The Experts below are selected from a list of 26838 Experts worldwide ranked by ideXlab platform
Karim Abdelhalim - One of the best experts on this subject based on the ideXlab platform.
-
320 Channel active probe for high resolution neuromonitoring and responsive neurostimulation
IEEE Transactions on Biomedical Circuits and Systems, 2015Co-Authors: R. Shulyzki, Jose Luis Perez Velazquez, Karim Abdelhalim, Peter L Carlen, Arezu Bagheri, Tariqus M Salam, Carlos M Florez, Roman GenovAbstract:We present a 320-Channel active probe for high-spatial-resolution neuromonitoring and responsive neurostimulation. The probe comprises an integrated circuit (IC) cell array bonded to the back side of a pitch-matched microelectrode array. The IC enables up to 256-site neural Recording and 64-site neural stimulation at the spatial resolution of 400 $\mu$ m and 200 $\mu$ m, respectively. It is suitable for direct integration with electrode arrays with the shank pitch of integer multiples of 200 $\mu$ m. In the presented configuration, the IC is bonded with a 8 $\,\times\,$ 8 400 $\mu$ m-pitch Utah electrode array (UEA) and up to additional 192 Recording Channels are used for peripheral neuromonitoring. The 0.35 $\mu$ m CMOS circuit array has a total die size of 3.5 mm $\,\times\,$ 3.65 mm. Each stimulator Channel employs a current memory for simultaneous multi-site neurostimulation, outputs 20 $\mu$ A–250 $\mu$ A square or arbitrary waveform current, occupies 0.02 mm $^{2}$ , and dissipates 2.76 $\mu$ W quiescent power. Each fully differential Recording Channel has two stages of amplification and filtering and an 8-bit single-slope ADC, occupies 0.035 mm $^{2}$ , and consumes 51.9 $\mu$ W. The neural probe has been experimentally validated in epileptic seizure propagation studies in a mouse hippocampal slice in vitro and in responsive neurostimulation for seizure suppression in an acute epilepsy rat model in vivo .
-
915 mhz fsk ook wireless neural Recording soc with 64 mixed signal fir filters
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Karim Abdelhalim, Jose Luis Perez Velazquez, Larysa Kokarovtseva, Roma GenovAbstract:A system-on-chip (SoC) neural Recording interface with 64 Channels, 64 16-tap programmable mixed-signal FIR filters and a fully integrated 915 MHz OOK/FSK PLL-based wireless transmitter is presented. Each Recording Channel has a fully differential amplifier with 54 dB gain and utilizes a tunable low-distortion subthreshold MOS-resistor to reject DC offsets with an input-referred noise of 6.5 μV and a CMRR of 75 dB. Each Channel contains a modified 8-bit SAR ADC with an ENOB of 7.8-bits and can provide analog-digital multiplication by modifying the the sampling phase of the ADC. It is used in conjunction with 12-bit digital adders and registers to implement 64 programmable transposed FIR filters. The 915 MHz FSK/OOK transmitter offers data rates up to 1.5 Mbps and a maximum output power of 0 dBm. The 4×3 mm2 chip fabricated in a 0.13 μm CMOS process dissipates 5.03 mW from a 1.2 V supply. Experimental measurements characterize the electrical performance of the wireless SoC. In vivo measurement results from freely moving rats are also presented.
-
915 mhz wireless 64 Channel neural Recording soc with programmable mixed signal fir filters
European Solid-State Circuits Conference, 2011Co-Authors: Karim Abdelhalim, Roma GenovAbstract:A system-on-chip (SoC) neural Recording interface with 64 Channels, 64 16-tap programmable mixed-signal FIR filters and a fully integrated 915MHz OOK/FSK closed-loop wireless transmitter is presented. Each Recording Channel has a fully differential amplifier with 54dB of gain and utilizes a tunable low-distortion subthreshold MOS-resistor to reject DC offsets with an input-referred noise of 6.5μV and a CMRR of 78dB. Each Channel contains a modified 8-bit SAR ADC with an ENOB of 7.8-bits and can provide analog-digital multiplication by modifying the the sampling phase of the ADC. It is used in conjunction with 12-bit digital adders and registers to implement 64 programmable transposed FIR filters that enable precise separation of various bands in the neural spectrum. The 915MHz FSK/OOK transmitter offers data rates up to 1.5Mbps with a maximum output power of 0dBm. The 4×3mm chip fabricated in a 0.13μm CMOS process dissipates 5.03mW from a 1.2V supply.
