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John Gorcsan - One of the best experts on this subject based on the ideXlab platform.
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Abstract 13431: Global Longitudinal Strain Combined With Radial Strain Delay Before Cardiac Resynchronization Therapy is Associated With Long Term Survival
Circulation, 2014Co-Authors: Antonia Delgado-montero, Bhupendar Tayal, Keiko Ryo, Akiko Goda, David Schwartzman, Samir Saba, John GorcsanAbstract:Introduction: Identifying factors related to nonresponse in cardiac resynchronization therapy (CRT) remains clinically important. The interaction of factors of global longitudinal Strain (GLS), as an associated marker of scar burden, and Radial Strain delay, as a mechanical dyssynchony marker remains unclear. Hypothesis: Our aim was to test the hypothesis that GLS by speckle tracking echocardiography (STE) combined with positive Radial Strain delay have prognostic utility in CRT patients. Methods: We studied 128 heart failure patients with routine CRT indications according to current clinical guidelines (ischemic 68%, age 64.9 ± 11.7 years, QRS width 159.3 ± 29.5 ms, left ventricular (LV) ejection fraction (EF) 23.9 ± 5.4%). GLS was determined with speckle tracking as the average of the segmental values from routine 2D apical views. Baseline Radial Strain delay was assessed by speckle tracking Radial Strain with positive (+) pre-defined as anteroseptal to posterior wall delay ≥130 ms. Response was defined...
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Color-coded speckle tracking Radial Strain dyssynchrony analysis in a canine model of left bundle branch block and cardiac resynchronization therapy
Critical Care, 2008Co-Authors: Bouchra Lamia, John Gorcsan, Masaki Tanabe, Hyung Kook Kim, Michael R PinskyAbstract:Quantification of left ventricular (LV) dyssynchrony is important for heart failure patients with left bundle branch block to assess the effectiveness of cardiac resynchronization therapy (CRT). We tested the hypothesis that LV contraction dyssynchrony and the impact of CRT on restoration of efficient synchronous contraction could be quantified from discordant regional Radial Strain.
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Echocardiographic Speckle Tracking Radial Strain Imaging to Assess Ventricular Dyssynchrony in a Pacing Model of Resynchronization Therapy
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2008Co-Authors: Masaki Tanabe, Michael R Pinsky, David Schwartzman, Hidekazu Tanaka, Bouchra Lamia, John GorcsanAbstract:Background Speckle tracking imaging is a promising new echocardiographic method to assess left ventricular (LV) mechanical dyssynchrony. Our aim was to assess a new speckle tracking regional Strain algorithm by comparison with angle-corrected tissue Doppler (TD) in an animal model of left bundle branch block and cardiac resynchronization therapy. Methods and Results Ten open-chest dogs had routine gray-scale and TD images of the mid-LV short-axis plane. Electrical activation was altered by pacing from right ventricular, LV free wall, and biventricular sites to create various degrees of mechanical dyssynchrony and alter regional function. Segmental time to peak Strain, peak Strain, and frame-by-frame Strain were measured by angle-corrected TD, TD M-mode, and speckle tracking on the same digital cineloop. Of 240 possible paired TD and speckle tracking segments, data were available for 222 segments (93%); images with catheter artifacts were prospectively excluded. Comparative overall time to peak Strain by each method correlated well: r = 0.96, bias=−6 ± 20 ms. Of 80 possible paired M-mode TD and speckle tracking segments, Strain data were available for 76 segments (95%). Comparative overall time to peak Strain, peak Strain, and frame-by-frame Strain analysis in 1012 frames by each method correlated well: r = 0.98, bias of 1 ± 14 ms; r = 0.82, bias of 3% ± 7%; and r = 0.91, bias of 0% ± 6%, respectively. Conclusion Regional Strain analysis using echocardiographic speckle tracking Radial Strain strongly correlated with Strain by angle-corrected TD imaging in an animal model of dyssynchrony. Speckle tracking Radial Strain has potential for clinical applications.
