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Andrew C. Papanicolaou - One of the best experts on this subject based on the ideXlab platform.
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Assessment of hemispheric dominance for Receptive Language in pediatric patients under sedation using magnetoencephalography.
Frontiers in Human Neuroscience, 2014Co-Authors: Roozbeh Rezaie, Shalini Narayana, Katherine Schiller, Liliya Birg, James W. Wheless, Frederick A. Boop, Andrew C. PapanicolaouAbstract:Non-invasive assessment of hemispheric dominance for Receptive Language using Magnetoencephalography (MEG) is now a well-established procedure used across several epilepsy centers in the context of pre-surgical evaluation of children and adults while awake, alert and attentive. However, the utility of MEG for the same purpose, in cases of sedated patients, is contested. Establishment of the efficiency of MEG is especially important in the case of children who, for a number of reasons, must be assessed under sedation. Here we explored the efficacy of MEG Language mapping under sedation through retrospective review of 95 consecutive pediatric patients, who underwent our Receptive Language test as part of routine clinical evaluation. Localization of Receptive Language cortex and subsequent determination of laterality was successfully completed in 78% (n=36) and 55% (n=27) of non-sedated and sedated patients, respectively. Moreover, the proportion of patients deemed left hemisphere dominant for Receptive Language did not differ between non-sedated and sedated patients, exceeding 90% in both groups. Considering the challenges associated with assessing brain function in pediatric patients, the success of passive MEG in the context of the cases reviewed in this study support the utility of this method in pre-surgical Receptive Language mapping.
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Evidence for the solidarity of the expressive and Receptive Language systems: a retrospective study.
Journal of the International Neuropsychological Society, 2010Co-Authors: Dana C. Moser, Andrew C. Papanicolaou, Paul R. Swank, Joshua I. BreierAbstract:A strong tendency toward left hemisphere (LH) Language dominance has been well established, as evidenced by the high prevalence of Language impairment following sudden onset lesions in the LH. In the presence of progressive LH pathology, such as epilepsy, substantial deviations in Language organization can occur. However, the question regarding whether reorganization involves both expressive and Receptive Language functions or only the one directly affected by the primary location of pathology has not been settled. Using Wada testing scores from 296 epilepsy patients and estimated rates of typical dominance in the normal population, we assessed the frequency with which left frontal and temporal pathology resulted in reorganization of only the expressive or Receptive Language function or both. The comparisons revealed: (1) a significantly higher prevalence of atypical organization (i.e., deviations from LH dominance) among the LH patients compared to normal population estimates and right hemisphere patients, and (2) that regardless of pathology location within the LH, the rates of atypical reorganization for both expressive and Receptive Language were essentially equal. These results constitute evidence that the two Language functions are intimately yoked and that when disruption to the system results in reorganization, it usually yields functional changes throughout the system. ( JINS , 2010, 17 , 000–000)
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A comparison of functional MRI and magnetoencephalography for Receptive Language mapping
Journal of Neuroscience Methods, 2007Co-Authors: Rebecca Billingsley-marshall, Panagiotis G. Simos, Eduardo M. Castillo, Shirin Sarkari, Trustin Clear, Paul R. Swank, W. Einar Mencl, Disheng Men, Andrew C. PapanicolaouAbstract:We compared functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) for the mapping of Receptive Language function. Participants performed the same Language task in the two different imaging environments. MEG activation profiles showed prominent bilateral activity in superior temporal gyrus and left-lateralized activity in middle temporal gyrus. fMRI activation profiles revealed bilateral activity in prefrontal, superior temporal, middle temporal, and visual areas. Laterality quotients derived from the two modalities showed poor agreement between the two methods for commonly active regions of interest. Locations of peak activity also varied considerably within participants between the two methods.
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Organization of Receptive Language-specific cortex before and after left temporal lobectomy.
Neurology, 2005Co-Authors: Ekaterina Pataraia, Panagiotis G. Simos, Joshua I. Breier, Rebecca Billingsley-marshall, E. M. Castillo, Shirin Sarkari, Michele E. Fitzgerald, Trustin Clear, Andrew C. PapanicolaouAbstract:Objective: To examine brain activation associated with Receptive Language in patients with left temporal lobe epilepsy (TLE) before and after an anterior temporal lobectomy using magnetoencephalography (MEG), and to evaluate which patients were most likely to show a change in the lateralization and localization of the mechanisms supporting Receptive Language and if such changes were associated with neuropsychological function. Methods: Twelve patients with left TLE underwent preoperative Wada testing, and pre- and postoperative neuropsychological testing and MEG Language mapping. The anatomic location of Receptive Language-related activity sources observed with MEG was determined by coregistering MEG data with structural MRI scans. Language laterality indices were calculated based on the number of reproducible activity sources in each hemisphere. The proximity of Language-specific activity sources to Wernicke9s area was also examined. Results: Although the small sample size precluded formal statistical analyses, patients with atypical (bilateral) hemispheric dominance preoperatively were more likely than patients with typical (left-hemisphere) dominance to show evidence of increased right hemisphere participation in Language functions after surgery. Patients with left hemispheric dominance preoperatively were more likely to show intrahemispheric changes involving a slight inferior shift of the putative location of Wernicke9s area. Patients with bilateral representation tended to perform worse on neuropsychological test measures obtained both pre- and postoperatively. Conclusion: Interhemispheric functional reorganization of Language-specific areas may occur in patients undergoing left anterior temporal lobectomy. Intrahemispheric reorganization may take place even when the resection does not directly impinge upon Wernicke9s area.
