The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Felix Hernandez - One of the best experts on this subject based on the ideXlab platform.
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solid phase microextraction in pesticide Residue Analysis
Journal of Chromatography A, 2000Co-Authors: J Beltran, F J Lopez, Felix HernandezAbstract:The applications of solid-phase microextraction (SPME) for sample preparation in pesticide Residue Analysis are reviewed in this paper taking into account the different approaches of this technique coupled mainly to gas chromatography but also to high-performance liquid chromatography. A complete revision of the existing literature has been made considering the different applications divided according to the pesticide families (organochlorine, organophosphorus, triazines, thiocarbamates, substituted uracils, urea derivatives and dinitroanilines among others) and the sample matrices analysed which included environmental samples (water and soil), food samples and biological fluids. Details on the analytical characteristics of the procedures described in the reviewed papers are given, and new trends in the applications of SPME in this field are discussed.
Lynn Vanhaecke - One of the best experts on this subject based on the ideXlab platform.
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The economics of Residue Analysis
TrAC Trends in Analytical Chemistry, 2011Co-Authors: H.f. De Brabander, Lynn Vanhaecke, J. Vanden Bussche, Wim VerbekeAbstract:Abstract Since the onset of Residue Analysis some 40 years ago, much attention has been paid to several analytical aspects [e.g., the fight to achieve lower limits of detection (LODs), the gain in specificity, and quality assurance]. In recent years, “omic approaches” have also been introduced to accomplish these purposes. However, when reviewing the literature, one “omic” of Residue Analysis is not represented: the economic. Residue Analysis covers a broad working area, including banned (group A) substances and registered veterinary drugs (group B). Some 40 years ago, only thin-layer chromatography and gas chromatography with electron-capture detection were used for A substances, in combination with laborious sample clean-up and thus small sample throughput. The nominal or money price of such an Analysis remained relatively stable from 1970 to 2010. However, the operational costs of Analysis increased considerably over the years, in particular, personnel and equipment costs. But, higher operational costs were countered by much greater sample throughput, although this phenomenon remains limited. For B substances, the strategy of screening with microbiological inhibition tests at a very low price competes with sophisticated ultra-high-performance liquid chromatography with (high-resolution) mass spectrometry systems, where the number of analytes/run can theoretically reach 122,500. The question that we address in this contribution from an economics point of view is: “How do laboratories keep the balance between price of Analysis, specificity, LOD, number of analytes, quantification and quality assurance?”
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The state of the art of Residue Analysis: the 6th VDRA symposium 2010.
Drug testing and analysis, 2010Co-Authors: H.f. De Brabander, J. Vanden Bussche, Klaas Wille, Karen Bekaert, Lynn VanhaeckeAbstract:Since the onset of Residue Analysis (ca 40 years ago) a lot of attention has been paid to the amelioration of analytical methods, for example, lowering the limits of detection (LOD) and limits of quantification (LOQ) or decision limits (CCα) and detection capabilities (CCβ), including an increase in the number of analytes, shortening runtimes, increasing sample throughput, amongst others. The state of the art in Residue Analysis, which was presented at the VDRA 2010 symposium (Hormone and Veterinary Drug Residue Analysis) in Ghent is reviewed in this article. From an analytical point of view, the use of ultra high performance liquid chromatography (UHPLC) hyphenated with accurate mass spectrometry is often used in combination with other (biological) detection systems and ‘omic’ approaches. Through these techniques more xenobiotic substances turn out to be naturally occurring in some matrices and/or circumstances (e.g. thiouracil, chloramphenicol and semicarbazide). Copyright © 2010 John Wiley & Sons, Ltd.
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Residue Analysis future trends from a historical perspective
Journal of Chromatography A, 2009Co-Authors: H.f. De Brabander, Karolien Verheyden, Lynn Vanhaecke, Wim Reybroeck, Klaas Wille, H Noppe, J Vanden Bussche, L Okerman, Sigrid Ooghe, Siska CroubelsAbstract:A Residue is a trace (microg kg(-1), ng kg(-1)) of a substance, present in a matrix. Residue Analysis is a relatively young discipline and a very broad area, including banned (A) substances as well as registered veterinary medicinal products (B substances). The objective of this manuscript is to review future trends in the Analysis of Residues of veterinary drugs in meat producing animals out of historical perspectives. The Analysis of Residues in meat producing animals has known a tremendous evolution during the past 35-40 years. In the future, it can be foreseen that this evolution will proceed in the direction of the use of more and more sophisticated and expensive machines. These apparatus, and the necessary human resources for their use, will only be affordable for laboratories with sufficient financial resources and having guarantee for a sufficient throughput of samples.
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UHPLC Coupled with Fourier Transform Orbitrap for Residue Analysis
LC GC EUROPE, 2009Co-Authors: Lynn Vanhaecke, Karolien Verheyden, Frans Schoutsen, Julie Vanden Bussche, Hubert De BrabanderAbstract:The trend In Residue Analysis has changed from target-oriented procedures - mainly based on liquid chromatography combined with triple-quadrupole mass spectrometric (MS) detection -towards accurate mass full-scan MS techniques [e.g., time-of-flight (TOF) and Fourier transform mass spectrometry (FT-MS)]. Full-scan MS approaches allow the retrospective evaluation of old data and support multi-Residue applications, including different classes of Residues andlor metabolites. This article describes these developments and addresses the implications of 20021657lEC.