-
the 128 Channel fully differential digital integrated neural Recording and stimulation interface
IEEE Transactions on Biomedical Circuits and Systems, 2010Co-Authors: Farzaneh Shahrokhi, Karim Abdelhalim, Demitre Serletis, Peter L Carlen, Roman GenovAbstract:We present a fully differential 128-Channel integrated neural interface. It consists of an array of 8 X 16 low-power low-noise signal-Recording and generation circuits for electrical neural activity monitoring and stimulation, respectively. The Recording Channel has two stages of signal amplification and conditioning with and a fully differential 8-b column-parallel successive approximation (SAR) analog-to-digital converter (ADC). The total measured power consumption of each Recording Channel, including the SAR ADC, is 15.5 ?W. The measured input-referred noise is 6.08 ? Vrms over a 5-kHz bandwidth, resulting in a noise efficiency factor of 5.6. The stimulation Channel performs monophasic or biphasic voltage-mode stimulation, with a maximum stimulation current of 5 mA and a quiescent power dissipation of 51.5 ?W. The design is implemented in 0.35-?m complementary metal-oxide semiconductor technology with the Channel pitch of 200 ?m for a total die size of 3.4 mm × 2.5 mm and a total power consumption of 9.33 mW. The neural interface was validated in in vitro Recording of a low-Mg2+/high-K+ epileptic seizure model in an intact hippocampus of a mouse.
-
256 Channel neural Recording and delta compression microsystem with 3d electrodes
IEEE Journal of Solid-state Circuits, 2009Co-Authors: J N Y Aziz, Karim Abdelhalim, Demitre Serletis, Roman Genov, R. Shulyzki, Berj L Bardakjian, M Derchansky, Peter L CarlenAbstract:A 3D microsystem for multi-site penetrating extracellular neural Recording from the brain is presented. A 16 times 16-Channel neural Recording interface integrated prototype fabricated in 0.35 mum CMOS occupies 3.5 mm times 4.5 mm area. Each Recording Channel dissipates 15 muW of power with input-referred noise of 7 muVrms over 5 kHz bandwidth. A switched-capacitor delta read-out data compression circuit trades Recording accuracy for the output data rate. An array of 1.5 mm platinum-coated microelectrodes is bonded directly onto the die. Results of in vitro experimental Recordings from intact mouse hippocampus validate the circuit design and the on-chip electrode bonding technology.
Gert Cauwenberghs - One of the best experts on this subject based on the ideXlab platform.
-
sub mu v rms noise sub mu w Channel adc direct neural Recording with 200 mv ms transient recovery through predictive digital autoranging
IEEE Journal of Solid-state Circuits, 2018Co-Authors: Chul Kim, Siddharth Joshi, Hristos S Courellis, Jun Wang, Cory T Miller, Gert CauwenberghsAbstract:Integrated Recording of neural electrical potentials from the brain poses great challenges due to stringent dynamic range requirements to resolve small-signal amplitudes buried in noise amidst large artifact and stimulation transients, as well as stringent power and volume constraints to enable minimally invasive untethered operation. Here, we present a 16-Channel neural Recording system-on-chip with greater than 90-dB input dynamic range and less than 1- $\mu \text{V}_{\mathrm {rms}}$ input-referred noise from dc to 500 Hz, at 0.8- $\mu \text{W}$ power consumption, and 0.024-mm2 area per Channel in a 65-nm CMOS process. Each Recording Channel features a hybrid analog–digital second-order oversampling analog-to-digital converter (ADC), with the biopotential signal coupling directly to the second integrator for high conversion gain and dynamic offset subtraction in the digital domain. This bypasses the need for high-pass filtering pre-amplification in neural Recording systems, which often leads to signal distortion. The integrated ADC-direct neural Recording offers record figure-of-merit with a noise efficiency factor (NEF) of the combined front end and ADC of 1.81, and a corresponding power efficiency factor (PEF) of 2.6. Predictive digital autoranging of the binary quantizer further supports rapid transient recovery while maintaining fully dc-coupled operation. Hence, the neural ADC is capable of Recording ${\le}$ 0.01-Hz slow potentials as well as recovering from $\ge$ 200-mVpp transients within ${\le}$ 1 ms that are important prerequisites to effective electrocortical Recording for brain activity mapping. In vivo Recordings from marmoset primate frontal cortex demonstrate its unique capabilities in resolving ultra-slow local field potentials indicative of subject arousal state.