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cortical organization for Receptive Language functions in chinese english and spanish a cross linguistic meg study
Neuropsychologia, 2004Co-Authors: Panagiotis G. Simos, Fernando Maestú, C E Valaki, Wenbo Zhang, Alberto Fernandez, Carlos Amo, Tomas Ortiz, Andrew C. PapanicolaouAbstract:Chinese differs from Indo-European Languages in both its written and spoken forms. Being a tonal Language, tones convey lexically meaningful information. The current study examines patterns of neurophysiological activity in temporal and temporoparietal brain areas as speakers of two Indo-European Languages (Spanish and English) and speakers of Mandarin-Chinese were engaged in a spoken-word recognition task that is used clinically for the presurgical determination of hemispheric dominace for Receptive Language functions. Brain magnetic activation profiles were obtained from 92 healthy adult volunteers: 30 monolingual native speakers of Mandarin-Chinese, 20 Spanish-speaking, and 42 native speakers of American English. Activation scans were acquired in two different whole-head MEG systems using identical testing methods. Results indicate that (a) the degree of hemispheric asymmetry in the duration of neurophysiological activity in temporal and temporoparietal regions was reduced in the Chinese group, (b) the proportion of individuals who showed bilaterally symmetric activation was significantly higher in this group, and (c) group differences in functional hemispheric asymmetry were first noted after the initial sensory processing of the word stimuli. Furthermore, group differences in the degree of hemispheric asymmetry were primarily due to greater degree of activation in the right temporoparietal region in the Chinese group, suggesting increased participation of this region in the spoken word recognition in Mandarin-Chinese.
Stephen W Porges - One of the best experts on this subject based on the ideXlab platform.
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respiratory sinus arrhythmia a marker for positive social functioning and Receptive Language skills in children with autism spectrum disorders
Developmental Psychobiology, 2013Co-Authors: Michelle A Patriquin, Angela Scarpa, Bruce H Friedman, Stephen W PorgesAbstract:The current study builds on the emerging autism spectrum disorder (ASD) literature that associates autonomic nervous system activity with social function, and examines the link between respiratory sinus arrhythmia (RSA) and both social behavior and cognitive function. The RSA response pattern was assessed in 23 4- to 7-year-old children diagnosed with an ASD. Higher baseline RSA amplitudes were associated with better social behavior (i.e., more conventional gestures, more instances of joint attention) and Receptive Language abilities. Similar to reports of typically developing children, ASD children with higher RSA amplitude at baseline showed greater RSA and HP reactivity during an attention-demanding task. These results highlight the importance of studying RSA as a marker of positive function in children with ASD.
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respiratory sinus arrhythmia a marker for positive social functioning and Receptive Language skills in children with autism spectrum disorders
Developmental Psychobiology, 2013Co-Authors: Michelle A Patriquin, Angela Scarpa, Bruce H Friedman, Stephen W PorgesAbstract:The current study builds on the emerging autism spectrum disorder (ASD) literature that associates autonomic nervous system activity with social function, and examines the link between respiratory sinus arrhythmia (RSA) and both social behavior and cognitive function. The RSA response pattern was assessed in 23 4- to 7-year-old children diagnosed with an ASD. Higher baseline RSA amplitudes were associated with better social behavior (i.e., more conventional gestures, more instances of joint attention) and Receptive Language abilities. Similar to reports of typically developing children, ASD children with higher RSA amplitude at baseline showed greater RSA and HP reactivity during an attention-demanding task. These results highlight the importance of studying RSA as a marker of positive function in children with ASD. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 55: 101–112, 2013
Michelle A Patriquin - One of the best experts on this subject based on the ideXlab platform.
