The Experts below are selected from a list of 786 Experts worldwide ranked by ideXlab platform
Tamio Hayashi - One of the best experts on this subject based on the ideXlab platform.
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rhodium catalyzed asymmetric hydroarylation of 3 Pyrrolines giving 3 arylpyrrolidines protonation as a key step
Journal of the American Chemical Society, 2013Co-Authors: Satoshi Kume, Tamio HayashiAbstract:A hydroxorhodium complex coordinated with (R)-segphos was found to catalyze the hydroarylation of 3-Pyrrolines with arylboroxines under neutral conditions to give 3-arylpyrrolidines with high enantioselectivity in high yields.
Ohyun Kwon - One of the best experts on this subject based on the ideXlab platform.
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hydroxyproline derived pseudoenantiomeric 2 2 1 bicyclic phosphines asymmetric synthesis of and Pyrrolines
ChemInform, 2015Co-Authors: Christopher E. Henry, Qihai Xu, Tioga J Martin, Lee Belding, Travis Dudding, Ohyun KwonAbstract:Two diastereoisomeric 2-aza-5-phosphabicyclo[2.2.1]heptanes (I) and (II) are prepared and used as catalysts for the synthesis of enantiomerically enriched Pyrrolines with opposite absolute configurations.
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Hydroxyproline-Derived Pseudoenantiomeric [2.2.1] Bicyclic Phosphines: Asymmetric Synthesis of (+)- and (−)-Pyrrolines
2015Co-Authors: Christopher E. Henry, Lee Belding, Travis Dudding, Yi Chiao Fan, Tioga J. Martin, Ohyun KwonAbstract:We have prepared two new diastereoisomeric 2-aza-5-phosphabicyclo[2.2.1]heptanes from naturally occurring trans-4-hydroxy-l-proline in six chemical operations. These syntheses are concise and highly efficient, with straightforward purification. When we used these chiral phosphines as catalysts for reactions of γ-substituted allenoates with imines, we obtained enantiomerically enriched Pyrrolines in good yields with excellent enantioselectivities. These two diastereoisomeric phosphines functioned as pseudoenantiomers, providing their chiral Pyrrolines with opposite absolute configurations
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hydroxyproline derived pseudoenantiomeric 2 2 1 bicyclic phosphines asymmetric synthesis of and Pyrrolines
Journal of the American Chemical Society, 2014Co-Authors: Christopher E. Henry, Tioga J Martin, Lee Belding, Travis Dudding, Yi Chiao Fan, Ohyun KwonAbstract:We have prepared two new diastereoisomeric 2-aza-5-phosphabicyclo[2.2.1]heptanes from naturally occurring trans-4-hydroxy-l-proline in six chemical operations. These syntheses are concise and highly efficient, with straightforward purification. When we used these chiral phosphines as catalysts for reactions of γ-substituted allenoates with imines, we obtained enantiomerically enriched Pyrrolines in good yields with excellent enantioselectivities. These two diastereoisomeric phosphines functioned as pseudoenantiomers, providing their chiral Pyrrolines with opposite absolute configurations.
Bram Denolf - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of 3-Aryl-3-Pyrrolines and 3-Arylpyrroles via Spontaneous Rearrangement of N-Sulfinyl 2-Aryl-2-vinylaziridines.
ChemInform, 2011Co-Authors: Erika Leemans, Filip Colpaert, Sven Mangelinckx, Stijn De Brabandere, Bram Denolf, Norbert De KimpeAbstract:The addition of vinylmagnesium bromide to ketimines (I) forms intermediate 2-aryl-2-vinylaziridines which spontaneously rearrange to 3-Pyrrolines (III).
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Synthesis of 3-Aryl-3-Pyrrolines and 3-Arylpyrroles via Spontaneous Rearrangement of N-Sulfinyl 2-Aryl-2-vinylaziridines
Synlett, 2011Co-Authors: Norbert De Kimpe, Erika Leemans, Filip Colpaert, Sven Mangelinckx, Stijn De Brabandere, Bram DenolfAbstract:Addition of vinylmagnesium bromide across chiral achloro N-tert-butanesulfinyl ketimines afforded 3-aryl-1-(tert-butanesulfinyl)-3-Pyrrolines in high yield (65–91%) after purification by means of recrystallization from diethyl ether. The synthesis of these 3-aryl-3-Pyrrolines is explained by initial formation of 2-aryl-2-vinylaziridines which spontaneously rearrange via carbon–nitrogen bond cleavage to form stabilized 1,3-dipolar intermediates which in turn ring closed to 3-Pyrrolines
Junliang Zhang - One of the best experts on this subject based on the ideXlab platform.
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Silver-catalysed tandem hydroamination and cyclization of 2-trifluoromethyl-1,3-enynes with primary amines: modular entry to 4-trifluoromethyl-3-Pyrrolines
Chemical Communications, 2017Co-Authors: Xiaofan Zhou, Chaoqian Huang, Yu Zeng, Jiarui Xiong, Yuanjing Xiao, Junliang ZhangAbstract:A highly efficient tandem hydroamination and cyclization reaction of 2-trifluoromethyl-1,3-enynes with primary amines leading to 4-trifluoromethyl-3-Pyrrolines was developed by using AgNO3 as a catalyst under mild reaction conditions. This new method is compatible with alkyl, aryl, and allyl primary amines, representing an atom-economical protocol for the construction of 4-trifluoromethyl-3-Pyrrolines for the first time.
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dbu catalyzed tandem additions of electron deficient 1 3 conjugated enynes with 2 aminomalonates a facile access to highly substituted 2 Pyrrolines
Chemical Communications, 2012Co-Authors: Guanghua Zhou, Junliang ZhangAbstract:An efficient, metal free approach to highly substituted 2-Pyrrolines by DBU-catalyzed tandem additions (a formal [3+2] cycloaddition) of electron-deficient 1,3-conjugated enynes and 2-aminomalonates under mild conditions was developed.
Haibin Song - One of the best experts on this subject based on the ideXlab platform.
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phosphine catalyzed 4 1 annulation between α β unsaturated imines and allylic carbonates synthesis of 2 Pyrrolines
ChemInform, 2011Co-Authors: Junjun Tian, Rong Zhou, Haiyun Sun, Haibin SongAbstract:The title reaction provides a new, highly efficient, and diastereoselective approach to trans-substituted Pyrrolines of type (III) and fused Pyrrolines like (V).
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phosphine catalyzed 4 1 annulation between α β unsaturated imines and allylic carbonates synthesis of 2 Pyrrolines
Journal of Organic Chemistry, 2011Co-Authors: Junjun Tian, Rong Zhou, Haiyun Sun, Haibin SongAbstract:In this report, a phosphine-catalyzed [4 + 1] annulation between α,β-unsaturated imines and allylic carbonates is described. This reaction represents the first realization of catalytic [4 + 1] cyclization of 1,3-azadienes with in situ formed phosphorus ylides, which provides highly efficient and diastereoselective synthesis of 2-Pyrrolines.