-
a 92db dynamic range sub μv rms noise 0 8μw ch neural Recording adc array with predictive digital autoranging
International Solid-State Circuits Conference, 2018Co-Authors: Siddharth Joshi, Hristos S Courellis, Jun Wang, Cory T Miller, Gert CauwenberghsAbstract:High-density multi-Channel neural Recording is critical to driving advances in neuroscience and neuroengineering through increasing the spatial resolution and dynamic range of brain-machine interfaces. Neural-signal-acquisition ICs have conventionally been designed composed of two distinct functional blocks per Recording Channel: a low-noise amplifier front-end (AFE), and an analog-digital converter (ADC) [1,2]. Hybrid architectures utilizing oversampling ADCs with digital feedback [3-5] have seen recent adoption due to their increased power and area efficiency. Still, input dynamic range (DR) is relatively limited due to aggressive supply voltage scaling and/or kT/C sampling noise. This paper presents a neural-Recording ADC chip with 92dB input dynamic range and 0.99μV rms of noise at 0.8μW power consumption per Channel over 500Hz signal bandwidth, owing to 1) a predictive digital autoranging (PDA) scheme in a hybrid analog-digital 2nd-order oversampling ADC architecture, 2) no specific sampling process through capacitors, avoiding kT/C noise altogether. Digitally predicting the analog input at 12b resolution from a 1b quantization of the continuously integrated residue at effective 32 oversampling ratio (OSR), the PDA handles a ±130mV electrode differential offset (EDO) and recovers from >200mV pp transient artifacts within <1ms. Furthermore, using digital circuits for integration ensures the architecture benefits from process scaling and the resulting compactness makes it suitable for incorporation in high-density Recording arrays.
Roman Genov - One of the best experts on this subject based on the ideXlab platform.
-
320 Channel active probe for high resolution neuromonitoring and responsive neurostimulation
IEEE Transactions on Biomedical Circuits and Systems, 2015Co-Authors: R. Shulyzki, Jose Luis Perez Velazquez, Karim Abdelhalim, Peter L Carlen, Arezu Bagheri, Tariqus M Salam, Carlos M Florez, Roman GenovAbstract:We present a 320-Channel active probe for high-spatial-resolution neuromonitoring and responsive neurostimulation. The probe comprises an integrated circuit (IC) cell array bonded to the back side of a pitch-matched microelectrode array. The IC enables up to 256-site neural Recording and 64-site neural stimulation at the spatial resolution of 400 $\mu$ m and 200 $\mu$ m, respectively. It is suitable for direct integration with electrode arrays with the shank pitch of integer multiples of 200 $\mu$ m. In the presented configuration, the IC is bonded with a 8 $\,\times\,$ 8 400 $\mu$ m-pitch Utah electrode array (UEA) and up to additional 192 Recording Channels are used for peripheral neuromonitoring. The 0.35 $\mu$ m CMOS circuit array has a total die size of 3.5 mm $\,\times\,$ 3.65 mm. Each stimulator Channel employs a current memory for simultaneous multi-site neurostimulation, outputs 20 $\mu$ A–250 $\mu$ A square or arbitrary waveform current, occupies 0.02 mm $^{2}$ , and dissipates 2.76 $\mu$ W quiescent power. Each fully differential Recording Channel has two stages of amplification and filtering and an 8-bit single-slope ADC, occupies 0.035 mm $^{2}$ , and consumes 51.9 $\mu$ W. The neural probe has been experimentally validated in epileptic seizure propagation studies in a mouse hippocampal slice in vitro and in responsive neurostimulation for seizure suppression in an acute epilepsy rat model in vivo .