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respiratory sinus arrhythmia a marker for positive social functioning and Receptive Language skills in children with autism spectrum disorders
Developmental Psychobiology, 2013Co-Authors: Michelle A Patriquin, Angela Scarpa, Bruce H Friedman, Stephen W PorgesAbstract:The current study builds on the emerging autism spectrum disorder (ASD) literature that associates autonomic nervous system activity with social function, and examines the link between respiratory sinus arrhythmia (RSA) and both social behavior and cognitive function. The RSA response pattern was assessed in 23 4- to 7-year-old children diagnosed with an ASD. Higher baseline RSA amplitudes were associated with better social behavior (i.e., more conventional gestures, more instances of joint attention) and Receptive Language abilities. Similar to reports of typically developing children, ASD children with higher RSA amplitude at baseline showed greater RSA and HP reactivity during an attention-demanding task. These results highlight the importance of studying RSA as a marker of positive function in children with ASD.
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respiratory sinus arrhythmia a marker for positive social functioning and Receptive Language skills in children with autism spectrum disorders
Developmental Psychobiology, 2013Co-Authors: Michelle A Patriquin, Angela Scarpa, Bruce H Friedman, Stephen W PorgesAbstract:The current study builds on the emerging autism spectrum disorder (ASD) literature that associates autonomic nervous system activity with social function, and examines the link between respiratory sinus arrhythmia (RSA) and both social behavior and cognitive function. The RSA response pattern was assessed in 23 4- to 7-year-old children diagnosed with an ASD. Higher baseline RSA amplitudes were associated with better social behavior (i.e., more conventional gestures, more instances of joint attention) and Receptive Language abilities. Similar to reports of typically developing children, ASD children with higher RSA amplitude at baseline showed greater RSA and HP reactivity during an attention-demanding task. These results highlight the importance of studying RSA as a marker of positive function in children with ASD. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 55: 101–112, 2013
Michael Rutter - One of the best experts on this subject based on the ideXlab platform.
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association between nonmaternal care in the first year of life and children s Receptive Language skills prior to school entry the moderating role of socioeconomic status
Journal of Child Psychology and Psychiatry, 2007Co-Authors: Marieclaude Geoffroy, Sylvana M Cote, Anne I H Borge, Frank Larouche, Jean R Seguin, Michael RutterAbstract:Background: Studies have suggested that nonmaternal care (NMC) may either carry risks or be beneficial for children’s Language development. However, few tested the possibility that NMC may be more or less protective for children with different family backgrounds. This study investigates the role of the family environment, as reflected in the socioeconomic status (SES), in the association between NMC in the first year of life and children’s Receptive Language skills prior to school entry. Method: A representative sample of 2,297 Canadian children aged between 0 and 11 months at their first assessment was followed over 4 years. Receptive Language skills were assessed with the Peabody Picture Vocabulary Test Revised (PPVT-R) when the child was 4 to 5 years old. Results: After controlling for selection factors, SES was found to moderate the association between NMC and Receptive Language skills: Fulltime NMC in the first year of life was associated with higher PPVT-R scores among children from low SES families (d ¼ .58), but not among children from adequate SES families. Conclusion: Full-time NMC in infancy may contribute to reducing the cognitive inequalities between children of low and adequate SES. Keywords: Language development, cognitive development, nonmaternal care, child-care, socioeconomicstatus,infancy. Abbreviations: NMC:nonmaternalcare;SES:socioeconomicstatus;PPVT-R: Peabody Picture Vocabulary Test Revised. Over the past two decades, considerable attention has been given to the role of nonmaternal care (NMC) experiencesinchildren’searlycognitiveandLanguage development.StudieshavesuggestedthatNMCinthe first year of life may either carry risks (Waldfogel, Han, & Brooks-Gunn, 2002) or be beneficial for children’s cognitive and Language development (Andersson, 1992). Whereas some studies examined the features of NMC that may be related to its protective or detrimental impact, few tested the possibility that NMC may be more or less protective for children with different family backgrounds. Forinstance, NMC may be particularly beneficial for children who grow up in impoverished home environments. Conversely, NMC may be particularly detrimental for children who would otherwise benefit from an enriched home environment. Furthermore, the extent to which NMC may be beneficial or detrimental for subgroups of children may depend on the amount (e.g., part-time vs. full-time) of the experience. The general purpose of the present study was to examine the moderating role of socioeconomic status (SES) in the association between NMC in the first year of life and children’s Receptive Language skills prior to school entry. We refer to nonmaternal care (NMC) as the various forms of non-parental care experienced by preschool children (e.g., daycare centers, family daycare). The moderating role of SES
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autism and developmental Receptive Language disorder a comparative follow up in early adult life i cognitive and Language outcomes
Journal of Child Psychology and Psychiatry, 2000Co-Authors: Lynn Mawhood, Patricia Howlin, Michael RutterAbstract:In this paper we compare adult outcome in a group of young men with autism and a group with developmental Receptive Language disorders. The two groups were first assessed in early childhood, when aged 7 to 8 years of age. Although matched at that time for nonverbal IQ (mean 92-93) and expressive Language ability, the Autism group was significantly more impaired on most measures of social and communication skills and stereotyped behaviours. A later follow-up, in mid-childhood, suggested that although the groups were still quite distinct, social and behavioural problems had become more apparent in the Language group. The current study was completed when the participants were aged, on average, 23 to 24 years. The findings indicated that verbal IQ and Receptive Language scores had improved significantly more in the Autism group than in the Language group over time. Moreover, although the Language group were less severely impaired in their social use of Language, many showed a number of abnormal features in this domain. There were no differences between the groups on tests of reading or spelling. Discriminant function analysis, which had clearly distinguished between the groups as children, now showed much greater overlap between them. Regression analysis indicated that although early Language ability appeared to be related to outcome in the Autism group, in the Language group there was little association between measures of childhood functioning and later progress. The implications of these findings for understanding the nature of the underlying deficit in autism and the relationship between the two disorders are discussed.