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speckle tracking Radial Strain reveals left ventricular dyssynchrony in patients with permanent right ventricular pacing
Journal of the American College of Cardiology, 2007Co-Authors: Laurens F Tops, John Gorcsan, Matthew S. Suffoletto, Gabe B Bleeker, Eric Boersma, Ernst E Van Der Wall, Martin J SchalijAbstract:Objectives Speckle-tracking Strain analysis was used to assess the effects of permanent right ventricular (RV) pacing on the heterogeneity in timing of regional wall Strain and left ventricular (LV) dyssynchrony. Background Recent studies have shown detrimental effects of RV pacing, possibly related to the induction of LV dyssynchrony. Methods Fifty-eight patients treated with His bundle ablation and pacemaker implantation were studied. To assess the effect of RV pacing on time-to-peak Radial Strain of different LV segments, we applied speckle-tracking analysis to standard LV short-axis images. In addition, New York Heart Association (NYHA) functional class, LV volumes, and systolic function were assessed at baseline and after long-term RV pacing. Results At baseline, similar time-to-peak Strain for the 6 segments was observed (mean 371 ± 114 ms). In contrast, after a mean of 3.8 ± 2.0 years of RV pacing, there was a marked heterogeneity in time-to-peak Strain of the 6 segments. In 33 patients (57%), LV dyssynchrony, represented by a time difference ≥130 ms between the time-to-peak Strain of the (antero)septal and the posterolateral segments, was present. In these patients, a deterioration of LV systolic function and NYHA functional class was observed. In 11 patients, an “upgrade” of the conventional pacemaker to a biventricular pacemaker resulted in partial reversal of the detrimental effects of RV pacing. Conclusions Speckle-tracking analysis revealed that permanent RV pacing induced heterogeneity in time-to-peak Strain, resulting in LV dyssynchrony in 57% of patients, associated with deterioration of LV systolic function and NYHA functional class. Biventricular pacing may reverse these adverse effects of RV pacing.
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effects of Radial left ventricular dyssynchrony on cardiac performance using quantitative tissue doppler Radial Strain imaging
Journal of The American Society of Echocardiography, 2006Co-Authors: Kaoru Dohi, Hideaki Kanzaki, Donald A Severyn, Michael R Pinsky, John GorcsanAbstract:Our objective was to test the hypothesis that novel angle-corrected Radial Strain imaging can quantify left ventricular dyssynchrony associated with contractile impairment and improved with biventricular pacing. Eight open-chest dogs were studied by novel angle-corrected color-coded Radial Strain imaging and high-fidelity pressure-conductance catheters recording pressure-volume loops. Heart rate was controlled by right atrial pacing and all timing intervals were corrected by R-R interval (corrected interval=measured interval/(R-R interval) 1/2 ). Left bundle branch block, simulated by right ventricular free wall pacing, resulted in marked Radial dyssynchrony, which we defined as maximal time difference between peak segmental Strain, from 39 ± 17 to 354 ± 49 milliseconds and stroke work decreased from 157 ± 40 to 60 ± 37 mJ, ( P P P r = −0.93 ± 0.05 individually, r = 0.80 overall) and stroke work ( r = −0.88 ± 0.12 individually, r = −0.82 overall). Angle-corrected Radial Strain imaging has clinical potential to quantify mechanical dyssynchrony and effects of biventricular pacing.
David P. Dutka - One of the best experts on this subject based on the ideXlab platform.