-
the 128 Channel fully differential digital integrated neural Recording and stimulation interface
IEEE Transactions on Biomedical Circuits and Systems, 2010Co-Authors: Farzaneh Shahrokhi, Karim Abdelhalim, Demitre Serletis, Peter L Carlen, Roman GenovAbstract:We present a fully differential 128-Channel integrated neural interface. It consists of an array of 8 X 16 low-power low-noise signal-Recording and generation circuits for electrical neural activity monitoring and stimulation, respectively. The Recording Channel has two stages of signal amplification and conditioning with and a fully differential 8-b column-parallel successive approximation (SAR) analog-to-digital converter (ADC). The total measured power consumption of each Recording Channel, including the SAR ADC, is 15.5 ?W. The measured input-referred noise is 6.08 ? Vrms over a 5-kHz bandwidth, resulting in a noise efficiency factor of 5.6. The stimulation Channel performs monophasic or biphasic voltage-mode stimulation, with a maximum stimulation current of 5 mA and a quiescent power dissipation of 51.5 ?W. The design is implemented in 0.35-?m complementary metal-oxide semiconductor technology with the Channel pitch of 200 ?m for a total die size of 3.4 mm × 2.5 mm and a total power consumption of 9.33 mW. The neural interface was validated in in vitro Recording of a low-Mg2+/high-K+ epileptic seizure model in an intact hippocampus of a mouse.
-
256 Channel neural Recording and delta compression microsystem with 3d electrodes
IEEE Journal of Solid-state Circuits, 2009Co-Authors: J N Y Aziz, Karim Abdelhalim, Demitre Serletis, Roman Genov, R. Shulyzki, Berj L Bardakjian, M Derchansky, Peter L CarlenAbstract:A 3D microsystem for multi-site penetrating extracellular neural Recording from the brain is presented. A 16 times 16-Channel neural Recording interface integrated prototype fabricated in 0.35 mum CMOS occupies 3.5 mm times 4.5 mm area. Each Recording Channel dissipates 15 muW of power with input-referred noise of 7 muVrms over 5 kHz bandwidth. A switched-capacitor delta read-out data compression circuit trades Recording accuracy for the output data rate. An array of 1.5 mm platinum-coated microelectrodes is bonded directly onto the die. Results of in vitro experimental Recordings from intact mouse hippocampus validate the circuit design and the on-chip electrode bonding technology.
Roma Genov - One of the best experts on this subject based on the ideXlab platform.
-
915 mhz fsk ook wireless neural Recording soc with 64 mixed signal fir filters
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Karim Abdelhalim, Jose Luis Perez Velazquez, Larysa Kokarovtseva, Roma GenovAbstract:A system-on-chip (SoC) neural Recording interface with 64 Channels, 64 16-tap programmable mixed-signal FIR filters and a fully integrated 915 MHz OOK/FSK PLL-based wireless transmitter is presented. Each Recording Channel has a fully differential amplifier with 54 dB gain and utilizes a tunable low-distortion subthreshold MOS-resistor to reject DC offsets with an input-referred noise of 6.5 μV and a CMRR of 75 dB. Each Channel contains a modified 8-bit SAR ADC with an ENOB of 7.8-bits and can provide analog-digital multiplication by modifying the the sampling phase of the ADC. It is used in conjunction with 12-bit digital adders and registers to implement 64 programmable transposed FIR filters. The 915 MHz FSK/OOK transmitter offers data rates up to 1.5 Mbps and a maximum output power of 0 dBm. The 4×3 mm2 chip fabricated in a 0.13 μm CMOS process dissipates 5.03 mW from a 1.2 V supply. Experimental measurements characterize the electrical performance of the wireless SoC. In vivo measurement results from freely moving rats are also presented.
-
915 mhz wireless 64 Channel neural Recording soc with programmable mixed signal fir filters
European Solid-State Circuits Conference, 2011Co-Authors: Karim Abdelhalim, Roma GenovAbstract:A system-on-chip (SoC) neural Recording interface with 64 Channels, 64 16-tap programmable mixed-signal FIR filters and a fully integrated 915MHz OOK/FSK closed-loop wireless transmitter is presented. Each Recording Channel has a fully differential amplifier with 54dB of gain and utilizes a tunable low-distortion subthreshold MOS-resistor to reject DC offsets with an input-referred noise of 6.5μV and a CMRR of 78dB. Each Channel contains a modified 8-bit SAR ADC with an ENOB of 7.8-bits and can provide analog-digital multiplication by modifying the the sampling phase of the ADC. It is used in conjunction with 12-bit digital adders and registers to implement 64 programmable transposed FIR filters that enable precise separation of various bands in the neural spectrum. The 915MHz FSK/OOK transmitter offers data rates up to 1.5Mbps with a maximum output power of 0dBm. The 4×3mm chip fabricated in a 0.13μm CMOS process dissipates 5.03mW from a 1.2V supply.