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autism and developmental Receptive Language disorder a follow up comparison in early adult life ii social behavioural and psychiatric outcomes
Journal of Child Psychology and Psychiatry, 2000Co-Authors: Patricia Howlin, Lynn Mawhood, Michael RutterAbstract:This paper focuses on general social functioning in two groups of young men, one with autism and one with developmental Receptive Language disorders, who were first assessed at the ages of 7–8 years. At that time, although matched for nonverbal IQ (mean 92–93) and expressive Language, the Language group showed significantly fewer social and behavioural problems. At follow-up, when aged on average, 23 to 24 years, the Autism group continued to show significantly more impairments in terms of stereotyped behaviour patterns, social relationships, jobs, and independence. However, problems in all these areas were also common in the Language group. Many still lived with their parents, few had close friends or permanent jobs, and ratings of social interaction indicated abnormalities in a number of different areas. On a composite measure of social competence only 10% of the Language group was assessed as having severe social difficulties compared to 74% of the Autism group. Nevertheless, 65% were rated as having moderate social problems and only 25% were rated as being of near/normal social functioning. Two individuals in the Language group, but none in the Autism group, had also developed a florid paranoid psychosis in late adolescence. As in the follow-up of cognitive and linguistic functioning (see Mawhood et al., 2000, this volume, pp. 547–559), discriminant function analysis, which had clearly distinguished between the groups as children, now showed much greater overlap between them. Regression analysis indicated that although early Language ability appeared to be related to outcome in the Autism group, there was little association between any measures of childhood functioning and prognosis in the Language group. Theoretically, these findings have implications for our understanding of the nature of autism and other pervasive Language disorders, and of the relationship between them. Practically, they demonstrate the very persistent problems experienced by individuals with developmental Language disorders, and their need for much greater help and support than is presently available.
Katherine C. Hustad - One of the best experts on this subject based on the ideXlab platform.
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speech Language profile groups in school aged children with cerebral palsy nonverbal cognition Receptive Language speech intelligibility and motor function
Developmental Neurorehabilitation, 2021Co-Authors: Jennifer U Soriano, Katherine C. HustadAbstract:Purpose: To explore the relationship of intelligibility, Receptive Language, executive functioning, and motor skills to nonverbal cognitive skills among children with cerebral palsy (CP) in differe...
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Longitudinal growth of Receptive Language in children with cerebral palsy between 18 months and 54 months of age
Developmental Medicine & Child Neurology, 2018Co-Authors: Katherine C. Hustad, Ashley Sakash, Aimee Teo Broman, Paul J. RathouzAbstract:Aim We examined Receptive Language developmental trajectories between 18 months and 54 months for three clinical speech-Language profile groups of children with cerebral palsy (those with speech motor involvement, without speech motor involvement, and with anarthria) and quantified differences from age-level expectations. We identified latent classes of comprehension development, related these classes to clinical profile groups, and examined how well early Receptive Language predicted outcomes. Method We used a prospective longitudinal design. Eighty-five children with cerebral palsy (43 females, 42 males) were followed longitudinally from 18 to 54 months of age. Children were seen two to eight times (322 data points). Children were classified into clinical profile groups. Language comprehension age-equivalent scores were the primary measures of interest. Results Children with anarthria had significant Language delays, limited developmental change over time, and comprised their own latent class. Children with speech motor impairment had slight Receptive Language delays over time. Children with no speech motor impairment had age-appropriate Receptive Language over time. Early Language comprehension scores were highly predictive of later latent profile group membership. Interpretation Early Language comprehension abilities are highly predictive of Language comprehension growth trajectory and suggest that children with early Language delay, particularly those who are non-speaking, should receive Language intervention to support development. What this paper adds There are two growth trajectories for Language comprehension among children with cerebral palsy. Children with speech motor impairment had a constant 6-month Receptive Language delay. Children without speech motor impairment had age-appropriate Receptive Language. Non-speaking children had significant Receptive Language delay. Early Language comprehension change was highly predictive of later trajectory group.