H.f. De Brabander - One of the best experts on this subject based on the ideXlab platform.
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The economics of Residue Analysis
TrAC Trends in Analytical Chemistry, 2011Co-Authors: H.f. De Brabander, Lynn Vanhaecke, J. Vanden Bussche, Wim VerbekeAbstract:Abstract Since the onset of Residue Analysis some 40 years ago, much attention has been paid to several analytical aspects [e.g., the fight to achieve lower limits of detection (LODs), the gain in specificity, and quality assurance]. In recent years, “omic approaches” have also been introduced to accomplish these purposes. However, when reviewing the literature, one “omic” of Residue Analysis is not represented: the economic. Residue Analysis covers a broad working area, including banned (group A) substances and registered veterinary drugs (group B). Some 40 years ago, only thin-layer chromatography and gas chromatography with electron-capture detection were used for A substances, in combination with laborious sample clean-up and thus small sample throughput. The nominal or money price of such an Analysis remained relatively stable from 1970 to 2010. However, the operational costs of Analysis increased considerably over the years, in particular, personnel and equipment costs. But, higher operational costs were countered by much greater sample throughput, although this phenomenon remains limited. For B substances, the strategy of screening with microbiological inhibition tests at a very low price competes with sophisticated ultra-high-performance liquid chromatography with (high-resolution) mass spectrometry systems, where the number of analytes/run can theoretically reach 122,500. The question that we address in this contribution from an economics point of view is: “How do laboratories keep the balance between price of Analysis, specificity, LOD, number of analytes, quantification and quality assurance?”
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The state of the art of Residue Analysis: the 6th VDRA symposium 2010.
Drug testing and analysis, 2010Co-Authors: H.f. De Brabander, J. Vanden Bussche, Klaas Wille, Karen Bekaert, Lynn VanhaeckeAbstract:Since the onset of Residue Analysis (ca 40 years ago) a lot of attention has been paid to the amelioration of analytical methods, for example, lowering the limits of detection (LOD) and limits of quantification (LOQ) or decision limits (CCα) and detection capabilities (CCβ), including an increase in the number of analytes, shortening runtimes, increasing sample throughput, amongst others. The state of the art in Residue Analysis, which was presented at the VDRA 2010 symposium (Hormone and Veterinary Drug Residue Analysis) in Ghent is reviewed in this article. From an analytical point of view, the use of ultra high performance liquid chromatography (UHPLC) hyphenated with accurate mass spectrometry is often used in combination with other (biological) detection systems and ‘omic’ approaches. Through these techniques more xenobiotic substances turn out to be naturally occurring in some matrices and/or circumstances (e.g. thiouracil, chloramphenicol and semicarbazide). Copyright © 2010 John Wiley & Sons, Ltd.
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Residue Analysis future trends from a historical perspective
Journal of Chromatography A, 2009Co-Authors: H.f. De Brabander, Karolien Verheyden, Lynn Vanhaecke, Wim Reybroeck, Klaas Wille, H Noppe, J Vanden Bussche, L Okerman, Sigrid Ooghe, Siska CroubelsAbstract:A Residue is a trace (microg kg(-1), ng kg(-1)) of a substance, present in a matrix. Residue Analysis is a relatively young discipline and a very broad area, including banned (A) substances as well as registered veterinary medicinal products (B substances). The objective of this manuscript is to review future trends in the Analysis of Residues of veterinary drugs in meat producing animals out of historical perspectives. The Analysis of Residues in meat producing animals has known a tremendous evolution during the past 35-40 years. In the future, it can be foreseen that this evolution will proceed in the direction of the use of more and more sophisticated and expensive machines. These apparatus, and the necessary human resources for their use, will only be affordable for laboratories with sufficient financial resources and having guarantee for a sufficient throughput of samples.
J Beltran - One of the best experts on this subject based on the ideXlab platform.
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solid phase microextraction in pesticide Residue Analysis
Journal of Chromatography A, 2000Co-Authors: J Beltran, F J Lopez, Felix HernandezAbstract:The applications of solid-phase microextraction (SPME) for sample preparation in pesticide Residue Analysis are reviewed in this paper taking into account the different approaches of this technique coupled mainly to gas chromatography but also to high-performance liquid chromatography. A complete revision of the existing literature has been made considering the different applications divided according to the pesticide families (organochlorine, organophosphorus, triazines, thiocarbamates, substituted uracils, urea derivatives and dinitroanilines among others) and the sample matrices analysed which included environmental samples (water and soil), food samples and biological fluids. Details on the analytical characteristics of the procedures described in the reviewed papers are given, and new trends in the applications of SPME in this field are discussed.
Ming Keong Wong - One of the best experts on this subject based on the ideXlab platform.
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Minimization of solvent consumption in pesticide Residue Analysis
Journal of Chromatography A, 1996Co-Authors: Hai Bin Wan, Ming Keong WongAbstract:The present paper reviews various pathways that will lead to reduction of organic solvent usage in pesticide Residue Analysis. Considerable reduction of solvent consumption can be achieved by miniaturizing the scale of sample extraction and cleanup and by simplifying the analytical procedures. Adoption of new analytical techniques, such as solid-phase microextraction and supercritical fluid extraction can also help to reduce the solvent consumption considerably. With the development of various new techniques in analytical chemistry, reduction of solvent consumption in pesticide Residue Analysis should not be a big technical problem anymore. The important point is to treat the issue as equally important as sensitivity and accuracy when developing a method.