Peter L Carlen - One of the best experts on this subject based on the ideXlab platform.
-
320 Channel active probe for high resolution neuromonitoring and responsive neurostimulation
IEEE Transactions on Biomedical Circuits and Systems, 2015Co-Authors: R. Shulyzki, Jose Luis Perez Velazquez, Karim Abdelhalim, Peter L Carlen, Arezu Bagheri, Tariqus M Salam, Carlos M Florez, Roman GenovAbstract:We present a 320-Channel active probe for high-spatial-resolution neuromonitoring and responsive neurostimulation. The probe comprises an integrated circuit (IC) cell array bonded to the back side of a pitch-matched microelectrode array. The IC enables up to 256-site neural Recording and 64-site neural stimulation at the spatial resolution of 400 $\mu$ m and 200 $\mu$ m, respectively. It is suitable for direct integration with electrode arrays with the shank pitch of integer multiples of 200 $\mu$ m. In the presented configuration, the IC is bonded with a 8 $\,\times\,$ 8 400 $\mu$ m-pitch Utah electrode array (UEA) and up to additional 192 Recording Channels are used for peripheral neuromonitoring. The 0.35 $\mu$ m CMOS circuit array has a total die size of 3.5 mm $\,\times\,$ 3.65 mm. Each stimulator Channel employs a current memory for simultaneous multi-site neurostimulation, outputs 20 $\mu$ A–250 $\mu$ A square or arbitrary waveform current, occupies 0.02 mm $^{2}$ , and dissipates 2.76 $\mu$ W quiescent power. Each fully differential Recording Channel has two stages of amplification and filtering and an 8-bit single-slope ADC, occupies 0.035 mm $^{2}$ , and consumes 51.9 $\mu$ W. The neural probe has been experimentally validated in epileptic seizure propagation studies in a mouse hippocampal slice in vitro and in responsive neurostimulation for seizure suppression in an acute epilepsy rat model in vivo .
-
the 128 Channel fully differential digital integrated neural Recording and stimulation interface
IEEE Transactions on Biomedical Circuits and Systems, 2010Co-Authors: Farzaneh Shahrokhi, Karim Abdelhalim, Demitre Serletis, Peter L Carlen, Roman GenovAbstract:We present a fully differential 128-Channel integrated neural interface. It consists of an array of 8 X 16 low-power low-noise signal-Recording and generation circuits for electrical neural activity monitoring and stimulation, respectively. The Recording Channel has two stages of signal amplification and conditioning with and a fully differential 8-b column-parallel successive approximation (SAR) analog-to-digital converter (ADC). The total measured power consumption of each Recording Channel, including the SAR ADC, is 15.5 ?W. The measured input-referred noise is 6.08 ? Vrms over a 5-kHz bandwidth, resulting in a noise efficiency factor of 5.6. The stimulation Channel performs monophasic or biphasic voltage-mode stimulation, with a maximum stimulation current of 5 mA and a quiescent power dissipation of 51.5 ?W. The design is implemented in 0.35-?m complementary metal-oxide semiconductor technology with the Channel pitch of 200 ?m for a total die size of 3.4 mm × 2.5 mm and a total power consumption of 9.33 mW. The neural interface was validated in in vitro Recording of a low-Mg2+/high-K+ epileptic seizure model in an intact hippocampus of a mouse.
-
256 Channel neural Recording and delta compression microsystem with 3d electrodes
IEEE Journal of Solid-state Circuits, 2009Co-Authors: J N Y Aziz, Karim Abdelhalim, Demitre Serletis, Roman Genov, R. Shulyzki, Berj L Bardakjian, M Derchansky, Peter L CarlenAbstract:A 3D microsystem for multi-site penetrating extracellular neural Recording from the brain is presented. A 16 times 16-Channel neural Recording interface integrated prototype fabricated in 0.35 mum CMOS occupies 3.5 mm times 4.5 mm area. Each Recording Channel dissipates 15 muW of power with input-referred noise of 7 muVrms over 5 kHz bandwidth. A switched-capacitor delta read-out data compression circuit trades Recording accuracy for the output data rate. An array of 1.5 mm platinum-coated microelectrodes is bonded directly onto the die. Results of in vitro experimental Recordings from intact mouse hippocampus validate the circuit design and the on-chip electrode bonding technology.