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Radial Strain delay based on segmental timing and Strain amplitude predicts left ventricular reverse remodeling and survival after cardiac resynchronization therapy
Circulation-cardiovascular Imaging, 2013Co-Authors: Anna C. Kydd, Fakhar Z. Khan, Peter J. Pugh, Munmohan Virdee, Denis Ohalloran, David P. DutkaAbstract:Background— Dyssynchrony assessment based on the timing of regional contraction is inherently independent of underlying myocardial contractility. We tested the hypothesis that patient selection for cardiac resynchronization therapy (CRT) would be enhanced using a parameter derived from the net Radial Strain delay (RSD) for the 12 basal and mid–left ventricular segments (calculated Radial Strain delay RSD [RSDc]), based on not only timing but also amplitude of segmental Strain. Methods and Results— Echocardiographic data were analyzed in 240 patients with symptomatic heart failure undergoing CRT (New York Heart Association class III/IV; QRS >120 milliseconds; ejection fraction, 23±7%). RSDc was calculated as the sum of difference between peak Radial Strain and Radial Strain at aortic valve closure before CRT implantation. CRT response was defined as >15% reduction in left ventricular end-systolic volume at 6 months. In a derivation group (n=102), RSDc was higher in responders compared with nonresponders (74±39% versus 29±15%; P 40% predicted remodeling (sensitivity, 87%; specificity, 88%). In the validation group (n=108), RSDc similarly predicted response (sensitivity, 89%; specificity, 84%). Survival at long-term follow-up was greater in patients with RSDc >40% ( P <0.0001). Conclusions— RSDc, based on both the timing and the amplitude of segmental Strain, has a strong predictive value for CRT remodeling response and long-term survival.
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Radial Strain delay based on segmental timing and Strain amplitude predicts left ventricular reverse remodeling and survival after cardiac resynchronization therapy.
Circulation. Cardiovascular imaging, 2013Co-Authors: Anna C. Kydd, Fakhar Z. Khan, Denis O’halloran, Peter J. Pugh, Munmohan Virdee, David P. DutkaAbstract:Background— Dyssynchrony assessment based on the timing of regional contraction is inherently independent of underlying myocardial contractility. We tested the hypothesis that patient selection for cardiac resynchronization therapy (CRT) would be enhanced using a parameter derived from the net Radial Strain delay (RSD) for the 12 basal and mid–left ventricular segments (calculated Radial Strain delay RSD [RSDc]), based on not only timing but also amplitude of segmental Strain. Methods and Results— Echocardiographic data were analyzed in 240 patients with symptomatic heart failure undergoing CRT (New York Heart Association class III/IV; QRS >120 milliseconds; ejection fraction, 23±7%). RSDc was calculated as the sum of difference between peak Radial Strain and Radial Strain at aortic valve closure before CRT implantation. CRT response was defined as >15% reduction in left ventricular end-systolic volume at 6 months. In a derivation group (n=102), RSDc was higher in responders compared with nonresponders (74±39% versus 29±15%; P 40% predicted remodeling (sensitivity, 87%; specificity, 88%). In the validation group (n=108), RSDc similarly predicted response (sensitivity, 89%; specificity, 84%). Survival at long-term follow-up was greater in patients with RSDc >40% ( P
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effect of low amplitude two dimensional Radial Strain at left ventricular pacing sites on response to cardiac resynchronization therapy
Journal of The American Society of Echocardiography, 2010Co-Authors: Fakhar Z. Khan, Peter J. Pugh, Munmohan Virdee, Philip A Read, Denis Ohalloran, Michael T Fahey, Maros Elsik, David Begley, Simon P Fynn, David P. DutkaAbstract:Background Left ventricular (LV) lead placement to areas of scar has detrimental effects on response to cardiac resynchronization therapy (CRT). Speckle-tracking Radial two-dimensional Strain offers assessment of the extent of regional myocardial deformation. The aim of this study was to assess the impact of LV lead placement at areas of low-amplitude Strain on CRT response. Methods The optimal cutoff of Radial Strain amplitude at the LV pacing site associated with an unfavorable CRT response was determined in a derivation group ( n = 65) and then tested in a second consecutive validation group ( n = 75) of patients with heart failure. Patients had concordant LV leads if placed at the most delayed site, and dyssynchrony was defined as anteroseptal to posterior delay ≥ 130 msec. CRT response was defined as a ≥15% reduction in LV end-systolic volume at 6 months. Results In the derivation group, a derived cutoff for Radial Strain amplitude of n = 16), CRT response was significantly lower (62.7% vs 31.3%, P Conclusion LV lead placement over segments with two-dimensional Radial Strain amplitudes
