) activity. Additionally, 37 metabolic compounds were detected in Purslane. Through pathway analysis, 17 metabolites were directly involved in the glycolysis metabolic pathway. The present study indicated that combined drought and heat stress caused more serious damage in Purslane than individual stress. To survive, Purslane has a high capability to cope with environmental stress conditions through activation of physiological and metabolic pathways.