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086 Going beyond segmental timing alone to predict response to cardiac resynchronisation therapy: evaluation of a novel Radial Strain dyssynchrony index
Heart, 2010Co-Authors: Fakhar Z. Khan, Peter J. Pugh, Munmohan Virdee, Philip A Read, David Begley, Simon P Fynn, D O'halloran, David P. DutkaAbstract:Introduction In selecting patients that may benefit from cardiac resynchronisation therapy (CRT), dyssynchrony assessment by echocardiography based only upon the timing of regional contraction is limited by being inherently independent of underlying myocardial contractility. We hypothesised that patient selection may be enhanced using a Strain-based parameter based not only the timing of myocardial segmental motion, but also on the amplitude of contraction, a potential measure of contractile reserve. We assessed a combined early and late Strain index (ELSI) to predict CRT response. Methods Speckle tracking Radial Strain was performed in 67 heart failure patients scheduled for CRT (age 69±9 years, ischaemic 56%, QRS 154±12 ms, NYHA III/IV—63/4, ejection fraction 23±7%). The ELSI was calculated as the sum for each of the 12 non apical segments of the difference in peak Radial Strain and Strain at aortic valve closure. CRT response was defined as a >15% reduction from baseline in LV end systolic volume (LVESV) at 6 months. The predictive value of the ELSI was compared to previously reported dyssynchrony measures including the SD of time to peak myocardial longitudinal velocity of the 12 non apical segments (Ts SD12), the anteroseptal–posterior wall Radial Strain delay (AS-P delay) and the SD of time to peak Radial Strain of 12 segments (Rs-SD12). Results Response to CRT occurred in 38/67 (57%) patients. Significant differences were seen between responders and non responders in the ELSI (91±45 vs 27±14%, p Conclusion A combined early and late Strain parameter based on both the timing and amplitude of segmental Strain has a stronger predictive value in determining CRT response compared to widely reported dyssynchrony parameters based on segmental timing alone.
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Abstract 3788: Effect of Low Amplitude 2D Radial Strain at Left Ventricular Pacing Sites on Response to Cardiac Resynchronization Therapy
Circulation, 2009Co-Authors: Fakhar Z. Khan, Munmohan Virdee, Philip A Read, Simon P Fynn, David P. DutkaAbstract:Introduction Left ventricular (LV) lead placement to areas of scar has detrimental effects on response to resynchronization therapy (CRT). Speckle tracking 2D Radial Strain offers assessment not on...
Martin J Schalij - One of the best experts on this subject based on the ideXlab platform.
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assessment of left ventricular dyssynchrony by speckle tracking Strain imaging comparison between longitudinal circumferential and Radial Strain in cardiac resynchronization therapy
Journal of the American College of Cardiology, 2008Co-Authors: Victoria Delgado, Nina Ajmone Marsan, Claudia Ypenburg, Rutger J Van Bommel, Laurens F Tops, Sjoerd A Mollema, Gabe B Bleeker, Martin J Schalij, Jeroen J BaxAbstract:Objectives The objective of this study was to assess the usefulness of each type of Strain for left ventricular (LV) dyssynchrony assessment and its predictive value for a positive response after cardiac resynchronization therapy (CRT). Furthermore, changes in extent of LV dyssynchrony for each type of Strain were evaluated during follow-up. Background Different echocardiographic techniques have been proposed for assessment of LV dyssynchrony. The novel 2-dimensional (2D) speckle tracking Strain analysis technique can provide information on Radial Strain (RS), circumferential Strain (CS), and longitudinal Strain (LS). Methods In 161 patients, 2D echocardiography was performed at baseline and after 6 months of CRT. Extent of LV dyssynchrony was calculated for each type of Strain. Response to CRT was defined as a decrease in LV end-systolic volume ≥15% at follow-up. Results At follow-up, 88 patients (55%) were classified as responders. Differences in baseline LV dyssynchrony between responders and nonresponders were noted only for RS (251 ± 138 ms vs. 94 ± 65 ms; p Conclusions Speckle tracking Radial Strain analysis constitutes the best method to identify potential responders to CRT. Reduction in LV dyssynchrony after CRT was only noted in responders.
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assessment of left ventricular dyssynchrony by speckle tracking Strain imaging comparison between longitudinal circumferential and Radial Strain in cardiac resynchronization therapy
Journal of the American College of Cardiology, 2008Co-Authors: Victoria Delgado, Nina Ajmone Marsan, Claudia Ypenburg, Laurens F Tops, Sjoerd A Mollema, Gabe B Bleeker, Rutger J Van Bommel, Martin J SchalijAbstract:OBJECTIVES: The objective of this study was to assess the usefulness of each type of Strain for left ventricular (LV) dyssynchrony assessment and its predictive value for a positive response after cardiac resynchronization therapy (CRT). Furthermore, changes in extent of LV dyssynchrony for each type of Strain were evaluated during follow-up. BACKGROUND: Different echocardiographic techniques have been proposed for assessment of LV dyssynchrony. The novel 2-dimensional (2D) speckle tracking Strain analysis technique can provide information on Radial Strain (RS), circumferential Strain (CS), and longitudinal Strain (LS). METHODS: In 161 patients, 2D echocardiography was performed at baseline and after 6 months of CRT. Extent of LV dyssynchrony was calculated for each type of Strain. Response to CRT was defined as a decrease in LV end-systolic volume >/=15% at follow-up. RESULTS: At follow-up, 88 patients (55%) were classified as responders. Differences in baseline LV dyssynchrony between responders and nonresponders were noted only for RS (251 +/- 138 ms vs. 94 +/- 65 ms; p /=130 ms was able to predict response to CRT with a sensitivity of 83% and a specificity of 80%. In addition, a significant decrease in extent of LV dyssynchrony measured with RS (from 251 +/- 138 ms to 98 +/- 92 ms; p < 0.001) was demonstrated only in responders. CONCLUSIONS: Speckle tracking Radial Strain analysis constitutes the best method to identify potential responders to CRT. Reduction in LV dyssynchrony after CRT was only noted in responders.
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Abstract 2816: Assessment Of Left Ventricular Mechanical Dyssynchrony With Radial Strain By Speckle-tracking Best Predicts Response To Cardiac Resynchronization Therapy
Circulation, 2007Co-Authors: Victoria Delgado, Nina Ajmone Marsan, Claudia Ypenburg, Laurens F Tops, Sjoerd A Mollema, Martin J Schalij, Ernst E. Van Der Wall, Jeroen J BaxAbstract:Background: Recently, 2-dimensional Strain by speckle tracking imaging has emerged as a new technology for assessment of myocardial deformation in three dimensions: Radial, circumferential and longitudinal. The current study evaluates which type of deformation study can best identify left ventricular mechanical dyssynchrony (LVMD) and predicts response to cardiac resynchronization therapy (CRT). Methods: One-hundred fifty-two consecutive patients underwent echocardiographic study before implantation of the CRT device and at 6 months follow-up. Radial (RS) and circumferential (CS) Strains were applied to midventricular short axis views; difference in time to peak systolic Strain value between anteroseptal-to-posterior walls was used to study LVMD. Longitudinal Strain (LS) was applied to apical 4-chamber views and LVMD was calculated as the difference between basal septum-to-basal lateral walls. Patients with a decrease of LV end-systolic volume ≥15% at 6 months follow-up were considered responders. Results: After 6 months of CRT, 85 pts (56%) showed response to CRT. Compared to non-responders, responders had significant more LVMD when it was assessed by RS (212±146 ms vs. 127±108 ms; p Conclusions: Radial Strain by speckle-tracking imaging is a useful tool to assess LVMD and best predicts echocardiographic response to CRT.
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speckle tracking Radial Strain reveals left ventricular dyssynchrony in patients with permanent right ventricular pacing
Journal of the American College of Cardiology, 2007Co-Authors: Laurens F Tops, John Gorcsan, Matthew S. Suffoletto, Gabe B Bleeker, Eric Boersma, Ernst E Van Der Wall, Martin J SchalijAbstract:Objectives Speckle-tracking Strain analysis was used to assess the effects of permanent right ventricular (RV) pacing on the heterogeneity in timing of regional wall Strain and left ventricular (LV) dyssynchrony. Background Recent studies have shown detrimental effects of RV pacing, possibly related to the induction of LV dyssynchrony. Methods Fifty-eight patients treated with His bundle ablation and pacemaker implantation were studied. To assess the effect of RV pacing on time-to-peak Radial Strain of different LV segments, we applied speckle-tracking analysis to standard LV short-axis images. In addition, New York Heart Association (NYHA) functional class, LV volumes, and systolic function were assessed at baseline and after long-term RV pacing. Results At baseline, similar time-to-peak Strain for the 6 segments was observed (mean 371 ± 114 ms). In contrast, after a mean of 3.8 ± 2.0 years of RV pacing, there was a marked heterogeneity in time-to-peak Strain of the 6 segments. In 33 patients (57%), LV dyssynchrony, represented by a time difference ≥130 ms between the time-to-peak Strain of the (antero)septal and the posterolateral segments, was present. In these patients, a deterioration of LV systolic function and NYHA functional class was observed. In 11 patients, an “upgrade” of the conventional pacemaker to a biventricular pacemaker resulted in partial reversal of the detrimental effects of RV pacing. Conclusions Speckle-tracking analysis revealed that permanent RV pacing induced heterogeneity in time-to-peak Strain, resulting in LV dyssynchrony in 57% of patients, associated with deterioration of LV systolic function and NYHA functional class. Biventricular pacing may reverse these adverse effects of RV pacing.
Genjiro Kimura - One of the best experts on this subject based on the ideXlab platform.
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myocardial Radial Strain in early diastole is useful for assessing left ventricular early diastolic function comparison with invasive parameters
Journal of The American Society of Echocardiography, 2008Co-Authors: Kazuaki Wakami, Nobuyuki Ohte, Seiichiro Sakata, Genjiro KimuraAbstract:BACKGROUND: Peak myocardial systolic Strain determined using myocardial Strain imaging is a useful index of left ventricular (LV) myocardial systolic function. We investigated the relationship between peak myocardial Radial Strain during early diastole and LV early diastolic function. METHODS: A total of 85 patients without localized LV wall-motion abnormality underwent myocardial Strain imaging and diagnostic cardiac catheterization. Peak myocardial Radial Strain during early diastole was obtained at the LV posterior-sided wall in the short-axis image. Invasive parameters of LV function were determined during cardiac catheterization. RESULTS: Peak myocardial Radial Strain during early diastole significantly correlated with both the time constant tau (r = 0.80, P < .0001) and the peak negative dP/dt (r = -0.64, P < .0001). Although it correlated with the LV ejection fraction, LV end-diastolic pressure, LV end-systolic volume index, and mean pulmonary capillary wedge pressure, the time constant tau was the prime determinant of peak myocardial Radial Strain during early diastole. CONCLUSION: Peak myocardial Radial Strain during early diastole could be used to evaluate LV early diastolic function. Myocardial Strain imaging is a promising noninvasive tool for assessing LV function in systole and early diastole.
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Myocardial Radial Strain in Early Diastole is Useful for Assessing Left Ventricular Early Diastolic Function: Comparison with Invasive Parameters
Journal of The American Society of Echocardiography, 2007Co-Authors: Kazuaki Wakami, Nobuyuki Ohte, Seiichiro Sakata, Genjiro KimuraAbstract:Background Peak myocardial systolic Strain determined using myocardial Strain imaging is a useful index of left ventricular (LV) myocardial systolic function. We investigated the relationship between peak myocardial Radial Strain during early diastole and LV early diastolic function. Methods A total of 85 patients without localized LV wall-motion abnormality underwent myocardial Strain imaging and diagnostic cardiac catheterization. Peak myocardial Radial Strain during early diastole was obtained at the LV posterior-sided wall in the short-axis image. Invasive parameters of LV function were determined during cardiac catheterization. Results Peak myocardial Radial Strain during early diastole significantly correlated with both the time constant τ ( r = 0.80, P r = −0.64, P Conclusion Peak myocardial Radial Strain during early diastole could be used to evaluate LV early diastolic function. Myocardial Strain imaging is a promising noninvasive tool for assessing LV function in systole and early diastole.
Joao A C Lima - One of the best experts on this subject based on the ideXlab platform.
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usefulness of Radial Strain mapping by multidetector computer tomography to quantify regional myocardial function in patients with healed myocardial infarction
American Journal of Cardiology, 2010Co-Authors: Veronica Fernandes, Boaz D Rosen, Thomas M Hellevalle, Joao A C LimaAbstract:We introduce and evaluate Strain mapping by multidetector computer tomography as a new noninvasive method for assessment of myocardial function. In patients (n = 16) with healed myocardial infarction, peak systolic Radial Strain was measured by automated pixel pattern matching analysis of multiple left ventricular 64-slice multidetector computer tomographic short-axis recordings. For comparison, Radial Strain and myocardial infarct extent were measured by tagged magnetic resonance imaging (MRI) and late enhancement MRI, respectively. In a linear mixed model analysis, myocardial infarct extent was a strong predictor of segmental Strain by multidetector computer tomography (beta = −0.44, p 50%) segments (p
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abstract 697 new simplified method for detailed quantification of regional myocardial function from untagged mri cine recordings Radial Strain mapping by multimodality tissue tracking mtt
Circulation, 2009Co-Authors: Thomas Hellevalle, Alban Redheuil, Veronica Fernandes, Boaz D Rosen, Joao A C LimaAbstract:Background: Assessment of regional myocardial function is clinically important. Circumferential Strain analysis by tagged MRI is considered the reference method, despite its complexity. We introduce Radial Strain mapping by multimodality tissue tracking (MTT) of untagged MRI cines as a new simplified method for detailed quantification of regional LV function. To validate our approach Radial Strain was compared to measures of circumferential Strain by tagged MRI and to infarct transmurality by contrast MRI. Methods: In patients revascularized after myocardial infarction (n=20) and in healthy subjects (n=8), Radial Strain was quantified in 12 LV midventricular segments by MTT from untagged MRI short-axis recordings (Figure 1[⇓][1]). MTT is a pixel-based pattern matching technique that allows automated tracking of endo- and epicardial border features. Circumferential Strain and infarct transmurality was quantified by tagged- and contrast MRI, respectively. Results: Mean Radial Strain was significantly lower in patients compared to healthy subjects (10.6±10.3 vs. 33.5±12.8%, P<0.0001, respectively). In a linear mixed model analysis, myocardial infarct extent was a strong predictor of Radial Strain ( β = 0.13, P<0.00001). Radial Strain could differentiate between remote, non-infarcted and infarcted border zone, and infarct centre segments (P<0.001). In a 6-segment analysis, there was an inverse relationship between circumferential Strain by tagged- and Radial Strain by untagged MRI (r=0.70, P<0.0001; Figure 1[⇓][1]). Conclusion: We have demonstrated that Radial Strain mapping of untagged MRI by MTT is a simple new clinical method for detailed quantification of LV function. ![][2] FIGURE 1 [1]: #graphic-1 [2]: /embed/graphic-1.gif
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Abstract 697: New Simplified Method for Detailed Quantification of Regional Myocardial Function From Untagged MRI Cine Recordings: Radial Strain Mapping by Multimodality Tissue Tracking (MTT)
Circulation, 2009Co-Authors: Thomas Helle-valle, Alban Redheuil, Veronica Fernandes, Boaz D Rosen, Joao A C LimaAbstract:Background: Assessment of regional myocardial function is clinically important. Circumferential Strain analysis by tagged MRI is considered the reference method, despite its complexity. We introduce Radial Strain mapping by multimodality tissue tracking (MTT) of untagged MRI cines as a new simplified method for detailed quantification of regional LV function. To validate our approach Radial Strain was compared to measures of circumferential Strain by tagged MRI and to infarct transmurality by contrast MRI. Methods: In patients revascularized after myocardial infarction (n=20) and in healthy subjects (n=8), Radial Strain was quantified in 12 LV midventricular segments by MTT from untagged MRI short-axis recordings (Figure 1[⇓][1]). MTT is a pixel-based pattern matching technique that allows automated tracking of endo- and epicardial border features. Circumferential Strain and infarct transmurality was quantified by tagged- and contrast MRI, respectively. Results: Mean Radial Strain was significantly lower in patients compared to healthy subjects (10.6±10.3 vs. 33.5±12.8%, P
